LOCUS       NM_001107678            5665 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DEAH-box helicase 36 (Dhx36), mRNA.
ACCESSION   NM_001107678 XM_001058645 XM_227203
VERSION     NM_001107678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5665)
  AUTHORS   Newman,M., Sfaxi,R., Saha,A., Monchaud,D., Teulade-Fichou,M.P. and
            Vagner,S.
  TITLE     The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA
            3'-End Processing Following UV-Induced DNA Damage
  JOURNAL   J Mol Biol 429 (21), 3121-3131 (2017)
   PUBMED   27940037
REFERENCE   2  (bases 1 to 5665)
  AUTHORS   Nie,J., Jiang,M., Zhang,X., Tang,H., Jin,H., Huang,X., Yuan,B.,
            Zhang,C., Lai,J.C., Nagamine,Y., Pan,D., Wang,W. and Yang,Z.
  TITLE     Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart
            Development
  JOURNAL   Cell Rep 13 (4), 723-732 (2015)
   PUBMED   26489465
REFERENCE   3  (bases 1 to 5665)
  AUTHORS   Gao,X., Ma,W., Nie,J., Zhang,C., Zhang,J., Yao,G., Han,J., Xu,J.,
            Hu,B., Du,Y., Shi,Q., Yang,Z., Huang,X. and Zhang,Y.
  TITLE     A G-quadruplex DNA structure resolvase, RHAU, is essential for
            spermatogonia differentiation
  JOURNAL   Cell Death Dis 6 (1), e1610 (2015)
   PUBMED   25611385
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5665)
  AUTHORS   Booy,E.P., McRae,E.K. and McKenna,S.A.
  TITLE     Biochemical characterization of G4 quadruplex telomerase RNA
            unwinding by the RNA helicase RHAU
  JOURNAL   Methods Mol Biol 1259, 125-135 (2015)
   PUBMED   25579584
REFERENCE   5  (bases 1 to 5665)
  AUTHORS   Booy,E.P., Howard,R., Marushchak,O., Ariyo,E.O., Meier,M.,
            Novakowski,S.K., Deo,S.R., Dzananovic,E., Stetefeld,J. and
            McKenna,S.A.
  TITLE     The RNA helicase RHAU (DHX36) suppresses expression of the
            transcription factor PITX1
  JOURNAL   Nucleic Acids Res 42 (5), 3346-3361 (2014)
   PUBMED   24369427
REFERENCE   6  (bases 1 to 5665)
  AUTHORS   Creacy,S.D., Routh,E.D., Iwamoto,F., Nagamine,Y., Akman,S.A. and
            Vaughn,J.P.
  TITLE     G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex
            with high affinity and is the major source of tetramolecular
            quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell
            lysates
  JOURNAL   J Biol Chem 283 (50), 34626-34634 (2008)
   PUBMED   18842585
REFERENCE   7  (bases 1 to 5665)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   8  (bases 1 to 5665)
  AUTHORS   Iwamoto,F., Stadler,M., Chalupnikova,K., Oakeley,E. and Nagamine,Y.
  TITLE     Transcription-dependent nucleolar cap localization and possible
            nuclear function of DExH RNA helicase RHAU
  JOURNAL   Exp Cell Res 314 (6), 1378-1391 (2008)
   PUBMED   18279852
REFERENCE   9  (bases 1 to 5665)
  AUTHORS   Vaughn,J.P., Creacy,S.D., Routh,E.D., Joyner-Butt,C., Jenkins,G.S.,
            Pauli,S., Nagamine,Y. and Akman,S.A.
  TITLE     The DEXH protein product of the DHX36 gene is the major source of
            tetramolecular quadruplex G4-DNA resolving activity in HeLa cell
            lysates
  JOURNAL   J Biol Chem 280 (46), 38117-38120 (2005)
   PUBMED   16150737
REFERENCE   10 (bases 1 to 5665)
  AUTHORS   Tran,H., Schilling,M., Wirbelauer,C., Hess,D. and Nagamine,Y.
  TITLE     Facilitation of mRNA deadenylation and decay by the exosome-bound,
            DExH protein RHAU
  JOURNAL   Mol Cell 13 (1), 101-111 (2004)
   PUBMED   14731398
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_001107678.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107678.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JACYVU010000069.1  13366698-13366992   c
            296-420             JACYVU010000069.1  13362577-13362701   c
            421-655             JACYVU010000069.1  13361397-13361631   c
            656-694             JACYVU010000069.1  13358318-13358356   c
            695-865             JACYVU010000069.1  13356982-13357152   c
            866-945             JACYVU010000069.1  13355709-13355788   c
            946-1020            JACYVU010000069.1  13354603-13354677   c
            1021-1187           JACYVU010000069.1  13353991-13354157   c
            1188-1269           JACYVU010000069.1  13352579-13352660   c
            1270-1410           JACYVU010000069.1  13350236-13350376   c
            1411-1513           JACYVU010000069.1  13349869-13349971   c
            1514-1601           JACYVU010000069.1  13349454-13349541   c
            1602-1657           JACYVU010000069.1  13348510-13348565   c
            1658-1722           JACYVU010000069.1  13346032-13346096   c
            1723-1866           JACYVU010000069.1  13345172-13345315   c
            1867-1984           JACYVU010000069.1  13342151-13342268   c
            1985-2083           JACYVU010000069.1  13341181-13341279   c
            2084-2257           JACYVU010000069.1  13339711-13339884   c
            2258-2344           JACYVU010000069.1  13339486-13339572   c
            2345-2428           JACYVU010000069.1  13337640-13337723   c
            2429-2528           JACYVU010000069.1  13335421-13335520   c
            2529-2619           JACYVU010000069.1  13335224-13335314   c
            2620-2740           JACYVU010000069.1  13332778-13332898   c
            2741-2893           JACYVU010000069.1  13332122-13332274   c
            2894-5665           JACYVU010000069.1  13328889-13331660   c
FEATURES             Location/Qualifiers
     source          1..5665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..5665
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /note="DEAH-box helicase 36"
                     /db_xref="GeneID:310461"
                     /db_xref="RGD:1308767"
     exon            1..295
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3079
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /EC_number="3.6.4.13"
                     /EC_number="3.6.4.12"
                     /note="probable ATP-dependent RNA helicase DHX36; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 36; G4-resolvase-1;
                     MLE-like protein 1; DEAH-box protein 36; DEAD/H box
                     polypeptide 36; RNA helicase associated with AU-rich
                     element protein"
                     /codon_start=1
                     /product="ATP-dependent DNA/RNA helicase DHX36"
                     /protein_id="NP_001101148.1"
                     /db_xref="GeneID:310461"
                     /db_xref="RGD:1308767"
                     /translation="MSYDYHQSWSRDGGPRGSGQGSGGGGGGSRGSGGGGGGRGGRGR
                     HPAHLKGREIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKNDKDS
                     EAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSE
                     YLLQQNEPNLGLDQQLLEDLQKKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVT
                     VISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESC
                     GNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQ
                     SDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLED
                     IIEKIRYFPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELQTRYSAST
                     IDVLEMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS
                     DRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKE
                     THFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEIL
                     RTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQEELTPLG
                     VHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKEL
                     AKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLL
                     GAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSD
                     GLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKD
                     KDQEIIAVDEWIVFQSPERIAHLVKGLRKELDILLQEKIECPHPVDWNDTKSRDCAVL
                     SAILDLIKTQEKAIPRNLPPRSQDGYYS"
     exon            296..420
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..655
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..694
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..865
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..945
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1020
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1187
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1269
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1410
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1513
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1601
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1657
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1722
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1866
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1984
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2083
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2257
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2344
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2428
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2528
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2619
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2740
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2893
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..5665
                     /gene="Dhx36"
                     /gene_synonym="G4R1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgtgcgcc cgcttccggt cctgggcgcc attttcagcg gttgagtttt ggtggtacct
       61 gtagtcgtct cggacaatga gctacgacta tcatcagagc tggagccgcg acgggggccc
      121 acggggctcc ggccagggct ctggcggcgg cggtggaggg agccggggct ccggcggcgg
      181 cggagggggc cgcggcggcc ggggccggca tccggcccac cttaagggtc gcgagatagg
      241 cctatggtac gcaaaaaagc aaacgcagaa gaacaaggag gctgagagac aagagagagc
      301 tgtagtgcac atggatgaac ggcgagaaga gcaaattgtg cagctgctaa attcagtcca
      361 agcaaagaat gataaagatt cagaagcaca gatatcctgg tttgctcctg aggatcatgg
      421 gtatggtact gaagtttctt cagagaaaaa aataaactca gagaagaaac ttgacaacca
      481 ggaaaagaaa ttgctgaacc aagaaaaaaa gacatatagg atcacagaca aatcatatat
      541 tgaccgagat tctgagtatt tattgcaaca aaatgaacca aacctaggct tagaccaaca
      601 attattggaa gatttacaaa agaaaaaaac tgaccctcgg tatatagaga tgcagcgttt
      661 cagaaaaaag ctgccttcat atggaatgca gaaggagctg gtaaatttaa tcaataacca
      721 tcaggtgaca gtgataagtg gtgagactgg ttgtggcaaa accactcagg ttactcagtt
      781 catcttggat aactacatcg aaagaggaat agggtctgcc tgcagaatag tgtgtactca
      841 gccaagaaga attagtgcca tttcagttgc tgagagggtg gctgcagaaa gggcagagtc
      901 ttgtggcaat ggtaatagta ctggatacca gattcgtctc caaagtcggt tgccaaggaa
      961 acaaggctct atcctatact gcacaacagg aatcattctt cagtggctcc agtcagactc
     1021 acgtttgtcc agtgttagtc atattgtact tgatgaaatt catgaaagga atctacagtc
     1081 agatgtttta atgactgtta ttaaagatct cctccatttt cgatcggatc tcaaagtaat
     1141 attgatgagt gcaaccttga atgctgagaa attttcagaa tattttggta actgtccaat
     1201 gatacatata cctgggttta cttttccagt tgtggaatat cttttggaag atatcattga
     1261 aaaaataaga tattttccag aacaaaaaga acatagatcc cagttcaaaa ggggtttcat
     1321 gcagggtcat gtaaatagac aagaaaaaga agaaaaagag gcgatctata aagaacgctg
     1381 gccagcttat ataaaggaac tacagacaag atactctgca agtaccatag atgttttgga
     1441 aatgatggat gatgataaag ttgatctgaa tttgattgct gcccttattc gatacattgt
     1501 tttggaagaa gaggacggtg caatattggt ctttctacca ggctgggaca atatcagtac
     1561 tttgcatgat ctcttgatgt cacaagtgat gtttaaatca gataggtttc ttattatacc
     1621 tttacattca ctgatgccca ctgtaaacca gacacaggta tttaaaaaaa ctcctcctgg
     1681 tgttcggaaa atagtaattg ctaccaacat tgcagagact agcatcacca tagatgatgt
     1741 ggtctatgta atagatggag ggaaaattaa agaaacacac tttgacacac agaacaacat
     1801 cagtaccatg tctgctgagt gggttagtaa agctaatgcc aaacagagga aagggagagc
     1861 tggaagagtt cagcctggtc attgttatca tctgtataat ggtcttagag caagtcttct
     1921 agatgactac caactaccag aaattttgag aactcctttg gaagaacttt gtttgcaaat
     1981 aaagatcttg aggctgggtg gaattgctta ttttctgagt aggttaatgg atccaccatc
     2041 agatgaggca gtagtgctct ccataaaaca tctaatggaa ctgagtgctt tggataagca
     2101 agaagaattg acacctcttg gagtccattt agcccgactg cctgttgagc cacatattgg
     2161 aaaaatgatt ctctttggag ctttgttctg ttgcttagat ccagtcctca ccattgctgc
     2221 cagtctcagc tttaaagatc cctttgtcat tccattggga aaagaaaaga ttgcagatgc
     2281 aagaagaaag gaactggcaa aggaaactag aagtgatcat ctgacagttg tgaatgcgtt
     2341 tgagggctgg gaagaagcta aacggcgtgg tttcagatat gaaaaagact actgctggga
     2401 atattttctc tcttcaaaca cactacagat gctgcataac atgaagggac agtttgctga
     2461 gcatcttctt ggagctggat ttgtaagcag tagaagtccc aaagatccaa aagctaatat
     2521 aaattcagat aatgagaaga tcattaaagc tgtcatctgt gctggtttat atcccaaagt
     2581 tgctaaaatc cgactaaatt tgggtaaaaa aaggaaaatg gtgaaagttc acacaaagtc
     2641 tgatggtctg gtttctattc atcctaagtc tgtcaatgtg gagcagacag acttccacta
     2701 caactggctt atctatcacc tgaagatgag aacaagcagt atatacttgt acgactgcac
     2761 agaagtctca ccatactgcc tcttgttctt tggaggagat atttccatcc agaaagataa
     2821 ggatcaggaa attattgctg tagacgaatg gattgtgttt cagtctccag aaagaattgc
     2881 tcatcttgtt aagggactaa gaaaggaact ggatatcctt ctacaagaga agattgagtg
     2941 ccctcatcct gtagattgga acgacaccaa atccagagac tgtgcagtac tgtcagcgat
     3001 tctagacttg atcaaaacac aagaaaaggc tattccaagg aacttgccac cacgatcaca
     3061 ggatggatat tacagctgac agttttctgg ggtggcctaa acctatcctg atgtccataa
     3121 tttctggtct tttttttttt tttttttttt ttttttttgg ttttattttg tttttagttt
     3181 ttggcaaaat gccaagccct gggtcatgcc tgccttctgt gtgtaagtta gaacctttca
     3241 ttgagtagta aagagttaat gtgcatgact aaacagtgcc atctagctac tataaagaca
     3301 ttggaacaag cagtatgctt ctgaccttat cctatgttgt agatatgtcc acactttggg
     3361 agaattccca aagttgtaac attgagaaat tcctttatgc cattatgcaa aattaatttt
     3421 ctgtccataa tgactgtcta gagacagtaa aaatagaaag ttgggccaaa aagcaatgtg
     3481 aagtaagaat ttaaatacaa ccccatttta aaaaaatgaa tttctattta agtaatttgt
     3541 tgtaataaag cccagtattt aataaaatgt acaatgtata agtctcagct aacttcttgg
     3601 tttgatttct agagttctgc ctctcacttg gctcccttga ttggttttat ttgtttgttt
     3661 gcttgttttt taattttttt aaaaggttct tatattaacc taccttcctg ctctgtgtag
     3721 cataatgtag caactgagca cgcgtctgga tgtggtgctg gagttcctgt ctcagctcag
     3781 cccctttcct atttgagaga caggtaaaga ctgtgagggt taaatatggg aatacgtgta
     3841 aagggctcgg actagcgtct gatgcttatg gtgctcacac agtgcttgtt actatttgtc
     3901 catgaaatag tttttaacct ttagtactca attttaccct tttgtttttt gtactaggga
     3961 ccttggagat ggttgagcca agggcctcac atgtactaga tacgtgctgt atttctgagc
     4021 cacacccctg tgacaaaaca aggctgtttt caggcttatt agagttattg tttttctcct
     4081 acttttgact ccttccttgt tttccagttg tagtccctac ctctagcata aagatgttgc
     4141 ttttgtccta tccaagaccc attggttgtt ctaaggtaat caactgtggt cttatttccc
     4201 tagtaagttg tgagatgacc aggacatatg cataatactg ccatggattt gctgccggtg
     4261 ctggttcagg tactgctgcc atgtcatgta tatgtcatct gacattgtat acagagattt
     4321 gaatgtactg tgtccttagt ttattctttt ggattgaatc accaaaatta tgtttctccc
     4381 taaactctca gatttagtca tagtggtgtt gttatagcat atcagttttg ccccacaaag
     4441 tgtgtttata agcaagtatt tagtctccac atgctgctgc tctttgttgt ctctgacata
     4501 gctaagcagg atagagggtg gattgcgggt gctctgaacg ttcagcttct tgtttcacag
     4561 attaggacta ctaactcaaa aatttacgcc aagccctaaa atgacttgtc ctgtagtgct
     4621 cttaaaaaat aggtcaagaa gaaaaagctg tcttacatca ctttgcacag cacaaagaac
     4681 aaactagaaa aaacgctgta acagaaactt atgagtaaaa ttgaaatata ctgcttacat
     4741 aatgttttaa gagcattaag tacatgcata tggtaccttc ctcattaatt gatctggaaa
     4801 aaaaaagctg tagtaatttt aagtcaatta attacaaagt atattttgct gcatttgtaa
     4861 agcaaagtct actttaaaat tatttcacta tctgtctacc cagaccaatt aaatgatggc
     4921 ataatttctt ccattctcaa cactgagctt atattcttta ataactgtac ttatgtttta
     4981 tattgatatt tgtaataatc ctatatgtta aacagcattt ttattctgat ttttttaaaa
     5041 aacatcttca ctggagaata tttgaaaatg tatccaggaa agtaaatcat gttatcattg
     5101 ttagtttttt gatattcttc catacctttt taaagcttta aggtatttaa aagtataatt
     5161 tcaatgtatt ttgtctactg tatgaagttg tgtagctaac aacaccacag tctcgatgta
     5221 gaacattccc atcaacctaa gattttctct gttgctttta caggtaaaat gcccttcctt
     5281 gcttctaccc tctggtgccc aggaagcagt tgttcgtcag tagttttgcc ttttctaggt
     5341 tttctggtaa tggattcaca cagtctatat gtccagcctc tttcacttaa tataagcatc
     5401 gagataactc atgcttactg tacatattag taattttatt gtttagtatt ttcttttatg
     5461 gttatgttat tgtattcatt taccacttgg tggacatttc atgtattttc agcattttgc
     5521 tgttaatgaa taaagctgct ctaaatgtgt atatagttgt catgttttta ctttctgtgt
     5581 aaatattcag gattacgata atttcatcag atggtcaaca ttcatgtgtg taactgtagc
     5641 tatgtaaatt aatgtgtata catgc
//
