LOCUS       NM_212496               3357 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DEAH-box helicase 16 (Dhx16), mRNA.
ACCESSION   NM_212496 XM_215306
VERSION     NM_212496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3357)
  AUTHORS   Zhang X, Yan C, Zhan X, Li L, Lei J and Shi Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   2  (bases 1 to 3357)
  AUTHORS   Zang S, Lin TY, Chen X, Gencheva M, Newo AN, Yang L, Rossi D, Hu J,
            Lin SB, Huang A and Lin RJ.
  TITLE     GPKOW is essential for pre-mRNA splicing in vitro and suppresses
            splicing defect caused by dominant-negative DHX16 mutation in vivo
  JOURNAL   Biosci Rep 34 (6), e00163 (2014)
   PUBMED   25296192
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3357)
  AUTHORS   Chang TH, Tung L, Yeh FL, Chen JH and Chang SL.
  TITLE     Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing
  JOURNAL   Biochim Biophys Acta 1829 (8), 764-774 (2013)
   PUBMED   23454554
  REMARK    Review article
REFERENCE   4  (bases 1 to 3357)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3357)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3357)
  AUTHORS   Gencheva M, Kato M, Newo AN and Lin RJ.
  TITLE     Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing
  JOURNAL   Biochem J 429 (1), 25-32 (2010)
   PUBMED   20423332
REFERENCE   7  (bases 1 to 3357)
  AUTHORS   Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M and Furuichi Y.
  TITLE     Cloning and characterization of a human DEAH-box RNA helicase, a
            functional homolog of fission yeast Cdc28/Prp8
  JOURNAL   Nucleic Acids Res 26 (9), 2063-2068 (1998)
   PUBMED   9547260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883048.1.
            
            On Oct 16, 2009 this sequence version replaced NM_212496.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               BX883048.1         99480-99821
            343-584             BX883048.1         101174-101415
            585-750             BX883048.1         101521-101686
            751-807             BX883048.1         101898-101954
            808-1062            BX883048.1         102461-102715
            1063-1266           BX883048.1         102823-103026
            1267-1461           BX883048.1         103108-103302
            1462-1572           BX883048.1         103884-103994
            1573-1688           BX883048.1         104104-104219
            1689-1899           BX883048.1         105438-105648
            1900-1998           BX883048.1         105823-105921
            1999-2151           BX883048.1         106028-106180
            2152-2292           BX883048.1         107457-107597
            2293-2455           BX883048.1         107752-107914
            2456-2574           BX883048.1         108009-108127
            2575-2642           BX883048.1         108272-108339
            2643-2805           BX883048.1         109328-109490
            2806-2967           BX883048.1         109569-109730
            2968-3141           BX883048.1         110838-111011
            3142-3357           BX883048.1         112212-112427
FEATURES             Location/Qualifiers
     source          1..3357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3357
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /note="DEAH-box helicase 16"
                     /db_xref="GeneID:294232"
                     /db_xref="RGD:1302963"
     exon            1..342
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3270
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /EC_number="3.6.4.13"
                     /note="putative pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX16; DEAH (Asp-Glu-Ala-His) box polypeptide 16"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ATP-dependent RNA
                     helicase DHX16"
                     /protein_id="NP_997661.1"
                     /db_xref="GeneID:294232"
                     /db_xref="RGD:1302963"
                     /translation="MATPAGLERWVQEELHSVLGLSERHVAQFLIGTAQRCASAEEFV
                     QRLRDTETLDLGGPARDFALKLWSKVPRKAVVEKPARAAEREARALLEKNRSYKLLED
                     SESGEEAVARDGSSLQKKRKRRKHLRKKQQEEEEEEEEASESGKRKTGGSKSPTEEKP
                     ASEDEWERTERERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAE
                     EDRKAMVPELRKKSRREYLAKREREKLEDLEAELADEEVLFGDVELSRHERRELKYKR
                     RVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARATDIVEEESGAPGEEQRRWEEA
                     RLDAASLKFGARDAAAQEPQYQLVLEEDETIEFVRAAQLQGDEEPSSGPPLSAQAQQK
                     ESIQAVRRSLPVFPFREELLTAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTKKGMK
                     IACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREF
                     LSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLDTARFSAF
                     FDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEI
                     EAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAET
                     SLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRL
                     YTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQ
                     LYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSI
                     FYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRA
                     RDVREQLEGLLERVEVGLTSCQGDYVRVRKAITSGYFYHTARLTRSGYRTVKQQQTVF
                     IHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKELEDPHAK
                     KMPKKVGKTREELG"
     exon            343..584
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            585..750
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            751..807
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1062
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1266
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1461
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1572
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1688
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1899
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1998
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2151
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2292
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2455
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2574
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2642
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2805
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2967
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3141
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3357
                     /gene="Dhx16"
                     /gene_synonym="Dbp2; Ddx16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactacccaa tcttgcactg tggacgaggt gtctataccg cagccagtgc gaggccgtgg
       61 cacctcaggc ctcttctggc cccgccgcag tcctggccgt tccgcggttg cttgcccaga
      121 gcgagacgcg tcgccatggc gacgccggcg ggactggagc ggtgggtgca ggaggagctg
      181 cactcggtgc tggggctgag cgagcggcac gtcgcgcagt tcctgatcgg cacggcgcag
      241 cgctgcgcct ccgccgagga gtttgtgcag cgcttgcgtg acacagagac cctggacctc
      301 ggcgggccgg cgcgggactt cgcgctgaag ctctggagca aggtgccacg gaaggccgtg
      361 gttgaaaagc cagctcgtgc agctgagcga gaggcccgag ccctgctgga gaagaaccga
      421 tcttataaat tgttggagga cagcgagagc ggagaggaag cagtggccag ggacgggagc
      481 agcctccaga agaagcggaa gagacggaaa cacctgagga agaaacagca ggaggaggag
      541 gaggaggagg aggaagcctc tgagtcaggg aagaggaaga cagggggcag taaatcaccc
      601 acggaggaga agccagcctc agaggatgag tgggagagaa cagaacgtga gcgtctccag
      661 gacttggagg aacgggatgc ctttgcagag cgggttcggc aacgagacaa ggaccggacc
      721 cggaatgttc tggagcggtc agataagaag gcttatgaag aggctcagaa gcgcctcaag
      781 atggctgagg aagaccggaa agccatggtc cctgagctcc gtaagaagtc tcgtcgggaa
      841 tacctggcaa agcgggagcg ggaaaagctg gaggacctgg aggcagaact ggctgatgag
      901 gaggtcctgt ttggggacgt ggagctgagc cgccatgagc gccgggagct caagtacaag
      961 cggcgtgtgc gggacctggc tcgggagtac cgggcggctg gcgagcagga gaagctggag
     1021 gccactaatc gctaccacat gcccaaggag actcgaggac agcccgctcg agccaccgac
     1081 atcgtcgagg aggaatcagg ggccccgggc gaggagcagc ggcgctggga ggaggcccgt
     1141 ctggacgccg catccctcaa gtttggggcc cgagacgctg ctgcccagga accccagtac
     1201 cagctggtgc tggaggagga cgagaccatc gagttcgtcc gtgccgctca gctccagggc
     1261 gacgaggagc cgtcatcagg cccgcccctg tcagcccagg cccagcagaa ggagtccatc
     1321 caggccgtgc gccgcagcct gccagtgttc cccttccgag aggagctcct gaccgccatt
     1381 gccaaccatc aggtcctcat catcgagggc gagactgggt cagggaagac cacacagatc
     1441 ccacagtacc tctttgagga gggttacacc aagaagggta tgaagattgc ttgcacccag
     1501 ccccggagag tggcggccat gagtgtggca gcccgagtgg cccgggagat gggggtgaag
     1561 cttgggaatg aggtgggcta cagcatccgg tttgaggact gcacatcaga gcgaactgtt
     1621 ctccgctaca tgacagatgg aatgctactc cgggagttcc tctctgagcc tgacctcgca
     1681 agttacagtg tggtgatggt ggatgaagct catgagcgga ccttgcacac agacattctc
     1741 tttggattga tcaaagatgt tgctagattc cgacctgagc tcaaggtcct ggtggcttcg
     1801 gccacactgg acactgctcg tttttctgcc ttcttcgatg atgcccctgt cttccgaatc
     1861 cctggacgca ggtttccagt tgacatcttc tataccaagg ccccagaggc tgactacctg
     1921 gaagcctgtg tggtgtctgt gctgcagatc catgtgaccc agccccctgg ggatatactg
     1981 gtgttcctaa cgggacagga ggagattgag gctgcctgcg agatgctcca ggaccgctgc
     2041 cgcagactgg gctccaagat ccgggagctc ctggtgttgc ccatttacgc caacctgccc
     2101 tccgacatgc aggctcgaat cttccagccc acgccccccg gggcccggaa ggtggttgtg
     2161 gcaacaaaca ttgcagaaac ttccctcacc atcgaaggca tcatttatgt gctggatcca
     2221 gggttctgca agcagaagag ctacaaccct cgaacaggca tggagtcgct caccgtcaca
     2281 ccctgcagca aggcttcagc caatcagcgg gccggccgcg caggtcgagt ggctgcaggg
     2341 aagtgcttcc gcctgtatac agcctgggcc taccagcatg agctggagga gaccacagtt
     2401 cctgagatcc agaggactag cctgggcaat gtggtgctcc tgctaaagag cttagggatc
     2461 cacgacctga tgcactttga ctttctggac ccgccaccat atgagaccct gctgctggct
     2521 ttggaacaac tttatgcact tggcgccctc aaccaccttg gagagctcac tacgtctggt
     2581 cgaaagatgg cagagctgcc cgtggatcct atgttgtcta aaatgatctt ggcctctgag
     2641 aagtatagct gttcagaaga gatcctgacc gtggctgcta tgctgtctgt caacaattcc
     2701 atcttctacc ggcccaagga caaggttgtc catgctgaca acgcccgtgt caacttcttc
     2761 ctccctggtg gggaccacct ggttctgctg aatgtgtaca cgcagtgggc agagagcggc
     2821 tactcttccc agtggtgcta tgaaaatttc gtacagttca gatccatgcg ccgagcccgg
     2881 gatgtgcggg aacaactaga ggggctcttg gagcgcgtgg aagttggctt gacttcctgc
     2941 caaggtgact acgttcgtgt gcgaaaggcc atcacttcag gttattttta ccacacagca
     3001 aggctgactc ggagtggcta ccgcacagtg aagcagcagc agacagtgtt tattcatccc
     3061 aactcctctc tctttgaaca acagccacgc tggctgctct accatgagct tgtcttgacc
     3121 accaaggagt tcatgagaca ggtattggag atcgaaagca gctggctttt ggaagtggct
     3181 ccccactact ataaggccaa ggagctagaa gatccccatg ctaagaaaat gcccaaaaaa
     3241 gttggcaaga cacgagaaga gctgggttag acagtgacat ggactgtgcc tcacagctct
     3301 ttttttcctt ccatacttta tttaatatct agtaaataaa attatttttg gaatgaa
//
