LOCUS       NM_153315               1400 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dehydrogenase/reductase 4 (Dhrs4), mRNA.
ACCESSION   NM_153315
VERSION     NM_153315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Gabrielli,F. and Tofanelli,S.
  TITLE     Molecular and functional evolution of human DHRS2 and DHRS4
            duplicated genes
  JOURNAL   Gene 511 (2), 461-469 (2012)
   PUBMED   23036705
  REMARK    GeneRIF: R. norvegicus DHRS2 and DHRS4 genes are syntenic
            outparalogs that originated from a duplication of the DHRS4 gene
            that took place before the formation of the mammalian clade. R.
            norvegicus genes are orthologs of human DHRS2 and DHRS4 genes
            respectively.
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Su,Z., Li,R., Song,X., Liu,G., Li,Y., Chang,X., Li,C. and Huang,D.
  TITLE     Identification of a novel isoform of DHRS4 protein with a nuclear
            localization signal
  JOURNAL   Gene 494 (2), 161-167 (2012)
   PUBMED   22227495
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Matsunaga,T., Arakaki,M., Kamiya,T., Endo,S., El-Kabbani,O. and
            Hara,A.
  TITLE     Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of
            9,10-phenanthrenequinone leading to apoptosis in human endothelial
            cells
  JOURNAL   Chem Biol Interact 181 (1), 52-60 (2009)
   PUBMED   19442656
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Tanaka,N., Aoki,K., Ishikura,S., Nagano,M., Imamura,Y., Hara,A. and
            Nakamura,K.T.
  TITLE     Molecular basis for peroxisomal localization of tetrameric carbonyl
            reductase
  JOURNAL   Structure 16 (3), 388-397 (2008)
   PUBMED   18334214
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Song,X.H., Liang,B., Liu,G.F., Li,R., Xie,J.P., Du,K. and
            Huang,D.Y.
  TITLE     Expression of a novel alternatively spliced variant of
            NADP(H)-dependent retinol dehydrogenase/reductase with deletion of
            exon 3 in cervical squamous carcinoma
  JOURNAL   Int J Cancer 120 (8), 1618-1626 (2007)
   PUBMED   17230527
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Lei,Z., Chen,W., Zhang,M. and Napoli,J.L.
  TITLE     Reduction of all-trans-retinal in the mouse liver peroxisome
            fraction by the short-chain dehydrogenase/reductase RRD: induction
            by the PPAR alpha ligand clofibrate
  JOURNAL   Biochemistry 42 (14), 4190-4196 (2003)
   PUBMED   12680773
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Fransen,M., Van Veldhoven,P.P. and Subramani,S.
  TITLE     Identification of peroxisomal proteins by using M13 phage protein
            VI phage display: molecular evidence that mammalian peroxisomes
            contain a 2,4-dienoyl-CoA reductase
  JOURNAL   Biochem J 340 (Pt 2) (Pt 2), 561-568 (1999)
   PUBMED   10333503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070961.1.
            
            [WARNING] On Aug 15, 2024 this sequence was replaced by
            NM_153315.3.
            
            On Oct 3, 2005 this sequence version replaced NM_153315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070961.1, AB062758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              BC070961.1         1-1400
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1400
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /note="dehydrogenase/reductase 4"
                     /db_xref="GeneID:266686"
                     /db_xref="RGD:708482"
     exon            1..258
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..967
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /EC_number="1.1.1.184"
                     /EC_number="1.1.1.300"
                     /note="CR; NDRD; PHCR; dehydrogenase/reductase (SDR
                     family) member 4; peroxisomal short-chain alcohol
                     dehydrogenase; NADPH-dependent retinol
                     dehydrogenase/reductase; NADPH-dependent carbonyl
                     reductase/NADP-retinol dehydrogenase; DCR-AKL; short chain
                     dehydrogenase/reductase family 25C member 2"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 4"
                     /protein_id="NP_695227.2"
                     /db_xref="GeneID:266686"
                     /db_xref="RGD:708482"
                     /translation="MQKAGLLLRGWTRAWKSVRMASSGLTRQNPLANKVALVTASTDG
                     IGLAIARRLAEDGAHVVISSRKQQNVDRAVATLQGEGLSVTGVVCHVGKAEDREKLVN
                     MALKLHQGIDILVSNAAVNPFFGNLMDVTEEVWNKVLSINVTASAMMIKAVVPAMEKR
                     GGGSVVIVSSVAGFVLFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKT
                     HFSSVLWKEKAREEMIKETMQIRRLGKPEDCVGIVSFLCSEDASYINGETVVVGGGTP
                     SRL"
     exon            259..436
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            437..538
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            539..609
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            610..661
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            662..796
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            797..852
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1372
                     /gene="Dhrs4"
                     /gene_synonym="PSCD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggagcgg gtcctggaag cgtagcaggc tgtccaggga ggcaggacgc tcgcagctag
       61 accagcctcc tgtcctttga acgtcccctc ccctagcaga gttcaaccca gcttccggat
      121 ctgaactatg cagaaagcgg gactgctgtt aagaggctgg actcgagcgt ggaagtcggt
      181 gaggatggcc agttccgggc tgactcgcca gaacccactc gcgaataagg tggccctggt
      241 cacagcctcc accgacggga ttggccttgc catcgcccgg cgtctggctg aggacggggc
      301 ccacgtggtc atcagcagcc gcaaacagca gaatgtggac cgtgcagtgg ccacactcca
      361 gggagaggga ctgagtgtta ctggcgtcgt gtgccatgtg gggaaggcag aggatcgaga
      421 aaagctggta aacatggctc tgaagcttca ccaagggatt gatatcctgg tctccaatgc
      481 tgctgtcaac cctttctttg gaaatctaat ggacgtcaca gaggaggtgt ggaacaaggt
      541 tttgagcatt aatgtgacag cttcagcaat gatgattaag gcggtggtgc cagcgatgga
      601 aaaacgagga ggcggctcgg tggtgattgt gagttccgta gcaggcttcg ttctattccc
      661 ttctctgggc ccttacaatg ttagcaaaac agctttgctg ggtctcacta agaactttgc
      721 cgcagagttg gccccaaaga acattcgagt gaactgcttg gcacctggac tcatcaagac
      781 tcacttcagc agtgtgttgt ggaaggagaa agcaagagaa gaaatgataa aagaaaccat
      841 gcaaattaga aggctaggca agccagagga ttgtgtcggt atagtttcct tcttgtgctc
      901 tgaagatgcc agttacatca atggcgagac agtagtggtt gggggaggaa ccccttctcg
      961 cctctgagga cctagagaca gcctaccagg gcaagtgtgt ggggagggtg cactccacct
     1021 tgtctctgtc gcccttcctt gccaccgcca acatcttgtt cacctcacaa aatcagctct
     1081 gcccagtgtt aagttcctgc tttccgtgtg gtcaaagtgt ggtcagatga gcatcctcgc
     1141 tgttgctatg gccctgaaaa gggctttggg gagggggcgg ggagctaggg gataggtagt
     1201 ggaaacgggg cttgctgaga agactgtggc tactttagtg aagatcaaat ccctctcatt
     1261 ctcgtctctg gagactttaa agggagatag aaggaacgga cctgaacaga gatggaaatt
     1321 aacaatttac aaatacggta caaataaaat gaagatgatc gcgttggtct gaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa
//
