LOCUS       NM_001109332            1329 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus dickkopf WNT signaling pathway inhibitor 4
            (Dkk4), mRNA.
ACCESSION   NM_001109332 XM_001073293 XM_577537
VERSION     NM_001109332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Fliniaux,I., Mikkola,M.L., Lefebvre,S. and Thesleff,I.
  TITLE     Identification of dkk4 as a target of Eda-A1/Edar pathway reveals
            an unexpected role of ectodysplasin as inhibitor of Wnt signalling
            in ectodermal placodes
  JOURNAL   Dev Biol 320 (1), 60-71 (2008)
   PUBMED   18508042
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Niehrs,C.
  TITLE     Function and biological roles of the Dickkopf family of Wnt
            modulators
  JOURNAL   Oncogene 25 (57), 7469-7481 (2006)
   PUBMED   17143291
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001109332.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680441,
                              SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000016.1  76108794-76109044   c
            252-402             JAXUCZ010000016.1  76107764-76107914   c
            403-555             JAXUCZ010000016.1  76107290-76107442   c
            556-1329            JAXUCZ010000016.1  76105679-76106452   c
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1329
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /note="dickkopf WNT signaling pathway inhibitor 4"
                     /db_xref="GeneID:502097"
                     /db_xref="RGD:1563172"
     exon            1..251
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..806
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /note="dickkopf-related protein 4; dickkopf homolog 4"
                     /codon_start=1
                     /product="dickkopf-related protein 4 precursor"
                     /protein_id="NP_001102802.1"
                     /db_xref="GeneID:502097"
                     /db_xref="RGD:1563172"
                     /translation="MVLVALLGLSWFCSPLGALVLDFNNIKSSSDVQGSGKGSQCVSD
                     KDCNVGKFCFALHDERSFCATCRRVRRRCQRSAMCCPGTVCVNDVCTAVENTRPVMDR
                     NTDGQDGTYAEGTTKWPAEENRPQGKPSTKKSQSNKGQEGESCLRTSDCGPGLCCARH
                     FWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLSCRSQVTGNRQHTRLRVC
                     QRI"
     exon            252..402
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /inference="alignment:Splign:2.1.0"
     exon            403..555
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1329
                     /gene="Dkk4"
                     /gene_synonym="RGD1563172"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacaccttc cttgggcaga ttctctttca gaaaaggcct ctgtgggcaa cttgcagatc
       61 gtgcctagga ccactcagca gcccagcctt agaagactca agcggttctg gaactcccga
      121 gagaccagag tgactgaagg atggtcctgg tggccttgct tggactcagc tggttctgtt
      181 cacccctggg agccctggtt ctggatttta acaacatcaa gagctcctca gatgtgcaag
      241 gctctgggaa gggctcacag tgtgtgtcag acaaggattg caacgtagga aaattctgct
      301 tcgcgctcca tgatgaaagg tccttctgtg ccacgtgccg cagagttcgc aggagatgcc
      361 agaggagcgc catgtgctgc ccaggaacgg tctgcgtgaa tgatgtttgc actgcagtgg
      421 aaaacacgag gccagtgatg gacagaaaca ccgacggcca agatggcacc tacgcagagg
      481 gaaccaccaa atggccagcg gaggaaaaca gacctcaggg gaagcccagt acgaagaaat
      541 cacaaagcaa taagggacag gagggagaaa gctgtctcag aacctccgac tgcggccctg
      601 gactttgctg tgctcgccat ttttggacca aaatttgcaa gccagttcta ctagagggac
      661 aagtgtgttc caggaggggg cacaaagaca ctgcccaagc cccagaaatc ttccagcgct
      721 gtgactgtgg tcctggactg tcctgtcgaa gtcaggtgac tggtaaccga caacatacaa
      781 ggctaagagt atgccaaaga atataagttg tacagacatg ggacttgtcc tcgtgttcac
      841 acagaatccc tggcactaat tttattctat tttttatttt gttttctgag acagtggtct
      901 cgctgtgtag ccctggctgg ccttacactc atagagaccc acctgcctct gcctcctgga
      961 taatttttgg ggggaggggt aagggttctg agacagggtc tcagagtaag ctatatagcc
     1021 cagggtggct tcgaactcat gttcctcttg cctcgagtga gtcttgggat tacaggcaag
     1081 tacattatac ccagcacata aataaagctg aatcttctag caactgacag tgaccagacg
     1141 ctgtgatgag ttacttctga ctttgtgact accatctaca acatgacagg actctacaat
     1201 aaagccatcc agacacagtg gctcaatctg ctcaaataaa tctttcttaa aacttgaagt
     1261 tctttgttcg tgtacagaat gttatttgat aaacagtgga ctgtccacca gacgaactga
     1321 tgaatgcta
//
