LOCUS       NM_022389               2735 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7), mRNA.
ACCESSION   NM_022389
VERSION     NM_022389.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Sun,L., Lu,J., Yao,D., Li,X., Cao,Y., Gao,J., Liu,J., Zheng,T.,
            Wang,H. and Zhan,X.
  TITLE     Effect of DHCR7 for the co-occurrence of hypercholesterolemia and
            vitamin D deficiency in type 2 diabetes: Perspective of health
            prevention
  JOURNAL   Prev Med 173, 107576 (2023)
   PUBMED   37329988
  REMARK    GeneRIF: Effect of DHCR7 for the co-occurrence of
            hypercholesterolemia and vitamin D deficiency in type 2 diabetes:
            Perspective of health prevention.
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Kwak,S.Y., Cho,Y., Oh,H. and Shin,M.J.
  TITLE     Association of circulating 25-hydroxyvitamin D levels with
            hypertension and blood pressure values in Korean adults: A
            Mendelian randomization study on a subset of the Korea National
            Health and Nutrition Survey 2011-2012 population
  JOURNAL   Nutr Res Pract 13 (6), 498-508 (2019)
   PUBMED   31814925
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Fang,J., Hou,S., Xiang,Q., Qi,J., Yu,H., Shi,Y., Zhou,Y.,
            Kijlstra,A. and Yang,P.
  TITLE     Polymorphisms in genetics of vitamin D metabolism confer
            susceptibility to ocular Behcet disease in a Chinese Han population
  JOURNAL   Am J Ophthalmol 157 (2), 488-494 (2014)
   PUBMED   24184224
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Waterham,H.R.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Bae,S.H., Lee,J.N., Fitzky,B.U., Seong,J. and Paik,Y.K.
  TITLE     Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue
            distribution, expression, chromosomal localization, and regulation
            of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz
            syndrome-related protein
  JOURNAL   J Biol Chem 274 (21), 14624-14631 (1999)
   PUBMED   10329655
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Holmer,L., Pezhman,A. and Worman,H.J.
  TITLE     The human lamin B receptor/sterol reductase multigene family
  JOURNAL   Genomics 54 (3), 469-476 (1998)
   PUBMED   9878250
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Shefer,S., Salen,G., Honda,A., Batta,A.K., Nguyen,L.B., Tint,G.S.,
            Ioannou,Y.A. and Desnick,R.
  TITLE     Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase:
            substrate specificity, competitive and non-competitive inhibition,
            and phosphorylation/dephosphorylation
  JOURNAL   J Lipid Res 39 (12), 2471-2476 (1998)
   PUBMED   9831636
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Waterham,H.R., Wijburg,F.A., Hennekam,R.C., Vreken,P.,
            Poll-The,B.T., Dorland,L., Duran,M., Jira,P.E., Smeitink,J.A.,
            Wevers,R.A. and Wanders,R.J.
  TITLE     Smith-Lemli-Opitz syndrome is caused by mutations in the
            7-dehydrocholesterol reductase gene
  JOURNAL   Am J Hum Genet 63 (2), 329-338 (1998)
   PUBMED   9683613
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Lee,J.N., Paik,Y.K. and Glossmann,H.
  TITLE     Molecular cloning and expression of the human delta7-sterol
            reductase
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1899-1902 (1998)
   PUBMED   9465114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022389.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272393.1, SRR26643429.4225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680414, SAMN06680437
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000001.1  208444434-208444623
            191-318             JAXUCZ010000001.1  208447533-208447660
            319-531             JAXUCZ010000001.1  208450269-208450481
            532-754             JAXUCZ010000001.1  208451583-208451805
            755-845             JAXUCZ010000001.1  208452757-208452847
            846-1059            JAXUCZ010000001.1  208453456-208453669
            1060-1264           JAXUCZ010000001.1  208455552-208455756
            1265-1396           JAXUCZ010000001.1  208457746-208457877
            1397-2735           JAXUCZ010000001.1  208459070-208460408
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2735
                     /gene="Dhcr7"
                     /note="7-dehydrocholesterol reductase"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
     exon            1..190
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            191..318
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            319..531
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..1861
                     /gene="Dhcr7"
                     /EC_number="1.3.1.21"
                     /EC_number="3.3.2.11"
                     /note="7-DHC reductase; sterol Delta(7)-reductase;
                     cholesterol-5,6-epoxide hydrolase subunit DHCR7"
                     /codon_start=1
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="NP_071784.1"
                     /db_xref="GeneID:64191"
                     /db_xref="RGD:621769"
                     /translation="MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLL
                     FAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSF
                     QVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYL
                     LSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMG
                     IEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIY
                     VLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNAL
                     GVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLV
                     SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANK
                     YGRDWERYVAAVPYRLLPGIF"
     exon            532..754
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            755..845
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1059
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1264
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1396
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2735
                     /gene="Dhcr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccg actggagggc ccggtgggct ccgagtcagc tcactgcctt caccaatcac
       61 agggcgcggc tcacgaaatc cacttcggat tggtagtctg tgacctcacg tcacctgggg
      121 gcggtgcttc aggcagacac ttagggcgct gctggagctc gtgaatcaac cgcccggatc
      181 ccgcacgcag agtgttactc agcatatggg caaggattga tcagaccttg ggggacttct
      241 gaacctggac attttgagag ccacttttga gaaagacaac atcattctat tgtgaaacct
      301 gtggcccaga ggtcaaagaa cctgcggtgg gcgatcaggt actgagaaag ctaccaaggt
      361 tgcctgctct actcagcact tgagccctgg tgggggtcta tctttctgga aggatctgag
      421 cctctcctcc ttccctcaga tcctgatggc ttcaaagtcc cagcacaacg cttccaaagc
      481 caagaatcac aacgtcaagg ctgaatctca aggacaatgg ggccgtgcct gggaagtgga
      541 ctggttctcc ctggtcagcg tcattttcct gctgctcttc gcaccgttca ttgtgtacta
      601 cttcatcatg gcatgtgacc agtacagctg ctcgctgact gcccccatat tggacgtagc
      661 tacaggccgt gcgagtctgg cagacatctg ggccaagaca ccgcctgtga cagctaaggc
      721 tgcccaactg tatgccttgt gggtcagctt ccaggtgctg ctttactcct ggcttcctga
      781 cttctgccac agatttctgc caggttatgt gggaggcgtc caagaaggtg ccataactcc
      841 agcagggatt gtaaataagt atgaggtgaa tgggctgcaa gcctggctca ttacccactt
      901 cctctggttt gtgaacgctt acctcctatc ctggttctcc cccaccatca tctttgacaa
      961 ctggatcccg ttgctatggt gtgccaacat cctgggctac gctgtgtcca cctttgcaat
     1021 gatcaagggg tacctgttcc ccaccagcgc cgaagactgc aaattcacag gcaatttctt
     1081 ctacaactac atgatgggga ttgagttcaa cccccgcatc ggaaagtggt ttgacttcaa
     1141 gctgttcttc aatgggcgcc cggggattgt ggcctggact cttatcaacc tgtcctttgc
     1201 tgccaagcag caggagcttt atggccatgt gaccaactcc atgattttgg tcaatgtctt
     1261 acaggccatc tatgtgttag acttcttctg gaacgaaacc tggtacctga agaccattga
     1321 catctgccat gaccactttg gatggtacct gggctgggga gattgcgtgt ggctgcccta
     1381 cctctacaca ctgcagggcc tgtacttggt gtaccaccct gtacagctct ccacccccaa
     1441 cgccttgggc gtcctgctgc tcggcctggt gggttactat atcttccgaa tgaccaacca
     1501 tcagaaggac ctgttccgcc ggacagatgg acactgcctc atctggggca agaaacccaa
     1561 ggccatcgag tgctcctaca cgtcagccga cgggctgaag caccgcagca agctgttggt
     1621 ttcaggcttc tggggtgtgg cccgccactt caactatacc ggagacctga tgggcagcct
     1681 cgcctactgc ctggcttgtg gcggcggcca cctcctcccc tacttctaca tcatctatat
     1741 gactatcctg cttacccacc gctgcctccg tgatgagcac cgctgtgcca acaagtatgg
     1801 ccgtgactgg gagcgctacg tagccgctgt gccctaccgc ctgctgcctg ggatcttctg
     1861 agggccaccc tggcaagcag aaagaggcgt cattgaatgt gtggagttgg gtgcatgggg
     1921 gccagcgtcc ggctttcccc tgcaggggcc tccttggttt gctcttctgg aggatggaga
     1981 gccaggcgcc ccacagtgtc tggctggtgg cagctagagc tgagttcaca ctgatgcccc
     2041 agcagaatga ctggttctcc ctgttcagca tcctgagggc agaggacctt ggccctttca
     2101 tgtctgttgg aagcccacca tctatgttgt ctagatagct taggcttacc aggtgtctcc
     2161 caggattggg ccatcctggt aaactggaga caatgtagga tctaaagagt ttggcaatgt
     2221 caccttcact cccacctgca atggtgggct ggaccccttt ttctgtctgt agtgtgatca
     2281 gcagagggtt caggggccat tgaaggagga aggctctttg tttaggttct ttactgtttt
     2341 tacccgagga atgccaagca gcggactgga atatcccact ctgcacatcc ctggctgact
     2401 tgataaagtc tgtctgacat atgagatggg gttcccagaa ctccccaagt accccagcta
     2461 gcagcttatc catctcccct cttccggaag gtgcttcttg tttacccctg agacttggct
     2521 cagaggtgaa cagacttggc tctgacaacc cagaatgtat caccagttag tggcctcagc
     2581 cacaccttcc ccaacaggag aaccagcgtt ggggaaggaa tccattctca ttagtgacac
     2641 tgccccccaa aactcagggt tattttgtaa aactagatag gctcatgtta gccttgcaag
     2701 cggttctttg tattaaatct gccttgttaa atgag
//
