LOCUS       NP_001178493            1561 aa            linear   ROD 30-MAR-2024
DEFINITION  disco-interacting protein 2 homolog A [Rattus norvegicus].
ACCESSION   NP_001178493 XP_002728980 XP_038955006
VERSION     NP_001178493.2
DBSOURCE    REFSEQ: accession NM_001191564.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1561)
  AUTHORS   Tanaka,M., Murakami,K., Ozaki,S., Imura,Y., Tong,X.P., Watanabe,T.,
            Sawaki,T., Kawanami,T., Kawabata,D., Fujii,T., Usui,T., Masaki,Y.,
            Fukushima,T., Jin,Z.X., Umehara,H. and Mimori,T.
  TITLE     DIP2 disco-interacting protein 2 homolog A (Drosophila) is a
            candidate receptor for follistatin-related protein/follistatin-like
            1--analysis of their binding with TGF-beta superfamily proteins
  JOURNAL   FEBS J 277 (20), 4278-4289 (2010)
   PUBMED   20860622
REFERENCE   2  (residues 1 to 1561)
  AUTHORS   Ouchi,N., Asaumi,Y., Ohashi,K., Higuchi,A., Sono-Romanelli,S.,
            Oshima,Y. and Walsh,K.
  TITLE     DIP2A functions as a FSTL1 receptor
  JOURNAL   J Biol Chem 285 (10), 7127-7134 (2010)
   PUBMED   20054002
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000020.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XP_038955006.1, NP_001178493.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.52960.1,
                                           SRR26643429.57464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..1561
                     /product="disco-interacting protein 2 homolog A"
                     /EC_number="6.2.1.1"
                     /note="DIP2 disco-interacting protein 2 homolog A"
                     /calculated_mol_wt=169237
     Region          10..121
                     /region_name="DMAP_binding"
                     /note="DMAP1-binding Domain; pfam06464"
                     /db_xref="CDD:368923"
     Region          341..917
                     /region_name="Dip2"
                     /note="Disco-interacting protein 2 (Dip2); cd05905"
                     /db_xref="CDD:341231"
     Site            order(502,505..510,512..513)
                     /site_type="other"
                     /note="putative acyl-activating enzyme (AAE) consensus
                     motif"
                     /db_xref="CDD:341231"
     Site            order(505,625..626,684..689,782,794,797,808,897)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341231"
     Site            order(505,546..547,597,599..600,603,625..626,644..649,782,
                     794,797,805..808,878)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341231"
     Site            order(546,599..600,603,625,805..807,865,878)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341231"
     Region          993..1557
                     /region_name="Dip2"
                     /note="Disco-interacting protein 2 (Dip2); cd05905"
                     /db_xref="CDD:341231"
     Site            order(1142,1145..1150,1152..1153)
                     /site_type="other"
                     /note="putative acyl-activating enzyme (AAE) consensus
                     motif"
                     /db_xref="CDD:341231"
     Site            order(1145,1271..1272,1326..1331,1422,1444,1447,1458,1537)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341231"
     Site            order(1145,1186..1187,1237,1239..1240,1243,1271..1272,
                     1289..1294,1422,1444,1447,1455..1458,1518)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341231"
     Site            order(1186,1239..1240,1243,1271,1455..1457,1505,1518)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341231"
     CDS             1..1561
                     /gene="Dip2a"
                     /coded_by="NM_001191564.3:136..4821"
                     /db_xref="GeneID:690211"
                     /db_xref="RGD:1582897"
ORIGIN      
        1 madrgcplea aplpaevles laelelelse gditqkgyek krakllaryi pliqgvdpcl
       61 qtesrvpgpl ltaptakpqk pransrderf rsdvhteavq aalakykerk mpmpskrrsa
      121 lvhssvetyt ppdtssased egslrrpgrl tstllqshsg iepwldrviq gsstsssass
      181 tsshpggrpa aapsastala gltahahidp hsappdvttg lvehshferp qmasvrgvpr
      241 ghgrnmleta dgvpvnsrvs skiqqllntl krpkrpplke ffvddfeell evqqpdpnqp
      301 kpegeqmavl kgeplsvgts gpptllaalq lwgttqpkap cltaldtsgk aictltygkl
      361 wsrslklayt llskltskne pllnpgdrva lvfpnsdpvm fmvafygcll aelvpvpiev
      421 pltrkdagsq hvgfllgscg vtlalttdac qkglpkaptg evatfkgwpp lawlvidgkh
      481 ltkppkdwyp laqdtgsrta yieyktskdg stvgvtvphs sllaqcqalt qvcgyteaet
      541 ltnvldfkrd aglwhgvlts vmnrmhvisi pyalmkvnpl swiqkvcsyk araalvksrd
      601 mhwsllaqrg qrdvclsslr mlivadganp wsisscdafl nvfqsrglrp evicpcassp
      661 ealtvairrp pdlggppprk avlsmnglsy gvirvdteek lsvltvqdvg qvmpgasvcv
      721 vkvdgvpylc ktdeigeicv ssvatgtayy gllgitknvf etvpvtadgv pvsdrpftrt
      781 gllgfigpen lvfvvgkldg ltvvgarrhn addivatala vepmkfvyrg riavfsvtvl
      841 hddrivlvae qrpdsseeds fqwmsrvlqa idsihqvgvy clalvpantl pkaplggihi
      901 setkqrfleg tlhpcnvlmc phtcvtnlpk prqkqpevgp asmivgnlva gkriaqasgr
      961 elahledsdq arkflfladv lqwrahttpd hplflllnak gtvtstatci qlhkraerva
     1021 aalmekgrld agdhvalvyp pgvdliaafy gclycgcvpv tvrpphpqnl gttlptvkmi
     1081 vevsksacvl stqaitrllk skeaaaavdv rtwptildtd dipkkkvasi frppspdvla
     1141 yldfsvsttg ilagvkmsha atsalcrsik lqcelypsrq iaicldpycg lgfalwclcs
     1201 vysghqsvlv pplelesnvs lwlsavsqyk arvtfcsysv memctkglga qtgalrmkgv
     1261 nlscvrtcmv vaeerprisl tqsfsklfkd lglparavst tfgcrvnvai clqgttgpdp
     1321 ttvyvdmral rhdrvrlver gsphslplme sgkilpgvkv iiahtetkgp lgdshlgeiw
     1381 vssphnatgy ytvygeealh adhfsarlsf gdtqtiwart gylgflrrte ltdasgerhd
     1441 alyvvgslde tlelrgmryh pidietsvir ahrsiaecav ftwtnllvvv veldgleqda
     1501 ldlvalvtnv vleehylvvg vvvivdpgvi pinsrgekqr mhlrdgflad qldpiyvayn
     1561 m
//
