LOCUS       NM_031639               3748 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus discs large MAGUK scaffold protein 3 (Dlg3),
            mRNA.
ACCESSION   NM_031639
VERSION     NM_031639.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   He,Q.L., Deng,H.S., Xu,L.S., Zhu,J.J., Ni,H.D., Wang,T.T.,
            Wang,Y.G., Shen,H., Pan,H. and Yao,M.
  TITLE     SAP102 contributes to hyperalgesia formation in the cancer induced
            bone pain rat model by anchoring NMDA receptors
  JOURNAL   Neurosci Lett 714, 134595 (2020)
   PUBMED   31682872
  REMARK    GeneRIF: SAP102 contributes to hyperalgesia formation in the cancer
            induced bone pain rat model by anchoring NMDA receptors.
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Liu,M., Shi,R., Hwang,H., Han,K.S., Wong,M.H., Ren,X., Lewis,L.D.,
            Brown,E.N. and Xu,W.
  TITLE     SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent
            mechanism
  JOURNAL   J Neurophysiol 120 (4), 1578-1586 (2018)
   PUBMED   30067114
  REMARK    GeneRIF: SAP102 regulates synaptic current kinetics via different
            AMPAR auxiliary subunits.
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Su,D., Liu,H., Liu,T., Zhang,X., Yang,W., Song,Y., Liu,J., Wu,Y.
            and Chang,L.
  TITLE     Dynamic SAP102 expression in the hippocampal subregions of rats and
            APP/PS1 mice of various ages
  JOURNAL   J Anat 232 (6), 987-996 (2018)
   PUBMED   29574717
  REMARK    GeneRIF: Our findings provide fundamental data to support the
            functional differences of SAP102 in different hippocampal
            subregions during postnatal periods
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Wei,Z., Behrman,B., Wu,W.H. and Chen,B.S.
  TITLE     Subunit-specific regulation of N-methyl-D-aspartate (NMDA) receptor
            trafficking by SAP102 protein splice variants
  JOURNAL   J Biol Chem 290 (8), 5105-5116 (2015)
   PUBMED   25555912
  REMARK    GeneRIF: These data shed new light on the role of SAP102 in the
            regulation of NMDAR trafficking.
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Williams,L.E. and Featherstone,D.E.
  TITLE     Regulation of hippocampal synaptic strength by glial xCT
  JOURNAL   J Neurosci 34 (48), 16093-16102 (2014)
   PUBMED   25429150
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Kim,J.H., Liao,D., Lau,L.F. and Huganir,R.L.
  TITLE     SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90
            protein family
  JOURNAL   Neuron 20 (4), 683-691 (1998)
   PUBMED   9581761
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   8  (bases 1 to 3748)
  AUTHORS   Lau,L.F., Mammen,A., Ehlers,M.D., Kindler,S., Chung,W.J.,
            Garner,C.C. and Huganir,R.L.
  TITLE     Interaction of the N-methyl-D-aspartate receptor complex with a
            novel synapse-associated protein, SAP102
  JOURNAL   J Biol Chem 271 (35), 21622-21628 (1996)
   PUBMED   8702950
REFERENCE   9  (bases 1 to 3748)
  AUTHORS   Muller,B.M., Kistner,U., Kindler,S., Chung,W.J., Kuhlendahl,S.,
            Fenster,S.D., Lau,L.F., Veh,R.W., Huganir,R.L., Gundelfinger,E.D.
            and Garner,C.C.
  TITLE     SAP102, a novel postsynaptic protein that interacts with NMDA
            receptor complexes in vivo
  JOURNAL   Neuron 17 (2), 255-265 (1996)
   PUBMED   8780649
REFERENCE   10 (bases 1 to 3748)
  AUTHORS   Sussman,H.M., MacNeilage,P.F. and Lumbley,J.L.
  TITLE     Pursuit auditory tracking of dichotically presented tonal
            amplitudes
  JOURNAL   J Speech Hear Res 18 (1), 74-81 (1975)
   PUBMED   1127911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031639.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U50147.1, SRR26360176.252065.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-702               JAXUCZ010000021.1  69900003-69900704
            703-756             JAXUCZ010000021.1  69903603-69903656
            757-807             JAXUCZ010000021.1  69903910-69903960
            808-932             JAXUCZ010000021.1  69904357-69904481
            933-1102            JAXUCZ010000021.1  69904676-69904845
            1103-1239           JAXUCZ010000021.1  69905130-69905266
            1240-1384           JAXUCZ010000021.1  69905569-69905713
            1385-1544           JAXUCZ010000021.1  69906361-69906520
            1545-1701           JAXUCZ010000021.1  69908089-69908245
            1702-1804           JAXUCZ010000021.1  69908700-69908802
            1805-1919           JAXUCZ010000021.1  69928526-69928640
            1920-2096           JAXUCZ010000021.1  69939452-69939628
            2097-2172           JAXUCZ010000021.1  69940126-69940201
            2173-2218           JAXUCZ010000021.1  69942878-69942923
            2219-2260           JAXUCZ010000021.1  69944571-69944612
            2261-2311           JAXUCZ010000021.1  69945812-69945862
            2312-2413           JAXUCZ010000021.1  69946494-69946595
            2414-2586           JAXUCZ010000021.1  69947184-69947356
            2587-2696           JAXUCZ010000021.1  69948235-69948344
            2697-2788           JAXUCZ010000021.1  69948644-69948735
            2789-3748           JAXUCZ010000021.1  69949737-69950696
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..3748
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /note="discs large MAGUK scaffold protein 3"
                     /db_xref="GeneID:58948"
                     /db_xref="RGD:68423"
     exon            1..702
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2895
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /note="SAP102; PSD-95/SAP90-related protein 1;
                     synapse-associated protein 102; SAP-102; discs, large
                     homolog 3"
                     /codon_start=1
                     /product="disks large homolog 3"
                     /protein_id="NP_113827.1"
                     /db_xref="GeneID:58948"
                     /db_xref="RGD:68423"
                     /translation="MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGG
                     NGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSG
                     PSWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLG
                     FSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV
                     EALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYIT
                     KIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLH
                     LNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHM
                     LAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRI
                     LSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMS
                     SGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARL
                     VTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNL
                     KGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH
                     KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQS
                     VRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKI
                     FDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL"
     exon            703..756
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..807
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..932
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1102
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1239
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1384
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1544
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1701
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1804
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1919
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2096
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2172
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2218
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2260
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2311
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2413
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2586
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2696
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2788
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3748
                     /gene="Dlg3"
                     /gene_synonym="Dlgh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgactccact cagatccatc ctggggacct gagcagaaga ggttctcgcc gcacctaacc
       61 cttgcctggg agcccgattc ttctttgccg ctgggcctcg gcccagaagc cacaacgggc
      121 gacacggagc cgccagtgct ggagggggag ccatgggtgc ggggcagcgt gggggcagag
      181 gccccgggac gcccgccggg ccccaggccc cgctccgccc gggcaccccc acgggtgccc
      241 cccccttctt ggtctgagca gtgcgagtgt gctagggagc ccagcggcgg cggcggcgtg
      301 gaaactggcg tgggctgggg ggtccgagcc gcggggggca gtgccatgca caagcaccag
      361 cactgctgta agtgccccga gtgctatgag gtgacccgcc tggccgccct gcggcgcctc
      421 gagcctcctg gctatgggga ctggcaggtg ccggacccct atgggccaag tgggggcaat
      481 ggggccagct ccggttatgg aggctacagc tcgcagaccc tgccttcaca ggcaggggct
      541 acccccaccc ctcgcaccaa ggccaagctc atccccacag gccgagatgt ggggccagtg
      601 ccccctaagc cagtacccgg caagaacacc ccaaaactca acggcagtgg ccccagctgg
      661 tggcccgagt gcacctgtac caatcgggac tggtatgagc aggccagccc tgcacccctc
      721 ctagtgaacc ccgaggctct ggagcccagc ctatcggtga atggcagtga tggcatgttc
      781 aagtatgagg agatagtcct ggagcggggc aactctggcc tgggcttcag tatcgcaggt
      841 ggcatcgaca accctcatgt ccctgatgac cctggcatct ttattaccaa gatcattcct
      901 ggtggagcag ctgccatgga tgggaggctg ggggtgaatg actgtgtgct acgggtgaat
      961 gaggtggacg tgtccgaggt ggtgcacagc cgggccgtgg aggcactgaa ggaggcaggc
     1021 cctgtggtgc ggttggtggt gcggaggcga cagcccccac ctgagactat catggaggtc
     1081 aacctgctca aagggccaaa aggcctgggt ttcagcattg ctgggggcat tggtaaccag
     1141 cacatcccag gagacaacag catctatatc accaagatca ttgaaggagg agctgctcag
     1201 aaagatggac gcctacagat tggggaccgg cttcttgcgg tgaacaacac caatctgcag
     1261 gatgtgaggc atgaggaagc tgtggcctca ctcaagaaca catcagacat ggtctatctg
     1321 aaggtggcca agccaggcag tctccacctc aacgacatgt atgctccccc cgactatgcc
     1381 agcactttca ctgccttggc tgacaatcat ataagccata attccagcct gggttatctt
     1441 ggggcagtgg agagcaaggt cacctaccct gctcctcctc aggtgccccc tactcgttac
     1501 tctcccattc ccagacacat gctggctgag gaagacttta ccagagagcc ccgcaagatc
     1561 atcctgcaca aaggttctac aggcctgggc ttcaacattg taggaggaga ggatggagag
     1621 ggcatttttg tttcattcat cctggcagga ggcccagcag acctaagtgg ggagttgcga
     1681 aggggagacc ggatcttatc ggtaaatgga gtcaacctga ggaatgctac ccatgagcag
     1741 gcagcggctg ctctaaaacg ggctggccaa tcagtcacca ttgtggccca gtatagacct
     1801 gaagagtaca gtcgctttga atccaagatc catgacttgc gagaacaaat gatgaacagc
     1861 agcatgagct cggggtccgg gtctctccga accagtgaga agaggtcctt gtatgtcagg
     1921 gccctgtttg attatgatcg gactcgtgac agctgcctac caagccaggg actcagtttc
     1981 tcttatggtg acattctaca cgtcattaac gcctctgatg atgagtggtg gcaagcaagg
     2041 ctggtgactc cacatggaga gagtgaacag attggtgtga tccctagtaa aaagagggtt
     2101 gaaaagaaag agcgagctcg attgaaaact gtgaaattcc atgccaggac agggatgatt
     2161 gagtctaatc gggacttccc tgggttaagt gacgattatt atggagcaaa gaacctgaag
     2221 ggagtgacat ccaacaccag tgacagcgaa agcagttcca aaggacaaga ggatgctatt
     2281 ttgtcatatg agccagtgac acgacaagaa attcattatg ccaggcctgt gatcatcttg
     2341 ggcccaatga aggaccgagt caatgatgac ctcatctctg agttcccgca taagtttgga
     2401 tcctgcgtgc cacataccac ccgacctcgg cgtgataacg aggtagatgg acaggattac
     2461 cactttgtgg tttcccggga acagatggag aaggatattc aggacaacaa gttcatcgag
     2521 gcaggccagt tcaatgataa tctctacggg accagcatcc agtctgtgcg ggcggttgca
     2581 gagaggggca agcactgcat cttagacgtg tccggcaacg ctataaagag actgcagcaa
     2641 gcacaacttt atcccattgc cattttcatc aagcccaagt ccatcgaagc acttatggaa
     2701 atgaaccgac ggcagacata cgaacaagca aataagatct ttgacaaagc catgaaactg
     2761 gagcaagaat ttggagaata ctttacagcc attgtacagg gtgactcact ggaagagatt
     2821 tataacaaaa tcaaacaaat cattgaggac cagtctgggc actacatttg ggtcccatcc
     2881 cctgaaaaac tctgaagaat cccctccaac cattctcttg tgaacagaag aaatcaagtc
     2941 cctcttccct ccttcctctt cattcctgtc cccacgggga gaacaaatga ctactgttct
     3001 tgtccccctt tttagatatg tcaaaaattg agttttctag tcctgttctt ttttaaaaat
     3061 gttgtttggt tttggtttat tttttgggat gatgccatct cactcatcat gtgaccgtgc
     3121 ccattcctgc atggaccttt cccgcgctag cacaggtgca aacccatcag agttgttgtt
     3181 ctcataaaca cccagcagaa gcgcagagaa gagacgagga ctgacggaaa gacagactct
     3241 ggacaactgc acagcttgtg aagtgagcga aacagcccac gtgatgaggt gcccctgggc
     3301 atttctaccc tgtactgctg gcttgcagct ctgaacagtg caacgtaacg gctacagaaa
     3361 gtatcttatt tatatataga tatatatatg taatttatat aaaatatata gaaattatta
     3421 tatatatata ttatacactc ttctataata tatatatata ttcacataca ttgggactag
     3481 aaaaatctat ggagatgtcc atcaatggta ctatgttatt agagaaatgc tttaattttc
     3541 atattccaat cagatgacat cctatgttcc actggttggg aaggggttga caacagtagt
     3601 aagtgctata ccaaagcact tggatttggt cattctcttc agagctaagg tttgctccag
     3661 gtggggccaa cctacagcgc aagagaaggg gctttggctg ggagcttgag cttggagact
     3721 tgactgaaag cagttgctgc ccctgcag
//
