LOCUS       NP_001101672             382 aa            linear   ROD 03-APR-2024
DEFINITION  protein delta homolog 2 precursor [Rattus norvegicus].
ACCESSION   NP_001101672 XP_001066514 XP_236931
VERSION     NP_001101672.1
DBSOURCE    REFSEQ: accession NM_001108202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Nueda,M.L., Naranjo,A.I., Baladron,V. and Laborda,J.
  TITLE     The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation
            and oncogenic potential of human SK-MEL-2 melanoma cells
  JOURNAL   Biochim Biophys Acta 1843 (11), 2674-2684 (2014)
   PUBMED   25093684
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Sanchez-Solana,B., Nueda,M.L., Ruvira,M.D., Ruiz-Hidalgo,M.J.,
            Monsalve,E.M., Rivero,S., Garcia-Ramirez,J.J., Diaz-Guerra,M.J.,
            Baladron,V. and Laborda,J.
  TITLE     The EGF-like proteins DLK1 and DLK2 function as inhibitory
            non-canonical ligands of NOTCH1 receptor that modulate each other's
            activities
  JOURNAL   Biochim Biophys Acta 1813 (6), 1153-1164 (2011)
   PUBMED   21419176
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Nueda,M.L., Baladron,V., Garcia-Ramirez,J.J., Sanchez-Solana,B.,
            Ruvira,M.D., Rivero,S., Ballesteros,M.A., Monsalve,E.M.,
            Diaz-Guerra,M.J., Ruiz-Hidalgo,M.J. and Laborda,J.
  TITLE     The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as
            a modulator of adipogenesis
  JOURNAL   J Mol Biol 367 (5), 1270-1280 (2007)
   PUBMED   17320102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001066514.1, XP_236931.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.30910.1,
                                           SRR26643294.35618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     Protein         1..382
                     /product="protein delta homolog 2 precursor"
                     /note="EGF-like protein 9; endothelial cell-specific
                     protein S-1; epidermal growth factor-like protein 9;
                     EGF-like-domain, multiple 9; protein delta homolog 2;
                     delta-like 2 homolog"
                     /calculated_mol_wt=37572
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2691
     mat_peptide     27..382
                     /product="Protein delta homolog 2. /id=PRO_0000410797"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZUK3.1)"
                     /calculated_mol_wt=37572
     Region          89..129
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(89,92,110)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            157
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZUK3.1)"
     Region          174..210
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(174,177,191)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          212..248
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(212,215,229)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            306..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZUK3.1)"
     CDS             1..382
                     /gene="Dlk2"
                     /gene_synonym="DLK-2; Egfl9"
                     /coded_by="NM_001108202.2:193..1341"
                     /db_xref="GeneID:316232"
                     /db_xref="RGD:1309143"
ORIGIN      
        1 mpsgcrclnl vcllcilgat sqparaddcs shcdlahgcc apdgscrcdp gweglhcerc
       61 vrmpgcqhgt chqpwqcich sgwagkfcdk dehictsqsp cqnggqcvyd gggeyhcvcl
      121 pgfrgrgcer kagpceqagf pcqnggqcqd nqgfalnftc rclagfmgah cevnvddclm
      181 rpcangatci dginrfsclc pegfagrfct inlddcasrp cqrgarcrdr vhdfdclcps
      241 gyggktcelv lpapdpatig tpqapasavv vpatgsaphs agagllrisv kevvrrqeag
      301 lgesslvalv vfgsltaalv latvlltlra wrrgicptgp ccdpaphyap arqdqecqvs
      361 mlpagfplsp dlppepgktt al
//
