LOCUS       NM_001008553            1535 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Rattus norvegicus dihydroorotate dehydrogenase (Dhodh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001008553 XM_341685
VERSION     NM_001008553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Schaefer,Ch.M., Schafer,M.K. and Lofflerr,M.
  TITLE     Region-specific distribution of dihydroorotate dehydrogenase in the
            rat central nervous system points to pyrimidine de novo synthesis
            in neurons
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 29 (4-6), 476-481 (2010)
   PUBMED   20544541
  REMARK    GeneRIF: High levels of both DHODH activity and immunoreactivity
            were observed in the neocortex, hippocampus, spinal cord and
            choroid plexus; lower levels were seen in the cerebellum, and only
            marginal expression in brainstem
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Loffler,M., Klein,A., Hayek-Ouassini,M., Knecht,W. and Konrad,L.
  TITLE     Dihydroorotate dehydrogenase mRNA and protein expression analysis
            in normal and drug-resistant cells
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 23 (8-9), 1281-1285 (2004)
   PUBMED   15571246
  REMARK    GeneRIF: Dihydroorotate dehydrogenase mRNA and protein expression
            analysis in normal and drug-resistant cells of different species
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Evans,D.R. and Guy,H.I.
  TITLE     Mammalian pyrimidine biosynthesis: fresh insights into an ancient
            pathway
  JOURNAL   J Biol Chem 279 (32), 33035-33038 (2004)
   PUBMED   15096496
  REMARK    Review article
REFERENCE   4  (bases 1 to 1535)
  AUTHORS   Kim,K.S., Choi,Y.H., Kim,K.H., Lee,Y.C., Kim,C.H., Moon,S.H.,
            Kang,S.G. and Park,Y.G.
  TITLE     Protective and anti-arthritic effects of deer antler
            aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on
            phosphate ions-mediated chondrocyte apoptosis and rat
            collagen-induced arthritis
  JOURNAL   Int Immunopharmacol 4 (7), 963-973 (2004)
   PUBMED   15182735
REFERENCE   5  (bases 1 to 1535)
  AUTHORS   Spodnik,J.H., Wozniak,M., Budzko,D., Teranishi,M.A., Karbowski,M.,
            Nishizawa,Y., Usukura,J. and Wakabayashi,T.
  TITLE     Mechanism of leflunomide-induced proliferation of mitochondria in
            mammalian cells
  JOURNAL   Mitochondrion 2 (3), 163-179 (2002)
   PUBMED   16120318
REFERENCE   6  (bases 1 to 1535)
  AUTHORS   Kunjara,S., Sochor,M., Bennett,M., Greenbaum,A.L. and McLean,P.
  TITLE     Pyrimidine nucleotide synthesis in the rat mammary gland: changes
            in the lactation cycle and effects of diabetes
  JOURNAL   Biochem Med Metab Biol 48 (3), 263-274 (1992)
   PUBMED   1476792
REFERENCE   7  (bases 1 to 1535)
  AUTHORS   Lakaschus,G. and Loffler,M.
  TITLE     Differential susceptibility of dihydroorotate dehydrogenase/oxidase
            to Brequinar Sodium (NSC 368 390) in vitro
  JOURNAL   Biochem Pharmacol 43 (5), 1025-1030 (1992)
   PUBMED   1313236
REFERENCE   8  (bases 1 to 1535)
  AUTHORS   Kunjara,S., Sochor,M., Ali,M., Drake,A., Greenbaum,A.L. and
            McLean,P.
  TITLE     Pyrimidine nucleotide synthesis in the rat kidney in early diabetes
  JOURNAL   Biochem Med Metab Biol 46 (2), 215-225 (1991)
   PUBMED   1723607
REFERENCE   9  (bases 1 to 1535)
  AUTHORS   Minana,M.D., Portoles,M., Jorda,A. and Grisolia,S.
  TITLE     Lesch-Nyhan syndrome, caffeine model: increase of purine and
            pyrimidine enzymes in rat brain
  JOURNAL   J Neurochem 43 (6), 1556-1560 (1984)
   PUBMED   6149265
REFERENCE   10 (bases 1 to 1535)
  AUTHORS   Hassan,A.S. and Milner,J.A.
  TITLE     Alterations in liver nucleic acids and nucleotides in arginine
            deficient rats
  JOURNAL   Metabolism 30 (8), 739-744 (1981)
   PUBMED   6167833
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008553.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X80778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000019.1  54482689-54482763   c
            76-288              JAXUCZ010000019.1  54480580-54480792   c
            289-488             JAXUCZ010000019.1  54478311-54478510   c
            489-571             JAXUCZ010000019.1  54476323-54476405   c
            572-759             JAXUCZ010000019.1  54471024-54471211   c
            760-873             JAXUCZ010000019.1  54470603-54470716   c
            874-1027            JAXUCZ010000019.1  54469796-54469949   c
            1028-1187           JAXUCZ010000019.1  54469501-54469660   c
            1188-1535           JAXUCZ010000019.1  54468690-54469037   c
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1535
                     /gene="Dhodh"
                     /note="dihydroorotate dehydrogenase"
                     /db_xref="GeneID:65156"
                     /db_xref="RGD:68352"
     exon            1..75
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1242
                     /gene="Dhodh"
                     /EC_number="1.3.5.2"
                     /note="dihydroorotate dehydrogenase, mitochondrial;
                     dihydroorotate dehydrogenase (quinone), mitochondrial;
                     DHOdehase; dihydroorotate oxidase"
                     /codon_start=1
                     /product="dihydroorotate dehydrogenase (quinone),
                     mitochondrial precursor"
                     /protein_id="NP_001008553.1"
                     /db_xref="GeneID:65156"
                     /db_xref="RGD:68352"
                     /translation="MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPG
                     LQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGE
                     AVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRL
                     RARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTA
                     GLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGI
                     DGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGG
                     VSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGAD
                     HRR"
     exon            76..288
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            289..488
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            489..571
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            572..759
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            760..873
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1027
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1187
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1535
                     /gene="Dhodh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcccagttt tccaatggaa tgcaggcgga ggcgagctta gtggtagaag aagcatggcg
       61 tggagacagc tgagaaagcg ggccctggat gcagtcatca tccttggagg tggaggactt
      121 ctcttcacct cttacctgac ggccacaggg gatgaccatt tctatgctga gtacctgatg
      181 ccaggtctgc agaggctgct tgatccagag tcagcccacc ggctagctgt tcgagtcacc
      241 tccctggggc tccttcctcg agctacattt caggactctg acatgctgga agtgaaagtc
      301 ctgggccata aattccgaaa tccagtagga attgctgcag gatttgacaa gaacggcgaa
      361 gctgtggacg gactctacaa gctgggcttt ggtttcgttg aggtaggaag tgtcactccc
      421 cagcctcagg aaggaaaccc caggcctaga gtattccgtc tccccgagga ccaagctgtc
      481 attaacaggt atggattcaa cagccatggg ctctcggtgg tggaacacag gctacgggcc
      541 agacagcaga agcaggccca gctcactgca gatgggctgc ctcttggaat aaacctgggg
      601 aagaataaga cttcggagga tgctgctgca gactatgcag agggtgttcg aaccctgggc
      661 cccttggctg actacctggt ggtaaacgtg tccagcccca acactgctgg tctgaggagc
      721 ctacagggga agaccgaact gcgccacctg ctgtccaagg tgctgcagga gagggacgcc
      781 ttgaagggca cacggaagcc agcagtgctg gtgaagattg cccctgacct cacggcccag
      841 gacaaggagg acattgccag cgtggcgaga gagctgggca tcgatggact gattgtcaca
      901 aacaccacag tgagtcgccc tgttggtctc cagggtgctc tgcgctctga gacaggagga
      961 ctgagtggga agccactccg agatctgtcg actcagacca tccgggagat gtacgccctt
     1021 acccaaggca ggattcccat tatcggggtt ggtggtgtga gcagcggaca ggacgccttg
     1081 gagaagatcc aggcaggggc ctccctggtg cagctctaca cagccctcat cttcctggga
     1141 ccaccagtcg tggtcagggt caagcgtgaa ctagaggccc ttctaaaaga gcggggtttt
     1201 accacagtca cggatgccat tggagcagat catcggaggt gaccatacgt gccagaagtc
     1261 ccatccagat tgtgccttcc aactcaggtg agctgtgtga ctgcaccgtg agggaagagc
     1321 cgtctcaatc catgtccctt gaactgtggc ctggacggac tgcacaggcc agttgtgggc
     1381 atcactagcc agtgaagaac ttctctaatc acttgaggag accacaaatc ccattgtcac
     1441 tccctagatc taaatcctgg gattgatcag tatcagaagg acattggctt cttgggagga
     1501 aaaatcgtgg agaaaataaa gccatttaaa cctgt
//
