LOCUS       NM_001415152            3549 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus diacylglycerol kinase zeta (Dgkz), transcript
            variant 1, mRNA.
ACCESSION   NM_001415152 XM_006234596
VERSION     NM_001415152.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Cui,H., Huang,Y., Wu,Y., Ma,J., Cao,X., Xie,J. and Zhang,Y.
  TITLE     The expression of diacylglycerol kinase isoforms alpha and zeta
            correlates with the progression of experimental autoimmune
            encephalomyelitis in rats
  JOURNAL   Histochem Cell Biol 156 (5), 437-448 (2021)
   PUBMED   34312706
  REMARK    GeneRIF: The expression of diacylglycerol kinase isoforms alpha and
            zeta correlates with the progression of experimental autoimmune
            encephalomyelitis in rats.
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Liu,T., Yu,B., Kakino,M., Fujimoto,H., Ando,Y., Hakuno,F. and
            Takahashi,S.I.
  TITLE     A novel IRS-1-associated protein, DGKzeta regulates GLUT4
            translocation in 3T3-L1 adipocytes
  JOURNAL   Sci Rep 6, 35438 (2016)
   PUBMED   27739494
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Takahashi,N., Hozumi,Y., Tanaka,T., Okada,M., Iseki,K., Hayasaka,K.
            and Goto,K.
  TITLE     Cellular expression and localization of DGKzeta-interacting
            NAP1-like proteins in the brain and functional implications under
            hypoxic stress
  JOURNAL   Histochem Cell Biol 142 (5), 461-471 (2014)
   PUBMED   24893663
  REMARK    GeneRIF: The results suggest that DGKzeta cytoplasmic translocation
            in neurons under hypoxic stress is regulated by some mechanism
            which differs from that mediated by NAP1-like proteins.
REFERENCE   4  (bases 1 to 3549)
  AUTHORS   Hozumi,Y., Matsui,H., Sakane,F., Watanabe,M. and Goto,K.
  TITLE     Distinct expression and localization of diacylglycerol kinase
            isozymes in rat retina
  JOURNAL   J Histochem Cytochem 61 (6), 462-476 (2013)
   PUBMED   23467923
  REMARK    GeneRIF: The DGKzeta and DGKalpha localize predominantly to the
            nucleus of ganglion cells.
REFERENCE   5  (bases 1 to 3549)
  AUTHORS   Gellett,A.M., Kharel,Y., Sunkara,M., Morris,A.J. and Lynch,K.R.
  TITLE     Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol
            kinases
  JOURNAL   Biochem Biophys Res Commun 422 (4), 758-763 (2012)
   PUBMED   22627129
REFERENCE   6  (bases 1 to 3549)
  AUTHORS   Ali,H., Nakano,T., Saino-Saito,S., Hozumi,Y., Katagiri,Y.,
            Kamii,H., Sato,S., Kayama,T., Kondo,H. and Goto,K.
  TITLE     Selective translocation of diacylglycerol kinase zeta in
            hippocampal neurons under transient forebrain ischemia
  JOURNAL   Neurosci Lett 372 (3), 190-195 (2004)
   PUBMED   15542238
  REMARK    GeneRIF: diacylglycerol kinase zeta might be involved in the
            process of selective vulnerability of hippocampal pyramidal neurons
            in postischemic brain
REFERENCE   7  (bases 1 to 3549)
  AUTHORS   Luo,B., Prescott,S.M. and Topham,M.K.
  TITLE     Diacylglycerol kinase zeta regulates phosphatidylinositol
            4-phosphate 5-kinase Ialpha by a novel mechanism
  JOURNAL   Cell Signal 16 (8), 891-897 (2004)
   PUBMED   15157668
REFERENCE   8  (bases 1 to 3549)
  AUTHORS   Hozumi,Y., Ito,T., Nakano,T., Nakagawa,T., Aoyagi,M., Kondo,H. and
            Goto,K.
  TITLE     Nuclear localization of diacylglycerol kinase zeta in neurons
  JOURNAL   Eur J Neurosci 18 (6), 1448-1457 (2003)
   PUBMED   14511325
  REMARK    GeneRIF: DGK zeta is primarily a nuclear protein in neurons, it can
            also be cytoplasmic in some conditions, and the subcellular
            location depends not only on the cell type but also on the
            developmental state or growth conditions of the cell.
REFERENCE   9  (bases 1 to 3549)
  AUTHORS   Goto,K. and Kondo,H.
  TITLE     A 104-kDa diacylglycerol kinase containing ankyrin-like repeats
            localizes in the cell nucleus
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11196-11201 (1996)
   PUBMED   8855332
REFERENCE   10 (bases 1 to 3549)
  AUTHORS   Goto,K., Watanabe,M., Kondo,H., Yuasa,H., Sakane,F. and Kanoh,H.
  TITLE     Gene cloning, sequence, expression and in situ localization of 80
            kDa diacylglycerol kinase specific to oligodendrocyte of rat brain
  JOURNAL   Brain Res Mol Brain Res 16 (1-2), 75-87 (1992)
   PUBMED   1339302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 22, 2022 this sequence version replaced XM_006234596.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.14269.1,
                                           SRR26643284.4378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               JAXUCZ010000003.1  98391481-98391810   c
            331-439             JAXUCZ010000003.1  98371104-98371212   c
            440-535             JAXUCZ010000003.1  98370729-98370824   c
            536-613             JAXUCZ010000003.1  98370381-98370458   c
            614-670             JAXUCZ010000003.1  98369156-98369212   c
            671-739             JAXUCZ010000003.1  98368757-98368825   c
            740-811             JAXUCZ010000003.1  98367948-98368019   c
            812-928             JAXUCZ010000003.1  98367740-98367856   c
            929-1000            JAXUCZ010000003.1  98367583-98367654   c
            1001-1096           JAXUCZ010000003.1  98367229-98367324   c
            1097-1179           JAXUCZ010000003.1  98366899-98366981   c
            1180-1240           JAXUCZ010000003.1  98366742-98366802   c
            1241-1354           JAXUCZ010000003.1  98366539-98366652   c
            1355-1495           JAXUCZ010000003.1  98366306-98366446   c
            1496-1574           JAXUCZ010000003.1  98365697-98365775   c
            1575-1630           JAXUCZ010000003.1  98365490-98365545   c
            1631-1693           JAXUCZ010000003.1  98365309-98365371   c
            1694-1767           JAXUCZ010000003.1  98365142-98365215   c
            1768-1879           JAXUCZ010000003.1  98364952-98365063   c
            1880-2079           JAXUCZ010000003.1  98364448-98364647   c
            2080-2180           JAXUCZ010000003.1  98364086-98364186   c
            2181-2260           JAXUCZ010000003.1  98363900-98363979   c
            2261-2330           JAXUCZ010000003.1  98363738-98363807   c
            2331-2371           JAXUCZ010000003.1  98363555-98363595   c
            2372-2511           JAXUCZ010000003.1  98362882-98363021   c
            2512-2543           JAXUCZ010000003.1  98362140-98362171   c
            2544-2587           JAXUCZ010000003.1  98361873-98361916   c
            2588-2708           JAXUCZ010000003.1  98361146-98361266   c
            2709-2742           JAXUCZ010000003.1  98361040-98361073   c
            2743-2842           JAXUCZ010000003.1  98360728-98360827   c
            2843-3549           JAXUCZ010000003.1  98359804-98360510   c
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3549
                     /gene="Dgkz"
                     /note="diacylglycerol kinase zeta"
                     /db_xref="GeneID:81821"
                     /db_xref="RGD:70929"
     exon            1..330
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2959
                     /gene="Dgkz"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DGK-IV; DGK-zeta; DAG kinase zeta; diglyceride kinase
                     zeta; 104 kDa diacylglycerol kinase"
                     /codon_start=1
                     /product="diacylglycerol kinase zeta isoform 1"
                     /protein_id="NP_001402081.1"
                     /db_xref="GeneID:81821"
                     /db_xref="RGD:70929"
                     /translation="MSALGAGHSAGGGCDVAAAVGPAKVLGTKEAELPGALRQMWRSR
                     SWDVPQIPAEVPQTQKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGE
                     HIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKP
                     SFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQ
                     AYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRS
                     SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDL
                     SQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDL
                     ARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPL
                     DVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAK
                     HIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLE
                     VIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQ
                     ATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTV
                     VVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQE
                     HLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGE
                     ELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEI
                     LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAA
                     YLENRQHYQMIQREDQETAV"
     exon            331..439
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            440..535
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            536..613
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            614..670
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            671..739
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            740..811
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            812..928
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1000
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1096
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1179
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1240
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1354
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1495
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1574
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1630
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1693
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1767
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1879
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2079
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2180
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2260
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2330
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2371
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2511
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2543
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2587
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2708
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2742
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2842
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3549
                     /gene="Dgkz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttcggg ccccagtccc agtcagcgga aggcgccgag aagccctgtg gtcctcggct
       61 tgagcctcca gccggcctct agcagcagtc cccccctcaa cccccccccc ccacgtcagg
      121 aagtgcggaa agaggaagag agttgctggg caggatgagc gcactggggg ctggccacag
      181 cgccggggga ggctgcgatg tggctgctgc tgtgggcccc gcgaaggtgc tggggacgaa
      241 agaagccgag ctgccagggg cactgaggca gatgtggcgc tcccgctcct gggacgtgcc
      301 acagatccca gctgaggttc cccagacaca gaaagccatc accaagtcgg gcctccagca
      361 cctggcaccc cctcctccca cgcctggggc cccgtgcggt gaatctgagc ggcagatccg
      421 gagtactgtg gactggagtg agtcagcagc gtatggggag cacatctggt ttgagaccaa
      481 cgtgtccgga gatttctgct atgtcgggga gcagtactgt gtagctaaga tgctgccgaa
      541 gtcagcgccc agaagaaagt gtgcagcctg taagatcgtg gtgcataccc cttgcatcgg
      601 gcagctggaa aagatcaatt tccgctgtaa gccatccttc cgtgaatcag gctccaggaa
      661 tgtccgtgag ccaaccttcg taagacacca ctgggtccac aggcgacgcc aggatggcaa
      721 gtgtcggcac tgtgggaagg gcttccagca gaagttcacc ttccacagca aagagatcgt
      781 agctatcagc tgttcctggt gcaaacaggc gtaccacagc aaggtgtcct gcttcatgct
      841 gcagcagatt gaggagccct gttccctagg ggtgcatgca gccgtggtca tcccacccac
      901 ctggatccta cgggcccgga ggccccagaa caccctcaag gccagcaaga agaaaaagag
      961 agcatccttc aaaaggagat ccagtaagaa aggacctgag gaaggccgct ggagaccctt
     1021 catcatcagg cccaccccgt cccccctcat gaagcccctg ctagtgtttg taaaccccaa
     1081 gagtgggggt aaccagggcg ctaagatcat ccagtctttt ctgtggtatc tgaacccccg
     1141 gcaagtcttc gatctgagcc agggaggacc cagggaagcg ctggaaatgt accgcaaagt
     1201 ccataatttg aggattctgg cttgcggggg tgatggcacg gttggctgga ttctttccac
     1261 cctagaccag ctgcgcttaa aaccaccacc tcctgtggcc atcctgcccc tgggcactgg
     1321 caatgacctg gcccgaactc tcaactgggg tgggggttac acagatgagc cagtgtcaaa
     1381 gatcctttcc catgtagagg aggggaacgt ggtacagctg gaccgttggg acctccgagc
     1441 agagcccaac cctgaggcag ggcctgagga gcgagatgac ggagccactg accggctgcc
     1501 cctggatgtc ttcaacaact acttcagtct gggctttgat gcccacgtca ccctggagtt
     1561 tcatgagtct cgagaagcca acccagagaa gttcaacagc cgctttcgga ataagatgtt
     1621 ctatgctggg acggccttct ctgacttcct gatgggcagc tccaaggact tagccaagca
     1681 catccgagta gtgtgtgacg gaatggacct aacccccaag attcaggacc tgaaaccgca
     1741 gtgcatagtc tttctgaata tccccaggta ctgtgcaggc accatgccct ggggccaccc
     1801 tggggagcac catgacttcg agccccagag gcacgatgat ggctacctcg aggtcatcgg
     1861 cttcaccatg acatccttgg ccgcattgca ggtgggtgga cacggcgagc ggctgaccca
     1921 gtgccgagaa gtgctgctca ccactgccaa ggccatccct gtgcaggtgg atggtgaacc
     1981 ctgcaagctt gcagcatcgc ggattcgaat tgccctgcgc aaccaggcca ctatggtgca
     2041 gaaggccaag cgccggagta ctgccccact gcacagcgat cagcagccag ttcctgagca
     2101 gctgaggatc caagtgagca gggtcagcat gcacgactac gaggctctcc attatgacaa
     2161 ggagcagctc aaggaggcct ctgtgcctct gggtactgtg gtggtccccg gagacagtga
     2221 cctagagctc tgccgagccc acattgagag actccagcag gagcccgatg gggctggagc
     2281 caagtccccc atgtgccacc cactgtcctc caagtggtgt ttcctggacg ccaccactgc
     2341 cagccgcttc tacaggatcg acagggccca ggagcacctc aactatgtga cggagattgc
     2401 ccaggatgag atttatatcc tagacccaga gctgctgggt gcatcagccc gacctgacct
     2461 ccctacccct acctccccgc tccctgcctc cccctgctcc cctacacccg ggtcactgca
     2521 gggggatgcc gcactgcccc aaggtgaaga gctgattgaa gctgccaaga ggaatgactt
     2581 ctgcaagctc caggaactac accgagcagg aggtgacctc atgcaccgcg accatcagag
     2641 ccgcacactc ctgcaccacg cagtcagcac tggcagtaag gaagtggtcc gctatctgct
     2701 cgatcatgca ccaccagaga tcctcgatgc tgtggaggag aacggggaga cctgtctaca
     2761 ccaggcagcc gccctaggtc agcgcaccat ctgccactac attgtggaag ccggggcctc
     2821 cctcatgaag acagatcagc agggcgacac tcccaggcag cgagctgaga aggctcaaga
     2881 cacagagcta gctgcatacc tggagaacag acaacattac cagatgatcc aacgtgagga
     2941 ccaggagaca gctgtgtagt taaggggacc atggatcaac gagggacact accagaggac
     3001 tagagctctc cttgcccatc tcactgccac attcctgtca gatggctatg gggggaccct
     3061 gtcacaggga aggagccccg tgccaccccc tgagaagccg ttcagatcta gggctggact
     3121 ctaaggagct ggactctcac ctgtccctgg tttcatgggg aacaggaaac aagctgggct
     3181 gactgggtcc ctcccttcag ggcggcctcc ccctcaccac agctgatgga atggctggac
     3241 agctcagtca gggaggcctg ctctcagcag gactttctaa agccacctga tcccttgggc
     3301 tctttggaag gttctgggtg cctagccctc ctctctgacc cacacacctt gggcatccca
     3361 gaaactcaag agcctgctgt atttgcctgc ccgctgccct gcttggcacc taccctggtg
     3421 atcctcctca tgcacccagt catttcattt ccgactgtat ggcctggggt ggggggtggg
     3481 gctcccacgg tgacttgttt acagctgggt gtgactcagt aaagtgaagt ttttttcctt
     3541 tcttgttta
//
