LOCUS       NM_001008292            1981 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus diablo, IAP-binding mitochondrial protein
            (Diablo), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001008292 XM_039089284 XM_213814
VERSION     NM_001008292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Xiang,R.P., Zhou,M.J., Cui,R., Yu,H.Y., Chen,Q., Huang,Y.J., Li,Z.
            and Yu,C.
  TITLE     Effects of Different Degrees of Carotid Artery Stenosis on the
            Expression of XIAP and Smac in the Ischemic Penumbra of Rats with
            Cerebral Ischemia-Reperfusion
  JOURNAL   J Stroke Cerebrovasc Dis 30 (2), 105516 (2021)
   PUBMED   33310074
  REMARK    GeneRIF: Effects of Different Degrees of Carotid Artery Stenosis on
            the Expression of XIAP and Smac in the Ischemic Penumbra of Rats
            with Cerebral Ischemia-Reperfusion.
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Wang,K., Zhang,J., Liu,J., Tian,J., Wu,Y., Wang,X., Quan,L., Xu,H.,
            Wang,W. and Liu,H.
  TITLE     Variations in the protein level of Omi/HtrA2 in the heart of aged
            rats may contribute to the increased susceptibility of
            cardiomyocytes to ischemia/reperfusion injury and cell death :
            Omi/HtrA2 and aged heart injury
  JOURNAL   Age (Dordr) 35 (3), 733-746 (2013)
   PUBMED   22535253
  REMARK    GeneRIF: Omi/HtrA2, but not Smac/DIABLO, expression was increased
            in aging hearts.
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Li,J., Li,Y., Qin,D., von Harsdorf,R. and Li,P.
  TITLE     Mitochondrial fission leads to Smac/DIABLO release quenched by ARC
  JOURNAL   Apoptosis 15 (10), 1187-1196 (2010)
   PUBMED   20552279
  REMARK    GeneRIF: data reveal that Smac/DIABLO is a target of ARC in
            counteracting apoptosis
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Hostager,B.S., Fox,D.K., Whitten,D., Wilkerson,C.G., Eipper,B.A.,
            Francone,V.P., Rothman,P.B. and Colgan,J.D.
  TITLE     HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating
            component of the CD40 signaling complex
  JOURNAL   PLoS One 5 (6), e11380 (2010)
   PUBMED   20614026
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Zheng,M.Z., Jiang,J.P., Fu,L., Zhu,L., Chen,Y.Y. and Shen,Y.L.
  TITLE     [Dynamic changes of Smac/DIABLO protein expression in rat donor
            myocardium suffered from hypothermic preservation]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 25 (3), 296-300 (2009)
   PUBMED   21155217
  REMARK    GeneRIF: Prolonged hypothermic preservation of myocardium might
            lead to the expression of Smac/DIABLO protein and induce
            cardiomyocyte apoptosis.
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1981)
  AUTHORS   Potts,P.R., Singh,S., Knezek,M., Thompson,C.B. and Deshmukh,M.
  TITLE     Critical function of endogenous XIAP in regulating caspase
            activation during sympathetic neuronal apoptosis
  JOURNAL   J Cell Biol 163 (4), 789-799 (2003)
   PUBMED   14623868
REFERENCE   8  (bases 1 to 1981)
  AUTHORS   Leblanc,V., Dery,M.C., Shooner,C. and Asselin,E.
  TITLE     Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium
            in response to 17beta-estradiol at estrus
  JOURNAL   Reprod Biol Endocrinol 1, 59 (2003)
   PUBMED   12967350
  REMARK    GeneRIF: Smac/DIABLO was elevated at diestrus, proestrus and
            metestrus but was minimal at estrus. Smac/DIABLO and XIAP are
            regulated differently and may play important roles in the
            regulation of endometrial cell fate.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1981)
  AUTHORS   Li,S., Zhao,Y., He,X., Kim,T.H., Kuharsky,D.K., Rabinowich,H.,
            Chen,J., Du,C. and Yin,X.M.
  TITLE     Relief of extrinsic pathway inhibition by the Bid-dependent
            mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
  JOURNAL   J Biol Chem 277 (30), 26912-26920 (2002)
   PUBMED   12011074
REFERENCE   10 (bases 1 to 1981)
  AUTHORS   Verhagen,A.M., Silke,J., Ekert,P.G., Pakusch,M., Kaufmann,H.,
            Connolly,L.M., Day,C.L., Tikoo,A., Burke,R., Wrobel,C.,
            Moritz,R.L., Simpson,R.J. and Vaux,D.L.
  TITLE     HtrA2 promotes cell death through its serine protease activity and
            its ability to antagonize inhibitor of apoptosis proteins
  JOURNAL   J Biol Chem 277 (1), 445-454 (2002)
   PUBMED   11604410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 16, 2021 this sequence version replaced
            XM_039089284.1, NM_001008292.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.46439.1,
                                           SRR26643288.47734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680429, SAMN06680437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000012.1  38716668-38716824
            158-738             JAXUCZ010000012.1  38717485-38718065
            739-865             JAXUCZ010000012.1  38718780-38718906
            866-997             JAXUCZ010000012.1  38722794-38722925
            998-1108            JAXUCZ010000012.1  38724616-38724726
            1109-1205           JAXUCZ010000012.1  38724840-38724936
            1206-1981           JAXUCZ010000012.1  38730510-38731285
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1981
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /note="diablo, IAP-binding mitochondrial protein"
                     /db_xref="GeneID:288753"
                     /db_xref="RGD:1310885"
     exon            1..157
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            158..738
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     CDS             689..1402
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /note="diablo homolog, mitochondrial"
                     /codon_start=1
                     /product="diablo IAP-binding mitochondrial protein"
                     /protein_id="NP_001008293.1"
                     /db_xref="GeneID:288753"
                     /db_xref="RGD:1310885"
                     /translation="MAALRSWMTRSVTFLFRYGQRFPVSANSKKRCFSELIRPWHKTM
                     LTGFGVTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYT
                     KAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVS
                     LSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQLSQKAETKLAEVQTQELRQKT
                     QEASDEAADQEEEAYLRED"
     exon            739..865
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            866..997
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1108
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1205
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1981
                     /gene="Diablo"
                     /gene_synonym="Smac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggccgcta gaccacacct agttgttgag tgctcctgct gcctgaagac ctctcagctc
       61 tacccagatc gctggagtgc gcacaagtct actttcacca gaccagagag aagctgtgga
      121 agctgtggcg gtggaagagc cgtggaaact ttgccaaggc gatgccgacc tcgtccacta
      181 tccacgtgct gcagttgctg cgggagctgc tcgccttcgt gctcctcagc tacaccgtgc
      241 tcatcggggc gctcctgctg gccggctgga ccacctactt cttggtgctg aagtgacagc
      301 gctcgggccc gcgctcgccc cgccccgccc cgccccgccc cgactccgag cttcccctcc
      361 cggaggagcg cagttccttt tccaagagcg gccccccccg ccccaagccc actacacgcg
      421 tcacggctcg cgacccggct cagcacccgt gcactggagc ctgcggcggc ctgcgccgaa
      481 accggagcgg ttgaaagcca ggtgcgaccg ttaaagccgt ttcctggtgt tctggccccg
      541 cccattcctc ctgtccaatc gcaatcgcgt cctccagcgg gggcgtgacc atgaagcccc
      601 gggctccttg ggccccgcct cgctcgcgct tctgcttgct atgctgcgtc acttccggcg
      661 cgtgcgtccg gcgtccgtcc gccgcgggat ggcggctctg aggagttgga tgactcggag
      721 cgtaaccttt ctgttcaggt acggacagcg ttttcctgtc tctgctaact ctaagaaacg
      781 ctgtttctca gaattgataa gaccatggca caaaactatg ttgactggat tcggtgtgac
      841 actgtgcgcc gttcctattg ctcagaaatc agagcctcag tctctcagca acgaagcact
      901 gatgaggagg gctgtgtctt tggtaacgga cagcacctct acctttctgt ctcaaaccac
      961 gtacgcactg atcgaagcca tcaccgagta tactaaggct gtctacacgt tagtgtctct
     1021 gtaccgacag tatacaagct tgctggggaa gatgaattcc caggaggagg atgaggtgtg
     1081 gcaggtgatc ataggagcca gagttgagat gacttcaaag cagcaggagt acttgaagct
     1141 ggagaccacg tggatgacag cagtcagcct ttcagagatg gctgcggagg ctgcctatca
     1201 gactggagca gatcaggcct ctataaccgc caggaatcac atccagttgg tgaagtcgca
     1261 ggtgcaggag gtgcgccagc tctcccagaa ggcggaaacc aagctggcag aagtgcagac
     1321 acaagagctg cgccagaaaa cacaggaagc gagcgatgag gcagcggacc aggaagagga
     1381 ggcctaccta cgagaagatt gagggctcga gcccagtgcc ctgtccatcc actctgtggg
     1441 gaaagcaggt gcatgacatc cacccagtga cgtcccaact gcagaagctg accggttctg
     1501 ccattgacag tcagaccaga gcctttgcga gctgcgcctg gccccttctc tctgctcgca
     1561 gcctctctgg gcctggctct gcactgtccc tcacacagct tctctcttga tcttttacct
     1621 cactcccaaa gcacttcacc aaccggggcc aatggaggag gggccttttc tgccacaccc
     1681 ttaagttcaa tagctgttta actccagttt ttactgttac tcagatgttc aagtatgaat
     1741 tactgcttgc tcctccacag ggaagcttgt ctggtttgta acatttcttt gtgtttataa
     1801 tgtcctttct ccctgtgagc acagctcagc taaggcgtta ctcagtgtga acagttcccc
     1861 tggtgctccc cacagcacct tctccaacac gtgcttcttg ttcgttcctt ttttgaattt
     1921 ctctgctgta tccaaaggaa gagaagtttg gtgtttgcat taaaaaaaaa aaaaagtctt
     1981 c
//
