LOCUS       NM_022946               6417 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DLG associated protein 1 (Dlgap1), transcript
            variant 1, mRNA.
ACCESSION   NM_022946
VERSION     NM_022946.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6417)
  AUTHORS   Rademacher,N., Schmerl,B., Lardong,J.A., Wahl,M.C. and
            Shoichet,S.A.
  TITLE     MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1
            cell adhesion molecules to core components of the postsynaptic
            density
  JOURNAL   Sci Rep 6, 35283 (2016)
   PUBMED   27756895
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6417)
  AUTHORS   Tao-Cheng,J.H., Yang,Y., Reese,T.S. and Dosemeci,A.
  TITLE     Differential distribution of Shank and GKAP at the postsynaptic
            density
  JOURNAL   PLoS One 10 (3), e0118750 (2015)
   PUBMED   25775468
  REMARK    GeneRIF: Upon depolarization with high K+, neither the intensity
            nor distribution of label for GKAP changed, but labeling intensity
            for Shank at the postsynaptic density increased to ~150% of
            controls.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6417)
  AUTHORS   Tong,J., Yang,H. and Im,Y.J.
  TITLE     Crystallization and preliminary X-ray crystallographic analysis of
            the C-terminal domain of guanylate kinase-associated protein from
            Rattus norvegicus
  JOURNAL   Acta Crystallogr F Struct Biol Commun 70 (Pt 7), 949-954 (2014)
   PUBMED   25005096
  REMARK    GeneRIF: The C-terminal helical domain of GKAP from Rattus
            norvegicus was purified and crystallized as a fusion protein.
REFERENCE   4  (bases 1 to 6417)
  AUTHORS   Shin,S.M., Zhang,N., Hansen,J., Gerges,N.Z., Pak,D.T., Sheng,M. and
            Lee,S.H.
  TITLE     GKAP orchestrates activity-dependent postsynaptic protein
            remodeling and homeostatic scaling
  JOURNAL   Nat Neurosci 15 (12), 1655-1666 (2012)
   PUBMED   23143515
  REMARK    GeneRIF: Activity-dependent turnover of postsynnaptic density
            proteins orchestrated by GKAP is critical for homeostatic
            plasticity.
REFERENCE   5  (bases 1 to 6417)
  AUTHORS   Chua,J.J., Schob,C., Rehbein,M., Gkogkas,C.G., Richter,D. and
            Kindler,S.
  TITLE     Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via
            alternative translational initiation
  JOURNAL   Sci Rep 2, 484 (2012)
   PUBMED   22761992
REFERENCE   6  (bases 1 to 6417)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
REFERENCE   7  (bases 1 to 6417)
  AUTHORS   Kawashima,N., Takamiya,K., Sun,J., Kitabatake,A. and Sobue,K.
  TITLE     Differential expression of isoforms of PSD-95 binding protein
            (GKAP/SAPAP1) during rat brain development
  JOURNAL   FEBS Lett 418 (3), 301-304 (1997)
   PUBMED   9428732
REFERENCE   8  (bases 1 to 6417)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   9  (bases 1 to 6417)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   10 (bases 1 to 6417)
  AUTHORS   Kim,E., Naisbitt,S., Hsueh,Y.P., Rao,A., Rothschild,A., Craig,A.M.
            and Sheng,M.
  TITLE     GKAP, a novel synaptic protein that interacts with the guanylate
            kinase-like domain of the PSD-95/SAP90 family of channel clustering
            molecules
  JOURNAL   J Cell Biol 136 (3), 669-678 (1997)
   PUBMED   9024696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 17, 2015 this sequence version replaced NM_022946.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000009.1  117614084-117614187
            105-197             JAXUCZ010000009.1  117747562-117747654
            198-1241            JAXUCZ010000009.1  117858091-117859134
            1242-1456           JAXUCZ010000009.1  117934723-117934937
            1457-1634           JAXUCZ010000009.1  118000110-118000287
            1635-1875           JAXUCZ010000009.1  118004886-118005126
            1876-1905           JAXUCZ010000009.1  118065248-118065277
            1906-2276           JAXUCZ010000009.1  118118698-118119068
            2277-2368           JAXUCZ010000009.1  118123670-118123761
            2369-2790           JAXUCZ010000009.1  118140453-118140874
            2791-2882           JAXUCZ010000009.1  118162052-118162143
            2883-3035           JAXUCZ010000009.1  118167225-118167377
            3036-6417           JAXUCZ010000009.1  118170082-118173463
FEATURES             Location/Qualifiers
     source          1..6417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..6417
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /note="DLG associated protein 1"
                     /db_xref="GeneID:65040"
                     /db_xref="RGD:620223"
     exon            1..104
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..197
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..1241
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..3245
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /note="isoform 1 is encoded by transcript variant 1; disks
                     large-associated protein 1; PSD-95/SAP90-binding protein
                     1; SAP90/PSD-95-associated protein 1; PSD-95 binding
                     protein; guanylate kinase-associated protein; discs large
                     homolog associated protein 1"
                     /codon_start=1
                     /product="disks large-associated protein 1 isoform 1"
                     /protein_id="NP_075235.3"
                     /db_xref="GeneID:65040"
                     /db_xref="RGD:620223"
                     /translation="MKGLSGSRSHHHGITCESACDSLSHHSDHKPYLLSPVDHHPADH
                     PYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDESALVPRTLATKANRLPTN
                     LLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSK
                     GGVNGGKASPDGSQTVRYGKRSKSKERRSEPKARSNASNASPTSPSWWSSDDNLDGDM
                     CLYHTPSGVMTMGRCPDRSASQYFMEAYNTISEQAVKASRSNNDVKCSTCANLPVTLD
                     APLLKKSAWSSTLTVSRAREVYQKASVNMDQAVVKSEACQQERSCQYLQVPQDEWTGY
                     TPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTE
                     LTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRA
                     MSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGC
                     SQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTT
                     TKPFISITAQSSTESAQDAYMDGQGQRGDMISQSGLSNSTESLDSMKALTAAIEAANA
                     QIHGPASQHMGSNAAAVTTTTTIATVTTEDRKKDFKKNRCLSIGIQVDDAEESEKMAE
                     SKTSSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGP
                     MARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEA
                     VQRSVCHRDGHWFLKLLQAERDRMEGWCKQMEREERENNLPEDILGKIRTAVGSAQLL
                     MAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNW
                     KQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQN
                     SATESAESIEIYIPEAQTRL"
     exon            1242..1456
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1634
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1875
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1905
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2276
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2368
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2790
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2882
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3035
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..6417
                     /gene="Dlgap1"
                     /gene_synonym="DAP-1; Gkap; GKAP/SAPAP1; rGKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgacatc tggttaacgc catcaaggac agcaacaatc tgaagtcggg gtctcctgtg
       61 ttggaagctc ggaaaaataa aaacccagag agtgagcgtc aaaggttaca tctgctctgg
      121 ggtttgctga atgtcacctg aaggcccctg tgtctgcttc agagtgctgc tgttgaatga
      181 caaagacgct aagaacagtc tttgcccaag acgggtctgg aacttaacgg ggttcccatg
      241 acccctgtga ttgcttccag tcagcaatga aagggttatc gggtagccgc agccaccacc
      301 atgggatcac ctgtgagtcg gcctgtgact ccttgtcaca ccattcagac cacaagccgt
      361 acctgctgag cccggtagac caccaccctg cggaccatcc ctactacacc cagcggaatt
      421 ctttccaggc cgagtgtgtg gggcccttca gcgaccctct ggccagcagc accttcccgc
      481 gcaggcacta cacctctcag caggagctga aggacgagag tgccctggtg ccgcgcacac
      541 tggccaccaa ggcgaatcgc ctccccacca acctgctgga tcagtttgag aggcagctgc
      601 ccctcagccg agatggctat cacacgctac agtacaagcg caccgctgtg gagcatcgca
      661 gcgatagccc cggccgcatc cggcacctgg tccactcggt ccagaagctc ttcaccaagt
      721 ctcattccct ggaggggcca tccaaaggcg gcgtcaatgg gggcaaggcc agccctgacg
      781 ggtcgcaaac tgtgagatat ggcaagcgca gcaagagcaa ggagagacgg tcagagccca
      841 aggctagatc caatgcctct aacgcctccc cgacctctcc cagctggtgg agctcggatg
      901 acaacctgga tggggacatg tgcctctacc acacgccatc aggtgtgatg accatgggta
      961 ggtgccctga ccgctctgct tctcagtact tcatggaggc ctacaacacc atcagcgagc
     1021 aggcagtgaa ggcctcccgg agtaacaacg acgtcaagtg ctccacctgt gctaacctgc
     1081 cagtcacgct ggatgcccca cttctgaaga agagtgcctg gtcctccact ctcaccgtga
     1141 gcagagcccg agaggtttat cagaaagcct cagtgaacat ggatcaggcc gtggtgaagt
     1201 cggaggcttg tcaacaagag cggtcatgcc agtacctaca ggttccccag gatgaatgga
     1261 cagggtacac gcctcgcggg aaagacgacg agatcccgtg ccggaggatg cgcagtggca
     1321 gctacatcaa agccatgggg gatgaggaca gcggggactc ggacacgagc cccaagccat
     1381 ctcctaaggt ggctgcaaga agagaaagct atctcaaggc cacacagcca tcccttacag
     1441 agctcaccac cctcaagatc tccaacgaac actcccccaa actccagatc cggagtcaca
     1501 gctacctgag ggcagtaagt gaagtctcca ttaacagaag cctggacagc ctggatcctg
     1561 caggcttgct cacgtcacca aagttccgct ccagaaacga gagctacatg cgagctatga
     1621 gcaccataag ccaggtgagc gagatggagg tgaacggaca gttcgaatcc gtatgcgagt
     1681 ctgtgttcag cgaactggag tcgcaggcgg tggaagcgct ggacctgccc atgcctggct
     1741 gcttccgcat gcggagccat agctacgtgc gggctatcga gaagggctgc tcccaggatg
     1801 atgagtgcgt gtcgctgagg tcgtcctccc ctccacgcac aaccaccacc gtgaggacca
     1861 tccagagtag caccggtgtc ataaaactga gttctgccgt tgaagtgtca tcttgcatta
     1921 caacatataa gaagacacca cctccagtcc cacccagaac taccacgaaa cctttcattt
     1981 ctatcacagc ccagagtagc acagagtccg cgcaggatgc ctacatggac gggcaaggcc
     2041 agcgcgggga catgatcagc cagtctggcc tcagcaactc caccgaaagt ctggacagta
     2101 tgaaggctct cacggctgcc atcgaggctg caaacgcgca gatccacggc ccggcaagtc
     2161 aacacatggg cagcaacgct gctgccgtca ccaccaccac caccatagcc actgtcacca
     2221 ccgaggacag gaagaaagac tttaagaaaa acagatgcct atctattggg atacaggtgg
     2281 acgacgccga agagtcagag aaaatggcag agagtaagac gtccagtaag ttccagtccg
     2341 tgggagtgca agtagaagag gagaagtgct tccgcaggtt cactcggtcc aacagtgtaa
     2401 cgactgcagt acaggctgac ctggacttcc atgataatct ggaaaattct ctggagtcta
     2461 tagaggacaa ttcgtgtccc ggcccaatgg ccagacagtt ctcgcgagat gccagcacct
     2521 ctaccgtcag tatccagggt tcaggaaacc actaccatgc ctgtgcagcc gacgatgact
     2581 ttgacacgga ttttgacccc tctatcctgc ctcctccgga cccctggatt gactctatca
     2641 cagaagaccc tctggaggcc gttcaaaggt ccgtgtgcca ccgggacggc cactggttcc
     2701 tgaagcttct ccaggcagag cgagaccgca tggaagggtg gtgcaagcaa atggagagag
     2761 aagagaggga aaacaacctc ccagaagaca ttctagggaa aatcagaacc gcggtgggca
     2821 gtgcccagct tctcatggcg cagaaattct accagttcag agaactgtgt gaagagaacc
     2881 tgaatcccaa tgctcacccg agacccactt cccaggattt ggcggggttt tgggacatgc
     2941 tgcagttgtc catagaaaac attagtatga aatttgatga acttcatcag ttaaaggcca
     3001 ataattggaa acagatggat cctcttgaca agaaggagcg aagggcccct cctccagtgc
     3061 caaagaagcc ggcgaagggc cccgcgccgt tgatccggga gcgctcgctg gagagctcgc
     3121 agcgccagga ggcccgcaag cgcctgatgg ccgccaagcg cgcagcatca gtccgccaga
     3181 actcggccac cgagagcgcc gagagcatcg agatctacat ccccgaggcg cagacccggc
     3241 tctgagcgcg gccgacgagg accgtcccgc atccctgccc tcggccgtct ccccgccccc
     3301 tccgtctctg agctcagtga ccgccaccgt cgtggcgtag ttgtccacct cgcaggagcc
     3361 gtccccaggc cgccccgctt cctggaccac tttgcccatc ttctccaccg agcttcgctc
     3421 cccagtcctg aagcctcatg cagacatcca aaccctttat tttctgggcc aagcaaactt
     3481 gtgtagaaac gacacctgta ggtcactcac cctcctcagt tctctcaagc tagtgtgccc
     3541 ctagaactca gcaatataaa accatagggt atttcagaaa cccagtatta catagggtga
     3601 tcctttggga cttaccgtct tccacgcgaa agaaacgagg gctccgactc cctttatttg
     3661 cccccaaacg gttattttta caagcaaaga gcgctttatt tctaatctca gaaatcctac
     3721 catctcattg gaatcaaagt gacagagggg accaagctgg cctagggttg ggggcctggg
     3781 tatgtaggag agaagggcgg agcgcgcagg tgccctgcat ctgtgccctc gcagctgtac
     3841 aaactgcctc actggtactt catcaaccgc agcttcaaat gtttcaatca gcagaagatt
     3901 gtaaattcga tctttcaggg aaattaatct attctgaaag gcaataaaac gaagaaagtt
     3961 aaggcaaaag gaaacaccgg tggtttaaga tcctctataa ggaatccatt tatttatctt
     4021 aagaaaattt agacctgaat ttttttttta atcaactctt cttgtactct gtgtattata
     4081 atggcatggc aatgattttc aaatgggagg gtgggaagga attggttctg ttagtttcgt
     4141 gttcatcctg gtggggccac ttaagatttc acacacggaa gaaagcttct gcttccgagg
     4201 ggcggcaagg ccatttccag aggagagttc ccgtactccc gccacacttt gaatgctaca
     4261 catccgtcta gttcaaccca gcccttcaca tttcgggggc attttctcct tcggtctcct
     4321 ctcactccag tacggagttc acctgttccc cagcacagga tttttgttct atgtcaaatg
     4381 aataaaataa aaggttttct accccaattg acatgctgcc tcattccaaa gaactgtcgt
     4441 tatgattctg aagttccagt taatgagaga agtcatttga tatgcaaggg gtcaagaact
     4501 aggagtcagg gcagtagggc attcataaac gctgatagaa atccaaacgt ctgggtgggt
     4561 tccaggctcg ctgttggctt gcagttttgt catggccatg tgcactagct tccagacgaa
     4621 gtcttcaaat gccctttcct tgtagcagtt taagcattca gaatgtggca ttctgaaagg
     4681 atcagctgta taatttcaag ctggcaacct aaagaactag aaacttgcca tagaaaaaca
     4741 aaagacttaa aagaaaaaaa aaatgcttgc atcagagatg cttaaaaaaa aaaaaagaaa
     4801 gaaagaaaga aaagaaacaa acaaaaaacc actgtcatag ccaggtgcta atttaatttt
     4861 ctttacaaaa ttaagagaag cgatgggttc tggcgaccag tattttcaga catattctaa
     4921 aaccactaga gaattcgcta cctctcagag ccatcgaagc tttgaggtac ctttatcaac
     4981 agggcacaaa tgtttactgc tgcggtttac aagaaaaggg ctataactta ttaaaaaaaa
     5041 aacaaaacaa aacaccaaca acttttaact agggcagaca aagtcagcgc tgtgtccaac
     5101 tggagcagag atttttgagc ttcaagtatt tgctagtttc aaaaaaataa aaataaaaaa
     5161 gactcttgac agtggagcag caatgtaaga tcagaagcat tcaggagtaa ggccaacttc
     5221 caccttgggt agcccatggt cacacttatc caggaaagac atggaattca caggaagcag
     5281 tgttcattct ggtccatcct agtcctactt agaccccctc gcttactact gcagcccctt
     5341 gccctgaggt aatgctgaga tcagtttctg atgggattcc agatccttcg acaatgttat
     5401 ccttggggac cgatttagcc aaggctattt taaggagaga ccagagaagg cctattgatc
     5461 ttgtctaagc gaatggcatt tgtatattca taagctattt ttggtaagaa ttttaaatct
     5521 cttcactgaa cgcctgcagg gcatcagaac ctttgccttc ctgagaaaca cagtttaaac
     5581 tgtacaaaac actttataag aaaaaaaaaa gctaattatt gttgttagta catgaccccc
     5641 cacacacacg atacagcctg ttacccactg gaacctggaa actgacagcg ggaaccttta
     5701 ttgcgttctt ctttttgatg taatttgtag agatgttttt tagttcataa tgaacaatgt
     5761 atgtaccctg gaaaattact tattttgttt aactttggta taaaggtgtt gggcattttc
     5821 ttggggcggg gggaattaca aaagaagttt gtctccctca tcaaaaacaa caacaacaaa
     5881 aatacattca aagaaattaa gtatttatta tattttttgc agatgtttcc atacaattca
     5941 cataaccttt ttgtaaagag agatgaagaa atggattaaa gatttttaat atttgaaatg
     6001 gtaaatagaa ctaatttatt tgtaatatat ttctgttatt tatagatgtt cccttaatgt
     6061 tttgctgtga agtactgctt taatttaagc ccttgtgatt taccatttct tttttaagaa
     6121 catgtctaga tgcatatttt aaataactgg aatgtaaatc attagcatat ctgaattccc
     6181 taatgtaatt tttaaaaatt aatttggttt ggggagaaaa ggtttatttg aaagccttca
     6241 gatggagggc tggggaagat ttttatggct ttctgaattg gaatttcata ggcttattta
     6301 cctagactgt gtgtggacaa aaaaataaat aaataaaaat aacaacctgt aaatagatga
     6361 acgtttccca tcatgtaaaa agaagaaatt aataaaataa tcaatgcact gctttca
//
