LOCUS       NM_001008380            3314 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DIS3-like exosome 3'-5' exoribonuclease (Dis3l),
            mRNA.
ACCESSION   NM_001008380 XM_343408
VERSION     NM_001008380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Slomovic,S., Fremder,E., Staals,R.H., Pruijn,G.J. and Schuster,G.
  TITLE     Addition of poly(A) and poly(A)-rich tails during RNA degradation
            in the cytoplasm of human cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7407-7412 (2010)
   PUBMED   20368444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001008380.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085932.1, SRR26360190.1444219.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000008.1  73735274-73735527   c
            255-408             JAXUCZ010000008.1  73733706-73733859   c
            409-537             JAXUCZ010000008.1  73723039-73723167   c
            538-673             JAXUCZ010000008.1  73721767-73721902   c
            674-850             JAXUCZ010000008.1  73718382-73718558   c
            851-929             JAXUCZ010000008.1  73717535-73717613   c
            930-1109            JAXUCZ010000008.1  73714606-73714785   c
            1110-1279           JAXUCZ010000008.1  73713146-73713315   c
            1280-1441           JAXUCZ010000008.1  73711770-73711931   c
            1442-1689           JAXUCZ010000008.1  73708717-73708964   c
            1690-1782           JAXUCZ010000008.1  73708117-73708209   c
            1783-2316           JAXUCZ010000008.1  73704875-73705408   c
            2317-2471           JAXUCZ010000008.1  73702731-73702885   c
            2472-2650           JAXUCZ010000008.1  73702461-73702639   c
            2651-2796           JAXUCZ010000008.1  73700482-73700627   c
            2797-2971           JAXUCZ010000008.1  73699610-73699784   c
            2972-3314           JAXUCZ010000008.1  73699185-73699527   c
FEATURES             Location/Qualifiers
     source          1..3314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3314
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /note="DIS3-like exosome 3'-5' exoribonuclease"
                     /db_xref="GeneID:363077"
                     /db_xref="RGD:1308959"
     exon            1..254
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3280
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /EC_number="3.1.13.1"
                     /note="DIS3 mitotic control homolog-like"
                     /codon_start=1
                     /product="DIS3-like exonuclease 1"
                     /protein_id="NP_001008381.2"
                     /db_xref="GeneID:363077"
                     /db_xref="RGD:1308959"
                     /translation="MLQKREKVLLLRTFQGRTLRIVREHYLRPSVPCNSPLCPQPATC
                     RNDGKLLSAEVTHYVIPDWKVVQDYLEVLEFPELKGIIFMQTACQAVQHQRGRRQYNK
                     LRNLLKDARHDCVLFANEFQQHCYLPREKGEAMEKWQTRSIYNSAVWYYHHCEDRMPI
                     VMVTEDEEAIQQYGSETEGVFVISFKNYLDNFWPDLKAAHELCDSIIQSRRERESESQ
                     ETHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSGLVSD
                     ILIHGSKARNRSIHGDVVVVELLPKSEWKGRTAALCENDSEDKASGESPSEPMPTGRV
                     VGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAEALQDFRV
                     VVRIDSWETTSVYPNGHFVRVLGRIGDLEGEIATILVENSINVVPFSEAQMCEMPVNT
                     AENPWKVSPKEEQERRDLRSTHLVFSIDPKGCEDVDDALSVRTLNNGNLELGVHIADV
                     THFVAPNSYIDVEARTRATTYYLADRRYDMLPSILSADLCSLLGGVDRYAVSVMWELD
                     KTSYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNFSIVDDIPEFKTLEEQNRQAKLEE
                     LVWAIGKLTDIARHIRAKRDRCGALELEGVEVRVQLDDKKNIHDLIPKQPLEVHETVA
                     ECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLA
                     DSLDSANDPSDPLVNKLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSP
                     IRRYSDIVVHRLLMAAISKDKKVEIKENLFSNKNLEELCRHINNRNRAAQRSQKQSTE
                     LFQCMYFKDRDPETEERCVVDGIIYSIRTNGVLVFIPRFGIKGAAYLKNKDGLVISCG
                     PEGSSEWKPGSLQRSQNKIISTTAGGQSVTFHLFDHVTVRISVQPSRCHSDMIRLEIV
                     SNKPYMMPNTELCHQSSLLLKSELVKEVTRSVEEAQLAQEVKGKVIEEEHQEYRQTKG
                     RSLYTLLEEIRDLALLDVSDSYAM"
     exon            255..408
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            409..537
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            538..673
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            674..850
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            851..929
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1109
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1279
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1441
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1689
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1782
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2316
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2471
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2650
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2796
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2971
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3314
                     /gene="Dis3l"
                     /gene_synonym="RGD1308959"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacccaaaag ccgccgcctg cccggccagg ccggaggggc gggccccagg cctcggcctc
       61 gcctccacct gccgcccgcc gcttcccggc cactgtgccg ggcgacgccg ccagcatgct
      121 gcagaagcgg gagaaggtgc tgctgctgag gaccttccag ggccggacgc tgaggatcgt
      181 gcgcgaacac tatctgcggc ccagcgtacc ttgcaacagc cccctgtgcc cgcaacctgc
      241 cacctgccgc aacgatggga agctcttgtc tgctgaagtg actcattatg tgatcccaga
      301 ctggaaagtt gtccaggatt accttgaggt cctggagttc cctgagttga agggaattat
      361 tttcatgcaa acggcttgtc aagctgtgca gcatcagaga ggccggagac agtataacaa
      421 actgcgaaac ctcctgaagg atgctcgcca tgactgcgtt ctctttgcta acgagttcca
      481 gcagcactgt tacctccccc gggaaaaggg ggaagccatg gagaagtggc agaccaggag
      541 catatacaac tcagctgtgt ggtactacca ccactgcgag gacaggatgc ccatcgttat
      601 ggtgacagaa gacgaagagg ccattcagca gtatggaagc gaaacagaag gcgtatttgt
      661 aatttctttc aagaattacc tggacaactt ctggccagat ttaaaggctg cccatgagct
      721 gtgtgattcc atcattcagt ctcgccggga aagggagagc gagagtcagg aaacccatgg
      781 gaaagagtac ccggagcacc ttcccctgga agtgctggaa gcaggcatca aatctggacg
      841 ctacatccag ggaattctga acgtcaacaa gcacagagct caaatagagg cttttgtccg
      901 cctacaagga gccagcagca aggactcagg cttggtcagc gacatcctta tccatggctc
      961 aaaggctcgg aaccgctcca tccacggaga tgtggtggtg gtggagctgc tccccaaaag
     1021 tgagtggaaa ggaagaactg ctgccctgtg tgagaatgac agtgaagaca aggcctcggg
     1081 cgagtctccg agtgagccca tgcccacagg tcgagtggta ggcatccttc aaaagaactg
     1141 gcgagattat gtggtgacat ttccatccaa agaagaggtc cagtctcagg gcaaaaatgc
     1201 tcagaagatc ctagttacgc cgtgggatta cagaatcccc aaaatccgca tcagcaccca
     1261 gcaagcagag gccctccagg atttcagggt ggttgtgcgc attgattcct gggagacaac
     1321 atcggtgtat ccaaatggac actttgtgcg cgtcttaggg agaatcggtg atctggaagg
     1381 ggagattgcg accatcctgg tagagaacag tattaacgtc gtccccttct cggaagccca
     1441 gatgtgtgag atgccagtga acacagcaga aaacccttgg aaagtgagtc ccaaagaaga
     1501 gcaggagcgg agggacctga ggagcaccca ccttgtgttc agcatcgacc ctaaaggttg
     1561 tgaggacgtg gatgacgcgc tctcagtcag aaccttgaat aacggcaacc tggagctcgg
     1621 ggtccacata gctgatgtca cccactttgt ggcccccaac tcttacatcg atgttgaagc
     1681 tagaacgagg gccaccactt actacctagc cgaccgccgc tacgacatgc tgccttccat
     1741 cctcagcgca gacctctgct ccctcctggg aggcgttgac cggtatgctg tgtcagtcat
     1801 gtgggaatta gataaaacct cttatgaaat taagaaggtg tggtacggca gaaccattat
     1861 ccgatcagct tacaaactgt tctatgaggc ggcccaggaa cttctggatg gaaacttcag
     1921 cattgttgat gatattccag aattcaaaac cttggaggag cagaaccgac aggccaaact
     1981 ggaggagtta gtatgggcaa ttgggaagtt gactgacata gctcgccaca tccgagcaaa
     2041 gcgagaccgc tgcggcgcct tggagctaga aggtgtggag gttcgagtcc agctggatga
     2101 caagaagaac attcatgacc tcatccccaa gcagcccctg gaggttcatg agacggtggc
     2161 tgaatgcatg atcctggcca accactgggt ggccaagaag atctgggaga gcttccccca
     2221 ccaggcgctg ctgcgccaac accctcctcc acaccaggag tttttctcag agctccggga
     2281 atgtgcaaaa gcaaaaggct tcttcataga cacacggtcc aataaaaccc tggctgactc
     2341 tctggatagt gcaaatgacc ccagtgaccc cctggtaaac aagttgctgc gctccatggc
     2401 cacccaggcc atgtcaaacg cactctactt ctctacggga tcctgtgcag aggaggagtt
     2461 ccatcattat ggtcttgcat tggataaata tacccacttt acttctccaa taagaagata
     2521 ttcagatatt gtagtacatc gattattaat ggcagccatt tcaaaagaca agaaagtgga
     2581 aattaaagaa aatttgttca gcaacaaaaa tcttgaggaa ttatgcagac acatcaacaa
     2641 cagaaaccgg gcggcacagc gttctcagaa gcagtccacc gagctcttcc agtgcatgta
     2701 ctttaaagac agagacccgg agactgagga gcgctgcgta gtggatggaa ttatttattc
     2761 cattagaaca aatggtgtac ttgtatttat accgaggttt gggattaaag gtgctgctta
     2821 tctgaagaat aaagatggct tagtgatctc ctgtggccca gagggcagct ctgaatggaa
     2881 gccaggatcc ctacaaagat ctcaaaacaa gatcatctct accacagctg gagggcagtc
     2941 agttacattt catctgtttg accatgtgac ggtaaggatt tctgtccagc cctcacgttg
     3001 ccactctgat atgatcaggc ttgaaatagt aagcaacaaa ccatacatga tgccaaacac
     3061 ggaactctgt catcagagct ccctcctgct gaagagtgag ctggtgaagg aagtaacccg
     3121 atctgtggag gaagcgcagc ttgcacagga agtcaaaggc aaggtgattg aggaagagca
     3181 tcaagaatac cgccagacaa agggaagaag tctgtacacg cttctggagg agataaggga
     3241 cctagctctt ctggatgttt ccgacagtta tgcaatgtga gatactttgg tgccattaaa
     3301 gagctttgtc ttaa
//
