LOCUS       NM_001415857            3216 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus DEAH-box helicase 35 (Dhx35), transcript variant
            1, mRNA.
ACCESSION   NM_001415857 XM_006235423
VERSION     NM_001415857.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2023 this sequence version replaced XM_006235423.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.20199.1,
                                           SRR26643299.16956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000003.1  167870058-167870122
            66-199              JAXUCZ010000003.1  167876699-167876832
            200-292             JAXUCZ010000003.1  167880971-167881063
            293-370             JAXUCZ010000003.1  167881490-167881567
            371-475             JAXUCZ010000003.1  167887159-167887263
            476-537             JAXUCZ010000003.1  167889090-167889151
            538-607             JAXUCZ010000003.1  167890104-167890173
            608-667             JAXUCZ010000003.1  167892393-167892452
            668-780             JAXUCZ010000003.1  167897766-167897878
            781-877             JAXUCZ010000003.1  167899353-167899449
            878-1036            JAXUCZ010000003.1  167900927-167901085
            1037-1247           JAXUCZ010000003.1  167903251-167903461
            1248-1372           JAXUCZ010000003.1  167906241-167906365
            1373-1427           JAXUCZ010000003.1  167907998-167908052
            1428-1523           JAXUCZ010000003.1  167911255-167911350
            1524-1618           JAXUCZ010000003.1  167911888-167911982
            1619-1696           JAXUCZ010000003.1  167912435-167912512
            1697-1826           JAXUCZ010000003.1  167914010-167914139
            1827-1908           JAXUCZ010000003.1  167916488-167916569
            1909-1980           JAXUCZ010000003.1  167919401-167919472
            1981-2092           JAXUCZ010000003.1  167921519-167921630
            2093-3216           JAXUCZ010000003.1  167926177-167927300
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3216
                     /gene="Dhx35"
                     /note="DEAH-box helicase 35"
                     /db_xref="GeneID:362260"
                     /db_xref="RGD:1311165"
     exon            1..65
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2137
                     /gene="Dhx35"
                     /EC_number="3.6.1.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable ATP-dependent RNA helicase DHX35; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 35"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX35
                     isoform 1"
                     /protein_id="NP_001402786.1"
                     /db_xref="GeneID:362260"
                     /db_xref="RGD:1311165"
                     /translation="MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAA
                     LSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRV
                     VGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVRE
                     MMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRD
                     FFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGD
                     ILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHS
                     VRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAG
                     RGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSP
                     PPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEI
                     LSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQ
                     EHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHST
                     GAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP
                     HFYQQGTHLSLKAKRAKVQDQ"
     exon            66..199
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            200..292
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            293..370
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            371..475
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            476..537
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            538..607
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            608..667
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            668..780
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            781..877
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1036
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1247
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1372
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1427
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1523
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1618
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1696
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1826
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1908
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1980
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2092
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..3216
                     /gene="Dhx35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcttcgtg acctttcacc ccagcatggc tgcgcccttg ggaccagtga aattctggaa
       61 acccggtaca gaagggccag gtgtcagcat ctccgaagag agacaaagtg tcactgagaa
      121 ctctgggaca accgtcattt acaatcccta cgctgccctt tccatagagc agcagcggca
      181 gaagctgccc gtgttcaagc ttaggaacca cattttgtac ttggtagaaa actatcagac
      241 cgtggtgatt gttggagaaa cgggatgtgg gaagagcacc caggtcccac agtacctggc
      301 agaagctggc tggacagcgg aaggacgagt ggttggagtg acccagcctc gcagagtagc
      361 tgctgtgacg gttgcaggga gagtagctga tgaaaggggt gcagtgctgg gccacgaggt
      421 gggctactgt atccgcttcg atgactgcac cgacccactg gcgaccagaa ttaagttcct
      481 tacagatggc atgctggtcc gagaaatgat ggttgatcca ttgttaacaa aatatagtgt
      541 cgtcatgctg gacgaagccc acgagaggac cttgtacacg gacattgcta ttggcttgct
      601 gaagaagatt cagaaaaagc gaggggatct tcgcctgata gtggcctcag ccactctgga
      661 cgcagagaaa tttcgagatt tctttaacca gaatgagacc agtgacccag ccagggatac
      721 ctgtgtgata ctcacagtgg aaggacggac atttccagtg gatatctttt acctacaaag
      781 tcctgttcca gattatatca aggcgactgt ggacactgtg gtaaaaatcc atcagacaga
      841 gggagatgga gacatactag cctttcttac tggccaggaa gaagtagaaa ctgtcgtgtc
      901 catgctgatc gagcaggctc gggcgctggc tcgcactggg atgaagaaac acctccgggt
      961 tctccccatg tatgcaggac tgccttcttt tgagcagatg aaggtgtttg aaagggtgtc
     1021 acatagcgtc aggaaggtga tcgttgccac caatgtggca gagacttcta tcacaatcag
     1081 tggcattgtg tatgtgattg actgtggctt tatgaagctt cgagcctaca accctaggac
     1141 agctattgaa tgcttggtag tggtaccagt gtctcaggca tcagccaatc agcgggcagg
     1201 acgtggtggg cgcaaccgct cggggaaatg ttaccgcctt tatacagagg aagcctttga
     1261 acagttgcct cagtccaccg tccctgagat gcagcgcagt aatttggccc ctgtcgtcct
     1321 gcagctgaaa gccctaggga ttgacagcgt cctcaggttc cacttcatgt ctcccccgcc
     1381 ggcacagtcg atggttcaag ccttggagct gctctatgct ctcggaggtc tggacaaaga
     1441 ctgtcgccta accgagccgc ttggcatgag aattgcagag tttcctctga accccatgtt
     1501 tgccaagatg ctgctggagt cagggaactt tggctgctct caggagatcc tgagtatcgc
     1561 cgccatgatg cagatccaga atgtcttcgt gtttccctcc aaccagaagt ctcaggcgac
     1621 tcgagtgcac cggaagtttg ctgtggagga gggtgaccat ctcaccatgc tcaatgtgta
     1681 tgaagcgttt atcaaacaca acaagagctc gcagtggtgt caggagcatt tcctgaatta
     1741 caagggtctt gtcagagccg ccactgtgag agaccagttg aaaaagctcc tcgtcaagtt
     1801 ccaggtgccc aagatgtcca gcgaaggtga tccggacccg gtcctgaggt gtatcgtgtc
     1861 ggggttcttt gcaaatgcag cacggtttca ctccactgga gcatatagga ctatccgtga
     1921 tgaccacgag ctgcacatcc accctgcctc agtcctctat gcagagaagc caccccgctg
     1981 ggttatctac aatgaagtta tacagacctc caagtactac atgcgagatg tgaccgccat
     2041 agaatctgca tggctgctgg agctggcgcc tcacttttat caacaaggaa cgcatctgtc
     2101 cctgaaagcc aagagagcca aggtccagga ccagtgagcg gagctcagca agtggctgca
     2161 gggatgcgga gtgtggcctc ccttcgtgtt gtctctggca ccagctcagg ggaacaggca
     2221 gacactgctg tggaccgtac cctgctcatt accccccttt ctgctcccct cagcatttgc
     2281 cgccctcacg gggccataga ggaatctgag catggccagt gttctgcact tctcgtaggc
     2341 caagcaggag ttggctgggc catgctctgg ccccagtcct cgctctcagc agcctgcatg
     2401 ctactccagc aggccccgct cctggtccag ctctgtggtg aggaaagtga aggccgaagg
     2461 tggcggaaga cctgtgtaga caggactctc ttggcctccc gtgtctgcct gctgtggcca
     2521 cagttgttga ctactgaggc tactgctgct gtgtgtgtca agtatgaaag gaaatgctgg
     2581 gtatttctgt caatgtcacc aaagctgtgt caggcacagg ggcttccaga caaagcagct
     2641 tcttctttcc tccgcccatg ccctgcttat ccgcagtggg agacttagtg tagtgatggt
     2701 gggccactcg ggactcagcc cgtctttgtt agccacttgc tctgcaagtg ggcttagctt
     2761 tctctcagag cacgatgcca tatcctggtg ccagtctggg cgccagggaa tgctcaccaa
     2821 cctcgacccc gtggggcttc tctttagcag ggattcacca cagtttagat gccctaaact
     2881 tgtgtagctc aggaacataa cttgtaaatt tatctttatt tgtctgcttg cattcttgca
     2941 agaacacagg cagctccctg ggcactgttc ccaccgcacc ggggttgcct tgcggcgaca
     3001 gcgctgtcac ttcagcgcac ggcaagacag acttctcccg tactgtctca atgatgttta
     3061 ttttgaaaac gtggcttgaa agtttatttt tgtactggtc ttaatttgga tgtgtcactt
     3121 ttggcaccaa acctctgtca tttttatttc cattttataa tgtgtaaata gctgtggaaa
     3181 gttgttaacc gtagtaaata tttctacctg agggga
//
