LOCUS       NM_001395147            5657 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DIX domain containing 1 (Dixdc1), mRNA.
ACCESSION   NM_001395147 XM_006243042
VERSION     NM_001395147.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5657)
  AUTHORS   Lu,H., Jiang,R., Tao,X., Duan,C., Huang,J., Huan,W., He,Y., Ge,J.
            and Ren,J.
  TITLE     Expression of Dixdc1 and its Role in Astrocyte Proliferation after
            Traumatic Brain Injury
  JOURNAL   Cell Mol Neurobiol 37 (6), 1131-1139 (2017)
   PUBMED   27873129
  REMARK    GeneRIF: up-regulation of Dixdc1 protein expression is potentially
            involved in astrocyte proliferation after traumatic brain injury in
            the rat.
REFERENCE   2  (bases 1 to 5657)
  AUTHORS   Wu,W., Liu,Q., Liu,Y., Yu,Z. and Wang,Y.
  TITLE     Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to
            promote Schwann cell proliferation after sciatic nerve crush
  JOURNAL   Biochem Biophys Res Commun 478 (2), 956-963 (2016)
   PUBMED   27521891
  REMARK    GeneRIF: these data demonstrated that Dixdc1 might participate in
            Schwann cell proliferation by targeting CyclinD1 and p21 at least
            partially through the PI3K/AKT activation.
REFERENCE   3  (bases 1 to 5657)
  AUTHORS   Liu,Y.T., Dan,Q.J., Wang,J., Feng,Y., Chen,L., Liang,J., Li,Q.,
            Lin,S.C., Wang,Z.X. and Wu,J.W.
  TITLE     Molecular basis of Wnt activation via the DIX domain protein Ccd1
  JOURNAL   J Biol Chem 286 (10), 8597-8608 (2011)
   PUBMED   21189423
REFERENCE   4  (bases 1 to 5657)
  AUTHORS   Singh,K.K., Ge,X., Mao,Y., Drane,L., Meletis,K., Samuels,B.A. and
            Tsai,L.H.
  TITLE     Dixdc1 is a critical regulator of DISC1 and embryonic cortical
            development
  JOURNAL   Neuron 67 (1), 33-48 (2010)
   PUBMED   20624590
REFERENCE   5  (bases 1 to 5657)
  AUTHORS   Wu,Y., Jing,X., Ma,X., Wu,Y., Ding,X., Fan,W. and Fan,M.
  TITLE     DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293
            cells
  JOURNAL   Cell Biol Int 33 (6), 697-701 (2009)
   PUBMED   19375513
REFERENCE   6  (bases 1 to 5657)
  AUTHORS   Ikeuchi,Y., Stegmuller,J., Netherton,S., Huynh,M.A., Masu,M.,
            Frank,D., Bonni,S. and Bonni,A.
  TITLE     A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian
            brain
  JOURNAL   J Neurosci 29 (13), 4312-4321 (2009)
   PUBMED   19339625
  REMARK    GeneRIF: findings define a novel SnoN-Ccd1 link that promotes
            axonal growth in the mammalian brain, with important implications
            for axonal development and regeneration
REFERENCE   7  (bases 1 to 5657)
  AUTHORS   Shibata,N., Tomimoto,Y., Hanamura,T., Yamamoto,R., Ueda,M.,
            Ueda,Y., Mizuno,N., Ogata,H., Komori,H., Shomura,Y., Kataoka,M.,
            Shimizu,S., Kondo,J., Yamamoto,H., Kikuchi,A. and Higuchi,Y.
  TITLE     Crystallization and preliminary X-ray crystallographic studies of
            the axin DIX domain
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 63 (Pt 6), 529-531
            (2007)
   PUBMED   17554179
  REMARK    GeneRIF: The DIX domain of rat axin, which is important for its
            homooligomerization and interactions with other regulators in the
            Wnt pathway, has been purified and crystallized.
REFERENCE   8  (bases 1 to 5657)
  AUTHORS   Luo,W., Zou,H., Jin,L., Lin,S., Li,Q., Ye,Z., Rui,H. and Lin,S.C.
  TITLE     Axin contains three separable domains that confer intramolecular,
            homodimeric, and heterodimeric interactions involved in distinct
            functions
  JOURNAL   J Biol Chem 280 (6), 5054-5060 (2005)
   PUBMED   15579909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395147.2.
            
            On Jun 4, 2021 this sequence version replaced XM_006243042.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JACYVU010000198.1  12883048-12883228   c
            182-311             JACYVU010000198.1  12867151-12867280   c
            312-437             JACYVU010000198.1  12862587-12862712   c
            438-669             JACYVU010000198.1  12859603-12859834   c
            670-777             JACYVU010000198.1  12858458-12858565   c
            778-890             JACYVU010000198.1  12851906-12852018   c
            891-1039            JACYVU010000198.1  12849733-12849881   c
            1040-1129           JACYVU010000198.1  12846364-12846453   c
            1130-1183           JACYVU010000198.1  12845030-12845083   c
            1184-1234           JACYVU010000198.1  12843791-12843841   c
            1235-1339           JACYVU010000198.1  12841288-12841392   c
            1340-1393           JACYVU010000198.1  12840825-12840878   c
            1394-1486           JACYVU010000198.1  12840333-12840425   c
            1487-1558           JACYVU010000198.1  12840184-12840255   c
            1559-1648           JACYVU010000198.1  12839308-12839397   c
            1649-1816           JACYVU010000198.1  12838827-12838994   c
            1817-1883           JACYVU010000198.1  12838307-12838373   c
            1884-1989           JACYVU010000198.1  12827685-12827790   c
            1990-2098           JACYVU010000198.1  12825916-12826024   c
            2099-5657           JACYVU010000198.1  12821146-12824704   c
FEATURES             Location/Qualifiers
     source          1..5657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..5657
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /note="DIX domain containing 1"
                     /db_xref="GeneID:363062"
                     /db_xref="RGD:1309902"
     exon            1..181
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2176
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /note="coiled-coil-DIX1; coiled-coil protein DIX1; DIX
                     domain-containing protein 1"
                     /codon_start=1
                     /product="dixin"
                     /protein_id="NP_001382076.1"
                     /db_xref="GeneID:363062"
                     /db_xref="RGD:1309902"
                     /translation="MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPSVKPVQ
                     DLRQDLRDGVILAYLIEIVAGEKLSGVQLSPSNQQEMKSNVERVLQFVASKNIRMHQT
                     SAKDIVEGNLKSIMRLVLALAAHFKPGSSRTVSQGRDSRTSVQSHQPHCATAVAQGAA
                     AALADVCHDVSRSGRDVFRYRQRNASVDEEIENPYWSVRALVQQYEGQQRSPSESSCS
                     SLTSPSPIHSAKSESIITQSEEKADFVIIPSEGIENRTDETGSPLSRDWRPGSPGTYL
                     EATWEEQLLEQQEHLEKEMEEAKKMISGLQALLLNGSLPEDEQERPVALCEPGVNPEE
                     QLIIIRSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL
                     LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKDLGQKDRLLQQQQAKLEDALRKLSD
                     ASYQQVDLERELEQKDVLLAHRVKGDTDEVTNYNSHSSQRNGFVLPVAGRAATTATHR
                     GPQSSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLIERLHVIETQKKQERKV
                     RGRSPRNQASSEYRASWPPNSTLPHSQSSPAVSNTCTKVLYFTDRSLTPFMVNIPKRL
                     GEVTLKDFKAAIDREGSHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEDHR
                     EN"
     exon            182..311
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..437
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..669
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..777
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..890
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1039
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1129
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1183
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1234
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1339
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1393
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1486
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1558
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1648
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1816
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1883
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1989
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2098
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..5657
                     /gene="Dixdc1"
                     /gene_synonym="Ccd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttccagta agtggcatgc gggactccgg agagctccca gggagctgag ccgatcgcct
       61 ttgtgtgcag agggaggagg cggcggcgcg accccacccg ggaagccccg cggcaggaac
      121 aatgctagcc tgcttgaccc gcgggaactt actggacgtc ctgcaagagg gcttcaatga
      181 gcaacagcta caggcctatg tggcctgggt gaatgcccag ctgaagaaga ggccatccgt
      241 gaagcctgtg caggacctgc gacaggatct ccgagatgga gtaatcctgg cctatctcat
      301 cgagattgtt gcaggagaaa aactgagcgg agtacagttg agtcctagta accagcagga
      361 gatgaagagc aatgtggaga gggtcctaca gtttgtggct tccaaaaata ttcgtatgca
      421 ccagacttcg gctaaagata ttgtggaagg aaacctgaag tctatcatga ggctggtcct
      481 tgccttggca gctcatttta aacctggctc tagcaggacg gtgagccagg ggcgagactc
      541 cagaacctct gtgcagagtc atcaaccaca ctgtgccacc gctgtggccc aaggagcagc
      601 ggctgctctg gctgatgtgt gccatgacgt gtcacggtca ggacgggatg tcttcagata
      661 cagacagagg aatgccagtg tggatgagga gatcgagaac ccatactgga gtgtgcgagc
      721 acttgtgcag caatacgaag gccagcaaag gtccccatct gagtccagct gctccagtct
      781 gacttcaccc agtccaattc acagtgcaaa gagcgaatcc attataaccc agtcagagga
      841 aaaggccgat tttgtgatta ttccctctga aggaatagag aacagaacag acgagacagg
      901 ctctccatta tcccgagact ggaggccggg aagcccagga acctacctgg aagccacatg
      961 ggaagaacaa ctgttggagc aacaagaaca cttggaaaaa gaaatggagg aagccaagaa
     1021 aatgatttca ggactacagg ccttgctact caatggctct ctaccggagg atgaacagga
     1081 aagaccggtg gccctctgtg aaccaggagt caatcccgag gaacagctga ttataatccg
     1141 aagccgtctg gatcaaagta tggaggagaa tcaggacctt aagaaagaac tgctgaaatg
     1201 caaacaagaa gccagaaact tacaggggat aaaggatgcc ttgcagcaga ggttgactca
     1261 gcaggacacg tccgttcttc agctcaagca agagctgctg agggcaaata tggataagga
     1321 tgagctgcac aaccagaatg tggatctgca gaggaagctt gacgagagga accggctctt
     1381 aggagaatat aaaaaagatc tgggacagaa ggaccgcctt cttcaacagc agcaggccaa
     1441 gttggaagat gctcttcgga aactctcaga cgccagttac cagcaggtgg atctagaacg
     1501 ggagctagag caaaaagatg tccttctggc tcaccgcgtg aaaggagaca cagatgaggt
     1561 gacaaattac aacagtcaca gctctcagcg caatggcttt gtccttccgg tggcagggag
     1621 agccgccact actgccaccc acagagggcc acagagcagt gacctccagc tcgtccgaga
     1681 tgctctacgt agcctgcgaa acagcttcag tggtcatgac cctcagcatc acaccattga
     1741 cagcctggag cagggaatct ctagcctcat agagcgtctg catgtcatag agacacagaa
     1801 gaaacaggaa aggaaggttc gggggcggtc acccagaaat caagcaagca gtgaatatcg
     1861 agcctcctgg ccccccaatt ccacgttgcc tcactcccag agctccccgg ccgtcagcaa
     1921 cacctgcact aaagtgctct acttcacgga ccgctcactc acgcccttca tggtcaatat
     1981 accaaagagg ctgggggagg tgacactgaa ggactttaaa gcagctattg atcgagaagg
     2041 gagtcaccgg taccacttca aagcactgga tcccgagttt ggcactgtca aagaggaggt
     2101 tttccatgat gatgatgcca tccctggatg ggaagggaaa atcgtagcct gggtagaaga
     2161 tcatagagag aattaactgg acctggacac tccctggctg cttctctcag gaaagaggac
     2221 taacaccaga ggacactgag aagtttctaa ctcgtgctgc caaaaagaag cttcttcaag
     2281 tatgatggtc acgggccagt cctgtttgtg tgcctggcat atctggtact tcaaatctct
     2341 gtccaaaaca taggaatatg ggtccatctg gagctccttg tcagtgggaa cagtgttttc
     2401 ttctactctg aggacatcaa accgaaggcc ttaaccacca gggaaggatg acccctctct
     2461 cgtaggggca tggctgctat gatcggaacc tggagtggaa gcatcagtcc gtcggttggc
     2521 cttgatggtt gcagcaatca gagcccagca tttgtgctta cagacaaggc agaggtacca
     2581 actttgctgc ttctttgcag acactgcaaa ccaggagtga cttgtgaggt ggtaccaaag
     2641 atgagagcct aaatgcataa ctggcctgga cgtgaacgat actgacttgt tgactgggtg
     2701 gggagagggc cgcccatatt gtgctatact acgccaaaac cataactcag accttgggct
     2761 gcctcctgtt tttaactggc tctgcagctt gtccttagcc cactgtgggc atttttcaca
     2821 tgctgttggt tttctctggg gactctttaa ctttagagcc attttatttt tctccaaaca
     2881 gataaacctt gtgtttgaaa aggatgagag aagcgagagg ctccttaaga atccaggata
     2941 cagaaaggtg ctgttaccca catcccttga cacgaactca tggcatcgcc tttgcaagga
     3001 gacagacctt taatttgtgt ttgtgagttg agtactgagc acgacttact ggtctgcctc
     3061 tcccttcgcg gctggagtta ctttctatta cacatttagc ttgggctgct ccctgagggc
     3121 catgcccagt ggaacccttg ggcacggagc gtgagtgagt tgtgaatggc agggttgatt
     3181 caaggtgaag tcatttctta ttgcaacatt gccgagtatg aagctaaaga gttcaacttc
     3241 cagaggttcc tcactaactt gggttttctc attcactcac ctagcaccat ctgccagtca
     3301 gccatggtta tctgtttata cagtccctca agcagtctgc aaccacactg tacactgcca
     3361 aacagaagag tgggacagag ggctcagtct ggggcctgcc tgtctctgtc tcccattttc
     3421 agccatttga acagcatatt ctttggaacg ctgagataac gtcttattgt tttttataga
     3481 catgtctttt aaaaatagtc catgtttgag aattgttttg tacttgtttg cttttgtctg
     3541 agaaccatgt ctatttttct aacttgaatg acttctgtgt aatctcacgt tccctgtact
     3601 ctatccattt tctacaacac ccagtagctt ttctaccttc tcttcctact gcctcctgtg
     3661 gtttcagaac aagctttatt ttgttacgag tatactaatg gcagtttgtt ctgtccaatt
     3721 ctccctgctt ttagtggtgg agatcttttt tattttattt tttctagttg attgctcttc
     3781 taaaagacat gagatcaaaa agacctgatg tcttccatgc acactaccct ggtcttcttt
     3841 tgaagaacaa tttttcatca gctgtaacta ggaaagttca ggaaagtcag ccataagcaa
     3901 gaacaactca ttgtgaaagc caacagaaga aaaatgttat ttccgttttt ttccaagtca
     3961 attggaggga ttaaaaagtc cgtgtatcac caatttctct gttgcatgaa ctttagtgtt
     4021 ttactatctg acagcatgaa agtgatcagg ctaaacttca atactgtagt ccagatacaa
     4081 cttaccttga atgtctgctc ttaaataagg ttttccttgt ccgtttcctt tcagcagtct
     4141 taacattatg tgaaattaac ttttcagcca aaattaaatc agagaaaaaa cttcaagccc
     4201 tctacatcgt cttttttttt tttttttttc atttttggga aaggacctgc ctggcctcaa
     4261 tgcctacaca cagagcagag gtcgaatgga gttcattagc ctcatgtacc ataagtaaaa
     4321 tggccaagca tctctcccgg aggatgtatt tcattaattc ctgtacatag tgggtcagac
     4381 atcctcattc cggtccataa ttctggaatc ttcagaacag gggcaagcat aaattcattc
     4441 acttttaaat aatatcttat ttggctaaac tcaaggacag cagttctcta cctgtaggtt
     4501 gtgacccctc tggggatcaa acaactccca ggggctgcct aagacactgg aaaacacaga
     4561 tatttacatt atgatttata acagtaacaa aattagtttt atggtgggga tcacaacatg
     4621 aactgtacta aagggtcaca gcattaggta ggttgagacc actgctcttg gagaacttgt
     4681 ggcttaaaac tattgcttcc tggtgatact ggtatgggct agtccatttt gccattgctg
     4741 acatcctctt tccttgggaa aagtggtttc aaccctttaa tcccagcact ggggatgcag
     4801 aggcagggag gtctctttga gtttaaggct agcctggtct actcagtaag ttccatgaca
     4861 gccagaacta catagtgaga ctctgctttg aaaaacaaca gaaaacaaaa ccaaaacaaa
     4921 tgtactcatc tgtagaaatg ttcctacata cacctatata cacataagta aaaataaatc
     4981 ttaaaaatga cctcaaatgc taatttagtt atttaaaaac tgaagagtat catcttcttg
     5041 ctcaattccc tcaatcattg ggaacacttt acagtttgta cctgaagctt ctgcctggtc
     5101 atagatacat gcctgtaatt ccaacatttg ggaggctgag gcaggagtac tggttagtgc
     5161 cgatctggcc tataatgaga tctgtgcccg ggttaaatag aaggatgcgt tagatacatt
     5221 tggcaactcc agtgctcctt ttggactgag ttttcagctc ttttgactgg gataactaag
     5281 ttatgaaaag atctttatgt tctacatcca acttaagaat atcagttact gaacaacata
     5341 ccagttataa tcaaaattct catcttactc ataagtatca tcattacaca ctcttacttg
     5401 tcaaacttaa gaggtatagc ttgcttaaaa tacctatgtg taaagttcta ttttcttaga
     5461 aacatggatg tttgtaacca tggctttcag agattcttac cacgtattct gttttactgt
     5521 gctttcatag actgttatac cagaggtttc cgattatcaa agtaataacg tgttttaact
     5581 gcctatatgt accagagttg tgaacaagtc aaaaccaaac acacgcactc tgaataaaag
     5641 ggagtttgca aactaaa
//
