LOCUS       NM_001106472            3087 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus dickkopf WNT signaling pathway inhibitor 2
            (Dkk2), mRNA.
ACCESSION   NM_001106472 XM_001077211 XM_238256
VERSION     NM_001106472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3087)
  AUTHORS   Wang C, Qiao X, Zhang Z and Li C.
  TITLE     MiR-128 promotes osteogenic differentiation of bone marrow
            mesenchymal stem cells in rat by targeting DKK2
  JOURNAL   Biosci Rep 40 (2) (2020)
   PUBMED   31985779
  REMARK    GeneRIF: MiR-128 promotes osteogenic differentiation of bone marrow
            mesenchymal stem cells in rat by targeting DKK2.
REFERENCE   2  (bases 1 to 3087)
  AUTHORS   Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon
            J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi
            C, Kim YM, Hwang KC and Kwon YG.
  TITLE     The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and
            human endothelial cells
  JOURNAL   J Clin Invest 121 (5), 1882-1893 (2011)
   PUBMED   21540552
  REMARK    GeneRIF: there are distinct functions of DKK1 and DKK2 in
            controlling angiogenesis
REFERENCE   3  (bases 1 to 3087)
  AUTHORS   Niehrs C.
  TITLE     Function and biological roles of the Dickkopf family of Wnt
            modulators
  JOURNAL   Oncogene 25 (57), 7469-7481 (2006)
   PUBMED   17143291
  REMARK    Review article
REFERENCE   4  (bases 1 to 3087)
  AUTHORS   Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A,
            Melchiorri D, Terstappen GC and Nicoletti F.
  TITLE     Functional characterization of WNT7A signaling in PC12 cells:
            interaction with A FZD5 x LRP6 receptor complex and modulation by
            Dickkopf proteins
  JOURNAL   J Biol Chem 278 (39), 37024-37031 (2003)
   PUBMED   12857724
REFERENCE   5  (bases 1 to 3087)
  AUTHORS   Li L, Mao J, Sun L, Liu W and Wu D.
  TITLE     Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt
            signaling pathway via LRP-6 independently of dishevelled
  JOURNAL   J Biol Chem 277 (8), 5977-5981 (2002)
   PUBMED   11742004
REFERENCE   6  (bases 1 to 3087)
  AUTHORS   Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A and Niehrs C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_238256.4, XM_001077211.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3087
                     /gene="Dkk2"
                     /note="dickkopf WNT signaling pathway inhibitor 2"
                     /db_xref="GeneID:295445"
                     /db_xref="RGD:1308639"
     exon            1..965
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..1523
                     /gene="Dkk2"
                     /note="dickkopf homolog 4; dickkopf-related protein 2;
                     dickkopf homolog 2; dickkopf 2 homolog"
                     /codon_start=1
                     /product="dickkopf-related protein 2 precursor"
                     /protein_id="NP_001099942.1"
                     /db_xref="GeneID:295445"
                     /db_xref="RGD:1308639"
                     /translation="MAALMRVKDSSRCLLLLAAVLMVESSQLSSSRAKLNSIKSSLGG
                     ETPAQAANRSAGMNQGLAFGGSKKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACMV
                     CRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDL
                     GWQNLGRPHSKMPHIKGHEGDPCLRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQR
                     KKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI"
     exon            966..1116
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1272
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..3087
                     /gene="Dkk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagagagc actggccctc cacgcagcac atcactgctt cgctctcagg gcttggtggc
       61 cccgtgtgaa ccaagggaca acttttaacc gcaccagtgg gagcgcgctt gctgggacct
      121 cagcttgcct cagctctccg gagtccggtg gagggggtgg gggagcttct tgatcaccag
      181 tcacaaagcc tgcggacctg gaaaagaggg acttgagtgg tgcaaagttt gagagcttaa
      241 gcgcagggga ggacagagga gcaaccaaag ccgggggaaa caagaaaaaa gaaaggaaga
      301 aaaagaaaaa gaagaagtag ctgggggaga acccaggagc ggttaagagg gaggattcca
      361 tcaccgcgga aaatcgggcg aaagagcaaa ggtgttgcac accaagagaa gccggcgggg
      421 cgatctgcag ggctgggtct aacagcacct tgggtcacgc ctccttggcg agaaggcgtc
      481 tggcctttga ttgcttccag ggactgcaga acttcctgcc cgccagagga gcgggtctca
      541 ccggggtcgc gcttgctcca ggcttaaggc ttaagaccga gttctaaaga gtcctgagtg
      601 tctgatccag gaagggttgg gggaactgtg tctgtgagga gcccaccagc cccatcgtga
      661 ggggccgagt ctcggcgtcc tcactctcct ggctttcaca tctttcaggg ctccacccaa
      721 ctccgggaac ccctcacccg gagatggccg cgctgatgcg ggtcaaggat tcatcccgct
      781 gccttctcct actggccgcg gtgctgatgg tggagagttc acagctaagc agctcgcggg
      841 ccaaactcaa ctccatcaag tcctctctag gtggggagac gcctgctcag gctgccaatc
      901 gatctgcggg catgaaccaa ggactggctt tcggcggcag taagaagggc aaaagtctgg
      961 ggcaggccta cccttgcagc agcgataagg aatgcgaagt tggaagatac tgccacagtc
     1021 cccaccaagg atcttcagcc tgcatggtct gtcggaggaa aaagaagcga tgccatagag
     1081 atgggatgtg ttgccctggt acccgctgta ataatggcat ctgcattcca gtcactgaga
     1141 gcatcctgac cccacatatc ccggctctgg atggcactcg gcatagggat cgcaaccatg
     1201 gtcactattc caaccatgac ctgggatggc agaatctagg aaggccacac tccaagatgc
     1261 ctcatataaa gggacatgaa ggagacccct gtctgcggtc atcagactgc attgatgggt
     1321 tttgttgtgc tcgccacttc tggaccaaaa tctgcaaacc agtgctccat cagggggaag
     1381 tctgtaccaa acaacgcaag aagggttcac atgggctgga gattttccag aggtgtgact
     1441 gtgcaaaggg cctgtcctgc aaagtgtgga aggatgctac ctactcttcc aaagccagac
     1501 tccatgtgtg ccagaagatc tgataaacac tggaagagtc atcacgagca gactgtgaat
     1561 ttgtgtattt aatgcattat ggtgtgatgg aaaacccgga ttggaatggg gaagaatgag
     1621 gaatgtggta agaatgtgga gcagaagagg gcaggactga aataagtaga gacagtgaca
     1681 gccaaagcac taccagtgtt tccattgtgc acctcgtctg tgtaaataat gtacacattt
     1741 gtgaaaatgc tattattaaa agaaagcaca ccgtggaaat tactgatgaa taccatgtga
     1801 ttttccaaga gtttgacttg agctggaggg gacatgtcct tcagattggc aatggctata
     1861 aaataactta aagccacatt tctactcaaa gctatagttt aataaattac tctcactctc
     1921 ccttgacaaa agagagtctc taaaacatgg ggaaagctga tgaacaggca atgaaaacat
     1981 tcagcatcat taatcacatc tcaaaaaaaa aatcaccttt taattgggaa actgttcttt
     2041 tgatttttct caaataaagg ccttggtaga ccagaggaaa aggcagtcag tattttccag
     2101 atcacttcaa gatactgaga tgtcatttag acattagaaa acggtaaaca accagtagtc
     2161 atggtcaagt ggttaaggca atggactaga aaagggtaaa tgtgtctctt tagaccactc
     2221 atttctattt caaaaactta atttcacctg aattgctaaa gacagatgta agacaaaagc
     2281 agactctgca tcgtgaagga atggcattgc cagtatgatg tccactcaag ctggagccgt
     2341 taatcatgtc tagggcaata caagcacagc gcagaatttt cagattgcaa aaccattaaa
     2401 gatgtctgac ccatgagggg aacggaatca tggagtgagc actgcttgcc actactttga
     2461 cattcgatag actcataagt acatttgccc tcgcacagct ggagatcagt agggtgatgg
     2521 atgctggcac tagaggcctg agtgaaatct ggagtatggt ggagcacagc agggaagtag
     2581 agggaagctt gtcatctgtc caggctttaa ggtcacatgt ctgaagtgca ggctggattg
     2641 tcatgatggc catcagaggc tccagaagca aagttgaagc tctccatgag atttgctctc
     2701 aggcaggtga gttcggtgca atgctgcttg ccctcctctg cctcaaaatg tttcacggtt
     2761 ttgaggctgt aaaataatct cagtatgagg ggatcttaca gagtgggttc ccttatgcca
     2821 ggtgatagga gaggaaccca tcttctccct aagccttaga atgatgatgt catcagaagg
     2881 tagtgtccta acctcttgat ggagtgggta tttcattacc aaagatatag tccctatttt
     2941 ctgaaactat tgaaaattag aaggtaataa catatctcta atctgtagaa atgccctgaa
     3001 accatttcac tattttctga ttaaacatat ttctgaacac tatatctgga gcataaagga
     3061 caaaagtaaa aagcaaaaga aagaaag
//
