LOCUS       NM_001106408            2889 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DIM1 rRNA methyltransferase and ribosome
            maturation factor (Dimt1), mRNA.
ACCESSION   NM_001106408 XM_001065350 XM_215477
VERSION     NM_001106408.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2889)
  AUTHORS   Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgue-Hamard V and
            Lafontaine DL.
  TITLE     The human 18S rRNA base methyltransferases DIMT1L and
            WBSCR22-TRMT112 but not rRNA modification are required for ribosome
            biogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2080-2095 (2015)
   PUBMED   25851604
REFERENCE   2  (bases 1 to 2889)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2889)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1 and BC158729.1.
            
            [WARNING] On Apr 4, 2024 this sequence was replaced by
            NM_001106408.4.
            
            On Mar 4, 2021 this sequence version replaced NM_001106408.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00132296
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JACYVU010000065.1  30848356-30848425
            71-817              BC158729.1         71-817
            818-2299            JACYVU010000065.1  30872031-30873512
            2300-2888           BC158729.1         819-1407
            2889-4370           JACYVU010000065.1  30872031-30873512
FEATURES             Location/Qualifiers
     source          1..2889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2889
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /note="DIM1 rRNA methyltransferase and ribosome maturation
                     factor"
                     /db_xref="GeneID:294718"
                     /db_xref="RGD:1311752"
     exon            1..198
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            199..311
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            312..406
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1269
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /EC_number="2.1.1.183"
                     /note="DIM1 dimethyladenosine transferase 1-like; DIMT1
                     rRNA methyltransferase and ribosome maturation factor;
                     DIM1 dimethyladenosine transferase 1 homolog"
                     /codon_start=1
                     /product="probable dimethyladenosine transferase"
                     /protein_id="NP_001099878.3"
                     /db_xref="GeneID:294718"
                     /db_xref="RGD:1311752"
                     /translation="MPKAKSAASSRRRDRQEQRGELKRAGGLMFNTGIGQHILKNPLI
                     VNSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTP
                     LASKLQVLVGDVLKSDLPFFDACVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFA
                     LRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPI
                     NFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVQNTVIPEDFSIADKI
                     QQILTNTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS"
     exon            407..480
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            481..567
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            568..629
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            630..723
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            724..773
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            774..897
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            898..990
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1055
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1119
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1226
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2889
                     /gene="Dimt1"
                     /gene_synonym="Dimt1l; RGD1311752"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccagc gctggcatag gggaacctgt aactatggaa accgtatgtc ctgggaaaat
       61 cgatagtcct gcgctgatcg aaacctgagt caaaatcatt tcatcttctc tattctatat
      121 cagctacttg gttcatgagt ctgtcacgac agaagagggt catcaaaaga accccattaa
      181 tgaaccctgc caccatagga cgatcctgtg acgtaggatc catcattctg tccattttac
      241 agaagaagaa acggaactca agagaactta acgtgtctaa agttcaacgg ctagtaaatg
      301 caagcgttga gggactcctc ggagaagatg ccgaaggcca agtccgcagc gagtagccgc
      361 cggcgggatc gtcaggagca gcggggggag ctgaagcgag ctggaggact catgttcaac
      421 acagggatcg gacagcacat tttgaaaaat cctctaattg ttaacagcat catcgataag
      481 gccgctttaa gacccactga tgtggtgctg gaagttgggc ctgggactgg caacatgacg
      541 gtcaagctgt tagaaaaagc caaaaaggta gttgcctgtg aacttgatcc aaggctagta
      601 gctgaacttc acaaaagagt tcagggcacg cctctggcca gcaaactcca ggtcctggtc
      661 ggagatgtgt tgaagtcgga tttgccattc tttgatgctt gtgtggcaaa cttgccttat
      721 cagatctcct ctccctttgt cttcaagttg ctgctccacc ggccattttt cagatgtgct
      781 atacttatgt ttcaaagaga gtttgctctt cgtttggttg caaagcctgg agataaatta
      841 tactgtagac tctccatcaa tacacagctt ttagcacgtg tggaccacct aatgaaggtg
      901 gggaagaata atttcagacc accccccaag gtggagtcca gcgtggtaag gatagaaccg
      961 aagaatccac caccaccaat caattttcag gaatgggatg gcttagtaag aatcactttt
     1021 gttcgaaaaa acaagacact gtctgctgca ttcaaatcaa gtgcggtcca acagctattg
     1081 gaaaaaaact acagaattca ctgttcagta cagaatactg taataccaga agatttcagt
     1141 atagccgata aaatacagca gatcctaacc aacacaggtt ttagtgacaa acgggcacgt
     1201 tccatggaca tagatgattt tatcaggttg ctacacggat ttaatgcaga aggtatccac
     1261 ttctcctagc catctgaaaa ctattttttc aagaccaaga aaaaaatgaa gttacacaat
     1321 cctaatattt gagaatacca ctgattttgt tctataggac atcatttact ttttaaatta
     1381 tttaataata acttttatac cattgattat cctgtatgtg aaaggtggtt gttttttttt
     1441 tataaatata tattttctct agtgttttaa atatactgca aagggcaggg ttcaatataa
     1501 tggtcttcaa gtttgaaagt cgcggacatg cacaaccata tacttaagct ttgtaacgat
     1561 ttattgtatg aagacattac ttttattcac catgttttag accgtgaggc tcactgaggc
     1621 ctacagctca ctcaactagt caaaaagctg tcgtcctcct cattcacata ctgtaaggag
     1681 cttaaggtgg cttctcttca caccattcct atgtgttaat gcttgcctgc tgcatcacga
     1741 acaacacaat tctgggagct agagtctgct gcactgacag ggcaggcatg ttctgcatat
     1801 gacaatacct gtgaaatgca gaagcggaga aaaaaccaac tcctgtgtgg taaatcacat
     1861 tttcttaagg gagacaggat ctacaatttc aaatttagag gaattctgga aggttttgtc
     1921 aatcaaacag cttgtataat aatttattta attcctttat cgaatgagag ctttttcttt
     1981 tttttttttt tttggagctg gggaccgaac ccagggcctt gcgcttgcca ggcaagcact
     2041 ctacctctga gctaaatccc caacctctaa gaggtctttt tgaggtcaac tctaatctca
     2101 gaatcttgcc tcagccccct aaataaattc tgggttgcac ttgtacattg caaagtaagt
     2161 tttccagttt cagcttttta aaagaacaga ctacaactac aggctcctgg ttccctgact
     2221 tctagataac taaagttcca ctacctagtg tttcttttta agctacttaa aattcgtcag
     2281 aagataaatg ctgttcatat attttaataa attagctgtt ttatttatat aaggaaacta
     2341 gcttcattgg atatttggct ctctttatac ctaaaactta aaaggaatat gtccaattag
     2401 tttagaaaga ttgctaagta aacttaagaa tacaaatagt ttgcctacag tttttcctcc
     2461 aaaattcagc ttcaaagtca tagtgaacac ttatgttagc tatgaatagt tagcagcctt
     2521 taagtttgag aagtttctaa agaataatgt acaacagaaa aatttcactt agctgcagaa
     2581 gcagcttttg tcacatgagt agtaactgtc cttgaagtgc atgtttatcg tcagcgtcga
     2641 acaacagctt tgcagagtta gctcttacca cttctacctt agggagacgt ttctgcttgg
     2701 ccaggctttc tcagctagtt ttctgctgac taaagcttcc ctctgtaaag ctgaggctca
     2761 tcttacctcc cagaatgttt actgactaca gatcaggacg gagccaataa ggcaacatat
     2821 ccctattagg accttcaaag acaatgcctg tccaatgcca ataacattaa actattttgc
     2881 aagttataa
//
