LOCUS       NM_001419664            5688 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DLEC1 cilia and flagella associated protein
            (Dlec1), mRNA.
ACCESSION   NM_001419664 XM_006244144
VERSION     NM_001419664.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5688)
  AUTHORS   Hong,Q., Li,Y., Chen,X., Ye,H., Tang,L., Zhou,A., Hu,Y., Gao,Y.,
            Chen,R., Xia,Y. and Duan,S.
  TITLE     CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the
            bone marrow of patients with acute myeloid leukemia during
            chemotherapy
  JOURNAL   Exp Ther Med 11 (5), 1901-1907 (2016)
   PUBMED   27168825
REFERENCE   2  (bases 1 to 5688)
  AUTHORS   Daigo,Y., Nishiwaki,T., Kawasoe,T., Tamari,M., Tsuchiya,E. and
            Nakamura,Y.
  TITLE     Molecular cloning of a candidate tumor suppressor gene, DLC1, from
            chromosome 3p21.3
  JOURNAL   Cancer Res 59 (8), 1966-1972 (1999)
   PUBMED   10213508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 13, 2023 this sequence version replaced XM_006244144.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.48168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               JAXUCZ010000008.1  127704238-127704651
            415-565             JAXUCZ010000008.1  127707885-127708035
            566-676             JAXUCZ010000008.1  127711840-127711950
            677-864             JAXUCZ010000008.1  127713913-127714100
            865-1082            JAXUCZ010000008.1  127714252-127714469
            1083-1161           JAXUCZ010000008.1  127716480-127716558
            1162-1249           JAXUCZ010000008.1  127722076-127722163
            1250-1423           JAXUCZ010000008.1  127723245-127723418
            1424-1560           JAXUCZ010000008.1  127724262-127724398
            1561-1653           JAXUCZ010000008.1  127725808-127725900
            1654-1744           JAXUCZ010000008.1  127726488-127726578
            1745-1907           JAXUCZ010000008.1  127727270-127727432
            1908-2100           JAXUCZ010000008.1  127728565-127728757
            2101-2159           JAXUCZ010000008.1  127729466-127729524
            2160-2328           JAXUCZ010000008.1  127729861-127730029
            2329-2422           JAXUCZ010000008.1  127730468-127730561
            2423-2553           JAXUCZ010000008.1  127730724-127730854
            2554-2712           JAXUCZ010000008.1  127730975-127731133
            2713-2852           JAXUCZ010000008.1  127732417-127732556
            2853-3006           JAXUCZ010000008.1  127737708-127737861
            3007-3117           JAXUCZ010000008.1  127738269-127738379
            3118-3248           JAXUCZ010000008.1  127739713-127739843
            3249-3425           JAXUCZ010000008.1  127740279-127740455
            3426-3496           JAXUCZ010000008.1  127740610-127740680
            3497-3648           JAXUCZ010000008.1  127741054-127741205
            3649-3767           JAXUCZ010000008.1  127741704-127741822
            3768-3838           JAXUCZ010000008.1  127742282-127742352
            3839-4041           JAXUCZ010000008.1  127745504-127745706
            4042-4152           JAXUCZ010000008.1  127745788-127745898
            4153-4278           JAXUCZ010000008.1  127745979-127746104
            4279-4373           JAXUCZ010000008.1  127746219-127746313
            4374-4458           JAXUCZ010000008.1  127746482-127746566
            4459-4662           JAXUCZ010000008.1  127746741-127746944
            4663-4824           JAXUCZ010000008.1  127748744-127748905
            4825-4978           JAXUCZ010000008.1  127749749-127749902
            4979-5102           JAXUCZ010000008.1  127750127-127750250
            5103-5688           JAXUCZ010000008.1  127750344-127750929
FEATURES             Location/Qualifiers
     source          1..5688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5688
                     /gene="Dlec1"
                     /note="DLEC1 cilia and flagella associated protein"
                     /db_xref="GeneID:501070"
                     /db_xref="RGD:1561649"
     exon            1..414
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..5226
                     /gene="Dlec1"
                     /note="deleted in lung and esophageal cancer 1"
                     /codon_start=1
                     /product="deleted in lung and esophageal cancer protein 1
                     homolog"
                     /protein_id="NP_001406593.1"
                     /db_xref="GeneID:501070"
                     /db_xref="RGD:1561649"
                     /translation="MEPESKKELQSPASSFVMSSETMWESTPRQPESTSLSWSPRKSL
                     RSLTVFTDYCQFGYPTRSLRAGFQELPPLPEPQTLRLRPASLRTQDISHLLARVFRNL
                     YTAQVIGDDLSDSLIKARGSEDARHEEFLDQLQQARAIYKKRLDDVAMLEKHITQARA
                     RDIAETEHATKQGRLHVVEAPVKLPPVKTVFRWCIDNELMQKHHLISTEDYYNDPLPF
                     CPAPKRSPTPMYSKMTFSCEKRFTHKSDLERKAEEHCRKLVEFDDLEYTTDSLRSVSK
                     TKGKTKVTIKKASTPANKKWMEHLQVPQRALDRRLLARMQNRNHYLKNPRFFPPNTPH
                     GGKSLIVPSRKPERRGSLSAKPEWSCTDAPVFLAKPAVGFFTDYEIGPVYEMVIALQN
                     TTSTSRYLRVLPPSSPYFALGLGMFPGKGGMVAPGMTCQYIVQFIPDCLGDFDDFILV
                     ETQSPHTLVIPLQARRPPPVLTLSPVLDCGHCLIGGVKITKFICKNVGFSVGKFCIMA
                     QKSWPPPSFRAVATTGFVEQPPFGIMPSVFELAPGYAVLLEVLFLPTGLGKAEETFVI
                     VCDNCQTKEVVVVGTGQLVALDLIYVSGGKSEPEPGELKDLTAQYFIRFEPENVQSIA
                     RKQLIIRNATHVELAFHWQIMKPNLQPLMPGETHSLDSIKCHPDRETAFSIIPEKGIL
                     QAHSDHEFILSFSPYELKCFHSVLQMVLEAVPEPLSSGAENLGDYSYSVDDVIVLEIE
                     VKGLAEPFQVLLEPYALIIPGESYVGITVKKDFKMWNNSKSPIRYMWGKVSDCHIVEV
                     TPCTGVIEPNEVEDFELNLTGGVPGPTIQDLECEIKDSPCPVVLHIEATFKGPVVVID
                     VPALQFGLLRLGKKASISIQVRNISQLSAVWHLKESPGCLAERHEDASSLDIDPFCGQ
                     LPPLGECRVTITLEASHCQRLQTVLELEVENGPWSYLPVYAEVQQPHVYLQNSHVEFS
                     NLYLGVPAKSKTMLINGTLLPTRFHWGKLLGAQAALCKMTVSPKRGLLGPSEELQLNL
                     ELTAHTEETLTDLVLPCHVSGMEEPLALGISGKPLGLQVTITISVVESGGSAVSASQE
                     ELRLDFGSKVPLRTPVIRQIILTNCSPIHTPFSLTFVYFGSPQDSLDNKTSVPDVPPA
                     LLKSAHIQEHMAKKERLDFVESLLSHRKGAAFFPHISQGKLGAYQQLSINITGCANMW
                     GEYWDELLCTVGNLPVTVIPVYMAVVGCPISTLRNTCYSVAPFQKEPITRFGTQISGG
                     DTVTRSLRLFNSSHCDIRLDWETYIPEEKEDQLLELLVFYGPPFPLRDQDGNEIVYPE
                     TSEASLPGSPCPSNVSVSSHTVPSLGSRSGGTRVEEQIISVILQGHDGVPSSHIYQIS
                     PKQVVIPAGDYRTIHISFTPTVLAPGVMHKVGYTGYALGFMSLDKETDRQIPGRMQRL
                     QGFAVGPLRLDLNGHVRHAQLHAELDNSGYLEFWCQASDLIPQNPCCGVLSEWLTVRH
                     LKLTNTTEILYYFRAQVSRPFLVSQGGADWDNRASHQCEEEMASTAQQLEIHPQENML
                     VDVSFSLSLELLSYQKLSDDQMLPGVAIQESEDGERKMVFTQNLLLGFTNQTVQEVPL
                     RAFVALPALQLSTSWVDFGTCFVNQQYTREIYLMNLSSCLSYWTVLMGQEEPAREDHA
                     FGVSPGSGLLNARVTNAPPTSTPLLVFFNPKSSVLYESTLVVEGVLSEKPCVLRLRGQ
                     GSYDERYVKFHQF"
     exon            415..565
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..676
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..864
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1082
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1249
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1423
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1560
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1653
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1744
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1907
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2100
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2159
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2328
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2422
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2553
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2712
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2852
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3006
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3117
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3248
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3425
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3496
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3648
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3767
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3838
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..4041
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4152
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4278
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4373
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4458
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4662
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4824
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4978
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5102
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
     exon            5103..5688
                     /gene="Dlec1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgccatgg aacccgagag caagaaagag ctgcaatccc ccgcttcctc cttcgtaatg
       61 tcctcagaga ccatgtggga atctaccccg cgccagcccg agtccaccag tctcagctgg
      121 tcccccagga agtccttgcg gtccttgacc gtcttcaccg attattgcca gttcggctac
      181 ccgacgcggt cgctccgcgc cgggttccaa gagctcccgc cactcccgga gccacagacg
      241 ctgcgtttgc gccccgcctc gctgcgcacg caggatatct cccatctgct tgcccgagtc
      301 ttccgaaact tgtacaccgc ccaggtgatc ggagatgact tgagcgacag cttgatcaag
      361 gcccgcggca gtgaggatgc gcgccacgaa gagttcctgg accagctgca gcaggctcga
      421 gccatctata aaaagcgtct ggatgatgtt gccatgttgg agaaacatat cacccaggcc
      481 cgagcacggg atattgcaga aacagaacat gccaccaaac aaggcagact gcatgtcgtg
      541 gaggcccctg tcaaactgcc cccagtgaag acggtcttca ggtggtgtat agacaatgaa
      601 ttaatgcaaa agcatcactt aatctctaca gaggattact acaatgatcc gttgccattt
      661 tgcccagcgc ccaaacgctc acccaccccc atgtattcaa agatgacgtt tagctgtgag
      721 aagcgtttca cgcacaagtc agacctggag aggaaggctg aggagcactg caggaagctc
      781 gtggaatttg acgacttaga gtacaccaca gacagcttgc gctccgtgtc caagaccaaa
      841 gggaagacca aagtcaccat caagaaggca agtacaccgg ccaataagaa atggatggag
      901 cacctgcagg tgccacagag agccctggac agacggctgc tcgccaggat gcagaatcgg
      961 aatcactacc tgaaaaaccc tcgttttttc ccgcctaaca caccacatgg aggcaagtct
     1021 ctaattgtcc cttcgaggaa gccagagaga agaggatccc tgagtgcaaa gccagagtgg
     1081 agctgcacag atgcccctgt gttcctggcg aaaccagcag ttggattttt cacagattac
     1141 gagattggac cagtttacga gatggtgatc gctctgcaga acaccacttc caccagccga
     1201 tacttgcgtg tcctcccacc atcctctcca tacttcgctc taggacttgg gatgttccca
     1261 ggaaaaggcg gaatggtggc tcccgggatg acctgccagt acattgtcca gttcatcccg
     1321 gactgccttg gcgattttga tgacttcatt ttggtcgaga cccagtctcc ccacacgctg
     1381 gtaatccccc tgcaggcccg gagaccaccg ccagtgctga ccttgtcacc agtattggac
     1441 tgcggccact gcctcattgg aggtgtgaag ataaccaaat tcatctgcaa aaatgtgggc
     1501 ttcagcgtcg gcaaattctg catcatggcc caaaagagct ggccaccgcc gagtttccgg
     1561 gctgttgcaa ccactggctt tgtggagcag cctccctttg gaataatgcc ttccgtgttt
     1621 gagctggccc cagggtatgc cgtactgttg gaggtcttat ttctccctac tggcctaggg
     1681 aaggcagagg agaccttcgt catcgtgtgt gacaactgtc agacaaagga ggtggtcgtc
     1741 gtagggacag ggcagctggt ggctttggat ctgatctatg tttctggtgg gaaaagtgag
     1801 ccagaaccag gagagctgaa agacttgaca gcccagtact ttatccgctt tgagcctgaa
     1861 aacgtccagt ccatcgcaag gaagcagctc atcatcagaa atgctacaca tgtggagctg
     1921 gccttccact ggcagatcat gaagcccaac ctgcagcctc tgatgcctgg agagacgcac
     1981 agcttggaca gcatcaagtg ccaccctgac agggaaacag ccttctccat cattcctgag
     2041 aagggcatcc tccaggccca ctcggaccac gagttcatcc tgagtttttc tccttatgag
     2101 ctcaagtgtt tccacagtgt actgcagatg gttctagaag ctgtccccga gcccttgagc
     2161 tcaggggcgg agaacctggg ggactactcc tactcagtgg atgatgtcat tgtcctggaa
     2221 atcgaggtga aaggcttggc agaacccttc caggttcttc tagagcccta tgccctcatc
     2281 atccctggcg agagctatgt tggcatcacc gtgaagaaag attttaagat gtggaacaac
     2341 agcaagtcac ccatcagata catgtggggc aaggtcagcg actgtcacat cgtggaggtg
     2401 acgccctgca ctggggtgat agagcccaac gaggtcgaag attttgagtt aaacctaacc
     2461 ggtggtgtac ctggcccaac catccaggac ctggagtgtg aaatcaaaga ctcaccctgc
     2521 ccggtggtgc tccacatcga ggccacattt aagggacccg tggtggtcat cgatgtccca
     2581 gcccttcagt tcggtctgct tcgcctggga aagaaggctt cgatctccat ccaggtccgg
     2641 aacatcagcc agctctccgc tgtgtggcac ttgaaggaga gcccgggttg cctggcagag
     2701 aggcatgagg atgcatcctc cttggacatc gaccctttct gcggccagct tccccctctt
     2761 ggggagtgca gggtgaccat caccttagag gcctcccatt gccagcgcct gcagacagtt
     2821 ctagagctgg aagtggagaa cgggccctgg agttaccttc ctgtgtatgc agaagtacag
     2881 cagcctcacg tgtacctgca gaacagccac gtggagttca gcaacctcta cctgggtgtg
     2941 cccgcgaagt caaagaccat gcttatcaat ggcacactcc tgcccacccg gttccactgg
     3001 ggcaagctcc tgggtgctca agcagccttg tgcaaaatga cagtctctcc caaacgtggc
     3061 ctactgggcc ccagtgaaga gctgcagctc aacttggagt tgacagccca cacagaggaa
     3121 acgctgaccg atctggttct cccttgtcat gtgtctggca tggaggagcc gctggccctg
     3181 ggcatctctg ggaagcctct gggactgcag gtgaccatca ccatctccgt ggtggaatct
     3241 ggtggaagcg ctgtcagtgc ttcacaggaa gagctacgct tggacttcgg ttcaaaggtg
     3301 ccactgagga cccctgtgat tcgacaaatc atcctgacaa actgctcccc gatacacacc
     3361 cctttctccc tcacgtttgt gtactttggg agtccccagg acagcctgga caacaagacc
     3421 agtgtccctg atgtacctcc tgccctgcta aagtcagcac acatccagga gcacatggcc
     3481 aagaaggaaa ggctggactt tgtggagagc ctgttgtctc acaggaaggg agctgctttc
     3541 tttccccaca tctctcaggg caagctggga gcctaccagc agctgagtat taacatcaca
     3601 ggctgtgcca acatgtgggg cgagtactgg gatgagctcc tctgcacggt aggaaacctg
     3661 ccagtaactg tcatcccagt gtacatggcg gtggtgggct gccctatcag caccctgagg
     3721 aatacgtgct acagtgtggc tccattccag aaggagccta tcaccaggtt tgggacccag
     3781 atctctggag gagacacagt caccagaagt ctccgcctat ttaactccag tcactgtgac
     3841 atccgcctag actgggagac ctatatccca gaagagaagg aggaccagct gctggaactg
     3901 cttgtgtttt atgggccacc cttcccactg cgggatcaag atgggaatga gatcgtgtat
     3961 cccgagacct ctgaggccag cttaccggga tccccatgtc cctccaatgt gtcagtgtct
     4021 agccacactg tcccctcgtt gggcagccgc agtggtggca ccagggtcga agagcagatc
     4081 atctctgtca tcctgcaggg gcacgatggt gtgccttcca gccacatata tcaaatcagc
     4141 cccaagcagg tggtcatccc ggctggggac tacaggacca tccacatctc cttcacgccc
     4201 acggtgcttg ccccaggtgt tatgcacaag gtgggctata ctggctatgc cctgggcttc
     4261 atgagcttgg ataaggagac agacagacag attccaggtc gaatgcaacg ccttcaggga
     4321 tttgccgtgg gccccctgag actggacctg aatggccacg tgagacatgc acagctgcat
     4381 gcagagctgg acaacagtgg ctacttggaa ttctggtgcc aggccagcga cctcatcccc
     4441 cagaatccct gctgtggggt gctgagtgaa tggctcaccg tccgccatct gaagctgacc
     4501 aataccacgg aaatcctgta ctacttccgg gcccaggtct ccaggccctt cttggtttct
     4561 caaggtgggg ccgactggga caacagagcc tctcatcagt gtgaggagga gatggcctcc
     4621 acggcccagc agctggaaat ccacccgcag gagaacatgc tggtggatgt gtccttctca
     4681 ctgtccctgg aactgctgtc ctaccagaag ctctcagacg accagatgtt gcctggagtg
     4741 gccattcagg agagtgagga tggggagaga aagatggtgt tcacacagaa tctactcctg
     4801 ggcttcacca accagactgt tcaggaggtg cccctgcgag cctttgtggc cctgccggca
     4861 ttgcagctct ccaccagctg ggtggacttc gggacctgtt ttgtgaacca gcagtacacc
     4921 cgggagatct acctgatgaa cctcagtagc tgcctgagct actggacagt gctgatggga
     4981 caggaggaac ccgccaggga ggatcatgcg tttggggtct ctccaggcag tggactgctg
     5041 aatgcccgag tcaccaacgc accccctacc tccaccccgc ttctggtgtt cttcaaccct
     5101 aagagcagcg tcctgtatga gtccacactg gtggtggaag gcgtgctgag cgagaagccc
     5161 tgtgtcctga ggctgcgggg ccaaggctct tacgacgaga gatacgtaaa attccaccag
     5221 ttctgaggct ctgtagccct cagccccagc cccagctgag gacatcaatc tggctcaggg
     5281 tggaggggca gggctgccga actgggacag aggcgaggcc ctcctaggat gagggatccc
     5341 ctcccagggt gtggtgtgag ccaggccccg catgacaggt ctcaggtcta agaagcacag
     5401 gccaccacca gcagagtggc tgtggcattc actacaaaga cggcccacgg attccaacaa
     5461 agcaagagcc cggccctggg ggaaatgacc gcaagcaaga tgagataaca tacatttact
     5521 atgcccctca tgcccactat tcatgaggcc actgtccctc agaaacatgt tgtcctgtgg
     5581 tcacgtgtga cgtgcactgt ctttggttca actgagagga gtggattgga tgcccttgtg
     5641 cccgtattgc gattacattt tctaaattaa agtgctgtga caaatccc
//
