LOCUS       NM_022282               2993 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus discs large MAGUK scaffold protein 2 (Dlg2),
            mRNA.
ACCESSION   NM_022282
VERSION     NM_022282.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Griesius,S., Waldron,S., Kamenish,K.A., Cherbanich,N.,
            Wilkinson,L.S., Thomas,K.L., Hall,J., Mellor,J.R., Dwyer,D.M. and
            Robinson,E.S.J.
  TITLE     A mild impairment in reversal learning in a bowl-digging substrate
            deterministic task but not other cognitive tests in the Dlg2+/- rat
            model of genetic risk for psychiatric disorder
  JOURNAL   Genes Brain Behav 22 (6), e12865 (2023)
   PUBMED   37705179
  REMARK    GeneRIF: A mild impairment in reversal learning in a bowl-digging
            substrate deterministic task but not other cognitive tests in the
            Dlg2+/- rat model of genetic risk for psychiatric disorder.
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Griesius,S., O'Donnell,C., Waldron,S., Thomas,K.L., Dwyer,D.M.,
            Wilkinson,L.S., Hall,J., Robinson,E.S.J. and Mellor,J.R.
  TITLE     Reduced expression of the psychiatric risk gene DLG2 (PSD93)
            impairs hippocampal synaptic integration and plasticity
  JOURNAL   Neuropsychopharmacology 47 (7), 1367-1378 (2022)
   PUBMED   35115661
  REMARK    GeneRIF: Reduced expression of the psychiatric risk gene DLG2
            (PSD93) impairs hippocampal synaptic integration and plasticity.
            Erratum:[Neuropsychopharmacology. 2024 Mar;49(4):766. doi:
            10.1038/s41386-024-01801-w.. PMID: 38225398]
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Ali,S., Hoven,A., Dress,R.J., Schaal,H., Alferink,J. and Scheu,S.
  TITLE     Identification of a novel Dlg2 isoform differentially expressed in
            IFNbeta-producing plasmacytoid dendritic cells
  JOURNAL   BMC Genomics 19 (1), 194 (2018)
   PUBMED   29703139
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Matt,L., Kirk,L.M., Chenaux,G., Speca,D.J., Puhger,K.R.,
            Pride,M.C., Qneibi,M., Haham,T., Plambeck,K.E., Stern-Bach,Y.,
            Silverman,J.L., Crawley,J.N., Hell,J.W. and Diaz,E.
  TITLE     SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and
            Plasticity Underlying Cognitive Function
  JOURNAL   Cell Rep 22 (9), 2246-2253 (2018)
   PUBMED   29490264
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Takei,Y., Kikkawa,Y.S., Atapour,N., Hensch,T.K. and Hirokawa,N.
  TITLE     Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport,
            and Instability of Postsynaptic Density Proteins in Mice Lacking
            Microtubule-Associated Protein 1A
  JOURNAL   J Neurosci 35 (47), 15539-15554 (2015)
   PUBMED   26609151
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   Brenman,J.E., Topinka,J.R., Cooper,E.C., McGee,A.W., Rosen,J.,
            Milroy,T., Ralston,H.J. and Bredt,D.S.
  TITLE     Localization of postsynaptic density-93 to dendritic microtubules
            and interaction with microtubule-associated protein 1A
  JOURNAL   J Neurosci 18 (21), 8805-8813 (1998)
   PUBMED   9786987
REFERENCE   7  (bases 1 to 2993)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   8  (bases 1 to 2993)
  AUTHORS   Kim,E., Cho,K.O., Rothschild,A. and Sheng,M.
  TITLE     Heteromultimerization and NMDA receptor-clustering activity of
            Chapsyn-110, a member of the PSD-95 family of proteins
  JOURNAL   Neuron 17 (1), 103-113 (1996)
   PUBMED   8755482
REFERENCE   9  (bases 1 to 2993)
  AUTHORS   Brenman,J.E., Chao,D.S., Gee,S.H., McGee,A.W., Craven,S.E.,
            Santillano,D.R., Wu,Z., Huang,F., Xia,H., Peters,M.F.,
            Froehner,S.C. and Bredt,D.S.
  TITLE     Interaction of nitric oxide synthase with the postsynaptic density
            protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
  JOURNAL   Cell 84 (5), 757-767 (1996)
   PUBMED   8625413
REFERENCE   10 (bases 1 to 2993)
  AUTHORS   Sussman,H.M., MacNeilage,P.F. and Lumbley,J.L.
  TITLE     Pursuit auditory tracking of dichotically presented tonal
            amplitudes
  JOURNAL   J Speech Hear Res 18 (1), 74-81 (1975)
   PUBMED   1127911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022282.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000001.1  154539671-154539979
            310-471             JAXUCZ010000001.1  154880776-154880937
            472-525             JAXUCZ010000001.1  155191306-155191359
            526-576             JAXUCZ010000001.1  155263218-155263268
            577-701             JAXUCZ010000001.1  155333392-155333516
            702-871             JAXUCZ010000001.1  155366339-155366508
            872-1008            JAXUCZ010000001.1  155422595-155422731
            1009-1153           JAXUCZ010000001.1  155445301-155445445
            1154-1292           JAXUCZ010000001.1  155447625-155447763
            1293-1448           JAXUCZ010000001.1  155487504-155487659
            1449-1517           JAXUCZ010000001.1  155540876-155540944
            1518-1674           JAXUCZ010000001.1  155569809-155569965
            1675-1777           JAXUCZ010000001.1  155609676-155609778
            1778-1892           JAXUCZ010000001.1  155766560-155766674
            1893-2069           JAXUCZ010000001.1  155837540-155837716
            2070-2145           JAXUCZ010000001.1  155847224-155847299
            2146-2191           JAXUCZ010000001.1  155886937-155886982
            2192-2242           JAXUCZ010000001.1  155896375-155896425
            2243-2344           JAXUCZ010000001.1  155897217-155897318
            2345-2517           JAXUCZ010000001.1  155899334-155899506
            2518-2627           JAXUCZ010000001.1  155905139-155905248
            2628-2719           JAXUCZ010000001.1  155909848-155909939
            2720-2993           JAXUCZ010000001.1  155911635-155911908
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2993
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /note="discs large MAGUK scaffold protein 2"
                     /db_xref="GeneID:64053"
                     /db_xref="RGD:619895"
     exon            1..309
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2826
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /note="synaptic density protein PSD-93; chapsyn-110;
                     postsynaptic density protein PSD-93; channel-associated
                     protein of synapse-110; discs, large homolog 2; disks
                     large 1 tumor suppressor protein-like"
                     /codon_start=1
                     /product="disks large homolog 2"
                     /protein_id="NP_071618.2"
                     /db_xref="GeneID:64053"
                     /db_xref="RGD:619895"
                     /translation="MFFACYCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHV
                     SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLE
                     RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE
                     VSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPG
                     DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKV
                     GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHM
                     LVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDM
                     TSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFIL
                     AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARF
                     EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD
                     ILHVINASDDEWWQARRVILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDS
                     KGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISE
                     FPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS
                     VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQA
                     KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL"
     exon            310..471
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..525
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..576
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..701
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..871
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1008
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1153
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1292
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1448
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1517
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1674
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1777
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1892
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2069
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2145
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2191
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2242
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2344
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2517
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2627
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2719
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2993
                     /gene="Dlg2"
                     /gene_synonym="Dlgh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggttcta actttcggat gctgaatcct cggctaattg aaattactgg gcataatgct
       61 atatatagcc aatgaagaga ttctgagctc tcactcagtg ccttcaagac atgtcgtttt
      121 gtagtcagag gaaacaggga tcaatgcatt ttcaaactga cagagggaac ggatgctcct
      181 tagcagcaca tgcccaggat cgtgtgtgtg gggcttgcgc tgtgctgaga agctgatcac
      241 cggcccatat gccccttatt tactgcaatg ttctttgcat gttattgtgc actccggact
      301 aacgtgaaga agtatcgata ccaagatgag gacggtccac atgatcattc cttacctcgg
      361 ctaactcatg aagtaagagg tccagaactg gtgcatgtgt cggaaaagaa cctctctcaa
      421 atagaaaatg tccacggata tgtcttacag tctcacattt ctcctctgaa ggctagccct
      481 gctcctataa ttgtcaacac agacactttg gacactattc cttatgtcaa tggaacagaa
      541 attgaatatg aatttgaaga aattacattg gagaggggaa attcaggtct gggattcagt
      601 attgctggag ggacagataa tcctcacatt ggagatgacc ctggcatatt tattacgaag
      661 attattccag gaggtgctgc agcagaggat ggcagactca gggtcaacga ttgtatcttg
      721 cgggtgaatg aagttgatgt gtcggaggtt tcccacagta aagcagtgga ggccctcaag
      781 gaagcaggct ctattgttcg actgtatgta cgtagaagac gacccatcct ggagactgtt
      841 gtggaaatca aacttttcaa agggccaaaa ggtttaggct tcagtattgc tggaggggtg
      901 gggaaccaac acattcccgg agacaacagc atttatgtaa cgaaaattat agatggtgga
      961 gctgcacaga aagatggaag gttgcaagta ggagacagac tgctaatggt aaataactat
     1021 agtttagaag aagttacaca tgaagaggct gtagcgatat tgaaaaatac atctgatgtt
     1081 gtttatctaa aagttggcaa acccacaacc atttatatga ctgatcctta tgggccaccg
     1141 gatattactc actcttattc tccaccaatg gaaaatcatc tactgtctgg taacaatggc
     1201 acgttagaat acaaaacatc cctgccgccc atctctccag gaaggtactc accaattcca
     1261 aagcacatgc tggttgaaga tgactacaca aggcctccgg aacctgttta cagcactgtg
     1321 aataaactgt gtgataaacc tgcttctccc aggcactatt cccctgttga gtgtgacaaa
     1381 agcttccttc tctcaactcc ttacccccac taccacctag gcctgctccc tgactctgac
     1441 atgaccagtc attctcagca cagtactgca actcgtcagc cctcagtgac tctccaacgg
     1501 gccatctccc tggaagggga gccccgaaag gtggtccttc acaaaggctc cactggcctg
     1561 ggcttcaaca ttgtgggtgg agaagacgga gaaggtattt ttgtatcctt cattctggcc
     1621 ggtggaccag cagacctgag tggggagctc cagagaggag accagatctt atcggtgaat
     1681 ggtatcgatc tccgaggagc atctcatgaa caggcagctg cagcactgaa gggggcgggg
     1741 cagacagtga caatcatagc acaatatcaa cctgaagatt acgctcgatt cgaggccaaa
     1801 atccatgacc tacgagagca gatgatgaac cacagcatga gttccgggtc cgggtccctt
     1861 cgaaccaatc agaaacgctc cctgtatgtc agagccatgt ttgactatga caagagcaag
     1921 gacagtggac tgcctagcca aggacttagt tttaaatatg gagacatcct tcatgtcatc
     1981 aatgcctctg atgatgagtg gtggcaagcc agaagggtca tactagatgg ggacagcgag
     2041 gagatgggag tcattcccag caaacggagg gtggaaagaa aggagcgtgc ccgattgaag
     2101 acagtgaagt tcaatgcaaa acctggtgtg attgattcca aaggggacat ccccggatta
     2161 ggtgacgacg gttatggaac aaagactctg agaggacaag aagatctcat tctttcctat
     2221 gaacctgtca cgaggcagga aataaactac acccgaccag tgattatcct gggccccatg
     2281 aaggatcgaa tcaatgatga cttgatatct gaatttcctg ataaatttgg ctcctgtgtg
     2341 cctcatacta cgaggccaaa gcgtgactac gaagtcgacg gcagagacta tcactttgtc
     2401 atttctagag aacaaatgga gaaagatatc caagagcaca aatttataga agccggccag
     2461 tacaatgaca atttatatgg aaccagtgtg cagtctgtga gatttgtagc agaaaggggc
     2521 aaacactgta tacttgatgt atcgggaaat gctattaagc ggttacaagt tgcccagctc
     2581 tatcccattg ctatcttcat aaagcccaag tctctggaac ctctgatgga gatgaataag
     2641 cgtctaacgg aggaacaagc caagaaaacc tatgaccggg caattaagct agaacaagaa
     2701 tttggagaat attttacagc tattgtccaa ggagatacct tagaagatat ttacaaccaa
     2761 tgcaagcttg ttattgaaga gcagtctgga cctttcatct ggattccctc aaaggagaag
     2821 ttataaatta gctactgcac ctctgacaac gacagaagag catttagaag aacaaaatat
     2881 atataatata acacttggag gcttttatgt ttttgttgca tttatgtttt tgcagtcaat
     2941 gtgaatcctt atgaatgtac aacacaaact gtgtgaagcc atgaaggaaa cag
//
