LOCUS       NM_001105802            2716 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DEAH-box helicase 33 (Dhx33), mRNA.
ACCESSION   NM_001105802 XM_001080073 XM_213370
VERSION     NM_001105802.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Zhang Y, You J, Wang X and Weber J.
  TITLE     The DHX33 RNA Helicase Promotes mRNA Translation Initiation
  JOURNAL   Mol Cell Biol 35 (17), 2918-2931 (2015)
   PUBMED   26100019
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Liu Y, Lu N, Yuan B, Weng L, Wang F, Liu YJ and Zhang Z.
  TITLE     The interaction between the helicase DHX33 and IPS-1 as a novel
            pathway to sense double-stranded RNA and RNA viruses in myeloid
            dendritic cells
  JOURNAL   Cell Mol Immunol 11 (1), 49-57 (2014)
   PUBMED   24037184
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Mitoma H, Hanabuchi S, Kim T, Bao M, Zhang Z, Sugimoto N and Liu
            YJ.
  TITLE     The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3
            inflammasome
  JOURNAL   Immunity 39 (1), 123-135 (2013)
   PUBMED   23871209
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Zhang Y, Forys JT, Miceli AP, Gwinn AS and Weber JD.
  TITLE     Identification of DHX33 as a mediator of rRNA synthesis and cell
            growth
  JOURNAL   Mol Cell Biol 31 (23), 4676-4691 (2011)
   PUBMED   21930779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001080073.1, XM_213370.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2716
                     /gene="Dhx33"
                     /note="DEAH-box helicase 33"
                     /db_xref="GeneID:287464"
                     /db_xref="RGD:1307239"
     exon            1..317
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2152
                     /gene="Dhx33"
                     /EC_number="3.6.4.13"
                     /note="putative ATP-dependent RNA helicase DHX33; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 33"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX33"
                     /protein_id="NP_001099272.1"
                     /db_xref="GeneID:287464"
                     /db_xref="RGD:1307239"
                     /translation="MPEEAGLPPAKRFRPGSCPPGRRVVMLLTAGSGGGAGGGRRQTP
                     PLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYL
                     YEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKF
                     LTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKV
                     IVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEA
                     PSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPSMLVLPLYASLPYSQQLRVFQGA
                     PKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQ
                     RTGRAGREDSGICYRLYTEDEFDKFEKMAAPEIQRCNLASVMLQLLAMKVPNVLTFDF
                     MSRPSPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFH
                     CTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGN
                     KDWCKENFVNSKNMLLVAEVRAQLRDICLKMSMPIMSSRGDMESVRRCLAHSLFMSTA
                     ELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLY
                     EAAPDYFRRKLRTARN"
     exon            318..478
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            479..706
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            707..877
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1063
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1175
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1335
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1424
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1552
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1756
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1843
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2716
                     /gene="Dhx33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccacagctg agcggagctg tcggcgccga tacctccttc cgcgggcctc ccgacatgcc
       61 ggaggaggcg ggcctcccgc ccgccaagag attccggccg ggctcctgcc ctcccgggag
      121 gcgagtagta atgctgttga cggctggcag cggtggcgga gcaggaggag gccggaggca
      181 gacgccgccc ctggcccagc cttcggccag tccctaccgc gaggccctgg agctgcagcg
      241 ccggagtctg cccatcttcc gggcgcgggg gcagctattg gcacagctcc gaaacctgga
      301 caacgcggtc ctcatcgggg aaactggctc tgggaagaca actcagatcc cacagtacct
      361 ctatgaaggg ggaattagcc ggcagggcat cattgctgtg acccagcccc gtcgagtggc
      421 tgccatctct cttgccacta gagtctcaga tgagaagagg actgaactcg ggaagctggt
      481 tggctataca gtgcgctttg aggatgtcac ctcagaagat actaggatca agttcctgac
      541 agatggcatg cttttgcgtg aagcaatttc agattccttg cttcggaagt atagctgtgt
      601 cattttggac gaggcccatg agcggactat ccacacagat gtgctctttg gagtagtgaa
      661 gactgcacag aagaggcgaa aggagctagg gaagctgcct ctcaaagtga ttgtgatgtc
      721 agctaccatg gatgttgacc tgttttctca gtatttcaat ggcgcccctg tcctctacct
      781 tgagggtcgg cagcatccca tccagatctt ttataccaaa cagcctcagc aggattacct
      841 gcatgcagct cttgtctcag tcttccagat ccaccaggaa gccccctcct ctcaggacat
      901 cctggtcttc ctcactggtc aggaggagat cgaagcaatg agcaagacct gccgagacat
      961 tgcaaagcac ctcccagacg gctgcccttc catgctcgtc cttcctctgt acgcctcctt
     1021 gccctattca cagcagcttc gagtctttca aggagcccca aagggctatc gcaaagtgat
     1081 catttcaacc aacatcgctg agacctccat aaccattaca ggaataaaat acgtagttga
     1141 caccggcatg gttaaagcaa agaagtataa ccctgacagt ggtcttgagg tactcgctgt
     1201 gcagcgagtg tcgaagaccc aggcctggca gcgcacaggc cgggctggac gggaggacag
     1261 cggcatctgc taccggctct acactgagga cgagtttgac aagtttgaga agatggcagc
     1321 accagagatc cagaggtgta acctggcaag tgtgatgctt cagctcctgg caatgaaagt
     1381 cccaaatgtg ctcacctttg acttcatgtc cagaccatct ccagatcaca ttgaggcggc
     1441 cattgcccaa ctggacctgt taggtgctct tgaacataag gatgaccagc ttgccctgac
     1501 tccaatcgga agaaagatgg cagcatttcc tttagaacca aaatttgcca aaactatcct
     1561 cctgtcctcc aaattccact gtacagaaga gattctgacc atagtctccc tgctgtctgt
     1621 agacagtgtc ctctacaacc ctcctgcccg gagagatgag gtgcagagtg tccggaagaa
     1681 attcatatcc agtgaggggg atcatatcac cctgctcaat atctatcgga ccttcaaaaa
     1741 cataggtggg aataaggact ggtgcaaaga gaattttgtc aacagcaaga acatgctcct
     1801 agtagctgaa gtcagagcgc agctgaggga catctgctta aagatgtcaa tgccaatcat
     1861 gtcatctcga ggggacatgg agagtgtccg ccgttgcctg gctcacagcc tctttatgag
     1921 tactgctgaa ctccagccag atggcaccta tgccaccaca gacacacatc agccagtggc
     1981 catccaccca tcatctgtcc tcttccactg caagcctgcc tgcgtggtat acacttcact
     2041 gctctacacc aacaaatgct acatgcgtga cctgtgtgtt gtggatgccg agtggctgta
     2101 cgaggctgcc cctgactact tcaggaggaa gctgagaacg gccagaaact gagccatccc
     2161 agctgggcct ggagcttaga tcacagctgt cttccaaaca gactcagaag cttgcagcca
     2221 gactctcaac ttcaggagct taacagtatt gatgaggcct ctcagactca accatgcaga
     2281 catggtcgtg cttagaccat gagaaactga ggctgtgctt caggtttgac tatgcagttt
     2341 tgggtgactg aattaacatc cgagcctcag tttcctcata tgccagagag ggataagact
     2401 tacgagttca gagtaatgaa gtttagagaa aatgaacaga atattaccca gagatttgcc
     2461 aggtacaaga taagacaatc agtgacttgt aagccattgt gctttgtgat actaattagg
     2521 tacagcacag tcccttgagt tcttgtggct gggggaggag tcataggaga tccaatttgt
     2581 tgaaatgttt ctcccccctt cttactcctt cccctgtgga tcccagggcc tcctgcatgc
     2641 tatgcaaaac actttgcctc tgagccagtc cccagcccct acttctactt taatcctacc
     2701 tgtgtgtctt ttaaat
//
