LOCUS       NM_001105983            5005 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dispatched RND transporter family member 1
            (Disp1), transcript variant 1, mRNA.
ACCESSION   NM_001105983 XM_001063824 XM_213964
VERSION     NM_001105983.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5005)
  AUTHORS   Takahashi,T., Friedmacher,F., Zimmer,J. and Puri,P.
  TITLE     Expression of dispatched RND transporter family member 1 is
            decreased in the diaphragmatic and pulmonary mesenchyme of
            nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   Pediatr Surg Int 35 (1), 35-40 (2019)
   PUBMED   30382378
  REMARK    GeneRIF: Decreased Disp-1 expression during diaphragmatic
            development and lung branching morphogenesis may interrupt
            mesenchymal cell proliferation, thus leading to diaphragmatic
            defects and PH in the nitrofen-induced CDH model.
REFERENCE   2  (bases 1 to 5005)
  AUTHORS   Kantarci,S., Ackerman,K.G., Russell,M.K., Longoni,M., Sougnez,C.,
            Noonan,K.M., Hatchwell,E., Zhang,X., Pieretti Vanmarcke,R.,
            Anyane-Yeboa,K., Dickman,P., Wilson,J., Donahoe,P.K. and Pober,B.R.
  TITLE     Characterization of the chromosome 1q41q42.12 region, and the
            candidate gene DISP1, in patients with CDH
  JOURNAL   Am J Med Genet A 152A (10), 2493-2504 (2010)
   PUBMED   20799323
REFERENCE   3  (bases 1 to 5005)
  AUTHORS   Cohen,M.M. Jr.
  TITLE     Hedgehog signaling update
  JOURNAL   Am J Med Genet A 152A (8), 1875-1914 (2010)
   PUBMED   20635334
  REMARK    Review article
REFERENCE   4  (bases 1 to 5005)
  AUTHORS   Etheridge,L.A., Crawford,T.Q., Zhang,S. and Roelink,H.
  TITLE     Evidence for a role of vertebrate Disp1 in long-range Shh signaling
  JOURNAL   Development 137 (1), 133-140 (2010)
   PUBMED   20023168
REFERENCE   5  (bases 1 to 5005)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   6  (bases 1 to 5005)
  AUTHORS   Kawakami,T., Kawcak,T., Li,Y.J., Zhang,W., Hu,Y. and Chuang,P.T.
  TITLE     Mouse dispatched mutants fail to distribute hedgehog proteins and
            are defective in hedgehog signaling
  JOURNAL   Development 129 (24), 5753-5765 (2002)
   PUBMED   12421714
REFERENCE   7  (bases 1 to 5005)
  AUTHORS   Ma,Y., Erkner,A., Gong,R., Yao,S., Taipale,J., Basler,K. and
            Beachy,P.A.
  TITLE     Hedgehog-mediated patterning of the mammalian embryo requires
            transporter-like function of dispatched
  JOURNAL   Cell 111 (1), 63-75 (2002)
   PUBMED   12372301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 29, 2022 this sequence version replaced NM_001105983.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360186.2756173.1,
                                    SRR22582424.1625206.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000013.1  97398129-97398311   c
            184-271             JAXUCZ010000013.1  97381035-97381122   c
            272-400             JAXUCZ010000013.1  97344596-97344724   c
            401-919             JAXUCZ010000013.1  97303360-97303878   c
            920-949             JAXUCZ010000013.1  97272275-97272304   c
            950-1073            JAXUCZ010000013.1  97265742-97265865   c
            1074-1201           JAXUCZ010000013.1  97264746-97264873   c
            1202-1299           JAXUCZ010000013.1  97264346-97264443   c
            1300-1397           JAXUCZ010000013.1  97261905-97262002   c
            1398-5005           JAXUCZ010000013.1  97252574-97256181   c
FEATURES             Location/Qualifiers
     source          1..5005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..5005
                     /gene="Disp1"
                     /note="dispatched RND transporter family member 1"
                     /db_xref="GeneID:289338"
                     /db_xref="RGD:1307675"
     exon            1..183
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..271
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..400
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..919
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..4985
                     /gene="Disp1"
                     /note="dispatched homolog 1"
                     /codon_start=1
                     /product="protein dispatched homolog 1"
                     /protein_id="NP_001099453.1"
                     /db_xref="GeneID:289338"
                     /db_xref="RGD:1307675"
                     /translation="MAVISGSDSVLLSNGSISTSTTNPSPLTPSDGDLTAQQLAPRET
                     PRTKASPNGCLQLNGTVKSSFLPLDNQRTPQTALCCHPCPYHHPVTSHTSHQECHPEA
                     GLAASSALTSGCIQPHSEYSASLCPNHSPVYQAAHCRQPSPSLCLHHPWPDHFQHQPV
                     RQHLAIIGPSRPFRFPRSYAALLADWPVVVLGLCTLLIVVCALVGVLVPELPDFSDPL
                     LGFEPRGTAIGQRLVTWNNMMKNTGYKATLANYPYKYAEEQAKSRRDDRWSGDHHERE
                     RREVDWNFQKDSFFCDVPSDGYSRVVFASAGGETLWNLPAIKSMCDVDNSRIRSHPQF
                     SDLCQRTTAVSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTL
                     GPDCWDKAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTSKTADYAVPALKYS
                     MLFSPTEKGESMMNIYLDNFENWNSSDGITTVTGIEFGIKHSLFQDYLLMDTVYPAIA
                     IAIVLLIMCVYTKSVFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVG
                     IGADDAFVLCDVWNYTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSN
                     ITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERYLLNIFTCFRKPQPQAYHKSCWT
                     VLCRKGRKALFAISEASRIFFEKVLPCIVIKFRYLWLVWFLALTVGGAYIVCINPKMK
                     LPSLELSEFQVFRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGDP
                     LNPKSKGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQW
                     MENQDCDEPALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTPGPRFDIN
                     DTIRAVVLEFQSTFLFTLAYEKMQQFYKEVDSWISHELSSAPEGLSHGWFVSNLEFYD
                     LQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWE
                     LNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAIAVAALTTF
                     VAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPLPKKL
                     QCSAFSHTSAARPGGRAPGKATNAYSVDARGQKSELEHELYELQPLGSHSCTSSDMTA
                     YEGPCICSEFFNGQAKNLRMPMSAAYSSELTKSPRSEPGSALLQPCLEQDTMCHFSLN
                     PRCNCPNAYTHRKYGLPEIHCQQMGDSLCHKCASTAGSFVQIQNAAAPLKATHHAAEG
                     LLHPVQHMLPPGMQNSQSRNFFLHPVQHFQAQESLGPTSTRGRENTDERPPRTAEPPP
                     AGASRSSESFQRACCNPENNQRRLCKSRDSGDTEGSGGTETKVCGLANQTDKVEKEVK
                     PSLLQTDEIVNSEQLNHDEPKLIFSHLIREAGCRPCPDRPQGCRSLRLKCGSTDCQAP
                     DLEANVPAVPTHSDLSVSGESLLIKTLQ"
     exon            920..949
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1073
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1201
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1299
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1397
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..5005
                     /gene="Disp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccaggcg gaagcgcggc tccgggccag gatccgcgag ctccggctgg agcagagttc
       61 ggagcctcag tgtccgggac gcctgcggtc ggtgtggatg cttcttcgcg ctgcgtcccc
      121 gcggaccgga gaggccgggg aggcacgcgg gagtcggcgc ggcgggagag ccgggacccc
      181 tgggtgtctg aggatgaaga ctcgtcttgg ttgttgaatt atgtatagta aatggtgtac
      241 cgactgtcac aacagcatca ttgaaaaaga ggttggcctc aagctactgt ggctgcagaa
      301 gactcaagac tgagggcctg tagagatgag ctgtgctctg ggattggcat taaggtgaat
      361 catgtgacgc tcccagccac ggtgtccatc cccgtggaag gaccaagaac tcgggcatgg
      421 ctgtgatcag cggaagtgat tctgtgcttc tgagcaatgg cagcatctcc accagcacta
      481 ccaaccctag tcccctcacc cccagtgatg gagacctcac agctcagcag ctcgcaccca
      541 gagaaacccc gaggacaaaa gcaagtccaa atggatgcct gcaacttaat ggcacagtta
      601 agtcatcctt tctgccttta gacaaccaaa gaacgcctca gacagctctg tgctgccacc
      661 cttgtccata ccatcaccct gtgaccagcc ataccagtca ccaagagtgc catcctgagg
      721 ctggccttgc agcatcctcc gctttgacct cgggttgcat acagccacat tccgaatact
      781 ctgcctctct gtgtccaaac cattcacctg tgtatcaggc tgcgcactgc cgtcagccct
      841 cgccatctct ctgccttcat cacccgtggc ctgaccattt ccagcaccag cctgtacggc
      901 agcacctggc catcatcggg ccgtccagac ctttcaggtt cccgagaagt tatgctgccc
      961 tgctagccga ctggcctgtg gtggtcctgg gcttgtgcac gctgctcatc gtggtctgcg
     1021 ccctggtggg agtcttagtg ccggagctcc ccgacttctc tgacccactg ctgggttttg
     1081 aaccaagagg gactgcaata ggacagaggc tggtcacctg gaataacatg atgaaaaaca
     1141 caggctacaa agcgacgttg gccaactatc cgtataagta tgcagaagag caagccaaaa
     1201 gccgccggga tgacagatgg tcaggcgatc atcatgagag agagagaaga gaagtagact
     1261 ggaacttcca gaaggacagc ttcttctgcg acgttccaag tgatggctac tccagagtgg
     1321 tgtttgcttc agcaggaggg gagaccctgt ggaatttacc tgcaattaag tcaatgtgtg
     1381 atgtggataa ctccaggatc agatcccacc cccagttcag cgacctctgc cagaggacca
     1441 ccgccgtctc ctgctgcccc agctggaccc tggggaatta catcgccatt ctgaataaca
     1501 gatcgtcctg tcagaagatt gtcgagcgag atgtctctca cacgctgaag ctgcttcgga
     1561 cctgtgccaa gcactaccag aacggcaccc tggggccaga ctgctgggac aaggcggcca
     1621 gaaggaagga ccagctcaag tgcaccaacg tgccacgcaa gtgtaccaaa tacaacgccg
     1681 tgtaccagat tctccactac ttggtagaca aggacttcat gacctccaag acggctgact
     1741 acgccgtgcc agctttaaag tacagcatgc tcttctcccc cacggagaaa ggggagagca
     1801 tgatgaacat ctacctggac aactttgaga actggaactc ttcggacggc atcaccaccg
     1861 tgacagggat cgagtttggc atcaagcaca gtctgtttca ggattacctc ctcatggata
     1921 ccgtgtaccc cgccatcgcc atcgccatcg tccttctcat catgtgtgtc tacaccaagt
     1981 ccgtgttcat cacgctcatg accatgtttg ccatcatcag ctccctgatc gtctcctact
     2041 tcctttaccg agtcgtgttt aacttcgagt tcttcccatt catgaacctc actgcactca
     2101 tcatcctggt cgggatcggc gccgacgacg ccttcgtcct gtgcgacgtc tggaactaca
     2161 ccaagtccga caagccccgt gcagaaacgt ctgaggcggt aagcgtcacc ttgcagcatg
     2221 cagccctctc catgtttgtc accagcttca ccaccgccgc cgccttctac gctaactacg
     2281 tcagtaacat cacggcaatc aggtgcttcg gggtgtatgc ggggaccgct atattggtga
     2341 actatgtcct gatggttacc tggcttccgg ctgtcattgt tctgcatgag cgctatctcc
     2401 tcaatatatt cacctgcttc agaaagcccc agccgcaggc ctaccacaag agctgctgga
     2461 cagtgctctg ccggaagggc cgcaaggcgc ttttcgccat ctcagaggca tctcggattt
     2521 tctttgaaaa ggtgctgccc tgcatcgtca tcaagttccg ctacctttgg ctcgtctggt
     2581 tccttgccct gactgtgggc ggggcctaca tcgtgtgcat aaacccaaag atgaaactgc
     2641 cttccttgga gttatctgag ttccaggtgt tcaggtcctc tcatcctttc gagcgctatg
     2701 atgcggagtt caagaagctg ttcatgttcg agcgggttca ccatggagag gagctccaca
     2761 tgcccatcac agtaatctgg ggcgtgtctc cagaagacag cggtgaccct ctgaacccca
     2821 agagcaaagg ggagctgaca ctcgatagca cgttcaacat tgctagcccg gcctcccagg
     2881 cctggatttt acacttctgt cagaaactga ggaaccagac cttcttccac cagactgagc
     2941 agcaggactt caccagctgt ttcatcgaga ccttcaaaca gtggatggag aaccaggact
     3001 gtgacgagcc ggccctgtac ccctgctgca gccactgcag cttcccctat aagcaagagg
     3061 ttttcgagct gtgcatcaag aaggccatca tggagctgga caggagcacg gggtaccacc
     3121 tgaacaacaa gaccccgggg cctaggttcg acatcaacga caccatcagg gccgtggtgc
     3181 tggagttcca gagcaccttc ctcttcacct tggcgtatga gaagatgcag cagttctaca
     3241 aggaggtgga ctcatggatt tcccacgagc tgagttcggc ccccgagggc ctcagccacg
     3301 gctggttcgt cagcaacctg gagttctatg acctgcagga cagcctttcc gatggcaccc
     3361 tcattgccat ggggctctcg gtggccgtcg cgtttagtgt gatgctgctg accacatgta
     3421 atatcatcat aagcctgtat gccatcgcct ccatagctgg gaccatattt gtcacagttg
     3481 ggtcccttgt cctgctgggc tgggagctga acgtgctgga gtccgtcacc atctcggttg
     3541 cagttggctt gtcggtggac tttgcagtcc actacggggt ggcataccgc ctggccccag
     3601 atcccgaccg agagggcaag gtcatcttct ctctgggtcg tatgggctct gcgatcgccg
     3661 tggctgcact gaccaccttc gtggcgggtg ccatgatgat gccctccacg gtcctggctt
     3721 acacgcagct gggcaccttc atgatgcttg tcatgtgcgt cagctgggcc ttcgccacct
     3781 tcttcttcca gtgcctgtgt cggtgcctgg gacctcaagg cacctgtggc cagatccctt
     3841 tacccaaaaa gctccagtgt agtgcctttt cccacacctc ggctgcgagg cctgggggca
     3901 gggcaccagg caaagccacc aacgcttaca gtgtagatgc caggggccag aaatccgaac
     3961 tggaacatga gttgtatgag ttacagcccc tgggctctca cagctgcact tcctcagaca
     4021 tgaccgctta tgaagggcca tgcatctgct ccgaattttt caatggccaa gcaaagaatt
     4081 taaggatgcc catgtctgca gcctacagca gcgaactcac caaaagcccc agaagtgagc
     4141 caggctcggc cttgttgcag ccctgtctgg agcaggacac catgtgtcac ttctctctca
     4201 atccgagatg taactgcccc aatgcctaca cccaccgaaa gtatggattg ccagaaatcc
     4261 actgccagca gatgggtgac tccttatgcc acaagtgtgc ctccaccgca ggcagctttg
     4321 tccagattca gaatgctgcg gcgcctctaa aggccaccca ccacgccgcc gaaggccttc
     4381 tgcatcctgt ccagcacatg ctgccaccag ggatgcagaa ttctcagtct aggaattttt
     4441 ttctccaccc agtccagcac tttcaggccc aagagagcct gggtcccacc agcacccggg
     4501 gtcgtgagaa cacagatgag cgtccgcccc ggacagcaga gccaccacca gcaggagcca
     4561 gcaggagctc tgagtctttc caaagagctt gctgcaatcc tgagaataac caaaggagac
     4621 tctgcaaaag cagagactcg ggggacacag agggcagtgg agggacagaa accaaggttt
     4681 gtggtttagc aaaccagact gacaaggtag agaaggaagt gaagcccagc ctgctgcaga
     4741 cagatgaaat cgtgaactca gaacagttaa atcatgatga accaaaactt atattcagcc
     4801 atttaatacg ggaggccggc tgcaggccct gcccagacag gccgcagggc tgtagaagcc
     4861 tgagactgaa gtgcgggtcc acggactgcc aggcgccaga ccttgaagcc aatgtgcctg
     4921 ctgtaccaac ccactcagac ctgtctgtgt ctggcgaaag cctgttaata aaaacactac
     4981 aataaatgta gcgttgcgtc cagaa
//
