LOCUS       NM_130819               1633 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus dehydrogenase/reductase 9 (Dhrs9), mRNA.
ACCESSION   NM_130819
VERSION     NM_130819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Napoli,J.L.
  TITLE     Physiological insights into all-trans-retinoic acid biosynthesis
  JOURNAL   Biochim Biophys Acta 1821 (1), 152-167 (2012)
   PUBMED   21621639
  REMARK    Review article
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Wang,C., Kane,M.A. and Napoli,J.L.
  TITLE     Multiple retinol and retinal dehydrogenases catalyze
            all-trans-retinoic acid biosynthesis in astrocytes
  JOURNAL   J Biol Chem 286 (8), 6542-6553 (2011)
   PUBMED   21138835
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Everts,H.B., Sundberg,J.P. and Ong,D.E.
  TITLE     Immunolocalization of retinoic acid biosynthesis systems in
            selected sites in rat
  JOURNAL   Exp Cell Res 308 (2), 309-319 (2005)
   PUBMED   15950969
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Rexer,B.N. and Ong,D.E.
  TITLE     A novel short-chain alcohol dehydrogenase from rats with retinol
            dehydrogenase activity, cyclically expressed in uterine epithelium
  JOURNAL   Biol Reprod 67 (5), 1555-1564 (2002)
   PUBMED   12390888
  REMARK    GeneRIF: This novel short-chain alcohol dehydrogenase is an
            excellent candidate for the retinol dehydrogenase that catalyzes
            the first step in retinoic acid biosynthesis that occurs in uterine
            epithelial cells
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Soref,C.M., Di,Y.P., Hayden,L., Zhao,Y.H., Satre,M.A. and Wu,R.
  TITLE     Characterization of a novel airway epithelial cell-specific short
            chain alcohol dehydrogenase/reductase gene whose expression is
            up-regulated by retinoids and is involved in the metabolism of
            retinol
  JOURNAL   J Biol Chem 276 (26), 24194-24202 (2001)
   PUBMED   11304534
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Chetyrkin,S.V., Belyaeva,O.V., Gough,W.H. and Kedishvili,N.Y.
  TITLE     Characterization of a novel type of human microsomal 3alpha
            -hydroxysteroid dehydrogenase: unique tissue distribution and
            catalytic properties
  JOURNAL   J Biol Chem 276 (25), 22278-22286 (2001)
   PUBMED   11294878
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_130819.3.
            
            On Nov 26, 2020 this sequence version replaced NM_130819.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337953.1, SRR8487227.115588.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JACYVU010000115.1  47604655-47604801
            148-479             JACYVU010000115.1  47617840-47618171
            480-738             JACYVU010000115.1  47619318-47619576
            739-902             JACYVU010000115.1  47622831-47622994
            903-1633            JACYVU010000115.1  47626143-47626873
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1633
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /note="dehydrogenase/reductase 9"
                     /db_xref="GeneID:170635"
                     /db_xref="RGD:620655"
     exon            1..147
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            148..479
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1126
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="3alpha-HSD; 3-alpha hydroxysteroid dehydrogenase;
                     short-chain dehydrogenase/reductase retSDR8;
                     dehydrogenase/reductase (SDR family) member 9;
                     3-alpha-HSD; retinol dehydrogenase homolog"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 9
                     precursor"
                     /protein_id="NP_570832.1"
                     /db_xref="GeneID:170635"
                     /db_xref="RGD:620655"
                     /translation="MLLWVLALLFLCAFLWNYKGQLKIADIADKYIFITGCDSGFGNL
                     AARTFDRKGFRVIAACLTESGSEALKAKTSERLHTVLLDVTNPENVKETAQWVKSHVG
                     EKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVI
                     NVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTGLADPIK
                     TTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSSTSSVNLDLSLVVECMDHALTSLF
                     PKTRYTAGKDAKTFWIPLSHMPAALQDFLLLKEKVELANPQAV"
     exon            480..738
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            739..902
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1633
                     /gene="Dhrs9"
                     /gene_synonym="Rdhl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagctccg cagaagccct ggcaccttga gaggagcagt ttgatcgagc tgcacttcct
       61 tcccctggcc actacaggaa ggtgacaatc agcagccagc agagcaagtc accctcagct
      121 tctgcactcc aagccatctt cagcgaggac atacaggaaa aagaaaatgc tgctttgggt
      181 gttggccctc ctgttcctct gcgcttttct gtggaattat aaagggcagc tgaagatagc
      241 agacatcgct gacaagtaca ttttcatcac tggatgtgac tcaggcttcg gaaacttagc
      301 agccagaact tttgatagaa aaggcttccg tgtcattgct gcctgcctga ctgagtcagg
      361 atcagaggct ttgaaggcca aaacctcaga gagacttcac acagtgcttc tggatgtcac
      421 caacccagag aatgtcaagg agactgccca gtgggtgaag agccacgtag gagaaaaagg
      481 tctctggggt ctgatcaata atgctggtgt tcttggcgta ctggctccca ctgactggct
      541 gacagtggac gactacagag aacccattga agttaacctg tttggactca tcaacgtgac
      601 gctgaatatg cttccactgg tcaaaaaagc tcgagggcgt gttattaatg tctccagcat
      661 tggaggccga cttgcatttg gtggcggggg ctatactcca tccaagtatg cagtggaagg
      721 tttcaatgac agcttaaggc gggacatgaa agcttttgga gtgcacgtct catgcattga
      781 accagggctg ttcaaaacag gactggcaga tccaataaag acaactgaaa agaagctcgc
      841 catttggaaa catctgtctc cagacatcaa acaacaatat ggagagggct acattgaaaa
      901 aagtctacac agactgaaaa gcagtacctc ctctgtgaac ctggacctct ctctagtggt
      961 agagtgcatg gatcacgctc taacaagtct cttccccaag actcgataca ctgctggaaa
     1021 ggatgccaag acattttgga tacctctgtc tcacatgccg gcagctttac aagacttttt
     1081 actgttgaaa gagaaagtag agctggccaa tccccaagct gtgtgactca actctccaca
     1141 aatggctccc cccccccccc ggcttcgaga ctggctgact tcagagacgt agtacctgga
     1201 tctcgttctt taccagagcc aactgagact cagatagacc aggtttctgt ttttaaacga
     1261 agatattcca tggtcccttc tcaagtcttc ttcaggaaga aggacaggga gggcctatca
     1321 caaaagccag tctcgccgga tactgacact ttgcctgact gggaagatag aagagaaatt
     1381 gaaagacttc tccatccaaa ataggtgtgc tgctgcctgt cccttgctgg ttcagtaatc
     1441 tagagtatta agcattgtct cttatcaaaa tgttaagcag taagaagtct ttcataagtg
     1501 gatctgatgg ctttgttatc tggcagagac tcaggctggg actcaccacg ttctgataag
     1561 tttgaataag aatgagaaag agagaaaagg tactattaac cagggcacta gtattaactg
     1621 agaggtggct aga
//
