LOCUS       NM_001172159            3126 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus DIS3-like 3'-5' exoribonuclease 2 (Dis3l2),
            transcript variant 2, mRNA.
ACCESSION   NM_001172159
VERSION     NM_001172159.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3126)
  AUTHORS   Faehnle CR, Walleshauser J and Joshua-Tor L.
  TITLE     Mechanism of Dis3l2 substrate recognition in the Lin28-let-7
            pathway
  JOURNAL   Nature 514 (7521), 252-256 (2014)
   PUBMED   25119025
REFERENCE   2  (bases 1 to 3126)
  AUTHORS   Ustianenko,D., Hrossova,D., Potesil,D., Chalupnikova,K.,
            Hrazdilova,K., Pachernik,J., Cetkovska,K., Uldrijan,S., Zdrahal,Z.
            and Vanacova,S.
  TITLE     Mammalian DIS3L2 exoribonuclease targets the uridylated precursors
            of let-7 miRNAs
  JOURNAL   RNA 19 (12), 1632-1638 (2013)
   PUBMED   24141620
REFERENCE   3  (bases 1 to 3126)
  AUTHORS   Lubas M, Damgaard CK, Tomecki R, Cysewski D, Jensen TH and
            Dziembowski A.
  TITLE     Exonuclease hDIS3L2 specifies an exosome-independent 3'-5'
            degradation pathway of human cytoplasmic mRNA
  JOURNAL   EMBO J 32 (13), 1855-1868 (2013)
   PUBMED   23756462
REFERENCE   4  (bases 1 to 3126)
  AUTHORS   Chang HM, Triboulet R, Thornton JE and Gregory RI.
  TITLE     A role for the Perlman syndrome exonuclease Dis3l2 in the
            Lin28-let-7 pathway
  JOURNAL   Nature 497 (7448), 244-248 (2013)
   PUBMED   23594738
REFERENCE   5  (bases 1 to 3126)
  AUTHORS   Astuti D, Morris MR, Cooper WN, Staals RH, Wake NC, Fews GA, Gill
            H, Gentle D, Shuib S, Ricketts CJ, Cole T, van Essen AJ, van Lingen
            RA, Neri G, Opitz JM, Rump P, Stolte-Dijkstra I, Muller F, Pruijn
            GJ, Latif F and Maher ER.
  TITLE     Germline mutations in DIS3L2 cause the Perlman syndrome of
            overgrowth and Wilms tumor susceptibility
  JOURNAL   Nat Genet 44 (3), 277-284 (2012)
   PUBMED   22306653
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474004.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3126
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..3126
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /note="DIS3-like 3'-5' exoribonuclease 2"
                     /db_xref="GeneID:367307"
                     /db_xref="RGD:1560168"
     exon            1..53
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            54..201
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2780
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /note="gene_id=rCG23910.0 transcript_id=rCT23910.0
                     protein_id=rCP41047.0 isoform=CRA_d; isoform 2 is encoded
                     by transcript variant 2; DIS3 mitotic control homolog-like
                     2; DIS3-like exonuclease 2"
                     /codon_start=1
                     /product="DIS3-like exonuclease 2 isoform 2"
                     /protein_id="NP_001165630.1"
                     /db_xref="GeneID:367307"
                     /db_xref="RGD:1560168"
                     /translation="MNHPDYKLNLQSPGTPRGVSSVVGPNAVGASPGDKKSKNKSMRG
                     KKKSIFETYMSKEDVSEGLKKGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVAR
                     NRALNGDLVVVKLLPEDQWKGVKPESNDKETEATNETDISEESCGHHLLQKSPKGWNG
                     PDVIIEAQFDDSDSEDRHGNTSGLVDGMKKLSVCTPDKGKEDSSAPVMKDENTPKSQD
                     TRALSEKSLQKSAKVVYILEKKHSRAATGILKLLADKNSDLFKKYALFSPSDHRVPRI
                     YVPLKDCPQDFMTRPKDYANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGI
                     LTEYGVDFSDFSSEVLECLPQSLPWTIPPEEVGKRRDLRKDCIFTIDPSTARDLDDAL
                     SCRQLTDGTFEVGVHIADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEEL
                     CSLNPMTDKLTFSVIWKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPK
                     EELPPISPEHSIEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLPQ
                     GCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKMLSDLVEFCD
                     QMGLPMDVSSAGALNKSLTNTFGDDKYSLARKEVLTNMYSRPMQMALYFCSGMLQDQA
                     QFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALGYSEQPDVEPDALQKQADHCNDR
                     RMASKRVQELSIGLFFSILVKESGPLESEAMVMGVLNQAFDVLVLRFGVQKRIYCNAL
                     ALRSYHFQKVGKKPELTLVWEPDDLEEEPIQQVITIFSLVDVVLQAEATALKYSAILK
                     RPGPEHSLGLEKESDEEPED"
     exon            202..359
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            360..413
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            414..515
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            516..744
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            745..845
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1093
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1267
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1347
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1460
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1568
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1802
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1882
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2066
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2153
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2301
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2432
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2537
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2639
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..3126
                     /gene="Dis3l2"
                     /gene_synonym="RGD1560168"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctcccta gcaactgcgg gtctgcggcg gcgccggcct ccggggagcg acgctcgtga
       61 caactgagct gctcaaggca ggaagaactc tgagctgaat agtagtgggt ccctgaatct
      121 ggaaagaaga agccaccttg gaaccagtaa tgaaccatcc tgactacaag ctgaaccttc
      181 agtctccagg gactcccaga ggtgtgtcct ctgtggttgg cccgaatgct gttggtgctt
      241 cgccaggtga caaaaagtca aagaacaagt ccatgcgagg gaagaaaaag agcatatttg
      301 aaacctacat gtccaaggag gatgtttcag aaggcttgaa gaaaggaacg cttatccagg
      361 gtgtattgag gatcaatcca aagaagtttc atgaagcctt cattccttct ccggatggtg
      421 atcgggacat ttttattgat ggagttgttg ctcgtaatag agccttaaat ggggaccttg
      481 tggttgtaaa actgcttcct gaggaccagt ggaagggagt taaaccagag agcaacgaca
      541 aagaaacaga agctactaat gaaactgaca tctctgagga gtcctgtgga caccaccttc
      601 tgcagaagtc cccaaaaggc tggaatggtc ctgatgttat tatagaggct cagtttgatg
      661 acagcgactc agaagataga catggcaaca ccagtgggct ggttgatggt atgaagaaat
      721 tgtcagtctg tactcctgac aaaggaaaag aagattctag tgctccagtt atgaaagacg
      781 agaacacccc caagtcacag gacacaagag ctttatcaga gaagtcactc cagaaatcag
      841 caaaggtggt ttacatcttg gagaaaaagc attcccgagc agcaaccggc atcctgaaac
      901 tcttggctga caagaacagt gacctgttta agaaatatgc cctgttttct ccttcagacc
      961 accgagtacc tagaatttat gtaccactca aggactgtcc ccaggacttc atgacccgac
     1021 ccaaagacta tgccaacacg ctgttcatct gccgcatcat agactggaag gaggactgta
     1081 attttgccct ggggcaactg gctaagagtc ttgggcaagc tggtgaaatt gaacctgaaa
     1141 cagaagggat cctgacagaa tatggtgtgg acttctctga tttctcttca gaagttctcg
     1201 aatgtctccc tcaaagcctg ccatggacaa ttccacctga ggaggtgggc aagagaagag
     1261 acctaagaaa agactgtatc ttcaccattg acccatcaac tgctcgagac cttgatgacg
     1321 ccctctcctg caggcagctc actgacggca ccttcgaagt gggcgtccac atagccgatg
     1381 tgagttactt cgttcctgag ggatcctctt tggataaggt agctgctgag agagccacaa
     1441 gtgtctactt ggtccagaag gtggtcccca tgcttcccag gcttctgtgt gaggaactct
     1501 gcagcctcaa ccccatgact gacaagctga ccttctctgt gatctggaag ctgactcctg
     1561 aaggcaagat ccttgaggag tggtttggcc gcactatcat ccgttcttgc accaaattga
     1621 gctacgacca tgcgcagagc atgatcgaaa atccgactga gaagatcccc aaggaagagc
     1681 ttccccctat ttctccagag cacagcatcg aggaggtgca ccaggcagtc ctgaacctgc
     1741 acagcattgc aaagcaactc cgccgccagc gctttgtaga tggtgcactc cgtttagatc
     1801 agctgaagct tgctttcact ctggaccatg agactggatt gcctcaagga tgtcatatct
     1861 atgagtaccg agacagcaac aagcttgtag aggagttcat gctcctggcc aacatggcag
     1921 tggcccacaa gatcttccgc accttccctg agcaggccct gctgcgccgg catcccccac
     1981 cgcagacgaa gatgctcagt gacctggtgg agttctgtga ccagatgggg ctgcccatgg
     2041 atgtcagctc tgcaggggcc ctaaataaaa gcctgaccaa cacatttgga gatgacaagt
     2101 actctctggc ccggaaagag gtgctcacca acatgtactc ccggcccatg cagatggcac
     2161 tgtacttctg ctctgggatg ctgcaggacc aggcgcagtt ccggcattat gctctcaacg
     2221 ttcccctcta cacacacttc acctctccca tccgccgctt tgctgacgtc atagtgcacc
     2281 gcctcctggc tgctgctctg ggctacagtg agcagccaga tgtggagcct gatgccctac
     2341 agaagcaagc cgaccactgc aatgaccgcc gcatggcctc taagcgtgtg caggagctca
     2401 gcattggcct cttcttctca attctagtaa aagagagcgg ccccctggag tctgaagcca
     2461 tggtgatggg tgtcctgaac caagctttcg atgtgctggt actgcgcttt ggggtacaaa
     2521 aacgcatcta ctgcaacgca ctggccttga ggtcctacca cttccagaag gtggggaaga
     2581 agccagagct cactcttgtt tgggagccag atgaccttga agaggagcca atacagcagg
     2641 tcatcaccat cttcagcctg gtggatgtgg tcctgcaggc agaggccaca gccctcaagt
     2701 acagtgctat cctgaagcga ccaggcccgg agcattccct gggtctggag aaggagtctg
     2761 atgaggagcc tgaggactga atgctagccc aagccaggct tgtgcctgcc ctaccctgct
     2821 ggcttttagg aataggacct tctgacacca aaggggattt ttaatttggt ttttaacaac
     2881 tcaggggttt gtttttattt ttttttcatt ttattttact tttgctcaat ttttaaatga
     2941 actggaaggt taggggtcag ggcagggaat gctgaggctt ggccagtgct tccctgagaa
     3001 gagagaatcc cagtcctcct gggcaggcag ccccgcttct accaggcgac ccactgccct
     3061 tccctgccca ggaaacaggg ggtttcagca aatcagtgtc atggaataaa atcaagtgtg
     3121 aattgc
//
