LOCUS       NM_053901               3696 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus DLG associated protein 2 (Dlgap2), mRNA.
ACCESSION   NM_053901
VERSION     NM_053901.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3696)
  AUTHORS   Wu,G.M., Du,C.P. and Xu,Y.
  TITLE     Oligomeric Abeta25-35 induces the tyrosine phosphorylation of
            PSD-95 by SrcPTKs in rat hippocampal CA1 subfield
  JOURNAL   Int J Neurosci 133 (8), 888-895 (2023)
   PUBMED   34818135
  REMARK    GeneRIF: Oligomeric Abeta25-35 induces the tyrosine phosphorylation
            of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
REFERENCE   2  (bases 1 to 3696)
  AUTHORS   Jiang-Xie,L.F., Liao,H.M., Chen,C.H., Chen,Y.T., Ho,S.Y., Lu,D.H.,
            Lee,L.J., Liou,H.H., Fu,W.M. and Gau,S.S.
  TITLE     Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated
            aggressive behaviors and orbitofrontal cortex deficits
  JOURNAL   Mol Autism 5, 32 (2014)
   PUBMED   25071926
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3696)
  AUTHORS   Moore,C.L., Nelson,P.L., Parelkar,N.K., Rusch,N.J. and Rhee,S.W.
  TITLE     Protein kinase A-phosphorylated KV1 channels in PSD95 signaling
            complex contribute to the resting membrane potential and diameter
            of cerebral arteries
  JOURNAL   Circ Res 114 (8), 1258-1267 (2014)
   PUBMED   24585759
  REMARK    GeneRIF: Protein kinase A-phosphorylated KV1 channels in PSD95
            signaling complex contribute to the resting membrane potential and
            diameter of cerebral arteries.
REFERENCE   4  (bases 1 to 3696)
  AUTHORS   Kim,Y., Ha,C.M. and Chang,S.
  TITLE     SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95
            protein and is involved in activity-dependent dendritic spine
            formation in mature neurons
  JOURNAL   J Biol Chem 288 (41), 29453-29466 (2013)
   PUBMED   24003235
REFERENCE   5  (bases 1 to 3696)
  AUTHORS   Woods,G.F., Oh,W.C., Boudewyn,L.C., Mikula,S.K. and Zito,K.
  TITLE     Loss of PSD-95 enrichment is not a prerequisite for spine
            retraction
  JOURNAL   J Neurosci 31 (34), 12129-12138 (2011)
   PUBMED   21865455
REFERENCE   6  (bases 1 to 3696)
  AUTHORS   Hirao,K., Hata,Y., Yao,I., Deguchi,M., Kawabe,H., Mizoguchi,A. and
            Takai,Y.
  TITLE     Three isoforms of synaptic scaffolding molecule and their
            characterization. Multimerization between the isoforms and their
            interaction with N-methyl-D-aspartate receptors and
            SAP90/PSD-95-associated protein
  JOURNAL   J Biol Chem 275 (4), 2966-2972 (2000)
   PUBMED   10644767
REFERENCE   7  (bases 1 to 3696)
  AUTHORS   Yao,I., Hata,Y., Ide,N., Hirao,K., Deguchi,M., Nishioka,H.,
            Mizoguchi,A. and Takai,Y.
  TITLE     MAGUIN, a novel neuronal membrane-associated guanylate
            kinase-interacting protein
  JOURNAL   J Biol Chem 274 (17), 11889-11896 (1999)
   PUBMED   10207009
REFERENCE   8  (bases 1 to 3696)
  AUTHORS   Kawashima,N., Takamiya,K., Sun,J., Kitabatake,A. and Sobue,K.
  TITLE     Differential expression of isoforms of PSD-95 binding protein
            (GKAP/SAPAP1) during rat brain development
  JOURNAL   FEBS Lett 418 (3), 301-304 (1997)
   PUBMED   9428732
REFERENCE   9  (bases 1 to 3696)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   10 (bases 1 to 3696)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 2, 2020 this sequence version replaced NM_053901.1.
            
            Summary: The product of this gene is a membrane-associated protein
            that may play a role in synapse organization and signalling in
            neuronal cells. [provided by RefSeq, Jun 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000016.1  82198468-82198622   c
            156-255             JAXUCZ010000016.1  82119769-82119868   c
            256-310             JAXUCZ010000016.1  82050221-82050275   c
            311-343             JAXUCZ010000016.1  81792240-81792272   c
            344-409             JAXUCZ010000016.1  81626451-81626516   c
            410-1479            JAXUCZ010000016.1  81595888-81596957   c
            1480-1691           JAXUCZ010000016.1  81578867-81579078   c
            1692-1839           JAXUCZ010000016.1  81547489-81547636   c
            1840-2059           JAXUCZ010000016.1  81542220-81542439   c
            2060-2412           JAXUCZ010000016.1  81519470-81519822   c
            2413-2454           JAXUCZ010000016.1  81518450-81518491   c
            2455-2540           JAXUCZ010000016.1  81512391-81512476   c
            2541-2956           JAXUCZ010000016.1  81510694-81511109   c
            2957-3048           JAXUCZ010000016.1  81501992-81502083   c
            3049-3201           JAXUCZ010000016.1  81498430-81498582   c
            3202-3696           JAXUCZ010000016.1  81495374-81495868   c
FEATURES             Location/Qualifiers
     source          1..3696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..3696
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /note="DLG associated protein 2"
                     /db_xref="GeneID:116681"
                     /db_xref="RGD:620224"
     exon            1..155
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..255
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..3420
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /note="discs large homolog associated protein 2;
                     PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated
                     protein 2; PSD-95/SAP90-associated protein-2; postsynaptic
                     density 95"
                     /codon_start=1
                     /product="disks large-associated protein 2"
                     /protein_id="NP_446353.3"
                     /db_xref="GeneID:116681"
                     /db_xref="RGD:620224"
                     /translation="MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEGGDLAQP
                     GLSFPGPAEEDIDQQYSWSPTQHFNEERYSPAPRNMKGLTGSRNQPQLCVGHTCGLSP
                     ADECEHPHDHVRHGPDVRQPYLLSPAESCPMDHHRCSPRSSVHSECMMMPVMLGDHVS
                     SSTFPRMHYSSHYDTRDDCATSHASTKVNRIPANLLDQFEKQLPLHRDGFHTLQYQRA
                     SAATEQRNESPGRIRHLVHSVQKLFTKSHSLEGSSKSNINGTKSEGRMDDHHQSHLSK
                     HSKRSKSKERKPESKHKSGMSSWWSSDDNLDSDSTYRTPSVAHRHHMDHIPHCYPEAL
                     QSPFGDLSLKTSKSNSDVKCSACEGLALTPDTRYMKRSSWSTLTVSQAKEAYRKSSLN
                     LDKPLVHPEIKPSLQPCHYLQVPQDDWGAYPTGGKEEEIPCRRMRSGSYIKAMGDEES
                     GESDSSPKTSPTVALRPEPLLKSIIQRPLGDHQTQSYLQAATEVPVGHSLDPSVNYNS
                     PKFRSRNQSYMRAVSTLSQASCVSQMSEAEVNGQFESVCESVFSEVESQAMDALDLPG
                     CFRTRSHSYLRAIQAGYSQDDECIPVMTPSNMTSTIRSTAAVSYTNYKKTPPPVPPRT
                     TSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGGLYNSMDSLDSNKAMNLALE
                     SAAAQRHAADTQSSSTRSIDKAVLVSKAEELLKSRCSSIGVQDSEFPDHQPYPRSDVE
                     TATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHVSMED
                     KGLQFGSSFQRHSEPSTPTQYGALRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPS
                     LDTVETGRMSPCRRDGSWFLKLLHTETKRMEGWCKEMEREAEENDLSEEILGKIRSAV
                     GSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSVEDVSMKFDELHQ
                     LKLNDWKIMESPERKEERKIPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAA
                     KRAASFRQNSATERADSIEIYIPEAQTRL"
     exon            256..310
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..343
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..409
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..1479
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1691
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1839
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2059
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2412
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2454
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2540
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2956
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3048
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3201
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3696
                     /gene="Dlgap2"
                     /gene_synonym="DAP-2; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagactgcg gatcgacgca cagacccaag gattctcaag cttgggagct ggcggcagtg
       61 ctgtgcgcgc cgcctggcct gaggggtggc caccttgcca tgtcgctccg cacccactga
      121 actaggaaag cccaaggatg tccgctctga ggaaggcttc cccaccatct gaggcccggc
      181 catagtacta cgcgatctca cagcagcttg cgaaccccag cctgcacctt gccagccaaa
      241 atggggacgg ctcaggttct gcccggcatt ctgcagaagc attgctgcat cttaccagac
      301 aggaacacag agtctcagtg caccctttgc ggagagccag aagaggagga aggaggagac
      361 ttggcccagc cgggcctcag cttcccgggc ccggcagaag aggacataga ccagcagtac
      421 tcatggtccc caacgcagca cttcaatgaa gagaggtact cacccgcacc caggaacatg
      481 aaagggttaa ctggaagccg gaaccagcct cagctgtgtg tgggtcacac ctgtggcctg
      541 tcgcccgctg acgagtgtga gcacccccat gatcacgtgc gtcatgggcc agacgtgcgg
      601 caaccttatc ttctcagccc agccgagagc tgcccaatgg accaccaccg ctgctcaccc
      661 aggagctccg tccactcaga gtgtatgatg atgcctgtga tgttgggcga ccatgtgtcc
      721 agcagcacct tccccagaat gcactacagt tcacactacg acacgaggga tgactgtgcc
      781 acgtcccacg cgagtaccaa ggtaaaccgc attcccgcca accttttaga ccagtttgag
      841 aaacagctac ccctgcaccg ggatggtttc cacacactgc agtaccagag ggcctcagct
      901 gccacggaac agcgaaatga gagtccaggc agaatcaggc atctggtcca ctccgtccag
      961 aaactcttta ccaagtctca ttctttggag ggatcgtcca aaagcaacat caatgggacc
     1021 aagagcgagg gtcggatgga tgaccaccac cagagtcacc tttccaaaca cagcaaacgg
     1081 agtaagagca aggagcggaa gccagagagc aagcacaagt ctggtatgag cagctggtgg
     1141 agttccgatg acaacctgga cagtgacagc acataccgga cacccagcgt ggcccaccgc
     1201 caccacatgg accacatccc acactgctac cctgaggcac tgcagagccc gtttggggac
     1261 ctctcactaa agacttccaa aagcaacagt gatgttaagt gttccgcctg tgaaggcttg
     1321 gccctcacgc cagacaccag gtacatgaag cgtagctcct ggtccacgct cacggtgagc
     1381 caggctaagg aggcctaccg caagagctcc ctgaacttgg acaagcccct ggtccaccca
     1441 gagatcaagc cttccttgca gccatgccac tacctccagg tgcctcagga tgattggggt
     1501 gcatacccta caggcggcaa agaggaggag atcccctgcc gtaggatgag gagcggcagc
     1561 tacataaaag ccatgggtga cgaggagagt ggggaatcag actccagccc caaaacatcc
     1621 ccgacggtgg ccctccggcc ggagccgctg ctgaagtcca tcatacaaag accacttgga
     1681 gaccaccaaa cccagagcta cctgcaagct gccactgagg tgcctgtcgg tcacagcctg
     1741 gacccatcag tcaactacaa ctctccgaag ttccggtcca gaaaccagag ctacatgcgg
     1801 gctgtgagca ccctgagcca agccagctgt gtgagccaga tgagtgaagc ggaagttaat
     1861 gggcagttcg agtcagtgtg tgaatctgtc ttcagcgaag tcgaatctca ggccatggat
     1921 gcccttgacc ttcccgggtg tttccgaaca aggagtcaca gctaccttcg agccatccaa
     1981 gctggttact cccaagacga tgaatgtatt cccgtgatga caccgtccaa catgacgtca
     2041 accatcaggt caacagcagc tgtctcctac acaaattata agaagacgcc tcccccggtg
     2101 cctccacgga ccacctccaa gcctctgatc tctgtgacgg cccagagcag cacggaatcc
     2161 acacaggatg cctaccagga cagccgtgcc cagaggatgt ccccatggcc ccaagacagc
     2221 cgtggcggcc tctacaactc catggacagt ctagacagca acaaggccat gaatttggct
     2281 ctggagtcag cggcagctca gcgccacgcg gctgacactc agagcagctc cacaaggagc
     2341 attgacaagg cggtcctggt atccaaggct gaagagctcc tcaaaagccg ttgctcctcc
     2401 atcggggtcc aggattctga attccctgat catcaaccct acccaaggtc agatgtagag
     2461 acagccacgg attccgacac ggagagcaga ggcctacggg agtaccactc tgtaggcgtg
     2521 caagtggaag acgaaaaacg gcacggccgt ttcaagcgtt ccaacagcgt cacagctgct
     2581 gtgcaggctg acttagagtt ggagggcttc cctgggcatg tcagcatgga ggacaagggc
     2641 ctgcagttcg gatcctcctt ccagcgacat tcagagccca gtaccccgac ccagtatggg
     2701 gcactgagga ctgtgcggac gcagggcctc ttcagttaca gggaggacta taggacacag
     2761 gtggacactt ctactctgcc gccaccggat ccctggctgg agccatccct ggacacagtg
     2821 gagaccggga ggatgtctcc gtgccggaga gatggctcgt ggtttctgaa attgctgcac
     2881 acagagacga agaggatgga aggctggtgc aaagagatgg agagggaagc ggaagaaaat
     2941 gacctctccg aagaaattct aggaaagatc aggagtgctg tgggaagtgc ccagctgctc
     3001 atgtcccaga agttccagca gttttattgg ctttgtcagc agaacatgga ccccagcgcc
     3061 atgccaagac cgacatcaca ggatctagct ggctactggg atatgctgca gctgtctgtg
     3121 gaagatgtca gcatgaagtt cgatgaactg caccagctga agctcaatga ctggaagata
     3181 atggagtcgc ccgagagaaa ggaagaaagg aagatccccc ctccaatacc aaagaagccc
     3241 cccaagggga aattccccat cacaagggaa aagtccctgg acctgccaga cagacagcgc
     3301 caggaagccc ggcgccggct catggcagcc aagagagctg cctcgttccg ccagaactct
     3361 gccacggaga gggcagacag catcgagatc tacatccccg aggcccagac tcggctctga
     3421 ggaccagagg tggccacacg cacctggttt tgttcttttt cacaaaatgc ttgtacagtt
     3481 tattgcctac ctggtagttt ctgtctcacc ctccaccgga ttcgcccttg ccgtgctctc
     3541 tgcactgtag acagtggacg ctccaattcc tagtttgctg agctcctggc aagactgact
     3601 ctgaaggaca tcggctccga ggaacaggcc tggtgagccc tgacgtacgt ccctgttctc
     3661 agagggccgc caagtggcct cttgaaatgg acccta
//
