LOCUS       NM_001127483            3115 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DIS3 homolog, exosome endoribonuclease and 3'-5'
            exoribonuclease (Dis3), mRNA.
ACCESSION   NM_001127483 XM_001073902 XM_224449
VERSION     NM_001127483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Henras AK, Plisson-Chastang C, O'Donohue MF, Chakraborty A and
            Gleizes PE.
  TITLE     An overview of pre-ribosomal RNA processing in eukaryotes
  JOURNAL   Wiley Interdiscip Rev RNA 6 (2), 225-242 (2015)
   PUBMED   25346433
  REMARK    Review article
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck
            AJ, Raijmakers R and Pruijn GJ.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen
            KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP,
            Dziembowski A and Jensen TH.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Slomovic S, Fremder E, Staals RH, Pruijn GJ and Schuster G.
  TITLE     Addition of poly(A) and poly(A)-rich tails during RNA degradation
            in the cytoplasm of human cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7407-7412 (2010)
   PUBMED   20368444
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Preker P, Nielsen J, Kammler S, Lykke-Andersen S, Christensen MS,
            Mapendano CK, Schierup MH and Jensen TH.
  TITLE     RNA exosome depletion reveals transcription upstream of active
            human promoters
  JOURNAL   Science 322 (5909), 1851-1854 (2008)
   PUBMED   19056938
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E and
            Nishimoto T.
  TITLE     Human dis3p, which binds to either GTP- or GDP-Ran, complements
            Saccharomyces cerevisiae dis3
  JOURNAL   J Biochem 123 (5), 883-890 (1998)
   PUBMED   9562621
  REMARK    Erratum:[J Biochem (Tokyo) 1998 Jul;124(1):250]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166824.1.
            
            On or before May 22, 2008 this sequence version replaced
            XM_001073902.1, XM_224449.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166824.1, FQ210067.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..3115
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /note="DIS3 homolog, exosome endoribonuclease and 3'-5'
                     exoribonuclease"
                     /db_xref="GeneID:306103"
                     /db_xref="RGD:1304646"
     exon            1..314
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2960
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /note="DIS3 mitotic control homolog; DIS3 exosome
                     endoribonuclease and 3'-5' exoribonuclease"
                     /codon_start=1
                     /product="exosome complex exonuclease RRP44"
                     /protein_id="NP_001120955.1"
                     /db_xref="GeneID:306103"
                     /db_xref="RGD:1304646"
                     /translation="MLKSKTFLKKTRAGGVVKIVREHYLRDDIGCGTPACSACGAAHA
                     GPALELQPRDQASSLCPWPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRS
                     APIYKRIRDVTNNQEKHFYTFTNEHHKETYIEQEQGENANDRNDRAIRVAAKWYNEHL
                     KMSAENQLQVILITNDKKNKEKAAEEGIPAFTCEEYVKSLTANPELIDRLACLSDEMN
                     EIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEDEKEILI
                     QGLKHLNRAIHEDIVAVELLPKSQWVAPSSVVLHDEGQNEDDVEKDEERELLLKTAVS
                     EKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASAL
                     EGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSF
                     LPKMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADV
                     SHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMN
                     HNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNKLAKILKRGRI
                     EKGALTLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFS
                     EHALLRKHPAPPPSNYEVLVKAAKSKNLEIRTDTAKSLADSLDRAECPDFPYLNTLLR
                     ILATRCMMQAVYFCSGMDSDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADC
                     TYPELTDKHKLSDICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRK
                     NAIVVLIPKYGLEGTVFFEEKDKPKPRLTYDDEIPSLRIEGTVFHVFDKVKVKITLDS
                     SNLQHQKIRMALVEPQIPGINMPPDVSDMDLNGPGGKKRKLEK"
     exon            315..472
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            473..663
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            664..737
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            738..905
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1070
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1184
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1322
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1469
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1586
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1688
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1753
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1838
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1966
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2053
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2210
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2425
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2594
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2753
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2876
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3091
                     /gene="Dis3"
                     /gene_synonym="RGD1304646"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgcttctt atctgacgct ttttccgtca gagttttgga gcggtcggga ttccgctctt
       61 gtcggggttc cacgccgcga gacgagatgc tcaagtccaa aacattctta aagaagaccc
      121 gcgcgggcgg cgtggtgaag atcgtgcgcg agcactacct gcgggatgac atcggctgcg
      181 gcacgccggc ttgctcggcc tgtggcgcgg cgcacgcggg cccggccctg gagctgcagc
      241 cccgggacca ggcgagcagc ctctgcccat ggccgcacta cctcctgccg gacaccaatg
      301 tgctgctgca ccagattgat gttcttgagg accctgctat caggaacgta attgtgcttc
      361 agacagtcct gcaggaagtg agaaaccgga gtgcccccat atataagcga atcagggatg
      421 tgacgaataa ccaggagaag catttctata cgttcactaa cgagcaccat aaagaaacct
      481 acatagagca agaacagggg gagaatgcca atgacagaaa tgacagagcc attcgagtag
      541 cagcaaagtg gtacaatgaa catctaaaga tgtcagcaga aaatcagcta caagttatcc
      601 ttataacaaa cgacaagaag aacaaagaaa aggctgcaga agaaggaata ccagctttca
      661 catgtgaaga atatgtaaag agcctgactg ctaaccctga acttatagat cgtcttgctt
      721 gtttgtctga tgagatgaat gaaatagaaa gtgggaaaat aatattttca gagcatcttc
      781 ctttaagcaa gctccaacaa ggcataaaat ctggttcata ccttcaagga acattcagag
      841 ctagcaggga aaattactta gaagctacag tgtggattca tggagacaaa gaagatgaaa
      901 aagagatact tatacaagga cttaaacatc taaacagagc tattcatgaa gatattgtgg
      961 ctgtggaact attgcccaag agtcagtggg tggcaccatc ttctgtggtt ttacatgatg
     1021 aaggtcaaaa tgaagatgat gtggagaaag atgaggagag agaactcctg cttaagactg
     1081 ctgtaagtga aaaaatgttg aggcctacag gtagagttgt ggggataata aagaggaatt
     1141 ggagaccgta ctgtggcatg ctttccaagt ctgatattaa ggagtcaaga agacatctct
     1201 ttacacctgc tgataagaga attccacgaa ttcggataga aaccagacag gcttctgcat
     1261 tagaaggacg gagaattatt gtcgctattg atggttggcc cagaaattct agatatccaa
     1321 atggacactt tgtaaaaaat ttaggtgatg ttggagagaa agagacggaa acggaagttt
     1381 tgctgcttga gcatgacgtt cctcatcagc ccttttccca ggctgttctt agcttcctgc
     1441 cgaagatgcc ctggagcatt actgaggagg acatgaaaaa ccgagaagat ctgagacatc
     1501 tgtgtgtttg cagtgtggat cctccaggat gtactgacat agatgatgcc ctgcactgca
     1561 gagaactcag caatggaaac ttggaggttg gtgttcatat tgcggatgtt agccatttta
     1621 tcaggccagg aaatgcattg gatcaagaat cagcaagaag aggaacaact gtttatcttt
     1681 gtgaaaagag gattgacatg gtcccagagc tgctcagctc caacctctgt tccttaagat
     1741 ccaacgtgga caggttggca ttttcctgta tttgggaaat gaatcataat gctgaaatat
     1801 taaaaacgag atttaccaaa agtgtcatta attcaaaggc ttctcttaca tatgctgaag
     1861 cacagatgag aattgattca gccgctatga atgatgacat taccactagt ctccgtggac
     1921 tgaataaact agctaaaatt ctaaaaaggg gaaggattga aaagggggct ttgacactct
     1981 cttctccaga aattcgattt cacatggaca gtgaaactca cgacccaatt gacctgcaga
     2041 ccaaggagct gagagaaaca aattccatgg tggaagaatt tatgttactc gctaatattt
     2101 ctgttgcaaa aaaaattcat gaagagtttt ctgaacatgc tttgcttcga aaacatccag
     2161 ccccacctcc ctccaattat gaagttcttg ttaaggccgc taagtccaag aatttggaaa
     2221 ttcggactga tacagccaaa tctttggctg actctttgga ccgggctgaa tgtcctgatt
     2281 tcccatacct gaatactctg ttaaggatat tggccactcg ctgtatgatg caagctgtct
     2341 acttctgttc tgggatggat agtgactttc atcactatgg cttagcctcc ccaatataca
     2401 cacatttcac ttctcctatc agaagatatg cagacataat tgttcatcgg ctattagctg
     2461 tggcgattgg ggctgattgt acttatccag agttgacgga caaacacaag ctttcagata
     2521 tatgtaaaaa cctcaatttc cggcataaaa tggctcagta tgcccagcgt gcgtcagtag
     2581 cttttcatac acagttgttt ttcaaaagca aaggaatagt aagcgaagaa gcctatattc
     2641 tctttgtaag aaaaaatgca attgtagtgt taattccaaa gtatggctta gaaggtacag
     2701 ttttttttga agaaaaagat aaaccaaagc cacgccttac ttatgatgat gagatacctt
     2761 cactcagaat agaaggtaca gtgttccatg tgtttgataa agttaaagtg aaaatcacat
     2821 tagattcatc aaatcttcaa caccagaaaa tccgcatggc ccttgtagaa ccacagatac
     2881 caggaataaa tatgcctcct gatgtttcag acatggatct taatggacca gggggaaaga
     2941 agaggaaact tgaaaagtag ctacataaag cagaaaactc aaagactggc tactttgaca
     3001 acagcaacaa aattgaaagc atacttacaa gctctgtgtg atagctactt ttaaatacat
     3061 ttcaataatt ttaagaaatt tgcatttttg aaaaaaaaaa aaaaaaaaaa aaaaa
//
