LOCUS       NM_001108202            1513 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus delta like non-canonical Notch ligand 2 (Dlk2),
            mRNA.
ACCESSION   NM_001108202 XM_001066514 XM_236931
VERSION     NM_001108202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Nueda,M.L., Naranjo,A.I., Baladron,V. and Laborda,J.
  TITLE     The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation
            and oncogenic potential of human SK-MEL-2 melanoma cells
  JOURNAL   Biochim Biophys Acta 1843 (11), 2674-2684 (2014)
   PUBMED   25093684
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Sanchez-Solana,B., Nueda,M.L., Ruvira,M.D., Ruiz-Hidalgo,M.J.,
            Monsalve,E.M., Rivero,S., Garcia-Ramirez,J.J., Diaz-Guerra,M.J.,
            Baladron,V. and Laborda,J.
  TITLE     The EGF-like proteins DLK1 and DLK2 function as inhibitory
            non-canonical ligands of NOTCH1 receptor that modulate each other's
            activities
  JOURNAL   Biochim Biophys Acta 1813 (6), 1153-1164 (2011)
   PUBMED   21419176
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Nueda,M.L., Baladron,V., Garcia-Ramirez,J.J., Sanchez-Solana,B.,
            Ruvira,M.D., Rivero,S., Ballesteros,M.A., Monsalve,E.M.,
            Diaz-Guerra,M.J., Ruiz-Hidalgo,M.J. and Laborda,J.
  TITLE     The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as
            a modulator of adipogenesis
  JOURNAL   J Mol Biol 367 (5), 1270-1280 (2007)
   PUBMED   17320102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 13, 2022 this sequence version replaced NM_001108202.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.30910.1,
                                           SRR26643294.35618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000009.1  22179013-22179149   c
            138-268             JAXUCZ010000009.1  22178396-22178526   c
            269-332             JAXUCZ010000009.1  22178077-22178140   c
            333-463             JAXUCZ010000009.1  22176825-22176955   c
            464-608             JAXUCZ010000009.1  22176146-22176290   c
            609-1513            JAXUCZ010000009.1  22174667-22175571   c
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1513
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /note="delta like non-canonical Notch ligand 2"
                     /db_xref="GeneID:316232"
                     /db_xref="RGD:1309143"
     exon            1..137
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
     exon            138..268
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1341
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /note="EGF-like protein 9; endothelial cell-specific
                     protein S-1; epidermal growth factor-like protein 9;
                     EGF-like-domain, multiple 9; protein delta homolog 2;
                     delta-like 2 homolog"
                     /codon_start=1
                     /product="protein delta homolog 2 precursor"
                     /protein_id="NP_001101672.1"
                     /db_xref="GeneID:316232"
                     /db_xref="RGD:1309143"
                     /translation="MPSGCRCLNLVCLLCILGATSQPARADDCSSHCDLAHGCCAPDG
                     SCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTSQSPCQ
                     NGGQCVYDGGGEYHCVCLPGFRGRGCERKAGPCEQAGFPCQNGGQCQDNQGFALNFTC
                     RCLAGFMGAHCEVNVDDCLMRPCANGATCIDGINRFSCLCPEGFAGRFCTINLDDCAS
                     RPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPAPDPATIGTPQAPASAVVVPATGS
                     APHSAGAGLLRISVKEVVRRQEAGLGESSLVALVVFGSLTAALVLATVLLTLRAWRRG
                     ICPTGPCCDPAPHYAPARQDQECQVSMLPAGFPLSPDLPPEPGKTTAL"
     exon            269..332
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
     exon            333..463
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
     exon            464..608
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1513
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattcccga gcgctcggct ggcatggcag ccacctcggt gccgagcccc gcggccagct
       61 aggggcggcc ccctggccca gtccgtcgga tcccgcttga ctctgcgccc tggggacgcg
      121 tcgcctccca gccggaggtg tctacacgtc tggccgttca tccgtccgtc cctcctgagg
      181 ccggaactga ccatgcccag cggctgccgc tgcctaaatc tcgtgtgcct gctgtgcatc
      241 ctgggggcaa ccagccagcc tgccagagcg gatgactgca gctcccactg tgacctggcc
      301 cacggctgct gcgctcctga cggctcttgc aggtgtgacc caggctggga ggggctgcac
      361 tgtgagcgct gtgtgaggat gcccgggtgc cagcacggta cctgccacca gccctggcag
      421 tgcatctgcc acagtggctg ggcaggaaag ttctgtgaca aagatgagca catctgtact
      481 tcacaatcac cctgccagaa tggaggccag tgtgtgtatg acgggggtgg tgagtaccac
      541 tgtgtgtgcc tgccaggctt ccgtggacgt ggctgtgagc gcaaggctgg accttgtgag
      601 caggcaggct tcccgtgcca gaacggaggg cagtgccagg acaaccaggg ttttgccctc
      661 aacttcacct gccgctgctt ggcgggattc atgggtgccc actgtgaggt caatgtggat
      721 gactgtctga tgcggccttg cgctaacggt gccacatgta ttgacggcat aaaccgcttt
      781 tcctgcctct gtcctgaggg cttcgctgga cgcttctgca ccatcaacct agatgactgt
      841 gctagccgcc cgtgccagag aggggcccgc tgcagggacc gtgtccatga ctttgactgc
      901 ctgtgcccca gtggctatgg tggcaagact tgtgagcttg tcttacctgc tccggaccct
      961 gccacaatag gcaccccgca agcgcccgcc tcagctgtgg tggtgcctgc tacggggtcg
     1021 gcccctcaca gtgcaggggc aggcctgctg aggatctcag tgaaggaggt ggtgcggagg
     1081 caggaggctg ggcttggtga gtctagcctg gtcgctctgg tggtgtttgg gtccctcact
     1141 gctgctctgg tcctggccac tgtgttgctg accctgaggg catggcgccg aggtatatgc
     1201 cccactggac cctgttgtga cccagcccca cactacgcac cagctcggca ggatcaggag
     1261 tgtcaggtta gcatgctgcc agcagggttc cctctgtcac cagacctgcc ccctgagcct
     1321 gggaagacca cagcgctgtg atggagggtg gctttctagc tgccgtcctt acctcctttc
     1381 acctcagact gtcaccagcc ctcagctttg gtacacccat ccaggggatt tcagcctcac
     1441 atcagaaata ttattttttt aaaacacaga atgtaagata ggaattttat caaataaaat
     1501 tatgaaaatg caa
//
