LOCUS       NM_053367               2479 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus desert hedgehog signaling molecule (Dhh), mRNA.
ACCESSION   NM_053367 XM_001062733 XM_343327
VERSION     NM_053367.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Yoshida,T., Takizawa,N., Matsuda,T., Yamada,H., Kitada,M. and
            Tanaka,S.
  TITLE     GATA4/6 regulate DHH transcription in rat adrenocortical autografts
  JOURNAL   Sci Rep 10 (1), 446 (2020)
   PUBMED   31949236
  REMARK    GeneRIF: GATA4/6 regulate DHH transcription in rat adrenocortical
            autografts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Takizawa,N., Tanaka,S., Oe,S., Koike,T., Yoshida,T., Hirahara,Y.,
            Matsuda,T. and Yamada,H.
  TITLE     Involvement of DHH and GLI1 in adrenocortical autograft
            regeneration in rats
  JOURNAL   Sci Rep 8 (1), 14542 (2018)
   PUBMED   30266964
  REMARK    GeneRIF: Dhh and Gli1 might function in concert to regenerate
            adrenocortical autografts. This is the first report to clearly show
            Dhh expression and its elevation in the adrenal gland.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Lin,Y.C., Roffler,S.R., Yan,Y.T. and Yang,R.B.
  TITLE     Disruption of Scube2 Impairs Endochondral Bone Formation
  JOURNAL   J Bone Miner Res 30 (7), 1255-1267 (2015)
   PUBMED   25639508
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Makela,J.A., Saario,V., Bourguiba-Hachemi,S., Nurmio,M.,
            Jahnukainen,K., Parvinen,M. and Toppari,J.
  TITLE     Hedgehog signalling promotes germ cell survival in the rat testis
  JOURNAL   Reproduction 142 (5), 711-721 (2011)
   PUBMED   21893610
  REMARK    GeneRIF: Hh signalling is part of the paracrine signalling network
            in the rat testis. It promotes the survival of germ cells and is
            suppressed by FSH.
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Kawai,Y., Noguchi,J., Akiyama,K., Takeno,Y., Fujiwara,Y.,
            Kajita,S., Tsuji,T., Kikuchi,K., Kaneko,H. and Kunieda,T.
  TITLE     A missense mutation of the Dhh gene is associated with male
            pseudohermaphroditic rats showing impaired Leydig cell development
  JOURNAL   Reproduction 141 (2), 217-225 (2011)
   PUBMED   21062903
  REMARK    GeneRIF: A missense mutation of the Dhh gene is associated with
            male pseudohermaphroditic rats showing impaired Leydig cell
            development.
REFERENCE   6  (bases 1 to 2479)
  AUTHORS   Smith,P.M., Sim,F.J., Barnett,S.C. and Franklin,R.J.
  TITLE     SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS
            remyelination by transplanted olfactory ensheathing cells
  JOURNAL   Glia 36 (3), 342-353 (2001)
   PUBMED   11746771
REFERENCE   7  (bases 1 to 2479)
  AUTHORS   Thomas,M.K., Rastalsky,N., Lee,J.H. and Habener,J.F.
  TITLE     Hedgehog signaling regulation of insulin production by pancreatic
            beta-cells
  JOURNAL   Diabetes 49 (12), 2039-2047 (2000)
   PUBMED   11118005
REFERENCE   8  (bases 1 to 2479)
  AUTHORS   Umehara,F., Tate,G., Itoh,K., Yamaguchi,N., Douchi,T., Mitsuya,T.
            and Osame,M.
  TITLE     A novel mutation of desert hedgehog in a patient with 46,XY partial
            gonadal dysgenesis accompanied by minifascicular neuropathy
  JOURNAL   Am J Hum Genet 67 (5), 1302-1305 (2000)
   PUBMED   11017805
REFERENCE   9  (bases 1 to 2479)
  AUTHORS   Carpenter,D., Stone,D.M., Brush,J., Ryan,A., Armanini,M.,
            Frantz,G., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Characterization of two patched receptors for the vertebrate
            hedgehog protein family
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13630-13634 (1998)
   PUBMED   9811851
REFERENCE   10 (bases 1 to 2479)
  AUTHORS   Paradis,R.
  TITLE     Events which will have a decisive influence over the nursing
            assistant profession
  JOURNAL   Infirm Aux 65 (1), 7-10 (1992)
   PUBMED   1302240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_343327.3, XM_001062733.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.29532.1,
                                           SRR26643429.28728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               JAXUCZ010000007.1  131934755-131935352 c
            599-860             JAXUCZ010000007.1  131931743-131932004 c
            861-2479            JAXUCZ010000007.1  131929857-131931475 c
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2479
                     /gene="Dhh"
                     /note="desert hedgehog signaling molecule"
                     /db_xref="GeneID:84380"
                     /db_xref="RGD:620711"
     exon            1..598
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1486
                     /gene="Dhh"
                     /codon_start=1
                     /product="desert hedgehog protein precursor"
                     /protein_id="NP_445819.1"
                     /db_xref="GeneID:84380"
                     /db_xref="RGD:620711"
                     /translation="MALPASLLPLCCLALLALSVQSCGPGRGPVGRRRYVRKQLVPLL
                     YKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTER
                     CKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYG
                     LLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRE
                     LHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAA
                     RGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTL
                     LVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAE
                     ELMG"
     exon            599..860
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
     exon            861..2479
                     /gene="Dhh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcggagt cagggcgttt ctgggagcac cggagctggg cagcagaaac cgcctgggct
       61 ggcactcacc ctcgacccac ctgccctgta atggtagtct atcagtagta ggttccaggt
      121 tccccagggc atgtaggcag agttagcggc tgccaagtgg tcagagccac agcgctccag
      181 gtactctggg actttctcta tctgcagtgc tctctagctc ctgcggagat gccaaactga
      241 caggagagcc agtaaggaca agaacgctcc ctttcgaccc aagtccactg cacccatggc
      301 tctgccagcc agtctgttgc ccctgtgctg cttggcactc ctggcactat ctgtccagag
      361 ctgcgggcca ggccgaggac cggttggccg gcggcgttac gtgcgcaagc aacttgtgcc
      421 tctgctctac aagcagtttg tgcctagtat gcccgagcgg acccttggcg cgagtgggcc
      481 agcggagggg agggtaacaa gggggtcgga gcgcttccgg gacctcgtcc ccaactacaa
      541 ccccgacata atcttcaagg atgaggagaa cagcggcgct gaccgcctga tgacagagcg
      601 ttgcaaagag cgggtgaatg ctctagccat cgcggtgatg aacatgtggc ccggagtacg
      661 cctacgcgtg actgaaggtt gggacgagga tggccaccac gcacaggact cactgcacta
      721 cgaaggccgt gccctggaca tcaccacgtc tgaccgtgac cgtaataagt atggtttgtt
      781 ggcgcgccta gcagtggaag ccggattcga ctgggtctac tacgagtccc gcaaccacat
      841 ccacgtgtcg gtcaaagctg ataactcatt ggcggtccga gccggaggct gctttccggg
      901 aaatgccacg gtgcgcttgc ggagcggcga acggaagggg ctgagggaac tccatcgtgg
      961 tgactgggta ctggccgctg atgcagcggg ccgagtggta cccacgccgg tgctgctctt
     1021 cctggaccgg gacctgcagc gccgcgcctc gttcgtggct gtggagaccg agcggccacc
     1081 gcgcaaactg ttgctcacac cctggcatct ggtgttcgcc gctcgggggc cagcgcctgc
     1141 tccaggtgac tttgcaccgg tgttcgcgcg ccgcttacgc gctggggact cggtactggc
     1201 tcccggcggg gacgcgctcc ggcctgcgcg cgtagcccgc gtggcgcgcg aggaagccgt
     1261 gggcgtgttc gcaccgctca cggctcacgg gacgctgctg gtcaacgacg tcctcgcctc
     1321 ctgctacgcg gttctagaga gtcaccagtg ggcccaccgc gcctttgctc ctttgcgttt
     1381 gctgcacgcg ctcggggcgc tgctccccgg gggtgcagtc cagccgactg gcatgcattg
     1441 gtactcgcgc ctcctttacc gcttggcgga ggagttaatg ggttgagctt ccaaggacag
     1501 aggtccacca ggctttgcaa gaaaccgaag gccccgagac ctgctagctg agatctgaag
     1561 atgtgggcag caggtgggag agagggcggc gggaaagaga gagaaaaaaa ggtgggctgt
     1621 ggtttaggca atctgagagg agtggtacct ggtccttgat aactgggttt tgctggtagg
     1681 cactcttttt tttttttttt tttttttttt ttggagctgg ggaccgaacc cagggccttg
     1741 cgcttcctag gcaagcgctc taccactgag ctaaatccca acccctggta ggcactcttt
     1801 aaggaggact tttttgcggt ttccccagtc gcacggataa ttttatttcc tatttataat
     1861 ttgtaatatg atgatgcgct tgctcagccc accaaggtga ggacctggag tgtggcttta
     1921 acactgtctg acccagccag tcagcctgac agctcacact ttcactttct cctcctcagg
     1981 tgggttaata aagggaaggc ttattggaaa acaccttcac ttgggtgatt cacctccaaa
     2041 gaggaggaga actaggacta atcgagtcca caccttgctt ccagctcgcc cttcttcctc
     2101 agcaggatct tccaaaccct cttgctgaaa agggtgcccc aatctgtcag gaatggacca
     2161 gaaatatcct gtccttttta aggtactggt tccactacta gccgggacca gaactttgct
     2221 tatgaggatg tgtaccaact ttgagtgggg tgggacttac caagggagca cgaagattga
     2281 tgctcgaccc atttggagtt ttctattgtt agctattgtg acctaaccct gtagactgga
     2341 tcagcccagc agtcatcctg cctgctgaag tggtctgatt tttatcctgg gattttgtta
     2401 ggccaactga tgaaccatgg gtgttcctta cagttcacca cacattcgtg gccaaaataa
     2461 agatcctaga gtgagcagg
//
