LOCUS       NM_001037199            1685 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dehydrogenase/reductase 3 (Dhrs3), mRNA.
ACCESSION   NM_001037199
VERSION     NM_001037199.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Billings,S.E., Pierzchalski,K., Butler Tjaden,N.E., Pang,X.Y.,
            Trainor,P.A., Kane,M.A. and Moise,A.R.
  TITLE     The retinaldehyde reductase DHRS3 is essential for preventing the
            formation of excess retinoic acid during embryonic development
  JOURNAL   FASEB J 27 (12), 4877-4889 (2013)
   PUBMED   24005908
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Zolfaghari,R., Chen,Q. and Ross,A.C.
  TITLE     DHRS3, a retinal reductase, is differentially regulated by retinoic
            acid and lipopolysaccharide-induced inflammation in THP-1 cells and
            rat liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 303 (5), G578-G588 (2012)
   PUBMED   22790594
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107450.1.
            
            On Jun 10, 2007 this sequence version replaced NM_001037199.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107450.1, EF125189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1685
                     /gene="Dhrs3"
                     /note="dehydrogenase/reductase 3"
                     /db_xref="GeneID:313689"
                     /db_xref="RGD:1305584"
     exon            1..494
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1208
                     /gene="Dhrs3"
                     /EC_number="1.1.1.300"
                     /note="retinal dehydrogenase/reductase family member 3;
                     dehydrogenase/reductase (SDR family) member 3;
                     dehydrogenase/reductase member 2"
                     /codon_start=1
                     /product="short-chain dehydrogenase/reductase 3"
                     /protein_id="NP_001032276.3"
                     /db_xref="GeneID:313689"
                     /db_xref="RGD:1305584"
                     /translation="MVWKWLGALVVLPLQMIYLVTKAAVGLVLPPKLRDLSRESVLIT
                     GGGRGIGRHLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREE
                     VYQMAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHVNTLGQFWTTKAFLP
                     RMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVL
                     PFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQQNQALLLLPWTMNILIILKSI
                     LPQAALEEIHRFSGTYTCMNTFKGRT"
     exon            495..638
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..758
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..997
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1123
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1637
                     /gene="Dhrs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcccaatc ttctgagacg cttttttcct ctcaaccaga gcagagtttt ttgttttttg
       61 ttttttttct ttttcttgtt cttctttttc cccccatttt tcctcgccca gtcctttgca
      121 tctggaaaga gatcagttca aggttggcca ggtgggacgc ctctttttct ttatttagtt
      181 tattattgtt tgggggtgtt tctttctttc cttttttaat tcctgttttg cttagtccgg
      241 ggagttttgt ccaccgcctc ctacctcctc cccctgtgcc cggctccgcc gcgcggagga
      301 tggtgtggaa atggctgggc gcgctggtag tgctccctct gcaaatgatc tatctggtaa
      361 ccaaagcagc cgtgggactg gtgttgcccc ccaagcttcg ggacttgtcg cgggagtcag
      421 tcctcatcac cggcggtggg agaggcatcg gacgccacct cgctcgggag ttcgcagagc
      481 gtggcgccag aaagattgtt ctctggggcc ggactgagaa gtgcctgaag gagacaacag
      541 aggagattcg gcagatgggc acagagtgcc actacttcat ctgtgatgtg ggcaaccggg
      601 aagaggtata ccagatggcc aaagctgtcc gagagaaggt gggtgacatc accatcctgg
      661 tgaacaatgc tgctgtggtc catgggaaaa gcttgatgga cagcgatgat gatgccctcc
      721 tcaagtccca gcatgtcaac accctgggcc aattctggac caccaaggcc ttcttgccac
      781 gtatgctgga gctccagaac ggccatattg tgtgcctcaa ttctgtgctt gcactgtcgg
      841 ccatccctgg cgccattgac tactgcacat caaaagcatc agccttcgcc ttcatggaga
      901 gcctgacctt ggggctgttg gactgtccgg gtgtcagcgc caccaccgtt ctaccctttc
      961 acaccagcac cgagatgttt cagggcatga gagtcaggtt tcccaacctc ttcccgccat
     1021 tgaagccaga gacagtagcc cggaggacag tggaagctgt gcaacaaaac caggcccttc
     1081 tcttgctccc atggaccatg aatatcctca ttatcttgaa aagcatactc ccgcaggctg
     1141 ccctggagga gatccacagg ttctcgggga cttacacctg tatgaacacc tttaagggga
     1201 ggacatagag gcaggaggaa gacacacctg aggagctatg gaacctgagg gggaaaccac
     1261 agcaactggg cacacaccca tgtgcctatt cgttggcaca tctgctgggt gagcaagact
     1321 gttcttgtcc cccagggaag attttgcagc tccccaggtc aactccagga cctttgtgca
     1381 ggactgatgg gtgtaaccct gacccccatg gggaggcaag aggccagcag ccacccaaca
     1441 actttgtaca tttctcattc tgtagggttt atcgtgaaat tgcttctcca gtctaacctg
     1501 cctgagcagt gtgcatctac tatttccagg agagtctgcc cccagacact ctgcctttcc
     1561 ctccacaacc ctctcattcc cagctcatgc aaactggtca cgcggcagga atgcgaaata
     1621 aagaggtggc tttcgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaa
//
