LOCUS       NM_175596               6024 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus DISC1 scaffold protein (Disc1), mRNA.
ACCESSION   NM_175596 XM_008772616
VERSION     NM_175596.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6024)
  AUTHORS   Seidisarouei,M., Schable,S., van Wingerden,M., Trossbach,S.V.,
            Korth,C. and Kalenscher,T.
  TITLE     Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent
            phenotype
  JOURNAL   Sci Rep 12 (1), 10182 (2022)
   PUBMED   35715502
  REMARK    GeneRIF: Social anhedonia as a Disrupted-in-Schizophrenia
            1-dependent phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6024)
  AUTHORS   Wang,A.L., Chao,O.Y., Nikolaus,S., Lamounier-Zepter,V.,
            Hollenberg,C.P., Lubec,G., Trossbach,S.V., Korth,C. and Huston,J.P.
  TITLE     Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive
            Flexibility and Social Behaviors in a Transgenic Rat Model
  JOURNAL   Neuroscience 493, 41-51 (2022)
   PUBMED   35461978
  REMARK    GeneRIF: Disrupted-in-schizophrenia 1 Protein Misassembly Impairs
            Cognitive Flexibility and Social Behaviors in a Transgenic Rat
            Model.
REFERENCE   3  (bases 1 to 6024)
  AUTHORS   Glenn,M.J., Batallan Burrowes,A.A., Yu,W., Blackmer-Raynolds,L.,
            Norchi,A. and Doak,A.L.
  TITLE     Progression of behavioral deficits during periadolescent
            development differs in female and male DISC1 knockout rats
  JOURNAL   Genes Brain Behav 21 (1), e12741 (2022)
   PUBMED   33960643
  REMARK    GeneRIF: Progression of behavioral deficits during periadolescent
            development differs in female and male DISC1 knockout rats.
REFERENCE   4  (bases 1 to 6024)
  AUTHORS   Barnett,B.R., Anderson,J.M., Torres-Velazquez,M., Yi,S.Y.,
            Rowley,P.A. and Yu,J.J.
  TITLE     Exercise ameliorates deficits in neural microstructure in a Disc1
            model of psychiatric illness
  JOURNAL   Magn Reson Imaging 61, 90-96 (2019)
   PUBMED   31103832
  REMARK    GeneRIF: Mutations of the DISC1 gene have been implicated in the
            molecular intersection of schizophrenia and numerous other major
            psychiatric illnesses.
REFERENCE   5  (bases 1 to 6024)
  AUTHORS   Barnett,B.R., Torres-Velazquez,M., Yi,S.Y., Rowley,P.A.,
            Sawin,E.A., Rubinstein,C.D., Krentz,K., Anderson,J.M., Bakshi,V.P.
            and Yu,J.J.
  TITLE     Sex-specific deficits in neurite density and white matter integrity
            are associated with targeted disruption of exon 2 of the Disc1 gene
            in the rat
  JOURNAL   Transl Psychiatry 9 (1), 82 (2019)
   PUBMED   30745562
  REMARK    GeneRIF: global and sex-specific changes in white matter
            microstructural integrity and deficits in neurite density as a
            consequence of the Disc1 svDelta2 genetic variation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6024)
  AUTHORS   Sawamura,N., Sawamura-Yamamoto,T., Ozeki,Y., Ross,C.A. and Sawa,A.
  TITLE     A form of DISC1 enriched in nucleus: altered subcellular
            distribution in orbitofrontal cortex in psychosis and
            substance/alcohol abuse
  JOURNAL   Proc Natl Acad Sci U S A 102 (4), 1187-1192 (2005)
   PUBMED   15657124
REFERENCE   7  (bases 1 to 6024)
  AUTHORS   Hodgkinson,C.A., Goldman,D., Jaeger,J., Persaud,S., Kane,J.M.,
            Lipsky,R.H. and Malhotra,A.K.
  TITLE     Disrupted in schizophrenia 1 (DISC1): association with
            schizophrenia, schizoaffective disorder, and bipolar disorder
  JOURNAL   Am J Hum Genet 75 (5), 862-872 (2004)
   PUBMED   15386212
REFERENCE   8  (bases 1 to 6024)
  AUTHORS   Miyoshi,K., Honda,A., Baba,K., Taniguchi,M., Oono,K., Fujita,T.,
            Kuroda,S., Katayama,T. and Tohyama,M.
  TITLE     Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia,
            participates in neurite outgrowth
  JOURNAL   Mol Psychiatry 8 (7), 685-694 (2003)
   PUBMED   12874605
  REMARK    GeneRIF: DISC1 participates in neurite outgrowth through its
            interaction with FEZ1.
REFERENCE   9  (bases 1 to 6024)
  AUTHORS   Ozeki,Y., Tomoda,T., Kleiderlein,J., Kamiya,A., Bord,L., Fujii,K.,
            Okawa,M., Yamada,N., Hatten,M.E., Snyder,S.H., Ross,C.A. and
            Sawa,A.
  TITLE     Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents
            binding to NudE-like (NUDEL) and inhibits neurite outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 100 (1), 289-294 (2003)
   PUBMED   12506198
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969]
REFERENCE   10 (bases 1 to 6024)
  AUTHORS   Millar,J.K., Wilson-Annan,J.C., Anderson,S., Christie,S.,
            Taylor,M.S., Semple,C.A., Devon,R.S., St Clair,D.M., Muir,W.J.,
            Blackwood,D.H. and Porteous,D.J.
  TITLE     Disruption of two novel genes by a translocation co-segregating
            with schizophrenia
  JOURNAL   Hum Mol Genet 9 (9), 1415-1423 (2000)
   PUBMED   10814723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_008772616.3, NM_175596.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY177674.2 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA5760386,
                                    SAMEA5760433 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000019.1  69911976-69912185
            211-1181            JAXUCZ010000019.1  69946855-69947825
            1182-1251           JAXUCZ010000019.1  69949845-69949914
            1252-1399           JAXUCZ010000019.1  69977931-69978078
            1400-1523           JAXUCZ010000019.1  69985470-69985593
            1524-1759           JAXUCZ010000019.1  69988451-69988686
            1760-1814           JAXUCZ010000019.1  70002390-70002444
            1815-1917           JAXUCZ010000019.1  70009424-70009526
            1918-2106           JAXUCZ010000019.1  70017434-70017622
            2107-2167           JAXUCZ010000019.1  70075608-70075668
            2168-2375           JAXUCZ010000019.1  70090151-70090358
            2376-2493           JAXUCZ010000019.1  70108042-70108159
            2494-2633           JAXUCZ010000019.1  70116997-70117136
            2634-6024           JAXUCZ010000019.1  70117580-70120970
FEATURES             Location/Qualifiers
     source          1..6024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..6024
                     /gene="Disc1"
                     /note="DISC1 scaffold protein"
                     /db_xref="GeneID:307940"
                     /db_xref="RGD:631359"
     exon            1..210
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2630
                     /gene="Disc1"
                     /codon_start=1
                     /product="disrupted in schizophrenia 1 homolog"
                     /protein_id="NP_783186.2"
                     /db_xref="GeneID:307940"
                     /db_xref="RGD:631359"
                     /translation="MQGAGSRGAWIHSPSHCPGNGHGSPPAVAPQRRRLTRRPGYMRS
                     TASPGIGFLSPAVGMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKG
                     SLGPAVTSVGHLHPAQGSMRERMVHSGVHSGNDRRQSERLTGDSGCRQEFLSSDSSKS
                     LASSLDVAWSKGSRGLKTVRPLVSPASNGPVDIPSLPGFQDTFTSNFSFIRLSLGAAG
                     ERGEAEGCLPSREAEPLHQSPQEMAAEGSGSDRPHGEPRHLWTFSLHAAPGLVDLAQG
                     TRSNRQPECGMVSSSDAGFSSQDASPAGGRSDQDGGWADAHGWHALLREWEPMLQDYL
                     LSNRRQLEVTSLILKLQKLQEKAVEDGDYDMAETLRQRLEDLEQEKGRLPWALPSQQP
                     ALRSFLGYLATQTHAALHGAPQRAGSDDPEAPLEGQRRTTAQDSLPGLAVTRRDWLMR
                     EKEQLQKEIEALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQE
                     VSKALGETLTSARWAPFRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRK
                     RLADLDTRLPALLEAKMLALSGSCFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSR
                     NTRRLGSVKEDYLRCRQDLALQEAAHKTRVKANTVKCTEVLEGQLSCCRCPLLERVWK
                     ADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAAQTAALAVPRTPHPEEEKSPLQ
                     ESHVVFAEVGDKCEAIGMRLLHLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFL
                     QLQPAKEAGGEASASYSTAGAQEAED"
     exon            211..1181
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1251
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1399
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1523
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1759
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1814
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1917
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2106
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2167
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2375
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2493
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2633
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..6024
                     /gene="Disc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgtgtg cgagggggcc gaagctggag aggaagcggc ggtcctgggc aggaggaagg
       61 agccagccct cggctcggcc ccctgcccgt ttcccgccgc ctccgcggtc gcagtcacca
      121 ccgttgccgc cgtccggagc gcagccagcc gcacgatgca gggcgcgggt tcccggggcg
      181 cttggatcca cagtccgagc cactgcccag gcaatgggca tggctcgccg cctgcagtag
      241 cccctcagag gcggcggctg acacggagac caggctacat gagaagcaca gccagtcctg
      301 ggatcgggtt cctgtctcca gcagtgggca tgccacgtcc gatctcagcg gggctgacag
      361 gccaggagtt ctacccctca cagtccaagg ctagacagtg cagccttgac ctcagaagcc
      421 actgccaaga ctcattggtg ggcaaccctt ttctcaaggg ctcccttggc cctgctgtga
      481 cctctgtggg ccacctgcac ccagcccagg gctctatgag agaaaggatg gtgcactctg
      541 gggttcattc cgggaatgac agaagacaat ccgagaggct gactggggac agtggttgtc
      601 ggcaagaatt tttatcttca gacagctcta agtctctggc ttctagcctt gatgtagctt
      661 ggagcaaggg atcgaggggc ctgaagactg tgaggcctct ggtatcaccg gcgtcgaatg
      721 gccccgttga catcccatcc cttcctgggt tccaagacac ctttacttcc aacttcagct
      781 tcatccgact ctccctcggt gctgctggag aacgcggaga agcagaaggt tgcctgccat
      841 ccagagaggc cgaacccctg catcagagcc cccaagagat ggcagctgaa ggatccggct
      901 cagacaggcc ccacggggag cctcggcatc tctggacctt cagtcttcac gctgctccgg
      961 gcttggtgga cttggctcag gggacgagga gcaacaggca accagaatgt ggcatggtct
     1021 cctcctccga tgctggcttc tcttcccagg atgcatcccc cgctggaggg cggagcgacc
     1081 aggacggagg ctgggcggat gcccatggat ggcacgctct gctcagggaa tgggagccta
     1141 tgctgcagga ctacctactg agcaaccgca ggcagctgga ggtcacttcc ttgattttaa
     1201 agcttcagaa acttcaagaa aaagcggtcg aggatggcga ttacgacatg gcagagacac
     1261 tgagacagag attggaagac ctggaacagg agaaaggccg cctgccctgg gctctgccct
     1321 cacagcaacc agcccttcgc agcttcttgg ggtacctggc aacacagaca cacgcggcct
     1381 tgcatggagc cccccaaagg gctggcagcg atgacccaga agccccactt gagggacagc
     1441 ggaggaccac cgcccaggat agcctgccgg gactagccgt caccaggcgg gactggctga
     1501 tgcgagagaa agagcaattg cagaaggaaa tcgaagctct ccgggcaagg gtgtctgtgc
     1561 tggaggcgaa ggaacaacgg ctgagccaag agttggagga tcaggagatg ctgctccggt
     1621 ggcagggctg tgaccagatg gcactggtgg cacagctgtc cccaggccag ctgcaggagg
     1681 tcagcaaggc cttgggagag actctgacct ctgccagatg ggctcccttc cgcgtggagc
     1741 cacccgaaac cctcaggagc ctccgggaaa ggacaaagtc actcgacctg gctgttagag
     1801 aactcactga gcaggtatgc tcaggtgaga agctatgcag ctctctgagg aagagactcg
     1861 ctgaccttga caccaggctg cctgccttgc tggaagccaa gatgctggcc ctatcaggaa
     1921 gctgcttctc tacagccaag gagctcgcag aggagatttg ggccgtgtca tcggagcggg
     1981 aagggctaga gatgttcctg ggcaggctgc tggccctcag ctccaggaac acgagaagac
     2041 tgggcagcgt caaagaggac tacctcaggt gcaggcagga cctggccctc caggaagccg
     2101 cccacaaaac acgcgtgaag gcaaacactg tgaagtgcac ggaagtgttg gagggtcagc
     2161 tgagctgctg caggtgcccg ctgcttgaga gagtgtggaa agcggacttg gaggcgtgtc
     2221 agttgctgat gcagagccta gagatccagg aagcaggcag cagctcacat gtggaggatg
     2281 agaagcaggt gcacagcaca ggagaggcgg ctcagacagc tgccctggct gtccctagaa
     2341 caccccaccc cgaagaggaa aagtccccct tgcaggaatc tcatgtcgtt tttgctgaag
     2401 ttggagacaa atgcgaagcc ataggcatga ggctcctgca cctggaagac cagcttctcg
     2461 gcgccatgca cggtcacgat gaagctctct ttcagtctct ccagggggag ctccagatgg
     2521 ttaaggaaac actacagacc atgttcctgc agctccagcc agcaaaggag gcaggaggag
     2581 aggcctcagc ttcctattcg acagctggtg ctcaggaagc cgaggactga ggtctctgtc
     2641 tttctccgtt cgaaaccaaa cctgagaagg ccactgcacc tgccggcgtc tctctacagg
     2701 cactggaaca ccaggactcc acaaacctca gagtctgtgc aggtccttag ctccccaggc
     2761 tgcttcctct aggggctctg ctcagtctca ggagacgtct acagggtgcc tcagtcttta
     2821 tgttctccag caatggctgc agctcagaac caccatcacc accaccacca tcaccagcag
     2881 tgtctgctac gtcaggtcat tttgagattc cagccagtga ggtgggaggt gtgaatgtgg
     2941 ggagaggcat ggacgcagga ggagacaaag gacacccgtg agcctctcca gttcccgttt
     3001 tgtctccggg gaattacagc gtggagccta aagagcagtg tctattccct gaggcaatgt
     3061 ggactcaggc agctcacagc tccataatgg tgtgtggcag cttcctgtga attgctcctt
     3121 gggctcagcc gagactcctg cagaggcagc tgtgggcggt ttgttcaagc aggcagaaga
     3181 gatgagctaa gagagggcat caggtagttt ctggttgctg tgaaaaacta cctggcaaaa
     3241 acaacttggt aggaaggaag ggagggaggg agggacggaa ggaaggagga atgaagaaca
     3301 gaaagaagga aggaaggaag gatagaagga gggtaggtgg gtttccttgg gctcctcgtt
     3361 tgaggctgca gtctatcaca gtagggaatg catggtggca ggaccatgag gcagttgttc
     3421 acaccgtgtc ctcagacagg aagcaaagag atcaacgcca ctttaatctc ttcccccctc
     3481 tattcggtac aaagtctcag cccgtgtgat gccacagccc gcatttacag tgggtttccc
     3541 tcggtcacgt gtctttggaa acaccctttt ggacatactt ggagttttgc cttctaggtg
     3601 actctgagcc cagtaaagtt gataataatg atgaatgacc acaggagggt acctcagaga
     3661 cgtaagtcta tatggtaaga cctggcctca taactcctgc ttgggagtca actcagccag
     3721 ccgccctgtg agagggctgg tacgataaag tccaccagct tccatctaac ccaacattcc
     3781 caagcctaat ggacttcaga tctcttcctg tgaagctact ggccccttca gtcttggggg
     3841 acattatgct gtaccctctg ggatgactcc agtgacctgt attttggaga ccaagcccag
     3901 ccttctccca ctgagctcag catagcctga cctctctaag gtgctctact cgagtttgta
     3961 cctatggaga tagacacact cttgcctccc tctgggtcca cgggtccagc tttaaccttt
     4021 cctcatcacc cttccatttc ggggaggctc ctggtggttc tccaagccct ctgtgctgac
     4081 gatcactttg ccctcattga agagaagcct gctccctgac ttcggtgtta tctgaacaat
     4141 tttgaggaca cattttgtat atttgaataa gaagtatgtt tactttgttt ccagatattt
     4201 tgataatgaa acaaattcgt gaatcattta taattgtgcc cctaaaggtt tggtggatca
     4261 atcacatggc acctggagcc cccaaatcct cggtgtgatt ttagtggagc aaacttgata
     4321 tcaggatcac cccctgttgg caagaacctt cctgactctg acaccttcca agcatgagtc
     4381 acctgactgt cactaccagc ctgtgcattt tatgttattc tgacaccact gtagctctct
     4441 gtgaggtcat gaagcattta aaagcttaag gagatgagaa atccgtgagg gttcagggga
     4501 gggacaactg agtgcccagt tggttgaatg gcatttcaat cataagtcgt cccacatctc
     4561 ctggcattct ctgggcttaa agtgccatca ggattaactg ttgaaggctg gtgtctcctg
     4621 ggacctcgta accatctcat gacaaccttc ctctcattag ccacttggac cctaggagat
     4681 ccaggacttg tggatcccca actataggac aggacaggtt tttacatggc cacataaaaa
     4741 tgccccagag aggttggtgc ctgaatttag actcttagga gaggaccaag cccccagcaa
     4801 aggtatgtgt taaaaggggg acacaacatc aatcttgtct atgacgacag tgcacacgtt
     4861 tcaccttata aatacgctct attcccctta tccattcata tgttgatggg ctgatttcat
     4921 aatccggctg tcactgtgat gtgtcactgt gacttctgca agggaggaac ctggggggcg
     4981 ggaggggcag cggctccatg agcatcctca ttatctcatt attgccaggt ctagctcctg
     5041 aagctttaca gcattgatca atcaatccct gaatcaggtt aatatgtcac aattgattct
     5101 agtcctgcct ggtgatgagg ccgcctccca ccccaggaat gcttgtggat gggcaccacg
     5161 ctgagccctt caactgtctt ggcaatcata cctctctgcc tgaggagagt gttgcacaaa
     5221 tggtgttcac aggcctcagg ctttgggatg gccgagtcct cttcctaaga ctcagagttg
     5281 gtttgaatga cggtcatggg gaatcctgac ccccccacgg gcagctgttc ctaaccagtg
     5341 tcctttctaa agtgccttca acaccctctt tgcgttttga gctatgaaac tcatccacca
     5401 gctaaaaccc atgactgcct catgaattct gcctgagagc agcgagccac tgaacttggg
     5461 gtcccctcac ccccccccag caaaccatac tatgtagcct aggctctggt tggctataga
     5521 aaccccaaac tctatccact gccctggccc agcctttccc agtcacccaa agatcattcc
     5581 aggggcgcca ctcacagcct cctactgggt gggttttctg gaaactttca atgtaactgg
     5641 tgttttctca gaacgtattt gtttgctatg ggcaacatga gcaacatgta catgtgtgtc
     5701 caggtccatg tgctgcggtt aacagcaacc acgtacatgt tggtcagcgc cctcttgtgt
     5761 acatagctga cctttaatct taacgccacc actttatttg atcttcgatt ttgtcgtgta
     5821 agttattgct tgattaagct ctgtatgaaa tgaaaactga tacccagacc atggtgctcc
     5881 ctggggttat ttagtattct ggaggggaga tgacagaagg aggtcagatt ggctcatttc
     5941 accaatctgt ggcaagataa ttaaatagct gtgtgtttgc ttagaccgac cggagtcctt
     6001 gcaataaagt tacattgtaa aatc
//
