LOCUS       NM_173138               3881 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus DLG associated protein 3 (Dlgap3), transcript
            variant 1, mRNA.
ACCESSION   NM_173138
VERSION     NM_173138.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3881)
  AUTHORS   Chua,J.J., Schob,C., Rehbein,M., Gkogkas,C.G., Richter,D. and
            Kindler,S.
  TITLE     Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via
            alternative translational initiation
  JOURNAL   Sci Rep 2, 484 (2012)
   PUBMED   22761992
  REMARK    GeneRIF: alternative translation initiation events appear to
            regulate relative expression of distinct SAPAP3 isoforms in
            different brain regions, which may function to influence synaptic
            plasticity.
REFERENCE   2  (bases 1 to 3881)
  AUTHORS   Welch,J.M., Lu,J., Rodriguiz,R.M., Trotta,N.C., Peca,J., Ding,J.D.,
            Feliciano,C., Chen,M., Adams,J.P., Luo,J., Dudek,S.M.,
            Weinberg,R.J., Calakos,N., Wetsel,W.C. and Feng,G.
  TITLE     Cortico-striatal synaptic defects and OCD-like behaviours in
            Sapap3-mutant mice
  JOURNAL   Nature 448 (7156), 894-900 (2007)
   PUBMED   17713528
REFERENCE   3  (bases 1 to 3881)
  AUTHORS   Castejon,O.J., Fuller,L. and Dailey,M.E.
  TITLE     Localization of synapsin-I and PSD-95 in developing postnatal rat
            cerebellar cortex
  JOURNAL   Brain Res Dev Brain Res 151 (1-2), 25-32 (2004)
   PUBMED   15246689
  REMARK    GeneRIF: During the first postnatal week,PSD-95 immunoreactive
            strongly concentrated in the Purkinje cell layer.By P14, PSD-95
            localized to many small puncta in the ML and to large clusters at
            mossy fiber rosettes in the glomerular layer.
REFERENCE   4  (bases 1 to 3881)
  AUTHORS   Kindler,S., Rehbein,M., Classen,B., Richter,D. and Bockers,T.M.
  TITLE     Distinct spatiotemporal expression of SAPAP transcripts in the
            developing rat brain: a novel dendritically localized mRNA
  JOURNAL   Brain Res Mol Brain Res 126 (1), 14-21 (2004)
   PUBMED   15207911
REFERENCE   5  (bases 1 to 3881)
  AUTHORS   Welch,J.M., Wang,D. and Feng,G.
  TITLE     Differential mRNA expression and protein localization of the
            SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of
            the mouse
  JOURNAL   J Comp Neurol 472 (1), 24-39 (2004)
   PUBMED   15024750
REFERENCE   6  (bases 1 to 3881)
  AUTHORS   Kitano,J., Yamazaki,Y., Kimura,K., Masukado,T., Nakajima,Y. and
            Nakanishi,S.
  TITLE     Tamalin is a scaffold protein that interacts with multiple neuronal
            proteins in distinct modes of protein-protein association
  JOURNAL   J Biol Chem 278 (17), 14762-14768 (2003)
   PUBMED   12586822
REFERENCE   7  (bases 1 to 3881)
  AUTHORS   Kawabe,H., Hata,Y., Takeuchi,M., Ide,N., Mizoguchi,A. and Takai,Y.
  TITLE     nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that
            interacts with synapse-associated protein 90/postsynaptic
            density-95-associated protein (SAPAP)
  JOURNAL   J Biol Chem 274 (43), 30914-30918 (1999)
   PUBMED   10521485
REFERENCE   8  (bases 1 to 3881)
  AUTHORS   Tu,J.C., Xiao,B., Naisbitt,S., Yuan,J.P., Petralia,R.S.,
            Brakeman,P., Doan,A., Aakalu,V.K., Lanahan,A.A., Sheng,M. and
            Worley,P.F.
  TITLE     Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of
            postsynaptic density proteins
  JOURNAL   Neuron 23 (3), 583-592 (1999)
   PUBMED   10433269
REFERENCE   9  (bases 1 to 3881)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   10 (bases 1 to 3881)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 2, 2021 this sequence version replaced NM_173138.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript which can encode two isoforms based on alternate
            in-frame translation starts (PMID: 227619920). The longer isoform
            (1, also known as alpha) represented in this RefSeq is translated
            from the upstream AUG start codon.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29075.1,
                                           SRR26643292.23114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 22761992
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  144777295-144777457
            164-246             JAXUCZ010000005.1  144800268-144800350
            247-1398            JAXUCZ010000005.1  144801747-144802898
            1399-1604           JAXUCZ010000005.1  144806885-144807090
            1605-1677           JAXUCZ010000005.1  144807430-144807502
            1678-1891           JAXUCZ010000005.1  144820400-144820613
            1892-2205           JAXUCZ010000005.1  144820780-144821093
            2206-2291           JAXUCZ010000005.1  144821373-144821458
            2292-2776           JAXUCZ010000005.1  144843562-144844046
            2777-2868           JAXUCZ010000005.1  144845054-144845145
            2869-3012           JAXUCZ010000005.1  144845471-144845614
            3013-3881           JAXUCZ010000005.1  144846229-144847097
FEATURES             Location/Qualifiers
     source          1..3881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3881
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /note="DLG associated protein 3"
                     /db_xref="GeneID:286923"
                     /db_xref="RGD:708349"
     exon            1..163
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            164..246
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      230..301
                     /regulatory_class="uORF"
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:22761992]"
                     /note="this uORF is predicted to encode a 23 aa peptide
                     (PMID:22761992)"
     exon            247..1398
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3231
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /note="isoform 1 is encoded by transcript variant 1; disks
                     large-associated protein 3; PSD-95/SAP90-binding protein
                     3; SAP90/PSD-95-associated protein 3;
                     PSD-95/SAP90-associated protein-3; discs large homolog
                     associated protein 3"
                     /codon_start=1
                     /product="disks large-associated protein 3 isoform 1"
                     /protein_id="NP_775161.2"
                     /db_xref="GeneID:286923"
                     /db_xref="RGD:708349"
                     /translation="MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTE
                     PRFCAPRAGLGHLSPEGPLSLSEGPSSVGPEGGPGGVGAGGGSSTFPRMYPGQGPFDT
                     CEDCVGHPQGKGATRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGPGPGPGSGAAPE
                     ARSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKAEGRSSSGGDSYSGPGSGGP
                     PTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQTKATGWWSSDDNLDSDSGFLGGR
                     PPGEPGGPFCLDAPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMM
                     VSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRS
                     GSYIKAMGDEESGDSDGSPKTSPKALARRFASRRSSSVDTARINCCVPPRIHPRSSIP
                     GYSRSLTTGQLSEEFNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAG
                     CSQDDDCLPLLAAPASVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHES
                     FTAAEGPARRCSSADGLDGPTMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLA
                     RQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQAD
                     LELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREG
                     YPLPYEPPATDGSPGPPPVPAPGPGSGRRDSWMERGSRSLPDSGRTSPCPRDGEWFIK
                     MLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQS
                     LDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPI
                     PKKPSRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPE
                     AQTRL"
     exon            1399..1604
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1677
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1891
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2205
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2291
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2776
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2868
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3012
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3881
                     /gene="Dlgap3"
                     /gene_synonym="DAP-3; Dap3; SAPAP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgctc agcactcgct cggggctccg cagccggcgc agcccctccg ccgggggctc
       61 cgcagtgccg ggtctgggag cccgcactcg ctcccgcagc cgcagcgccc ccggcccggg
      121 ccgccggcac catgtaaccc cgaccggagc ccgaccgggc caggagccag tggtcctgcg
      181 cctgctgaag ttaggattct gcctggtggt ggggatcctg acatcaagga tgggacgccc
      241 cggatggagg ttcctggggc ctggccccca acagtatgaa gagcctttac tgaggccatg
      301 aggggttacc atggcgaccg aggcagccat ccccgcccag cccgctttgc tgaccaacag
      361 catatggacg tgggcccagc tgccagggcc ccgtacctgc tgggctccag ggaggccttc
      421 tccaccgagc cccgcttctg tgccccgaga gctggcctgg gacacctttc tccagaaggg
      481 cccctgagcc tgagtgaggg tccatcatct gtaggccccg agggaggccc agggggggtg
      541 ggggctgggg gaggcagcag taccttcccc aggatgtacc cgggccaggg ccccttcgac
      601 acctgtgaag actgtgtggg ccacccacag ggcaagggtg ccacccgcct gcctcccaca
      661 ctcctggatc agtttgaaaa gcagttgcca gttcaacaag atggcttcca cacactccca
      721 taccagcgag gtccagcagg gcctggtcct ggacctggat ctggcgctgc ccctgaggct
      781 cgcagcgaga gtcctagccg catccggcac ctggttcact ctgtgcagaa gctctttgcc
      841 aagtcccact ctctggaggc acctgggaag cgagactata atgggcctaa ggccgaggga
      901 agaagtagct ctgggggaga cagctactct ggtccaggct caggaggccc ccccacctcc
      961 caccaccacc atcaccacca ccaccatcac caccaccagt cccgccatgg caaacggagc
     1021 aagagcaagg accgcaaggg ggatgggcga caccagacca aggccacagg ctggtggagc
     1081 tctgatgaca atttggacag tgacagtggc tttctgggtg ggaggccccc tggagagccc
     1141 ggaggtccct tctgcctgga tgctccagat gggtcctacc gggacttgag cttcaagggg
     1201 cgttcgggcg ggtcagaagg ccgctgcctt gcctgcactg gcatgtccat gtccctggat
     1261 ggacagtcag tcaagcgaag tgcctggcat accatgatgg tcagccaggg ccgggatgga
     1321 tacccagggg ccgggccagg caaggggctc ctgggtccag agaccaaggc caaagccagg
     1381 acttatcact atttgcaggt gccgcaagat gactgggggg gttaccccac gggtggcaag
     1441 gatggggaga tcccctgccg caggatgcgg agcggcagct acatcaaagc catgggggac
     1501 gaggagagcg gagactcaga tggtagcccc aagacgtctc ccaaagcact tgcccgacgc
     1561 tttgcctccc gccgttcctc cagcgtggac acagccagga tcaactgctg tgtcccaccc
     1621 cggatccatc cccggagttc catccctggc tacagccgtt cccttacaac tggacagcta
     1681 agcgaagagt ttaaccagca gctggaggcc gtgtgcgggt ccgtgtttgg ggagcttgag
     1741 tcccaggccg tggacgccct ggacctgccc ggctgtttcc gcatgcggag ccacagctac
     1801 ctccgggcca tccaggccgg ctgctctcaa gacgacgact gcctacccct ccttgctgcc
     1861 cctgcctctg tctcagggag gcccggctcc tccttcaact tcagaaaggc cccgccccct
     1921 atcccgccgg gaagccaggc cccaccccgc atctccatca ccgcccagag cagcaccgac
     1981 tctgcccacg agagcttcac tgcagcagag ggcccggccc ggcgctgcag ctccgcggac
     2041 ggactggacg gccccaccat gggcgcacgc accctcgagt tggcaccggt gccaccccgg
     2101 gccagcccca agccccccac actcatcatc aagaccattc ctggccggga ggagctgcgg
     2161 agcctggcgc gacagcggaa gtggcggccg tccattgggg tgcaggtgga gacaatctca
     2221 gactcggaca ccgagaacag gagccgaaga gagttccact ccattggcgt tcaggtggaa
     2281 gaggacaaga ggcgggcgag gttcaagcgc tccaacagtg tgacagccgg tgtgcaggca
     2341 gacctggaac tggagggcct ggctggcctg gccactgtgg ccacagaaga caaagccctg
     2401 cagttcggac gctccttcca gaggcacgcc tctgagcccc agcccggacc ccgggccccc
     2461 acctactcag tcttccgcac ggtccacacg cagggccagt gggcctaccg cgagggctac
     2521 ccactgccgt atgagccgcc ggccaccgat gggtcgcctg gccctccccc tgtccccgcc
     2581 cccggccccg ggtccggccg ccgtgattcc tggatggagc ggggttcgcg tagcctcccc
     2641 gactcaggcc gcacgtcccc ctgcccacgg gatggcgagt ggttcatcaa gatgctgcgg
     2701 gcagaggtgg agaaactgga acactggtgc cagcagatgg agcgggaggc ggaggactat
     2761 gagctgccgg aggagatctt agagaagatt cgaagcgccg tgggcagcac acaacttctc
     2821 ctgtctcaga aggtccagca gttcttcagg ctgtgtcagc aaagcttgga ccccactgcg
     2881 ttccctgtgc ccaccttcca ggacctggcc ggtttctggg acctcctgca gctctccatt
     2941 gaggatgtga ccctcaagtt cctggagcta caacaactca aggccaacag ctggaaactc
     3001 ctggagccta aggaggagaa gaaggtccct ccgccgatac caaagaagcc ctcgcggggg
     3061 cggggcgtgc cggtgaagga gcgctccctg gactcggtgg accggcagcg gcaggaagcg
     3121 cgcaagcggc tcctggcggc caagcgcgcc gcctcgttcc gccacagttc ggctactgag
     3181 agcgcggaca gcatcgagat ctacatcccc gaggcccaga ccaggctgtg acccgcccgg
     3241 gccgccaagc ccgacccggg cccgcggttt tctacccgta ctgtacaccc agcgtcgagg
     3301 tcactgtgaa cgcgggctgc tccgtgcgcc cgccctgccg gcaccgcacg ccccggctcc
     3361 tgcccgccgc gctttcgtgg gttttttacc ttcctgatcc cacgcaaagg cgcccgggct
     3421 aggctggggg tcgtgcctct ccgccctgcg cccctcactt ggaactccca tcttcctggt
     3481 ccgacgcttt gacccccacc ttttcccccc atgggcacca tctctgtcat tattttaccc
     3541 ctccacgggc caggccgggc cgggtccccc atctgggctc tgcgtccccc ccacaccccg
     3601 cggggctggg cttcgtgggg atcaagcttc gtggcttttt atgaagaatc ccgaaccccg
     3661 cctaggagcc cgccccacct tcccagggct ccaccctcag ccctctgccc acagggccca
     3721 gggaccacag tggctggacc aatccaggac cagggcgcct gggcctctct cctttcccac
     3781 atctggggag gggagacagg ggctttccct caccacacct gtggctgttc ccacatccct
     3841 ttgagtatcc caggaaaaat aaaacgcaga actgcaccgg a
//
