LOCUS       NM_001106350            2295 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus dickkopf WNT signaling pathway inhibitor 1
            (Dkk1), mRNA.
ACCESSION   NM_001106350 XM_001079710 XM_219804
VERSION     NM_001106350.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Garcia-Velazquez,L., Alobayan,R., Morales-Moreno,D., Avila-Munoz,E.
            and Arias,C.
  TITLE     Differential changes in Wnt7 and Dkk1 levels in astrocytes exposed
            to glutamate or TNFalpha
  JOURNAL   Neuroreport 35 (8), 542-550 (2024)
   PUBMED   38597273
  REMARK    GeneRIF: Differential changes in Wnt7 and Dkk1 levels in astrocytes
            exposed to glutamate or TNFalpha.
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Huang,S., Fu,D., Wan,Z., Huang,Z., Li,M., Li,H. and Chong,T.
  TITLE     DKK1 Ameliorates Myofibroblast Differentiation in Urethral Fibrosis
            in Vivo and in Vitro by Regulating the Canonical Wnt Pathway
  JOURNAL   Int J Med Sci 20 (12), 1631-1643 (2023)
   PUBMED   37859694
  REMARK    GeneRIF: DKK1 Ameliorates Myofibroblast Differentiation in Urethral
            Fibrosis in Vivo and in Vitro by Regulating the Canonical Wnt
            Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Hsu,Y.C., Chang,C.C., Hsieh,C.C., Huang,Y.T., Shih,Y.H.,
            Chang,H.C., Chang,P.J. and Lin,C.L.
  TITLE     Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic
            Kidney Disease
  JOURNAL   Int J Mol Sci 24 (8), 7679 (2023)
   PUBMED   37108841
  REMARK    GeneRIF: Dickkopf-1 Acts as a Profibrotic Mediator in Progressive
            Chronic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Xu,X., Lan,X., Fu,S., Zhang,Q., Gui,F., Jin,Q., Xie,L. and Xiong,Y.
  TITLE     Dickkopf-1 exerts protective effects by inhibiting PANoptosis and
            retinal neovascularization in diabetic retinopathy
  JOURNAL   Biochem Biophys Res Commun 617 (Pt 2), 69-76 (2022)
   PUBMED   35691117
  REMARK    GeneRIF: Dickkopf-1 exerts protective effects by inhibiting
            PANoptosis and retinal neovascularization in diabetic retinopathy.
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Niu,J., Li,W., Liang,C., Wang,X., Yao,X., Yang,R.H., Zhang,Z.S.,
            Liu,H.F., Liu,F.Y., Pei,S.H., Li,W.Q., Sun,H., Fang,D. and Xie,S.Q.
  TITLE     EGF promotes DKK1 transcription in hepatocellular carcinoma by
            enhancing the phosphorylation and acetylation of histone H3
  JOURNAL   Sci Signal 13 (657) (2020)
   PUBMED   33172955
  REMARK    GeneRIF: EGF promotes DKK1 transcription in hepatocellular
            carcinoma by enhancing the phosphorylation and acetylation of
            histone H3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Yanagita,M., Oka,M., Watabe,T., Iguchi,H., Niida,A., Takahashi,S.,
            Akiyama,T., Miyazono,K., Yanagisawa,M. and Sakurai,T.
  TITLE     USAG-1: a bone morphogenetic protein antagonist abundantly
            expressed in the kidney
  JOURNAL   Biochem Biophys Res Commun 316 (2), 490-500 (2004)
   PUBMED   15020244
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Caricasole,A., Ferraro,T., Iacovelli,L., Barletta,E., Caruso,A.,
            Melchiorri,D., Terstappen,G.C. and Nicoletti,F.
  TITLE     Functional characterization of WNT7A signaling in PC12 cells:
            interaction with A FZD5 x LRP6 receptor complex and modulation by
            Dickkopf proteins
  JOURNAL   J Biol Chem 278 (39), 37024-37031 (2003)
   PUBMED   12857724
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Li,L., Mao,J., Sun,L., Liu,W. and Wu,D.
  TITLE     Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt
            signaling pathway via LRP-6 independently of dishevelled
  JOURNAL   J Biol Chem 277 (8), 5977-5981 (2002)
   PUBMED   11742004
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Semenov,M.V., Tamai,K., Brott,B.K., Kuhl,M., Sokol,S. and He,X.
  TITLE     Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
  JOURNAL   Curr Biol 11 (12), 951-961 (2001)
   PUBMED   11448771
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219804.4, XM_001079710.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09767679,
                              SAMN16418971 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2295
                     /gene="Dkk1"
                     /note="dickkopf WNT signaling pathway inhibitor 1"
                     /db_xref="GeneID:293897"
                     /db_xref="RGD:1307313"
     exon            1..379
                     /gene="Dkk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..946
                     /gene="Dkk1"
                     /note="dickkopf-related protein 1; dickkopf homolog 1;
                     dickkopf-like protein 1; dickkopf 1 homolog"
                     /codon_start=1
                     /product="dickkopf-related protein 1 precursor"
                     /protein_id="NP_001099820.1"
                     /db_xref="GeneID:293897"
                     /db_xref="RGD:1307313"
                     /translation="MTVVRAVAAVRFLVVLSTMALCSLPPLGVSATLNSVLINSNAIK
                     NLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGTDEYCSSPS
                     RGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHLPRGEIEEGIIE
                     NLGNDHGAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCATGLCCARHFWSKICKPVL
                     KEGQVCTKHRRKGSHGLEIFQRCYCGEGLACRIQKDHHQTSNSSRLHTCQRH"
     exon            380..548
                     /gene="Dkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..692
                     /gene="Dkk1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..2295
                     /gene="Dkk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgtgc gcctggcagc cgagactcca cccgccgagg ttccgaagtt gaggttccgc
       61 agcccagact ctgcagccgc tgtgcaaagt gatctctctc ttcctgactt tttcctgttt
      121 gcgaccttct gagatgacgg ttgtgcgtgc agtggcagct gtccggttct tggtcgtgct
      181 ttcaacgatg gctctctgca gcctccctcc gctcggagtc agcgccacct tgaactcagt
      241 tctcatcaat tccaacgcga tcaagaacct gcccccaccg ctgggtggtg ctggggggca
      301 gccgggctct gctgtcagcg tggcgcccgg agtcctctat gagggcggga acaagtacca
      361 gactcttgac aactaccagc cctacccttg cgcggaggat gaggagtgcg gcactgacga
      421 gtactgctcc agtcccagcc gcggggcagc cggcgtggga ggtgtacaaa tctgcctggc
      481 ttgccgaaag cgcaggaaac gctgcatgag gcacgctatg tgctgccccg ggaattactg
      541 caaaaacgga atatgcatgc cctctgacca cagccattta cctcgagggg aaatcgagga
      601 aggcatcatt gaaaaccttg gcaatgacca cggtgccggg gatggatatc ccagaagaac
      661 cacactgact tcaaaaatat atcacaccaa agggcaagaa ggctctgtct gcctccgatc
      721 atcagactgc gccacagggc tgtgttgtgc aagacatttc tggtccaaga tctgtaaacc
      781 tgtccttaaa gaaggtcagg tatgcaccaa gcacaggagg aaaggctccc acgggctgga
      841 gatattccag cgctgttact gtggggaagg tctggcttgc aggatacaga aagatcacca
      901 tcaaaccagc aattcttcca ggctccacac ctgccagaga cactaaaacc aacagcctaa
      961 atgcgatgga ctctcttatc taatatatgc tatgaaaatc cttaatgatt tgtcagctca
     1021 atcccaagga tgtaggaatc ttcagtgtgt aattaagcat tccgataata ccttccgaaa
     1081 actctggagt gtaaggactt tgtttcttga tggaactccc ctgtgattgc agtaaattac
     1141 tgtgttgtaa atcctcagtg tggcacttac ctgtaaatgc aacaaaactt tttaattatt
     1201 tttctagagg tgctacattg tctcgtttct cttgcatgta aattttttgt acacggttga
     1261 ttgtcttgac tcataaatat tctttattga agtaatttca gtttacagtt cttaaatgtg
     1321 gaaccctttc cacttttgtc tctagggtgc agaacgcaag gagtttttgg aatagtcaat
     1381 gataggcatc taaaatttaa cctgaaaatg ctcatttatt tcctgagatg tactctcttt
     1441 gcttagatat tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     1501 tctctctctc tctcctctcc tctctctctc tttctctgtc tctctcagct gtgatagtcc
     1561 ttaaaataaa atttaacatt tagtaatcat gaagttacaa gcatagatac atttgaggct
     1621 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gagagagaga gagagagaga gagccaagac
     1681 agagtcagag acagagagag acagagagag agctttttaa atgataagat atattgtcta
     1741 tgtgtgagtt actttaaaga gaatgtattc tacattgata aactcaaatg actttggtaa
     1801 tatgggtttg aatttgatat tactactttc aaaactacta ttttactatg tgtggttggt
     1861 gcttacgcct gtaatcccag ggttctgggg gatgaggcag gaggaatgtc catgaattca
     1921 ggtccatcct ggccaactta tgctataggg taaggttcga tttcaaaaat gcatcaacaa
     1981 aagatagtta acagcaaatt aatatttccc taagtgaccg acagtaattg gaagggtggg
     2041 aatgtgactt caaataatgg gcagagttca gaagagatta tgtggaagga aacccaccaa
     2101 cttaagccaa ataattaatt ctgaatattt tagatactct gacatgctga agaatggtcc
     2161 caattacttt gatttaaaaa taattactaa acaattataa attctagaat gtaatacctt
     2221 ttcttttctt gccaagaaat tattccattt tttgcttcgc ctgtactgca ttgattggaa
     2281 tgagtatggc tttat
//
