LOCUS       NM_021653               2095 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus iodothyronine deiodinase 1 (Dio1), transcript
            variant 1, mRNA.
ACCESSION   NM_021653
VERSION     NM_021653.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Liu,Y., Xu,Z., Li,Y., Jiang,W., Lan,M., Xie,X. and Wang,Y.
  TITLE     Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic
            Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats
  JOURNAL   Biomed Res Int 2021, 6681491 (2021)
   PUBMED   34195279
  REMARK    GeneRIF: Effect of Preeclampsia on Ultrastructure of Thyroid Gland,
            Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels
            in Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Di Munno,C., Busiello,R.A., Calonne,J., Salzano,A.M.,
            Miles-Chan,J., Scaloni,A., Ceccarelli,M., de Lange,P., Lombardi,A.,
            Senese,R., Cioffi,F., Visser,T.J., Peeters,R.P., Dulloo,A.G. and
            Silvestri,E.
  TITLE     Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With
            Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine
            Deiodinase Activities: A Functional and Proteomic Study
  JOURNAL   Front Endocrinol (Lausanne) 12, 631176 (2021)
   PUBMED   33746903
  REMARK    GeneRIF: Adaptive Thermogenesis Driving Catch-Up Fat Is Associated
            With Increased Muscle Type 3 and Decreased Hepatic Type 1
            Iodothyronine Deiodinase Activities: A Functional and Proteomic
            Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Ridruejo,E., Romero Caimi,G., Miret,N., Obregon,M.J., Randi,A.,
            Deza,Z., Kleiman de Pisarev,D. and Alvarez,L.
  TITLE     TGF-beta1 mediates cell proliferation and development of
            hepatocarcinogenesis by downregulating deiodinase 1 expression
  JOURNAL   Medicina (B Aires) 81 (3), 346-358 (2021)
   PUBMED   34137693
  REMARK    GeneRIF: TGF-beta1 mediates cell proliferation and development of
            hepatocarcinogenesis by downregulating deiodinase 1 expression.',
            trans 'La desregulacion de la deiodinasa 1, mediada por TGF-beta1,
            impulsa la proliferacion celular y el desarrollo de
            hepatocarcinogenesis.
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Ignacio,D.L., da S Silvestre,D.H., Cavalcanti-de-Albuquerque,J.P.,
            Louzada,R.A., Carvalho,D.P. and Werneck-de-Castro,J.P.
  TITLE     Thyroid hormone and estrogen regulate exercise-induced growth
            hormone release
  JOURNAL   PLoS One 10 (4), e0122556 (2015)
   PUBMED   25874614
  REMARK    GeneRIF: estrogen deficiency impairs the induction of thyroid
            hormone activating enzyme D1 in the pituitary, and GH release by
            acute exercise. Also, acute D1 activation is essential for
            exercise-induced GH response
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Arroyo-Helguera,O., Mejia-Viggiano,C., Varela-Echavarria,A.,
            Cajero-Juarez,M. and Aceves,C.
  TITLE     Regulatory role of the 3' untranslated region (3'UTR) of rat 5'
            deiodinase (D1). effects on messenger RNA translation and stability
  JOURNAL   Endocrine 27 (3), 219-225 (2005)
   PUBMED   16230777
  REMARK    GeneRIF: D1 3'UTR may play an important role in regulating the
            stability and translational efficiency of the D1 mRNA
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Macejova,D., Liska,J. and Brtko,J.
  TITLE     Mammary gland carcinoma-related increase of type I iodothyronine
            5'-deiodinase activity in Sprague-Dawley rats
  JOURNAL   Gen Physiol Biophys 20 (3), 293-302 (2001)
   PUBMED   11765219
  REMARK    GeneRIF: Mammary gland carcinoma-related increase of type I
            iodothyronine 5'-deiodinase activity in Sprague-Dawley rats.
REFERENCE   8  (bases 1 to 2095)
  AUTHORS   Schoenmakers,C.H., Pigmans,I.G., Poland,A. and Visser,T.J.
  TITLE     Impairment of the selenoenzyme type I iodothyronine deiodinase in
            C3H/He mice
  JOURNAL   Endocrinology 132 (1), 357-361 (1993)
   PUBMED   8419134
REFERENCE   9  (bases 1 to 2095)
  AUTHORS   Berry,M.J.
  TITLE     Identification of essential histidine residues in rat type I
            iodothyronine deiodinase
  JOURNAL   J Biol Chem 267 (25), 18055-18059 (1992)
   PUBMED   1517238
REFERENCE   10 (bases 1 to 2095)
  AUTHORS   Berry,M.J., Banu,L. and Larsen,P.R.
  TITLE     Type I iodothyronine deiodinase is a selenocysteine-containing
            enzyme
  JOURNAL   Nature 349 (6308), 438-440 (1991)
   PUBMED   1825132
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000005.1 and
            BC083557.1.
            
            On Apr 27, 2016 this sequence version replaced NM_021653.3.
            
            Summary: The protein encoded by this gene belongs to the
            iodothyronine deiodinase family. It catalyzes the activation, as
            well as the inactivation of thyroid hormone by outer and inner ring
            deiodination, respectively. The activation reaction involves the
            conversion of the prohormone thyroxine
            (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland,
            to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by
            5'-deiodination. This protein is expressed predominantly in the
            liver and kidney and provides most of the circulating T3, which is
            essential for growth, differentiation and basal metabolism in
            vertebrates. This protein is a selenoprotein, containing the rare
            amino acid selenocysteine (Sec) at its active site. Sec is encoded
            by the UGA codon, which normally signals translation termination.
            The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop
            structure, designated the Sec insertion sequence (SECIS) element,
            that is necessary for the recognition of UGA as a Sec codon, rather
            than as a stop signal. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57999.1, FQ219288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 1825132
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                JAXUCZ010000005.1  127319768-127319784 c
            18-1646             BC083557.1         1-1629
            1647-2095           JAXUCZ010000005.1  127303089-127303537 c
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2095
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /note="iodothyronine deiodinase 1"
                     /db_xref="GeneID:25430"
                     /db_xref="RGD:2504"
     exon            1..356
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..793
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /EC_number="1.21.99.4"
                     /note="UGA stop codon recoded as selenocysteine; isoform 1
                     is encoded by transcript variant 1; thyroxine deiodinase,
                     type I; type 1 DI; type-I 5'-deiodinase; DIOI; deiodinase,
                     iodothyronine, type I"
                     /codon_start=1
                     /transl_except=(pos:395..397,aa:Sec)
                     /product="type I iodothyronine deiodinase isoform 1"
                     /protein_id="NP_067685.5"
                     /db_xref="GeneID:25430"
                     /db_xref="RGD:2504"
                     /translation="MGLSQLWLWLKRLVIFLQVALEVATGKVLMTLFPERVKQNILAM
                     GQKTGMTRNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSG
                     QKCNVWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHAT
                     DGWAFKNNVDIRQHRSLQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYV
                     IQEGRICYKGKPGPWNYNPEEVRAVLEKLCIPPGHMPQF"
     exon            357..500
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..700
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..2095
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1535..1603
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Dio1"
                     /gene_synonym="5DI; ITDI1; TXDI1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
ORIGIN      
        1 agttctgccc cgtgctgaga tggggctgtc ccagctatgg ctgtggctga agcggcttgt
       61 gatattcctg caggtagcct tggaggtggc tacgggcaag gtgctaatga cactgttccc
      121 agagagagtc aagcagaaca tcctggccat gggccaaaag accggaatga ccaggaatcc
      181 ccgattcgcc cctgacaact gggtccccac cttcttcagc atccagtact tctggttcgt
      241 cctgaaggtc cgctggcaga gactggaaga cagggctgag tatggggggc tggcccccaa
      301 ctgcaccgtg gtccgcctct caggacagaa gtgcaacgtc tgggatttca ttcaaggcag
      361 cagacccctg gtgttgaact tcggcagctg cacctgacct tcatttcttc tcaaatttga
      421 ccagttcaag agactcgtag acgactttgc ctccacagct gacttcctca tcatttacat
      481 tgaagaagct cacgccacag atggatgggc ttttaagaac aacgtggaca tcaggcagca
      541 ccgaagcctc caggaccgcc tgcgggcagc acatctgctg ctggccagga gcccccagtg
      601 tcctgtggtg gtggacacaa tgcagaacca gagcagccag ctctatgcag ctctgcctga
      661 gaggctctat gtgatacagg aaggcaggat ctgctacaag ggtaaacctg gcccttggaa
      721 ctacaatcct gaggaagtcc gagctgttct ggaaaagctt tgcatcccac ctggacacat
      781 gcctcagttc tagggggcca gcaggaaggt cccccaagct tggtactcct ccccaccagt
      841 acagatgtcc tttagctttg accttcgttc ccagatcaat tactagctca gatttttctg
      901 atctgaacaa ataactaccc gggaggcaat tcagttcaca gcacccaacc agcacaaatt
      961 gttacaacca gagataaagc aataccgagc tgttagcaaa agtaagtgtg cagctttgca
     1021 ccactcccac agcggagacc aatccagtgt gtgccccttc tggtggaagg gtactcatgc
     1081 ttggttggct gacttctgaa gtgtagtgac tcatgatgat gacgtcaaaa gctcaatcca
     1141 tttgcccaag tttgccactc atagaatcag ttgtttagta ccaagcgaca ggcaggcgta
     1201 tttctacttg taggaaccaa agacattgga aacacttttc tggccctaag attgaaatcc
     1261 gttaatattg ttggtgatag gtgtttccat ggcaacctat aatctaattc tgctccctct
     1321 gccatctttg aatagattgc agagaaatct ggctctctgg tactgacaca aaagctttat
     1381 aactttaact aaaccaaatc acaggcgcca gcaaaagctg ccattcccct gctgtaactc
     1441 tgttccactg gcgcccagtc tcttactggt ctttcatgtt agatggcttt ggactgacgg
     1501 gtagccatgg gttcatctgt catgtctgct tctttttata tttgtttatg atggtcacag
     1561 tgtaaagttc acacagctgt gacttgattt ttaaaaatgt cggaagatgc agcaagctaa
     1621 cgattaaaat ccatcaggct aattttgaat ggctccggtg tgatccttac aatttccttt
     1681 ctgacttgtg tatgtgggcc tgctctgccg tcttttccga tagcccacgt gtaatgtaat
     1741 cagctaaggc atcgtttgct ggagggaccc cgtcctggag gaagaagctc gtatgtggca
     1801 cgcatccaac atgttgtcct gtgaagtgtt gtggaaggga cgtggctgtt cacgtcacag
     1861 caaagcacct ttaggggtga tgtgtgaatg gacctgggga gcattctcca gcatccaaac
     1921 agttcctcct tggctctgcc ttaggggcta cacccaatac tgtaacattg catttatgta
     1981 tggatttagg tgagtcagga tctagctata aagtcgagag tggctgtgaa cttacaatct
     2041 tcagactcag agtagctggg attccaggtc tgtcccccta tataaaaaat gtttt
//
