LOCUS       NM_053744               1539 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus delta like non-canonical Notch ligand 1 (Dlk1),
            mRNA.
ACCESSION   NM_053744 XM_346776
VERSION     NM_053744.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Perramon,M., Carvajal,S., Reichenbach,V., Fernandez-Varo,G.,
            Boix,L., Macias-Munoz,L., Melgar-Lesmes,P., Bruix,J., Melmed,S.,
            Lamas,S. and Jimenez,W.
  TITLE     The pituitary tumour-transforming gene 1/delta-like homologue 1
            pathway plays a key role in liver fibrogenesis
  JOURNAL   Liver Int 42 (3), 651-662 (2022)
   PUBMED   35050550
  REMARK    GeneRIF: The pituitary tumour-transforming gene 1/delta-like
            homologue 1 pathway plays a key role in liver fibrogenesis.
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Chen,Y., Gao,H., Liu,Q., Xie,W., Li,B., Cheng,S., Guo,J., Fang,Q.,
            Zhu,H., Wang,Z., Wang,J., Li,C. and Zhang,Y.
  TITLE     Functional characterization of DLK1/MEG3 locus on chromosome
            14q32.2 reveals the differentiation of pituitary neuroendocrine
            tumors
  JOURNAL   Aging (Albany NY) 13 (1), 1422-1439 (2020)
   PUBMED   33472171
  REMARK    GeneRIF: Functional characterization of DLK1/MEG3 locus on
            chromosome 14q32.2 reveals the differentiation of pituitary
            neuroendocrine tumors.
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Carreras-Badosa,G., Remesar,X., Prats-Puig,A., Xargay-Torrent,S.,
            Lizarraga-Mollinedo,E., de Zegher,F., Ibanez,L., Bassols,J. and
            Lopez-Bermejo,A.
  TITLE     Dlk1 expression relates to visceral fat expansion and insulin
            resistance in male and female rats with postnatal catch-up growth
  JOURNAL   Pediatr Res 86 (2), 195-201 (2019)
   PUBMED   31091532
  REMARK    GeneRIF: Decreased Dlk1 expression relates to visceral fat
            expansion and insulin resistance in a rat model of catch-up growth
            following prenatal growth restriction
            Erratum:[Pediatr Res. 2024 Jan;95(1):406. doi:
            10.1038/s41390-023-02691-2.. PMID: 37316710]
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Peng,Y., Jia,L.M., Li,B.X., Xie,L.P., Xie,Z.J. and Zheng,J.H.
  TITLE     Expression of Pref-1 and Related Chemokines during theDevelopment
            of Rat Mesenteric Lymph Nodes
  JOURNAL   Biomed Environ Sci 31 (7), 507-514 (2018)
   PUBMED   30145985
  REMARK    GeneRIF: Adipocyte progenitor cells are involved in the rat
            mesenteric lymph node (MLN) development through differentiation
            into fibroblastic reticular cells or follicular dendritic cells;
            expression of the relevant chemokines during the development of
            MLNs is dynamic and may be related to the maintenance of lymph
            nodes self-balance state.
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Baba,L.I., Gall,Z., Biro,I.L., Mezei,T., Kun,I.Z. and Kolcsar,M.
  TITLE     Chronic fluoxetine treatment induces lipid accumulation but does
            not alter the expression of Pref-1 in rat adipose tissue
  JOURNAL   Acta Pharm 68 (1), 109-115 (2018)
   PUBMED   29453913
  REMARK    GeneRIF: Neither of the two doses of FLX has significantly affected
            the Pref-1 expression in any type of adipose tissue.
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Hedlund,G.P., Carlsson,H.E., Shieck,E., Nilsson,I., Lundblad,C.,
            Arons,S., Iversen,A.K., Looman,C., Jensen,H.E. and Hau,J.
  TITLE     Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and
            pituitary gland
  JOURNAL   In Vivo 17 (1), 1-4 (2003)
   PUBMED   12655782
  REMARK    GeneRIF: localisation in rat was in the medulla and the zona
            glomerulosa of the cortex of the adrenal glands, in the pars
            distalis of the adenohypophysis, and in the ovarian granulosa
            lutein cells but no staining was found in the pancreas
REFERENCE   7  (bases 1 to 1539)
  AUTHORS   Halder,S.K., Takemori,H., Hatano,O., Nonaka,Y., Wada,A. and
            Okamoto,M.
  TITLE     Cloning of a membrane-spanning protein with epidermal growth
            factor-like repeat motifs from adrenal glomerulosa cells
  JOURNAL   Endocrinology 139 (7), 3316-3328 (1998)
   PUBMED   9645708
REFERENCE   8  (bases 1 to 1539)
  AUTHORS   Carlsson,C., Tornehave,D., Lindberg,K., Galante,P., Billestrup,N.,
            Michelsen,B., Larsson,L.I. and Nielsen,J.H.
  TITLE     Growth hormone and prolactin stimulate the expression of rat
            preadipocyte factor-1/delta-like protein in pancreatic islets:
            molecular cloning and expression pattern during development and
            growth of the endocrine pancreas
  JOURNAL   Endocrinology 138 (9), 3940-3948 (1997)
   PUBMED   9275085
REFERENCE   9  (bases 1 to 1539)
  AUTHORS   Jensen,C.H., Krogh,T.N., Hojrup,P., Clausen,P.P., Skjodt,K.,
            Larsson,L.I., Enghild,J.J. and Teisner,B.
  TITLE     Protein structure of fetal antigen 1 (FA1). A novel circulating
            human epidermal-growth-factor-like protein expressed in
            neuroendocrine tumors and its relation to the gene products of dlk
            and pG2
  JOURNAL   Eur J Biochem 225 (1), 83-92 (1994)
   PUBMED   7925474
REFERENCE   10 (bases 1 to 1539)
  AUTHORS   Smas,C.M. and Sul,H.S.
  TITLE     Pref-1, a protein containing EGF-like repeats, inhibits adipocyte
            differentiation
  JOURNAL   Cell 73 (4), 725-734 (1993)
   PUBMED   8500166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053744.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84336.1, BC167752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000006.1  134192597-134192799
            204-267             JAXUCZ010000006.1  134194047-134194110
            268-398             JAXUCZ010000006.1  134194564-134194694
            399-540             JAXUCZ010000006.1  134197270-134197411
            541-1539            JAXUCZ010000006.1  134198781-134199779
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1539
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /note="delta like non-canonical Notch ligand 1"
                     /db_xref="GeneID:114587"
                     /db_xref="RGD:619931"
     exon            1..203
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1288
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /note="delta-like 1 homolog; protein delta homolog 1;
                     preadipocyte factor 1"
                     /codon_start=1
                     /product="protein delta homolog 1 precursor"
                     /protein_id="NP_446196.1"
                     /db_xref="GeneID:114587"
                     /db_xref="RGD:619931"
                     /translation="MIATGALLRVLLLLLAFGHSTYGAECDPACDPQHGFCEADNVCR
                     CEPGWEGPLCEKCVTSPGCVNGLCEEPWQCVCKEGWDGKFCEIDIRACTSTPCANNGT
                     CVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGRASHASCLCPP
                     GFSGNFCEIVTNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCL
                     NGGTCLQHTQVSFECLCKPPFMGPTCAKKRGTSPVQVTHLPSGYGLTYRLTPGVHELP
                     VQQPEHHILKVSMKELNKSAPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCEAWV
                     SNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEDI"
     exon            204..267
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /inference="alignment:Splign:2.1.0"
     exon            268..398
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /inference="alignment:Splign:2.1.0"
     exon            399..540
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /inference="alignment:Splign:2.1.0"
     exon            541..1539
                     /gene="Dlk1"
                     /gene_synonym="DLK-1; Pref-1; Zog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggtgcaa ccctggcttt ctttccgctg gacacccgtg cccccttcgt ggtccgcaac
       61 cagaagccca gcgcagcccc cggagcagcc cctgcaccgc caccgctacc cggaccacga
      121 cccaggccgc cccgagatga tcgcgaccgg agccctcctg cgcgtcctct tgctcctgct
      181 ggctttcggc cacagcacct atggggctga gtgcgacccg gcctgtgacc ctcagcatgg
      241 attctgtgag gctgacaatg tctgcaggtg tgagcctggc tgggagggcc ccctgtgtga
      301 gaagtgcgta acctcccctg gctgtgttaa tggactctgt gaagaaccat ggcagtgtgt
      361 ctgcaaggaa ggctgggacg ggaaattctg cgaaatagat attcgggctt gcacctctac
      421 cccctgcgcc aacaatggga cttgcgtgga cctcgagaaa ggccagtacg aatgctcctg
      481 cacccctgga ttctctggaa aggactgtca gcacaaggct gggccctgcg tgatcaatgg
      541 ttctccctgc cagcacggag gcgcctgcgt ggatgatgag ggccgggcct cgcatgcttc
      601 ctgcctgtgc ccccctggct tctcgggcaa cttctgtgag atcgtgacca acagctgtac
      661 ccctaaccca tgcgagaacg atggcgtctg caccgacatc gggggcgact tccgttgccg
      721 ctgcccagct ggattcgtcg acaagacctg cagccgtccg gtgagcaact gcgccagtgg
      781 cccgtgcctg aacgggggca cctgcctcca gcacacccag gtgagcttcg agtgtctgtg
      841 caagcccccg ttcatgggtc ccacatgcgc gaagaagcgc gggaccagcc ccgtgcaggt
      901 cacccaccta cccagcggct acgggctcac ctaccgcctg acccccgggg tgcacgagct
      961 acctgtccag cagcccgagc accacatcct gaaggtgtcc atgaaagagc tcaacaagag
     1021 tgcccctctc ctcaccgagg gacaggccat ctgcttcacc atcctgggcg tgctcaccag
     1081 cctggttgtg ctgggcaccg tggccatcgt ctttctcaac aagtgcgagg cctgggtgtc
     1141 caacctgcgc tacaaccaca tgcttcgcaa gaagaagaac ctgctgttgc agtacaacag
     1201 cggcgaggag ctggcggtca atatcatctt cccggagaag atcgacatga ccaccttcaa
     1261 caaggaggct ggtgatgagg atatctaagc agcgtgtccc ctccccctcc cccaggccct
     1321 tctacattat cggggttcct cacagctccc tctatgcgct ctatgcttct ttgtggtgga
     1381 gttcgctctt gtgtggaatc tagtgaacgc tacgcttaca tttattgtct cgtgttgctg
     1441 tgtgacaagc tgccgctaag aacccctccc tccctccctc cctccctccc tattaatgca
     1501 tgatataatg aataataata agaatttcat ctctaaatg
//
