LOCUS       NM_001393734            4667 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus discs large MAGUK scaffold protein 1 (Dlg1),
            transcript variant 2, mRNA.
ACCESSION   NM_001393734
VERSION     NM_001393734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4667)
  AUTHORS   Liang,Z., Li,L., Bai,L., Gao,Y., Qiao,Y., Wang,X., Yv,L. and
            Xu,J.T.
  TITLE     Spinal nerve transection-induced upregulation of SAP97 via
            promoting membrane trafficking of GluA1-containing AMPA receptors
            in the dorsal horn contributes to the pathogenesis of neuropathic
            pain
  JOURNAL   Neurobiol Dis 194, 106471 (2024)
   PUBMED   38461868
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of SAP97 via
            promoting membrane trafficking of GluA1-containing AMPA receptors
            in the dorsal horn contributes to the pathogenesis of neuropathic
            pain.
REFERENCE   2  (bases 1 to 4667)
  AUTHORS   Kay,Y., Tsan,L., Davis,E.A., Tian,C., Decarie-Spain,L.,
            Sadybekov,A., Pushkin,A.N., Katritch,V., Kanoski,S.E. and
            Herring,B.E.
  TITLE     Schizophrenia-associated SAP97 mutations increase glutamatergic
            synapse strength in the dentate gyrus and impair contextual
            episodic memory in rats
  JOURNAL   Nat Commun 13 (1), 798 (2022)
   PUBMED   35145085
  REMARK    GeneRIF: Schizophrenia-associated SAP97 mutations increase
            glutamatergic synapse strength in the dentate gyrus and impair
            contextual episodic memory in rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4667)
  AUTHORS   Guo,J., Li,C., Fang,Q., Liu,Y., Wang,D., Chen,Y., Xie,W. and
            Zhang,Y.
  TITLE     The SF3B1R625H mutation promotes prolactinoma tumor progression
            through aberrant splicing of DLG1
  JOURNAL   J Exp Clin Cancer Res 41 (1), 26 (2022)
   PUBMED   35039052
  REMARK    GeneRIF: The SF3B1(R625H) mutation promotes prolactinoma tumor
            progression through aberrant splicing of DLG1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4667)
  AUTHORS   Ambroziak,W., Fourie,C. and Montgomery,J.M.
  TITLE     SAP97-mediated rescue of NMDA receptor surface distribution in a
            neuronal model of Huntington's disease
  JOURNAL   Hippocampus 28 (10), 707-723 (2018)
   PUBMED   30067285
  REMARK    GeneRIF: This study reveals plasticity in surface NMDAR
            localization driven by mutant HTT and identifies the similar but
            independent roles of SAP97 N-terminal isoforms in maintaining
            normal synaptic function in pathological states.
REFERENCE   5  (bases 1 to 4667)
  AUTHORS   Noseda,R., Guerrero-Valero,M., Alberizzi,V., Previtali,S.C.,
            Sherman,D.L., Palmisano,M., Huganir,R.L., Nave,K.A., Cuenda,A.,
            Feltri,M.L., Brophy,P.J. and Bolino,A.
  TITLE     Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold
  JOURNAL   PLoS Biol 14 (4), e1002440 (2016)
   PUBMED   27070899
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4667)
  AUTHORS   Lue,R.A., Brandin,E., Chan,E.P. and Branton,D.
  TITLE     Two independent domains of hDlg are sufficient for subcellular
            targeting: the PDZ1-2 conformational unit and an alternatively
            spliced domain
  JOURNAL   J Cell Biol 135 (4), 1125-1137 (1996)
   PUBMED   8922391
REFERENCE   7  (bases 1 to 4667)
  AUTHORS   Matsumine,A., Ogai,A., Senda,T., Okumura,N., Satoh,K., Baeg,G.H.,
            Kawahara,T., Kobayashi,S., Okada,M., Toyoshima,K. and Akiyama,T.
  TITLE     Binding of APC to the human homolog of the Drosophila discs large
            tumor suppressor protein
  JOURNAL   Science 272 (5264), 1020-1023 (1996)
   PUBMED   8638125
REFERENCE   8  (bases 1 to 4667)
  AUTHORS   Niethammer,M., Kim,E. and Sheng,M.
  TITLE     Interaction between the C terminus of NMDA receptor subunits and
            multiple members of the PSD-95 family of membrane-associated
            guanylate kinases
  JOURNAL   J Neurosci 16 (7), 2157-2163 (1996)
   PUBMED   8601796
REFERENCE   9  (bases 1 to 4667)
  AUTHORS   Muller,B.M., Kistner,U., Veh,R.W., Cases-Langhoff,C., Becker,B.,
            Gundelfinger,E.D. and Garner,C.C.
  TITLE     Molecular characterization and spatial distribution of SAP97, a
            novel presynaptic protein homologous to SAP90 and the Drosophila
            discs-large tumor suppressor protein
  JOURNAL   J Neurosci 15 (3 Pt 2), 2354-2366 (1995)
   PUBMED   7891172
REFERENCE   10 (bases 1 to 4667)
  AUTHORS   Sussman,H.M., MacNeilage,P.F. and Lumbley,J.L.
  TITLE     Pursuit auditory tracking of dichotically presented tonal
            amplitudes
  JOURNAL   J Speech Hear Res 18 (1), 74-81 (1975)
   PUBMED   1127911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.48545.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               JAXUCZ010000011.1  82607379-82607797   c
            420-471             JAXUCZ010000011.1  82606873-82606924   c
            472-603             JAXUCZ010000011.1  82606060-82606191   c
            604-770             JAXUCZ010000011.1  82593424-82593590   c
            771-935             JAXUCZ010000011.1  82544723-82544887   c
            936-989             JAXUCZ010000011.1  82507058-82507111   c
            990-1040            JAXUCZ010000011.1  82497521-82497571   c
            1041-1165           JAXUCZ010000011.1  82495009-82495133   c
            1166-1335           JAXUCZ010000011.1  82493122-82493291   c
            1336-1472           JAXUCZ010000011.1  82491259-82491395   c
            1473-1617           JAXUCZ010000011.1  82488023-82488167   c
            1618-1738           JAXUCZ010000011.1  82479213-82479333   c
            1739-1895           JAXUCZ010000011.1  82471841-82471997   c
            1896-1998           JAXUCZ010000011.1  82463123-82463225   c
            1999-2113           JAXUCZ010000011.1  82455366-82455480   c
            2114-2290           JAXUCZ010000011.1  82453459-82453635   c
            2291-2360           JAXUCZ010000011.1  82447817-82447886   c
            2361-2460           JAXUCZ010000011.1  82443572-82443671   c
            2461-2502           JAXUCZ010000011.1  82435941-82435982   c
            2503-2553           JAXUCZ010000011.1  82433629-82433679   c
            2554-2655           JAXUCZ010000011.1  82432662-82432763   c
            2656-2828           JAXUCZ010000011.1  82432165-82432337   c
            2829-2938           JAXUCZ010000011.1  82426313-82426422   c
            2939-3030           JAXUCZ010000011.1  82421635-82421726   c
            3031-4667           JAXUCZ010000011.1  82416853-82418489   c
FEATURES             Location/Qualifiers
     source          1..4667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4667
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /note="discs large MAGUK scaffold protein 1"
                     /db_xref="GeneID:25252"
                     /db_xref="RGD:2505"
     exon            1..419
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            420..471
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..3137
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /note="isoform 2 is encoded by transcript variant 2; disks
                     large homolog 1; synapse-associated protein 97; discs
                     large homolog 1, scribble cell polarity complex component;
                     Drosophila discs-large tumor suppressor homologue (synapse
                     associated protein); discs, large homolog 1"
                     /codon_start=1
                     /product="disks large homolog 1 isoform 2"
                     /protein_id="NP_001380663.1"
                     /db_xref="GeneID:25252"
                     /db_xref="RGD:2505"
                     /translation="MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSN
                     LFQALIDIQEFYEVTLLDNPKCVDHSKQCEPVQPGNPWESGSLSSAAVTSESLPGGLS
                     PPVEKYRYQDEEVLPSERISPQVPNEVLGPELVHVSEKSLSEIENVHGFVSHSHISPI
                     KANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDS
                     SIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKR
                     RKPASEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI
                     GDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYINDGYAPPDITNSSSQ
                     SVDNHVSPSSYLGQTPASPARYSPISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG
                     EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI
                     VAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVRALFDYDKTKDSG
                     LPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKT
                     VKFNSKTRGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESS
                     YRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPK
                     RDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCIL
                     DVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTDEQARKTFERAVRLEQEFTE
                     HFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAKEKL"
     exon            472..603
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            604..770
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            771..935
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            936..989
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1040
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1165
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1335
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1472
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1617
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1738
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1895
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1998
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2113
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2290
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2360
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2460
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2502
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2553
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2655
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2828
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2938
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3030
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..4667
                     /gene="Dlg1"
                     /gene_synonym="Dlgh1; SAP97"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgactgggg gcgcggaagg aggcgaggtt ccgggggtgg ggcggcccgg aggcgagcgg
       61 gcgagcgggg ccgcgagcgg cggcgagagg gcaggcggcg gcggccgagg cggagagagc
      121 ggcgcggggg tgcggccgcc gagaggagct cctcccccgt cccctcaccc cctcagctga
      181 gctcgagtcg gggcggggcg gggtacgtgg agcggggccg ggcggggagc tgctccgagt
      241 ctggccggag cgcacccggg gcgcccgcgt tcgccgctcg cgggaacttt gcggcggagc
      301 cgcaggtgtg gaggccgcgg aggggtgcat gagcggcgcg agggcggcgc acagagcggc
      361 ggctgtccgg tccggcccct gctggagtcg ccgccgggag gaggcgagcg aggagccagg
      421 tgtgtgtgcc ttcttcctgc ttctgggaaa aaatgccggt ccggaagcaa gatacccaga
      481 gagcattgca tctgttggaa gaatatcggt cgaaactaag ccaaaccgaa gacagacagc
      541 tcaggagttc catagagcgg gttattagca tatttcagag caacctcttt caggctttaa
      601 tagacattca agaattttat gaagtgacct tacttgataa tccaaaatgt gtggatcatt
      661 caaagcagtg tgaaccggtc caacccggga atccttggga gagtggcagc ctttcaagtg
      721 ctgctgtgac ttcagagagc ctgcccggcg gccttagccc tccagtagag aaataccggt
      781 atcaggacga agaggtgctg ccttcagagc ggatttcccc gcaagtccca aatgaggtgc
      841 tgggtccgga gctggttcac gtctcggaga agagcctgtc agagattgag aatgtccacg
      901 ggtttgtctc tcactctcat atctcaccca taaaggcaaa tcctcctcct gtgctggtca
      961 acacagacag cttggagaca ccaacttatg ttaatggtac tgatgcagat tatgaatatg
     1021 aggaaatcac acttgaaagg ggaaattcag gccttggttt cagcattgca ggaggtacag
     1081 acaacccaca cattggagat gactcaagta ttttcatcac caaaattatc acgggaggag
     1141 cagctgccca ggatggaaga ttgcgggtaa atgactgtat actgagagta aatgaagcag
     1201 atgttcgtga tgtaacccac agcaaagcag ttgaagcatt gaaagaagct ggatcgatag
     1261 tgcgattata tgtgaaaagg cggaagccag cctcagaaaa aatcatggaa ataaaactta
     1321 ttaaaggccc taaaggtctt gggttcagca ttgctggagg tgttggaaac cagcacattc
     1381 ctggggataa cagcatctat gtaaccaaaa taattgaagg aggtgcagca cacaaggacg
     1441 gcaaacttca gattggagac aagcttctag cagtgaacag tgtctgttta gaagaagtta
     1501 ctcatgaaga agcagtgact gccttaaaga atacatctga ttttgtttat ttgaaagtgg
     1561 caaaaccaac aagtatgtat ataaatgatg gctatgcacc acccgacatc actaattctt
     1621 cttctcagtc tgttgacaac catgttagcc cgtcttcata cttgggccag actccagcgt
     1681 caccagccag atactcaccc atttctaaag cagtgcttgg agatgatgag atcactaggg
     1741 aacctagaaa agttgttctt catcgtggct caacgggact tggtttcaac attgtgggag
     1801 gcgaagatgg agaagggatt tttatctctt tcatccttgc tgggggacct gctgacctaa
     1861 gcggagagct cagaaaagga gatcgcatta tatcggtaaa cagtgttgac ctcagagctg
     1921 caagtcatga acaagcagct gccgcattaa aaaacgcagg ccaagctgtc actattgtcg
     1981 cacagtatcg gcctgaagag tacagtcgtt ttgaagctaa aattcacgac ttgcgggagc
     2041 agatgatgaa cagcagtgtc agctcagggt cagggtctct ccgaaccagc caaaagcggt
     2101 ccctctatgt cagagccctt tttgattacg acaagactaa agacagtggc cttcccagtc
     2161 aagggttgaa cttcaaattc ggagatattc tccatgttat caatgcttct gatgacgagt
     2221 ggtggcaggc cagacaggtg accccagatg gtgagagtga cgaagttgga gtaattccta
     2281 gtaaacgcag agttgagaag aaagaacgag cccgattaaa aacagtcaaa ttcaattcta
     2341 aaacaagagg agataaaggg cagtcattca atgacaagcg taaaaagaac ctcttttccc
     2401 gaaaatttcc cttctacaag aacaaggacc agagtgagca ggaaacaagt gatgctgacc
     2461 agcacgtaac ttctaatgcc agcgatagcg aaagtagtta ccgtggtcaa gaagaatatg
     2521 ttttatcgta tgagccggtg aatcagcaag aagttaatta tacccgacca gtcatcatat
     2581 taggacctat gaaagacaga gtaaatgatg acttaatctc agaatttcct gacaaatttg
     2641 gatcctgtgt ccctcataca actagaccaa agcgtgacta tgaggtggat ggacgagatt
     2701 accattttgt gacttcaaga gaacagatgg agaaagatat ccaggagcat aaattcattg
     2761 aagctggcca gtataacaac catctatacg gaacgagtgt ccaatctgtg cgagcagtag
     2821 cagagaaggg caagcattgt atccttgatg tgtctggaaa tgccatcaag aggttgcaga
     2881 ttgcacagct ctatccaata tctattttta ttaaacccaa atccatggaa aatatcatgg
     2941 aaatgaataa acgcctaaca gacgaacagg ccagaaaaac gtttgagaga gcagtgagac
     3001 tggagcagga gttcactgag catttcacag ctattgtcca gggagacacg ctggaggaca
     3061 tttacaatca agtgaagcag atcatagaag agcagtctgg tccttacatc tgggtcccag
     3121 caaaagaaaa attatgaaga cagatgttgc tctttctttt ttccatggtc tcatctctct
     3181 gccctgctct ggagtctgtc ttcagcgttc cttccacact gacgcagacc cctcctcacg
     3241 gtcggcggtt gtgccgtctc tgacatctgt gtcccttcgt gttgcgtcat ctgtactact
     3301 ctgtgttact attggtttct ggccactttt cagaactgaa gatgaatgga tgaatggcct
     3361 gaccagctat ctagggtttg gggagatgca aaattgtaaa attccttaat gtttaaggga
     3421 aagttaactt ctaagagatt ttcagaaaag ctttgtatac attcttttcc aatctcagta
     3481 ccaacgaaag agaagtggtt ttaatcagtg attcagtgga ccttgagcaa ctgtgcacgc
     3541 ttaactctaa tagcatggtt tggccagtgt attagctctc aagttctttc ctcaattgac
     3601 ttctgctctt aaagtaatta tttcattaaa aacataagaa aaatagggat ttatttcaga
     3661 attaatgtct gagttaactc ataatttcag gagggctgtt cgttactcag gacaggcctt
     3721 tatcatgtgt gccctcccct gggacacttg ccaggaataa ccatagaatg ttttcagtcg
     3781 gcctctgcac tctgtggaga gtgactcagc gagttgtccg tacactttgt ggtcacagct
     3841 ctgtcaaggc gcagagagcc cacctcacac acagatctgt agacggaagg cgttttggtg
     3901 ggtgtgtagc agtcatggca gcagaaagga gcccaattca tagcctaaaa tgttgatgta
     3961 tgctgagggg tcagatttta atgactattt tacccacaat aactgcctat tttgttataa
     4021 taaaatatat ataaatatat atataaaact ttctttaact aaactgtaac tatgggaatt
     4081 attttcttta catagttgca cacacaaaca tatatatatt taaaatatat ttttcttttg
     4141 ccacctactt ctaacttttt gtttggtttt taaattaaat attaattgat gagacttacc
     4201 gtccttaatc atgtgaactg aagcaagtgt atggtggcga tgaggaggag cctctaggga
     4261 gattggattg cgagtcgacg ccaggcctgt tctcctcttt cctacagaat tccagaggtt
     4321 cctaggtttt ctgtcagtgc tgtgttcttg ttgtggagtt tgatttgggt cctctgcctt
     4381 tcctccgagt tctcctcatt ttattactag acagacaaac tccatttttg agattcccca
     4441 aacacttcat cttgcatagc tgcactgaac tagaatgcct cagaagtcag tcctctactc
     4501 cattattaat atcatttggc ttcccattgc tctttggaat tgttattcaa tatgtgattt
     4561 tggcaactcc ttaaaatttc ttaaatgagt actggtttgt aaagaattat ccattccatt
     4621 tatgagaaag aggagaacag ttaataaact ttattgtaaa atccata
//
