LOCUS       NM_001080148            3907 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus 24-dehydrocholesterol reductase (Dhcr24), mRNA.
ACCESSION   NM_001080148 XM_001065263 XM_216452
VERSION     NM_001080148.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3907)
  AUTHORS   Yavuz,U., Alaylioglu,M., Sengul,B., Karras,S.N., Gezen-Ak,D. and
            Dursun,E.
  TITLE     Protein disulfide isomerase A3 might be involved in the regulation
            of 24-dehydrocholesterol reductase via vitamin D equilibrium in
            primary cortical neurons
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (7), 704-714 (2021)
   PUBMED   34338991
  REMARK    GeneRIF: Protein disulfide isomerase A3 might be involved in the
            regulation of 24-dehydrocholesterol reductase via vitamin D
            equilibrium in primary cortical neurons.
REFERENCE   2  (bases 1 to 3907)
  AUTHORS   Samara,A., Galbiati,M., Luciani,P., Deledda,C., Messi,E., Peri,A.
            and Maggi,R.
  TITLE     Altered expression of 3-betahydroxysterol
            delta-24-reductase/selective Alzheimer's disease indicator-1 gene
            in Huntington's disease models
  JOURNAL   J Endocrinol Invest 37 (8), 729-737 (2014)
   PUBMED   24916565
  REMARK    GeneRIF: Data suggest that expression of Dhcr24 is
            up-/down-regulated in rat striatal precursor cell line during
            oxidative stress depending on co-expression level of
            wild-type/mutant human huntingtin.
REFERENCE   3  (bases 1 to 3907)
  AUTHORS   Gilanchi,S., Esmaeilzade,B., Eidi,A., Barati,M., Mehrabi,S.,
            Moghani Ghoroghi,F. and Nobakht,M.
  TITLE     Neuronal differentiation of rat hair follicle stem cells: the
            involvement of the neuroprotective factor Seladin-1 (DHCR24)
  JOURNAL   Iran Biomed J 18 (3), 136-142 (2014)
   PUBMED   24842139
  REMARK    GeneRIF: Expression of the seladin-1 gene (DHCR24) on days 9, 10,
            and 11 may contribute to the development of hair follicle stem
            cells.
REFERENCE   4  (bases 1 to 3907)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3907)
  AUTHORS   Battista,M.C., Roberge,C., Martinez,A. and Gallo-Payet,N.
  TITLE     24-dehydrocholesterol reductase/seladin-1: a key protein
            differentially involved in adrenocorticotropin effects observed in
            human and rat adrenal cortex
  JOURNAL   Endocrinology 150 (9), 4180-4190 (2009)
   PUBMED   19520779
  REMARK    GeneRIF: seladin-1 expression and intracellular localization are
            correlated with both the intensity and nature of ACTH-induced
            steroidogenesis and resultant oxidative stress.
REFERENCE   6  (bases 1 to 3907)
  AUTHORS   Wechsler,A., Brafman,A., Shafir,M., Heverin,M., Gottlieb,H.,
            Damari,G., Gozlan-Kelner,S., Spivak,I., Moshkin,O., Fridman,E.,
            Becker,Y., Skaliter,R., Einat,P., Faerman,A., Bjorkhem,I. and
            Feinstein,E.
  TITLE     Generation of viable cholesterol-free mice
  JOURNAL   Science 302 (5653), 2087 (2003)
   PUBMED   14684813
REFERENCE   7  (bases 1 to 3907)
  AUTHORS   Herman,G.E.
  TITLE     Disorders of cholesterol biosynthesis: prototypic metabolic
            malformation syndromes
  JOURNAL   Hum Mol Genet 12 Spec No 1, R75-R88 (2003)
   PUBMED   12668600
  REMARK    Review article
REFERENCE   8  (bases 1 to 3907)
  AUTHORS   Andersson,H.C., Kratz,L. and Kelley,R.
  TITLE     Desmosterolosis presenting with multiple congenital anomalies and
            profound developmental delay
  JOURNAL   Am J Med Genet 113 (4), 315-319 (2002)
   PUBMED   12457401
REFERENCE   9  (bases 1 to 3907)
  AUTHORS   Waterham,H.R., Koster,J., Romeijn,G.J., Hennekam,R.C., Vreken,P.,
            Andersson,H.C., FitzPatrick,D.R., Kelley,R.I. and Wanders,R.J.
  TITLE     Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause
            desmosterolosis, an autosomal recessive disorder of cholesterol
            biosynthesis
  JOURNAL   Am J Hum Genet 69 (4), 685-694 (2001)
   PUBMED   11519011
REFERENCE   10 (bases 1 to 3907)
  AUTHORS   Greeve,I., Hermans-Borgmeyer,I., Brellinger,C., Kasper,D.,
            Gomez-Isla,T., Behl,C., Levkau,B. and Nitsch,R.M.
  TITLE     The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to
            Alzheimer's disease-associated neurodegeneration and oxidative
            stress
  JOURNAL   J Neurosci 20 (19), 7345-7352 (2000)
   PUBMED   11007892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 7, 2022 this sequence version replaced NM_001080148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.15657.1,
                                           SRR26643292.22273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               JAXUCZ010000005.1  126573366-126573681
            317-472             JAXUCZ010000005.1  126576734-126576889
            473-578             JAXUCZ010000005.1  126582246-126582351
            579-697             JAXUCZ010000005.1  126583051-126583169
            698-961             JAXUCZ010000005.1  126584542-126584805
            962-1105            JAXUCZ010000005.1  126588997-126589140
            1106-1303           JAXUCZ010000005.1  126596719-126596916
            1304-1482           JAXUCZ010000005.1  126597248-126597426
            1483-3907           JAXUCZ010000005.1  126597516-126599940
FEATURES             Location/Qualifiers
     source          1..3907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3907
                     /gene="Dhcr24"
                     /note="24-dehydrocholesterol reductase"
                     /db_xref="GeneID:298298"
                     /db_xref="RGD:1306529"
     exon            1..316
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1636
                     /gene="Dhcr24"
                     /EC_number="1.3.1.72"
                     /note="delta(24)-sterol reductase; seladin-1;
                     3-beta-hydroxysterol delta-24-reductase"
                     /codon_start=1
                     /product="delta(24)-sterol reductase precursor"
                     /protein_id="NP_001073617.2"
                     /db_xref="GeneID:298298"
                     /db_xref="RGD:1306529"
                     /translation="MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSL
                     IFDIYYYVRAWVVFKLSSAPRLHEQRVQDIQKQVREWKEQGSKTFMCTGRPGWLTVSL
                     RVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELD
                     DLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSC
                     GTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTHESQRLENHFVEGLLYSLDE
                     AVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRS
                     IFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMK
                     CLSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEA
                     RSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYD
                     KICKAARH"
     exon            317..472
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            473..578
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            579..697
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            698..961
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1105
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1303
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1482
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..3907
                     /gene="Dhcr24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgcagag ccggcggagc gcggagcggg ctacggtgac gggcggcgcg agcccgcacc
       61 ctcccgcgcg gcgcgccgcg acaccatgga gcccgccgtg tcgctggccg tgtgcgcgct
      121 gctctttctg ctctgggtgc gagtgaaggg gttggagttc gttctcatcc accaacgctg
      181 ggtgtttgtg tgcctcttcc tgctaccgct ctccctcatc ttcgacatct actactacgt
      241 gcgcgcctgg gtggtgttca agctgagcag tgcgccgcgc ttgcacgagc agcgcgtgca
      301 ggacatccag aaacaggtac gggagtggaa ggagcagggc agtaagacct tcatgtgcac
      361 ggggcgtcct ggatggctca ctgtctcact gcgggttggg aagtacaaga agacgcataa
      421 gaacatcatg atcaacctga tggacattct ggaggtggac accaagaaac agattgtgcg
      481 agtggagccc ttggtgtcta tgggtcaggt gacagctttg ctgaactcca ttggctggac
      541 tctgcctgtg ttgcctgaac tcgatgacct cacagtgggg ggcctgatca tgggcaccgg
      601 catcgagtca tcgtcccaca agtatggcct gttccaacac atctgtacgg cctacgagct
      661 aatcctggca gatggcagct ttgtgcgctg cacaccgtct gaaaactcag acctgttcta
      721 tgccgtaccc tggtcctgtg ggaccctggg cttcctggtg gctgccgaga tccgcatcat
      781 ccctgccaag aagtatgtca aactgcggtt tgagccagtg cggggcctgg aggccatctg
      841 tgagaaattc acccatgagt cccagcggct ggagaaccac ttcgtggaag ggttgctgta
      901 ttccttggat gaggctgtca tcatgacagg ggtcatgacg gatgatgtag agcccagcaa
      961 gctgaatagc attggcagtt actacaagcc gtggttcttc aagcatgtgg agaactacct
     1021 gaagacaaac cgagagggcc ttgaatacat tcccctgagg cactactacc accgccacac
     1081 gcgcagcatc ttctgggagc tccaggacat catccctttt ggcaacaacc ccatcttccg
     1141 ctacctcttt ggctggatgg tgcctcccaa gatctccctc ctgaagctga cccagggcga
     1201 gactctgcgt aaactgtatg aacagcatca tgtggtacag gacatgctgg tgcccatgaa
     1261 atgcctgtct caggccctgc ataccttcca aaatgacatc cacgtctacc ccatctggct
     1321 gtgcccgttc atcctgccca gccagccagg acttgtgcat cccaagggag atgaggctga
     1381 gctctacgtg gacatcgggg catatgggga gccacgggtg aagcacttcg aggccaggtc
     1441 ctgcatgagg cagctggaga agtttgtgcg gagcgtgcac gggttccaga tgttatacgc
     1501 cgattgctat atgaaccggg aggaattctg ggagatgttc gatggctcct tgtaccacaa
     1561 gctgcgcaag cagcttggct gccaggacgc cttccctgag gtgtatgaca agatctgcaa
     1621 ggctgcgagg cactgagcag ggcccctggg gagccagctg catgggaatg gactcgctct
     1681 ccctcgctcc aacttctctg ctttcccaga tttcagagag aaaccccttc agaaatcccc
     1741 gaggtagccc gacggcctcc agggcagctc aagcaagtgg aagcacgtgg gatttggagt
     1801 cagacagagc taagtcccag tcccagatta gccactcatt agctgtgtga ctgagtctgg
     1861 gctagtcacc tgaccctgtg tgccccgtgt tcatctgtga aaggaggtat aaatccctac
     1921 ctgctggacg tcattcacac aaagggccca tcgtgtggga ggggcttcgt aagtggtagc
     1981 caacaccgct gcttccatgt aacctcacac ccggctcatg ctttggattc aacagctgag
     2041 tccagacagg ttccccaccg gtcacctgtg cacgggtttg gctggcacca tgaaggggat
     2101 tccttggagt ttcacctgca taacctgcat cagccccaag agggccttcc cctgggtctc
     2161 ggggattgag ggtcatctga ttggcaggca ggcccaggat gtgctgtgcc aaagccaggt
     2221 ctgctccaaa gtgctctctg ccatcttcgg accgtcctgc ccctacttgt gtgctcaggc
     2281 cctcgggcca ccccagccat cactgagccc actcaagact gttcctggaa gacatctcaa
     2341 gatgggaagc ctagccttcc tgggctttcc tttcttgact tccggcatcc aggcctcctc
     2401 tagagtccac tgagtcacaa tgggggcaca tgctcatgac tgtgtcacct aggggtggtt
     2461 cccacactga gtgagaaagg ggcaaccgcc ctgttgttac tgtgaggacc ctccctgggg
     2521 ttggagagaa agcatccagg gtcactcatc cccctctccc atttcgttcc cactcccccg
     2581 gctctagtta atttcagtgc cttacaaatc ctaagctcag agaaagttag ctccatttcc
     2641 gttcctgagg gaggggcctc tgaggtcctc ctgccttgtt aaagaagtgt ggttggttgt
     2701 gcagccccca ccttcagaac tgcctggccc agctgagaac ccagagtctg agggggaatc
     2761 aagttctgga aggaaagcca gaactcaagc actgagctgg ttgcagtctc ccccaccccg
     2821 ccacccctgc tccccgctcc aaaagctgca attttctcac ccgtcatgtc ggaacataag
     2881 agctcctgaa acctttctac cagatggcgg ttagggaccg ttcatcagta gcccttccct
     2941 cctccaccaa gccagctccc atccatgatt ttcatccatc tggcaagggc cagaaccctt
     3001 agagtcatag tcgaaggatg ctcactgatg ctgctgtggg ggtggggatc ctggtcagtg
     3061 ctactgcagt cctgtgaagg ccggtgcact cggggcagtt ggaaggcaga agaatcacct
     3121 catccatttg acctgtgaag gaagtaacct cactttgctg tctgagcagc atgcgttcct
     3181 ggcatgggct ctcctcgtgg tccgtgtgca tccttgcgct cgcagaccga tgaccctgct
     3241 tgctgcaggt gactggtcag tgcgagctag cttagttagt gtggtgtata aggcgccatc
     3301 attcctccag taagcctcca tcccaaagca actgaggctg tggcagtgat gccagcaacc
     3361 tgtgtcaccc aaaattatcc agccctccac gggcactgcc taggacctgg ggagggaagg
     3421 gactttgcat cacagtagcc tcaggttcgt gtttggctct ggtaatatct tgcctgaaaa
     3481 gtggtggtct tccaggcatg gtgtacgggg tcccagcctt gtcttaaagc ctgtcctgtc
     3541 atcatccagc cacgcagtgg cttggtggag tcactttgct cctgtgggac agtgcgtgta
     3601 ggaagtcaat gcaaagcctc tccccttcat ggctctggtt tcttggctgc atggttctct
     3661 gtaaatccag ttatagccac tgtctggcta gaaagctgaa ttggctgatg ctgaaaggga
     3721 agagggggat gggtgtggca gtgtgtgctg tgtgatattt tttaatttgg tcatggggac
     3781 caaggagaag gcatgaattc cccttgtcag gctcctgcag ccttgggcac tgtgcctact
     3841 ctccagaaca cgtccctgtg gctctggggc caccacttgt gtaaaataaa gtatggcctg
     3901 gacgatg
//
