LOCUS       NM_138519               5010 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus dickkopf WNT signaling pathway inhibitor 3
            (Dkk3), mRNA.
ACCESSION   NM_138519 XM_346553
VERSION     NM_138519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5010)
  AUTHORS   Busceti,C.L., Carrizzo,A., Bianchi,F., De Lucia,M., Damato,A.,
            Cazzin,C., Venturini,E., Di Pietro,P., Ginerete,R.P., Di Menna,L.,
            Cotugno,M., Stanzione,R., Marchitti,S., Migliarino,S.,
            Ciccarelli,M., Sciarretta,S., Bruno,V., Battaglia,G., Fornai,F.,
            Volpe,M., Rubattu,S., Nicoletti,F. and Vecchione,C.
  TITLE     Role of Dickkopf-3 in Blood Pressure Regulation in Mice and
            Hypertensive Rats
  JOURNAL   Circ Res 132 (11), 1489-1504 (2023)
   PUBMED   37144413
  REMARK    GeneRIF: Role of Dickkopf-3 in Blood Pressure Regulation in Mice
            and Hypertensive Rats.
REFERENCE   2  (bases 1 to 5010)
  AUTHORS   Zhang,L.Q., Gao,S.J., Sun,J., Li,D.Y., Wu,J.Y., Song,F.H.,
            Liu,D.Q., Zhou,Y.Q. and Mei,W.
  TITLE     DKK3 ameliorates neuropathic pain via inhibiting
            ASK-1/JNK/p-38-mediated microglia polarization and
            neuroinflammation
  JOURNAL   J Neuroinflammation 19 (1), 129 (2022)
   PUBMED   35658977
  REMARK    GeneRIF: DKK3 ameliorates neuropathic pain via inhibiting
            ASK-1/JNK/p-38-mediated microglia polarization and
            neuroinflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5010)
  AUTHORS   Zhang,X., Du,Y., Ling,J., Li,W., Liao,Y. and Wei,X.
  TITLE     Dickkopf-related protein 3 negatively regulates the osteogenic
            differentiation of rat dental follicle cells
  JOURNAL   Mol Med Rep 15 (4), 1673-1681 (2017)
   PUBMED   28259940
  REMARK    GeneRIF: DKK3 expression negatively regulates the osteogenic
            differentiation of dental follicle cells.
REFERENCE   4  (bases 1 to 5010)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 5010)
  AUTHORS   Chen,M. and Hornsby,P.J.
  TITLE     Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary
            cultures of adrenocortical cells
  JOURNAL   Horm Metab Res 38 (9), 549-555 (2006)
   PUBMED   16981135
REFERENCE   6  (bases 1 to 5010)
  AUTHORS   Caricasole,A., Ferraro,T., Iacovelli,L., Barletta,E., Caruso,A.,
            Melchiorri,D., Terstappen,G.C. and Nicoletti,F.
  TITLE     Functional characterization of WNT7A signaling in PC12 cells:
            interaction with A FZD5 x LRP6 receptor complex and modulation by
            Dickkopf proteins
  JOURNAL   J Biol Chem 278 (39), 37024-37031 (2003)
   PUBMED   12857724
  REMARK    GeneRIF: WNT7A can specifically act via a Frizzled-5.LRP6 receptor
            complex in PC12 cells and that this activity can be antagonized by
            Dickkopf-1 and Dickkopf-3.
REFERENCE   7  (bases 1 to 5010)
  AUTHORS   Suwa,T., Chen,M., Hawks,C.L. and Hornsby,P.J.
  TITLE     Zonal expression of dickkopf-3 and components of the Wnt signalling
            pathways in the human adrenal cortex
  JOURNAL   J Endocrinol 178 (1), 149-158 (2003)
   PUBMED   12844346
REFERENCE   8  (bases 1 to 5010)
  AUTHORS   Montero-Pedrazuela,A., Bernal,J. and Guadano-Ferraz,A.
  TITLE     Divergent expression of type 2 deiodinase and the putative
            thyroxine-binding protein p29, in rat brain, suggests that they are
            functionally unrelated proteins
  JOURNAL   Endocrinology 144 (3), 1045-1052 (2003)
   PUBMED   12586781
  REMARK    GeneRIF: data do not support that thyroxine-binding protein p29 has
            a functional relationship with D2, but expression of p29 in the
            blood-CSF barrier suggests that it might be involved in T(4)
            transport to and from the CSF
REFERENCE   9  (bases 1 to 5010)
  AUTHORS   Leonard,D.M., Stachelek,S.J., Safran,M., Farwell,A.P., Kowalik,T.F.
            and Leonard,J.L.
  TITLE     Cloning, expression, and functional characterization of the
            substrate binding subunit of rat type II iodothyronine
            5'-deiodinase
  JOURNAL   J Biol Chem 275 (33), 25194-25201 (2000)
   PUBMED   10829019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC160821.1 and JAXUCZ010000001.1.
            
            On Sep 12, 2012 this sequence version replaced NM_138519.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160821.1, SRR26643291.2590.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2416              BC160821.1         1-2416
            2417-5010           JAXUCZ010000001.1  175672834-175675427 c
FEATURES             Location/Qualifiers
     source          1..5010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..5010
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /note="dickkopf WNT signaling pathway inhibitor 3"
                     /db_xref="GeneID:171548"
                     /db_xref="RGD:621846"
     exon            1..118
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            119..354
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1188
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /note="dickkopf-related protein 3; dickkopf homolog 3;
                     dickkopf 3 homolog"
                     /codon_start=1
                     /product="dickkopf-related protein 3 precursor"
                     /protein_id="NP_612528.2"
                     /db_xref="GeneID:171548"
                     /db_xref="RGD:621846"
                     /translation="MQWLRDILLCMLLAAVVPTAPTPAPTATWTPAEPGPALNYPQEE
                     ATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAARTSSEVTLSSLPANYHNETNTET
                     RMENNTAHVHREVHKITNNQSGQTVFSETVITSVEDGEGKKSHECIIDEDCGPTRYCQ
                     FSSFKYTCQPCRDQQMLCTRDSECCGDQLCAWGHCTQKATKGSNGTICDNQRDCQPGL
                     CCAFQRGLLFPVCTPLPVEGELCHDPTSQMLDLITWELEPEGALDRCPCASGLLCQPH
                     SHSLVYMCKPAFVGSHDHNEESQLPREALDDYEDVGFIGEVRQELEDLERSLAQEMAF
                     EEATPVDSLGGEKI"
     exon            355..492
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            493..576
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            577..669
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            670..814
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            815..971
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
     exon            972..5010
                     /gene="Dkk3"
                     /gene_synonym="p29; Reic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcatccac gccgcgtaca gtgcatattc tgctccggct gctctgtgga agccctgcga
       61 ccggtcgtga ccagatccat cttgcagctc agctttgttc attcgaagtg ggtgagcggc
      121 ggcggccagc gcggagcaaa catgcagtgg ctccgggata ttttgctgtg tatgctgcta
      181 gcggcggtgg tccccactgc ccccactcct gccccgacgg ccacttggac tccggcagag
      241 ccgggcccgg ctcttaacta ccctcaggag gaagctacgc tcaatgagat gttccgagag
      301 gtagaggagc tgatggaaga cactcagcac aaactgcgca gcgcggtgga ggagatggag
      361 gcggaagaag cggctgctag aacgtcctct gaggtgaccc tgtcaagttt acctgccaac
      421 taccacaacg agaccaacac ggagaccagg atggaaaata acacagccca tgtgcaccgg
      481 gaggttcaca agataaccaa caaccagagt ggacagacgg tcttttctga gacagtcatt
      541 acatctgtag aggatggaga aggcaagaag agccatgaat gtatcattga tgaggactgc
      601 ggacccacca ggtactgcca gttctccagc ttcaagtata cctgccagcc gtgccgggac
      661 cagcagatgc tatgcacccg agacagtgag tgctgtggag accagctttg tgcctggggt
      721 cactgcaccc aaaaggccac caaaggtagc aatgggacca tctgtgacaa ccagagggat
      781 tgccagcctg gcctgtgctg cgccttccaa agaggcctgc tgttccctgt gtgcacaccc
      841 ctgcccgtgg agggggagct ctgtcatgac cccaccagcc agatgctgga cctcatcacc
      901 tgggaactgg agcctgaagg cgctttggac cgatgcccct gtgccagtgg cctcctctgc
      961 cagccacaca gccacagtct ggtatacatg tgcaagccag ccttcgttgg cagccatgac
     1021 cacaatgagg agagccagct gcccagggag gccctggatg actacgaaga tgttggcttc
     1081 ataggggagg tgcgtcagga gctggaagac ctggagcgga gcctggccca ggagatggca
     1141 tttgaggagg ccacccctgt ggattcacta ggtggagaga agatttagac ctagacccag
     1201 ctgagttgct ggtagatgtg caataggaat ggctaattta ttttcccagg agtgtcccca
     1261 ggtgtggaat ggccacagct ccttcccagt agcttttcct ctggcttgac aaggtacagt
     1321 gcagtgcatt tcttccagct gccccacttc tctggcttag gaaagaaaga caggcgtggc
     1381 aggtaagggg agcggtgagc tgccccacat tgttgctaga catgctgcct tgtttgttct
     1441 tcatggattg aagatttgtt tgaagggaga ggatgggaaa gggggtaagt ctgcccatga
     1501 taggtttggg ggatacaggg aggacagtgc ctgccttgca aacgtggacc tggcaaaatg
     1561 tagccgttgt ttttgtcttg tgcccctccc atgggctgag gaagtgacta cacaggagct
     1621 atgctgctct tgtggccttc cacacattca tcccccagtc ccctagtgtt ttagctccta
     1681 cctcactgtc aacacagcct ttcatagcca tgttccttcc tgatcaccac agcctagaag
     1741 gggataggag tgggtttctc tccaagcccc atgttctctc actcaacccc acaccagcct
     1801 tggtaccacc aacagtactt tcaaaaggag gggagtaaaa cccttttgtt tttatttttt
     1861 tttactcctc caaggcatgc ctggaaccaa ggtcagggta gtttgcatgt ccccctgtta
     1921 gtagcagtgt ggtgggcatt gtcctccacc atatgcgtca atacctccga aagtcagtgt
     1981 acattaattt gcaagaaata tgcttgggta attgtagggc caggattgtg aatgaaactt
     2041 gcaaagttgc ttagcaataa tggaaggtct ttctcaatca cacagagaaa tcaaaaccaa
     2101 gccaggctgt gtaaaataca gctgtgacat ccagacagaa ggctgggctg gctgtcaggt
     2161 ctcagatgac agtttcaggt gccaggaact atttccattc tgtatttatc cagagttatt
     2221 aaaatttaaa gttgcacaca gttgtataag catgcttttt cccctgaggt ttaaattatg
     2281 tgtacacaaa tgtgttgctc tcaaagatta ttcagaaatc actttggcta ctctttggta
     2341 attcttggac tttttgattt tcaataaata taaaccctct tcatgtaaaa taaaataaaa
     2401 taatctgtag tataaaggga ccaaaaatta aaattccata gaagcagatt ttccaggcat
     2461 ctgcagctca cctcatttag agtctgaata tgttggaact cctatccttg tctggatggg
     2521 aattagtttt aagagagaaa atactttacc gtctcccaaa agaacaaatg gaatatatga
     2581 gtcttctctt ggaggctctc tgagcaaatg cagtcctggg gctgtgctag catcgttact
     2641 gtagcaaaac agctgaggtg attaacttat gcatttttta aaaagggtta attgggttca
     2701 gcatttcatg tttctgtcat gatcctattg cgttgaaact atagagaggc agcacaacac
     2761 ggcaggggca tgtggtagag tcaagctgct ccctttctgg ctaagagaga gggcaatgtg
     2821 cagtcttgtc caggggtctg ggcactctca caaggaccca ccccgtaaag accactctac
     2881 agccttgggt ttagttactc ttctgggtgc tacaatcaaa cacccaacaa gaagcaacct
     2941 gagggaggag ggtttatttg ggctcctggt tcaagcaggg agtccttgat ggcagggagg
     3001 gtatggcgtt agagtgtggg gctccatccc gcagtatagg ggatcgggaa gcaaaggaag
     3061 caatgtagga ctcagctttc tccctctttc ccttttcatt tattctggga ccccaaccct
     3121 tggggaggtg ccacccacaa taagggtgag ttttctttcc tcagaaccct ctggaaactt
     3181 ctggcctaat agatatgtgc agaggtgtgc ccctaagtga gtcaactcca tccggttcca
     3241 agacatataa gcgtgacgca ctaactctgc cacatagcac cgagtccctc ttaaaagcct
     3301 ttacttctca tccgaagata tcacagaaaa gagatgtaaa catttagaaa gacaataaat
     3361 gtacttgatg aagtcacctg tgtctgtggt atgggtccat ttgtcactaa aacctgtgct
     3421 ggttaggatt tgctgtattc tgtctgctat gctgaaatcc ttgggtttta cagataaatg
     3481 ttaagattca gaataactga ataacattta aaaaaatagt ctcaggttga taaagattgt
     3541 tgtagcctct caatattggc atggggacaa gtaggttttg cagggggata ttttatccag
     3601 cttgcaacag aattgtgaca cattaagctc tttaaagagt agattaatga ggtcactgtg
     3661 tatttaggtc agcagggcag cagggtcttg attcattatg tctctgaatt ctacaagata
     3721 ctaacagatg aggaaatgtg gcttcaaaag ggtggattga ggtcacagtc agatgacatg
     3781 gcatctaggg tacatctagg gggcgtcctg tattcagtgt caaaacttac cagggtcact
     3841 catctcctga atcacctgac agctaggtgc cgagggcttc ctcagagcca ggggtcgtga
     3901 tgtgccctga aggttcccag atgagagttc cagttttgaa atcatcacag tagaaagcag
     3961 gacacagcta caccaagcag tgactgacac agtcaagcca gcatggagtg tggaggagcc
     4021 ccagcagaga gtactttgct tgaaaggctg gccaggaaat ggcctgaaag atgacatact
     4081 taccaggaag tcagaagggg gactcgaagg ggaaatagat aggattctca aaggataggg
     4141 tgactggaag cttgaggaaa tgcttagatg aggctggaaa tagttttgaa aacgaaagca
     4201 aaactgaagc aactcctccc cccctcccaa aaaaaaaaac aaataatgaa caaccctgtc
     4261 cggtgactgt catgtatcag gccctgtctc aagagtcaga gtgagtcgtg aatgagggaa
     4321 aaccagagtc tccttcctag tgctaactcc caaatcctaa ggacccagga gaggcctgaa
     4381 tgctcagctg agatgcctcg ccattgttaa ggaaccatgg gaagagttgg agagactgtg
     4441 gctctcaact ccatgcctgc tccttccttg gatcccgttc ctgccaggga agtggtagca
     4501 gcagctgaag gtttggctcc tcagtgatcc cagcaaagga ccagactgcc aagaagggat
     4561 cttccccttt ccctgacaag gaaaatggaa gagttcccac ttttccatct tccaggacag
     4621 gcacttaaga tgtggcattt ggcttcaccc gcccctgggg gagctgggag ctaccaggct
     4681 gccatcctcc ggggccttct gaaaacactc acttcttagc ttctgttagt ctttaagctg
     4741 gcaggcattc ctggactcac agtccacgca tgacttttct tatttttatg gctgttagta
     4801 cctggcaaga gtgacttagg gaaggtttag aatttggagg aattgcccac gatgtttgca
     4861 ggcatttttg caggagtgga ggtgactgcc cacaggactt tcctatgggg aagcagagtc
     4921 aatgggaagt ggtgtagatt gcaaggcccc tccagtgacc cacctgtgcc agcaaggctc
     4981 tacaacttcc caaggcagtg ctgcaagctg
//
