LOCUS       NM_001013249            3853 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus DExH-box helicase 30 (Dhx30), mRNA.
ACCESSION   NM_001013249 XM_345985
VERSION     NM_001013249.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Lessel,D., Schob,C., Kury,S., Reijnders,M.R.F., Harel,T.,
            Eldomery,M.K., Coban-Akdemir,Z., Denecke,J., Edvardson,S.,
            Colin,E., Stegmann,A.P.A., Gerkes,E.H., Tessarech,M., Bonneau,D.,
            Barth,M., Besnard,T., Cogne,B., Revah-Politi,A., Strom,T.M.,
            Rosenfeld,J.A., Yang,Y., Posey,J.E., Immken,L., Oundjian,N.,
            Helbig,K.L., Meeks,N., Zegar,K., Morton,J., Schieving,J.H.,
            Claasen,A., Huentelman,M., Narayanan,V., Ramsey,K., Brunner,H.G.,
            Elpeleg,O., Mercier,S., Bezieau,S., Kubisch,C., Kleefstra,T.,
            Kindler,S., Lupski,J.R. and Kreienkamp,H.J.
  CONSRTM   DDD study; C4RCD Research Group
  TITLE     De Novo Missense Mutations in DHX30 Impair Global Translation and
            Cause a Neurodevelopmental Disorder
  JOURNAL   Am J Hum Genet 101 (5), 716-724 (2017)
   PUBMED   29100085
  REMARK    Erratum:[Am J Hum Genet. 2018 Jan 4;102(1):196. doi:
            10.1016/j.ajhg.2017.12.016.. PMID: 29304375]
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Antonicka,H. and Shoubridge,E.A.
  TITLE     Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA
            Processing and Ribosome Biogenesis
  JOURNAL   Cell Rep 10 (6), 920-932 (2015)
   PUBMED   25683715
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Zheng,H.J., Tsukahara,M., Liu,E., Ye,L., Xiong,H., Noguchi,S.,
            Suzuki,K. and Ji,Z.S.
  TITLE     The novel helicase helG (DHX30) is expressed during gastrulation in
            mice and has a structure similar to a human DExH box helicase
  JOURNAL   Stem Cells Dev 24 (3), 372-383 (2015)
   PUBMED   25219788
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Ye,P., Liu,S., Zhu,Y., Chen,G. and Gao,G.
  TITLE     DEXH-Box protein DHX30 is required for optimal function of the
            zinc-finger antiviral protein
  JOURNAL   Protein Cell 1 (10), 956-964 (2010)
   PUBMED   21204022
REFERENCE   8  (bases 1 to 3853)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091359.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345985.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091359.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3853
                     /gene="Dhx30"
                     /note="DExH-box helicase 30"
                     /db_xref="GeneID:367172"
                     /db_xref="RGD:1308888"
     exon            1..50
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            51..142
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            143..197
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3754
                     /gene="Dhx30"
                     /EC_number="3.6.4.13"
                     /note="putative ATP-dependent RNA helicase DHX30; DEAH box
                     protein 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30;
                     DEAH (Asp-Glu-Ala-His) box helicase 30; DEAH-box helicase
                     30"
                     /codon_start=1
                     /product="ATP-dependent RNA helicase DHX30"
                     /protein_id="NP_001013267.1"
                     /db_xref="GeneID:367172"
                     /db_xref="RGD:1308888"
                     /translation="MFTLDSFRKDRTQHRQRQCKLPPPRLPPMCVNPAPGGTISRASR
                     DLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGY
                     GSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTM
                     PPTSWRQLNPENIRPAGTGGLSRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNP
                     LRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTK
                     LATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLAS
                     LRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILPLGKDSGP
                     LSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQH
                     PVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELG
                     PSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDV
                     NTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLE
                     DILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIK
                     GVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITV
                     NDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRS
                     RLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQ
                     EIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSS
                     LQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSL
                     RFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQV
                     RQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFV
                     RDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALG
                     RMVERSLRSELAALPLSVQQEHGQLLALLAELLRGPCGSFDVRKTADD"
     exon            198..293
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            294..424
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            425..535
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            536..837
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            838..958
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1108
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1261
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2098
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2174
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2279
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2455
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2662
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2744
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2938
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3098
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3256
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3360
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3500
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3827
                     /gene="Dhx30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctcat gcgccgtgca ccgaggcttg tttcacatct gtaacaacag gaggcccagc
       61 ctcgtgatga ggaatagcaa ggagagaatt cagctccagt tcgaaagcct gcaaaatctg
      121 agcccctcac tgcttttata aggattccag ctttctctcc tggccagaaa tgttcaccct
      181 ggactcattc agaaaagatc ggacccagca caggcagcgt caatgcaagc ttcccccacc
      241 ccgccttcca cccatgtgtg tcaaccctgc ccctggaggg accatctctc gagcttctag
      301 ggacctatta aaagagtttc cacagcctaa aaaccttctc aacagcgtga ttggaagagc
      361 tcttggcatc tcacatgcaa aagacaagct agtctatgtg cacacgaatg gaccgaagaa
      421 aaagaaagtc acactgcaca taaagtggcc caagagcgtg gaggtggaag gctatggcag
      481 caagaagatc gatgccgagc ggcaggcggc ggcggcagcc tgccaactct tcaagggctg
      541 gggtctcctg ggtccacgga atgagctgtt tgatgcagcc aaatatcgag tgctagctga
      601 tcgttttgga tctccagctg acagctggtg gcgcccagaa cccaccatgc ctccaacttc
      661 ctggcggcag ctgaatcctg agaacatacg gccagcgggt actggaggac tgtcccgatc
      721 cttaggccga gaggaagagg aggatgagga ggaagagcta gaagagggga ccattgatgt
      781 gacggagttt ttgtccatga cccagcaaga ctcccacaac ccactcaggg actcaagggg
      841 gggctccttt gaaatgacag atgatgacag tgctattaga gctctgaccc agtttccact
      901 tcccaagaac cttctggcca aagtgattca gattgcaaca tcttcctcca cagctaagaa
      961 cctcatgcag ttccatactg tgggtaccaa gaccaagctg gctacactca ctctgctctg
     1021 gccctgtccc atgacctttg tcgccaaagg gcgccgcaaa gctgaggctg agaataaggc
     1081 agcagccttg gcttgcaaga aactgaagag cctgggcctt gtggacagaa acaatgagcc
     1141 acttacccat gccatgtaca acctggcttc cctgcgtgag ttgggtgaga cccagcgccg
     1201 gccatgtacc atccaggtgc ctgagcccat ccttcgcaag atagaggcct tcctgagtca
     1261 ttacccggtg gacagttcat ggatttcccc agaactccgg ctgcagagtg atgacatctt
     1321 gcccttaggc aaggactcag ggcccttgag tgaccctatc acaggcaagc catacatgcc
     1381 cctgtcagaa gcagaggagg tgcgcctgag ccagagcctg ctagagctgt ggcggaggag
     1441 agggccaatc tggcaggagg ccccccagct acctgtggac cctcatcggg acactatcct
     1501 cagtgccatt gaacaacacc cagtggtagt catctctggg gacacaggct gtgggaagac
     1561 cacgcgtatc cctcagctgc tattggagcg ctatgtgact gagggtcgag gtgcccgctg
     1621 caatgtgatc atcacacaac ctcgccgaat ctcagctgtg tctgtggccc agcgggtcag
     1681 ccatgaactg ggaccctcct tgcgccggaa tgtgggcttc caggtacgct tggaaagcaa
     1741 gcctccagcc cgaggtgggg cgctgctctt ctgcactgtg ggtatcctgc ttcgaaagct
     1801 gcagagcaac cccagcctgg agggtgtgag ccacgtcatt gtggatgagg tccatgagcg
     1861 ggatgtgaac acagacttcc tgctgattct gctcaagggc ctgcagcggc tcaacccagc
     1921 ccttcggctg gtgctcatga gtgctacagg agataatgag cgcttttccc ggtactttgg
     1981 gggctgccct gtcatcaagg tacctggctt catgtatcct gtcaaggaac actacctaga
     2041 ggacatcttg gccaagctgg gtaaacacca gtacccacac cggcaccggc accatgagtc
     2101 tgaagatgag tgtgcacttg atttggacct tgtgactgat ctggttctgc acatcgatgc
     2161 ccgtggggaa ccaggtggga tcctgtgctt tctgcctggt tggcaagaaa tcaaaggagt
     2221 gcaacagcgg ctgcaggaag ccctgggcat gcatgagagc aagtacctta tcctaccagt
     2281 gcactccaat atccccatga tggaccagaa ggccatattc caacagcctc cacttggggt
     2341 gcgcaagatt gtattggcca ccaacattgc tgaaacctcc atcacagtta acgacatcgt
     2401 gcatgtcgtg gacagcggtc tgcacaaaga agaacgctat gacctgaaga ccaaggtgtc
     2461 ctgcctggag accgtgtggg tgtcgagagc aaatgtgatt cagcgccggg gcagggcagg
     2521 ccgctgccag tcaggttttg cctaccactt gttcccgagg agccggctgg agaaaatggt
     2581 tcctttccaa gtgccagaga tcctgcgcac acctcttgag aacctggtgc tgcaagccaa
     2641 aatccacatg cctgagaaga cggcagtgga gttcctctct aaggctgtgg acagtccaaa
     2701 tatcaaggca gtggatgagg ccgtgatact gctccaggag attggggtgc tggaccagcg
     2761 ggagtacctg actaccttgg ggcagcgcct ggcccacatc tctactgatc cccgactggc
     2821 caaggccata gtgttggctg ccatcttccg ttgcctgcac ccactgctgg tggttgtttc
     2881 ctgccttacc cgggacccct tcagcagcag tttgcagaac cgggcagagg tagacaaggt
     2941 gaaggcattg ctgagccatg acagtggcag tgaccatttg gccttcgtgc gggctgtggc
     3001 tggctgggag gaggtactgc gctggcagga ccgtacctcc agggaaaact acctggaaga
     3061 aaaccttctg tatgccccca gcttgcgctt catccacggg ctcatcaagc agttctcaga
     3121 gaatatttac gaggccttcc tagtgggaaa gccctctgac tgcacactgc cctctgctca
     3181 gtgcaatgag tacagcgagg aagaggagct ggtgaagggt gtgctgatgg ctggcctcta
     3241 ccccaacctc atccaggtga ggcaaggtaa ggttactcgg caaggcaagt tcaaacccaa
     3301 cagtgtcact tacaggacca aatctggcaa catcttgctg cacaagtcaa ccattaacag
     3361 ggaggccacc cggttacgga gccgatggct gacatatttc atggccgtca agtccaatgg
     3421 tagcgtcttt gttcgagatt cttcccaggt gcacccacta gctgtgttgc tcctaacaga
     3481 tggggacgtg cacattcgag atgacggacg tcgggccacc atttcactga gtgacagtga
     3541 cctgctgcgg ctggaaggtg attcacgaac tgtgcggttg ctaagggagc ttcggcgggc
     3601 cctaggaagg atggtggagc ggagcctccg cagcgagctg gctgcacttc ctcttagtgt
     3661 gcagcaagaa cacgggcagc tgcttgcact gctggcagag ctactgcggg gaccttgtgg
     3721 cagctttgac gtgcgcaaga cagctgatga ctgagcccct cttccgctgg ggctatgtac
     3781 agagtgcaaa tgtttattta aaataaagtt atatttatcc cttgtgaaaa aaaaaaaaaa
     3841 aaaaaaaaaa aaa
//
