LOCUS       NM_001011978            1447 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dehydrodolichyl diphosphate synthase subunit
            (Dhdds), mRNA.
ACCESSION   NM_001011978 XM_216541
VERSION     NM_001011978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Grabinska,K.A., Edani,B.H., Park,E.J., Kraehling,J.R. and
            Sessa,W.C.
  TITLE     A conserved C-terminal RXG motif in the NgBR subunit of
            cis-prenyltransferase is critical for prenyltransferase activity
  JOURNAL   J Biol Chem 292 (42), 17351-17361 (2017)
   PUBMED   28842490
REFERENCE   2  (bases 1 to 1447)
  AUTHORS   Park,E.J., Grabinska,K.A., Guan,Z., Stranecky,V., Hartmannova,H.,
            Hodanova,K., Baresova,V., Sovova,J., Jozsef,L., Ondruskova,N.,
            Hansikova,H., Honzik,T., Zeman,J., Hulkova,H., Wen,R., Kmoch,S. and
            Sessa,W.C.
  TITLE     Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase,
            causes a congenital disorder of glycosylation
  JOURNAL   Cell Metab 20 (3), 448-457 (2014)
   PUBMED   25066056
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085875.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216541.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085875.1, SRR8487231.59124.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1447
                     /gene="Dhdds"
                     /note="dehydrodolichyl diphosphate synthase subunit"
                     /db_xref="GeneID:298541"
                     /db_xref="RGD:1311560"
     exon            1..77
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            78..191
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1130
                     /gene="Dhdds"
                     /EC_number="2.5.1.87"
                     /codon_start=1
                     /product="dehydrodolichyl diphosphate synthase complex
                     subunit DHDDS"
                     /protein_id="NP_001011978.1"
                     /db_xref="GeneID:298541"
                     /db_xref="RGD:1311560"
                     /translation="MSWIKEGELSLWERFCANIIKVGPVPKHIAFIMDGNRRYAKKCQ
                     VERQEGHTQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLLDLARQKFS
                     CLMEEQEKLKKHGVCIRVLGDLHLLPLDLQKKIAQAVQATKNYNKCFLNVCFAYTSRH
                     EITNAVREMAWGVEQGLLEPSDVSESLLDQCLYSNHSPQPDILIRTSGEVRLSDFLLW
                     QTSHSCLVFQPVLWPEYTFWNLCEAILQFQMNHSALQKARDMYAEERKRHQLERDQAA
                     VTEQLLREGLQANGDAQLRRTRLHKLSAKREERVRGFLQALNLKRADWLALWGTASA"
     exon            192..308
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            309..451
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            452..568
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            569..670
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            671..785
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            786..893
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1421
                     /gene="Dhdds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagggga agctggctgt agagttagcc acgaagacac taaagtccag ccgggagagt
       61 gattcttgac ccttgaggtt atctggctgt ttttttgttc ttgtgtgatt tctgacatag
      121 caagaactat gtcatggatc aaagaaggag agctgtcact ttgggaacgg ttctgtgcca
      181 atatcataaa ggttggccca gtgcccaaac acattgcatt cataatggat ggcaaccgtc
      241 gctatgccaa gaagtgccag gtggagcgac aggagggcca cacacagggc ttcaataagc
      301 ttgctgagac tctgcgctgg tgtttgaacc tgggcatcct agaagtgact gtctatgcgt
      361 tcagcattga gaacttcaaa cgttccaaga gtgaggttga cgggctcctg gatctagccc
      421 gacagaagtt cagctgcttg atggaagaac aggagaagct gaagaagcat ggggtgtgca
      481 tccgagtcct gggcgatctg cacctgctgc ccttggacct ccagaagaag attgcacagg
      541 ctgtccaggc taccaagaac tacaacaagt gtttcctcaa cgtctgcttt gcatacacgt
      601 cacgtcacga gatcaccaat gccgtgagag agatggcctg gggtgtggaa caaggtctgc
      661 tggaacccag tgatgtttcc gagtctctgc ttgatcagtg cctctatagc aaccactctc
      721 ctcagcccga catcttgatt cggacttccg gggaagtgcg gctcagtgac ttcttgctct
      781 ggcagacctc ccactcctgc ctcgtgttcc agcctgtcct gtggccagaa tacacatttt
      841 ggaacctttg tgaggcaatc ctgcagtttc agatgaacca tagtgcactt cagaaggccc
      901 gagacatgta tgctgaggaa cggaagaggc accagctgga gagggaccag gcggcagtga
      961 cagagcagct gcttcgagag gggctccagg ccaatgggga tgcccaactc cgacggacac
     1021 gcttgcacaa actctccgcc aaacgggaag agcgagtgcg aggcttcctg caggccttga
     1081 acctcaagcg ggctgactgg ctggcacttt ggggcactgc atctgcctaa gtgaggagtc
     1141 tgactaccag gcactttgcc ctgtcctctg ccctcgcccc ccccccccat cttcctttcc
     1201 ctttcttttc tttctttggg aaaggcacct ccctgttttt gatgaattgg gctccctgtt
     1261 ctgcagggaa ccccaaaggc aagttctgct gcctatagat acctttgggc aacctgtgag
     1321 agttactctt gaagtttgag atacaatctc tactgtgtac actaaatcca agtccagcca
     1381 ctaatacatt cgggggaaca ggagacccta actcttagct aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaa
//
