LOCUS       NM_001198804            4536 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus diacylglycerol kinase, theta (Dgkq), mRNA.
ACCESSION   NM_001198804 XM_002728069
VERSION     NM_001198804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Goldschmidt,H.L., Tu-Sekine,B., Volk,L., Anggono,V., Huganir,R.L.
            and Raben,D.M.
  TITLE     DGKtheta; Catalytic Activity Is Required for Efficient Recycling of
            Presynaptic Vesicles at Excitatory Synapses
  JOURNAL   Cell Rep 14 (2), 200-207 (2016)
   PUBMED   26748701
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   Cai,K., Lucki,N.C. and Sewer,M.B.
  TITLE     Silencing diacylglycerol kinase-theta expression reduces steroid
            hormone biosynthesis and cholesterol metabolism in human
            adrenocortical cells
  JOURNAL   Biochim Biophys Acta 1841 (4), 552-562 (2014)
   PUBMED   24369117
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Cai,K. and Sewer,M.B.
  TITLE     Diacylglycerol kinase theta; couples farnesoid X receptor-dependent
            bile acid signalling to Akt activation and glucose homoeostasis in
            hepatocytes
  JOURNAL   Biochem J 454 (2), 267-274 (2013)
   PUBMED   23767959
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   Cai,K. and Sewer,M.B.
  TITLE     cAMP-stimulated transcription of DGKtheta; requires steroidogenic
            factor 1 and sterol regulatory element binding protein 1
  JOURNAL   J Lipid Res 54 (8), 2121-2132 (2013)
   PUBMED   23610160
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Tu-Sekine,B. and Raben,D.M.
  TITLE     Dual regulation of diacylglycerol kinase (DGK)-theta;: polybasic
            proteins promote activation by phospholipids and increase substrate
            affinity
  JOURNAL   J Biol Chem 287 (50), 41619-41627 (2012)
   PUBMED   23091060
REFERENCE   6  (bases 1 to 4536)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 4536)
  AUTHORS   Tabellini,G., Billi,A.M., Fala,F., Cappellini,A., Evagelisti,C.,
            Manzoli,L., Cocco,L. and Martelli,A.M.
  TITLE     Nuclear diacylglycerol kinase-theta is activated in response to
            nerve growth factor stimulation of PC12 cells
  JOURNAL   Cell Signal 16 (11), 1263-1271 (2004)
   PUBMED   15337525
  REMARK    GeneRIF: nuclear DGK-theta is a down-stream target of nerve growth
            factor signaling in PC12 cells.
REFERENCE   8  (bases 1 to 4536)
  AUTHORS   Tabellini,G., Bortul,R., Santi,S., Riccio,M., Baldini,G.,
            Cappellini,A., Billi,A.M., Berezney,R., Ruggeri,A., Cocco,L. and
            Martelli,A.M.
  TITLE     Diacylglycerol kinase-theta is localized in the speckle domains of
            the nucleus
  JOURNAL   Exp Cell Res 287 (1), 143-154 (2003)
   PUBMED   12799190
REFERENCE   9  (bases 1 to 4536)
  AUTHORS   Bregoli,L., Baldassare,J.J. and Raben,D.M.
  TITLE     Nuclear diacylglycerol kinase-theta is activated in response to
            alpha-thrombin
  JOURNAL   J Biol Chem 276 (26), 23288-23295 (2001)
   PUBMED   11309392
  REMARK    Erratum:[J Biol Chem 2002 Mar 29;277(13):11614-5]
REFERENCE   10 (bases 1 to 4536)
  AUTHORS   Houssa,B., de Widt,J., Kranenburg,O., Moolenaar,W.H. and van
            Blitterswijk,W.J.
  TITLE     Diacylglycerol kinase theta binds to and is negatively regulated by
            active RhoA
  JOURNAL   J Biol Chem 274 (11), 6820-6822 (1999)
   PUBMED   10066731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 11, 2010 this sequence version replaced XM_002728069.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.48043.1,
                                           SRR26643299.53668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000014.1  1203575-1203914
            341-420             JAXUCZ010000014.1  1206285-1206364
            421-520             JAXUCZ010000014.1  1208023-1208122
            521-606             JAXUCZ010000014.1  1208414-1208499
            607-732             JAXUCZ010000014.1  1208573-1208698
            733-886             JAXUCZ010000014.1  1209000-1209153
            887-961             JAXUCZ010000014.1  1209229-1209303
            962-1062            JAXUCZ010000014.1  1209388-1209488
            1063-1292           JAXUCZ010000014.1  1209685-1209914
            1293-1383           JAXUCZ010000014.1  1209996-1210086
            1384-1438           JAXUCZ010000014.1  1210219-1210273
            1439-1500           JAXUCZ010000014.1  1210466-1210527
            1501-1651           JAXUCZ010000014.1  1210834-1210984
            1652-1690           JAXUCZ010000014.1  1211388-1211426
            1691-1806           JAXUCZ010000014.1  1212091-1212206
            1807-1958           JAXUCZ010000014.1  1213658-1213809
            1959-2107           JAXUCZ010000014.1  1214020-1214168
            2108-2286           JAXUCZ010000014.1  1214278-1214456
            2287-2387           JAXUCZ010000014.1  1214715-1214815
            2388-2534           JAXUCZ010000014.1  1214905-1215051
            2535-2646           JAXUCZ010000014.1  1215149-1215260
            2647-2799           JAXUCZ010000014.1  1215340-1215492
            2800-4536           JAXUCZ010000014.1  1215800-1217536
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4536
                     /gene="Dgkq"
                     /note="diacylglycerol kinase, theta"
                     /db_xref="GeneID:100361138"
                     /db_xref="RGD:2320722"
     exon            1..340
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2901
                     /gene="Dgkq"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="DGKtheta; DAG kinase theta"
                     /codon_start=1
                     /product="diacylglycerol kinase theta"
                     /protein_id="NP_001185733.1"
                     /db_xref="GeneID:100361138"
                     /db_xref="RGD:2320722"
                     /translation="MATAAESGARTWPGSGSPRLGSPAGSPVLGISGRARPGSGPERT
                     GRAIGSVAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPC
                     TSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACS
                     DCRQCHQDGQHDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHS
                     VCSTALTPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGLDGS
                     AAVGTGREVSAATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYI
                     NEDPKDFQLQALPLTLLSGNAQALGKAGTTEEETSKDSGPGDSVPEAWVIRSLPRTQE
                     ILKIYPDWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGRQVEDQERFQLIEVLMSSRQ
                     VQRTVLVDEEPLLDRLRDIRQTSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSPQ
                     DYSNLLHEAMATKAAVVSVSHVYSLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTA
                     LVLPDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPG
                     FHLFSQVPCFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLR
                     WGAGYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNY
                     CGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQ
                     QEVELPSIEGLIFINIPSWGSGADLWGSDSDSRFEKPRIDDGLLEVVGVTGVVHMGQV
                     QGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWIQAPGHMIISATAPKVHMLRKAKQK
                     PRKAGAIRDTRVDTLPAPEGNPL"
     exon            341..420
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            421..520
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            521..606
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            607..732
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            733..886
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            887..961
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1062
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1292
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1383
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1438
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1500
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1651
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1690
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1806
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1958
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2107
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2286
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2387
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2534
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2646
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2799
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..4536
                     /gene="Dgkq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggagca ggcacagcct aaggccctcg ttacaccgcg gacctggctt tagcgtgcac
       61 ctggagttgg ggcgctcggg ttgtgagatg gcgacggcag ccgagtccgg ggcccggacc
      121 tggccgggca gtggttcccc acgtctcggc agcccggccg gcagccctgt gctgggcatc
      181 tcgggccgcg cacgcccggg gtcagggccg gagcggactg gcagagctat cggctccgta
      241 gcacccggcc acagctttcg caaggtgaca ctcaccaagc ctaccttctg ccacctctgc
      301 tcggacttca tctggggatt ggccggcttc ctgtgcgatg tctgcaactt catgtcccat
      361 gagaagtgcc taaagcaggt gaagaccccg tgcacaagca ttgcgccaag cctcgtccgg
      421 gtccctgtag cccactgctt tggttccctt ggtctctaca agcgcaagtt ctgtgtggtc
      481 tgccgcaaga gcctggaggt acctgcgttc cgctgtgaag tgtgtgagct gcacgttcac
      541 cccgactgtg tgcccttcgc ctgcagcgac tgtcgtcagt gtcaccagga tggacagcac
      601 gattatgaca cgtatcacca ccactggagg gaggggaatc tgccttctgg tgctcgatgt
      661 gaggtctgta ggaagacttg tggctcctcg gatgtgctgg ctggtgtacg ctgcgagtgg
      721 tgtggtgtac aggctcactc cgtgtgctcc acagcactca cccctgagtg tacatttgga
      781 cgtctacgct ccatggtact gcctccttcg tgtgtgcgcc tgttgtcccg aaacttcagc
      841 aagatgcact gcttccgaat ccccgagacc atggtcctgg agctcggtga tggggatgat
      901 ggcctagatg ggagtgctgc agtcggcaca ggcagagagg tatcggcagc tacagaatct
      961 accaaacaga ccctgaagat ctttgatggc aacgactcca tgaggaaaaa tcagtttcgc
     1021 ctggttacag tttcccgcct agctcggaat gaggaagtga tggaggcagc actccgggcc
     1081 tactatatca acgaggaccc taaggacttc cagctgcagg cactgcccct aacgttactg
     1141 tctggcaatg cccaggctct ggggaaggcc gggaccactg aggaggagac aagtaaagac
     1201 tccgggcccg gggattccgt gcctgaggcc tgggtcatca ggtctctgcc tcgtacccaa
     1261 gagatcctga agatctaccc tgactggctc aaggtaggtg tggcctacgt gtccatccgt
     1321 gtgaactccc agagtacagc acggtctgtg gttcaagagg ttctcccact gtttggacga
     1381 caggttgagg atcaggagag attccagctg attgaggtgc ttatgagcag cagacaagtc
     1441 caacggacgg tgctggtgga tgaagaacct ctgctagatc gactccggga catccgacag
     1501 acatctgtgc gccaggcgag ccagacgcgg ttctatgtgg ccgaggccag ggccgtgacc
     1561 ccacatgtct ccctgtttgt gggtggcctg ccacctggct tgtcccctca ggattacagc
     1621 aacctgctgc atgaggccat ggccaccaaa gctgctgtgg tgtctgtgag tcacgtctac
     1681 tccttacaag gtgcggtagt tctggatgtc acctgcttcg cggaggctga gcggctatac
     1741 atgctggcca gggacacagc agtgcatggc cggccactga ctgcactagt gcttccagat
     1801 gtgctgcaca cgaagctgcc tcctgactgc tgccctctcc tcgtgtttgt gaaccccaag
     1861 agtgggggcc tcaagggacg agaactgctc tgcagtttcc ggaagctgct gaatccacac
     1921 caggtctttg agctcaccaa cgggggccct cttcctgggt tccacctttt ctcccaggtg
     1981 ccctgctttc gggtactggt ctgtggtgga gatggcaccg tgggctgggt gctcgctgcc
     2041 ctggaggaga caaggcgcca tctggcctgc ccagagccat ctgtggccat cctacccctg
     2101 ggtacaggga atgaccttgg ccgggtcctc cgttggggag caggctatag tggtgaggac
     2161 ccattttctg tgctggtgtc tgtggatgag gctgatgctg tgctcatgga tcgatggaca
     2221 atcctgctgg acgctcatga aattgatagt acagagaaca atgtggtaga aacagagccc
     2281 cccaagattg ttcagatgaa taactactgt ggcattggca ttgatgcgga gctcagccta
     2341 gacttccacc aggcacgtga agaggagcct ggcaaattca caagcaggtt ccacaacaag
     2401 ggcgtgtatg tgcgggttgg gctgcagaag atcagccact ctcgaagcct gcacaaggag
     2461 atccgtctgc aggtggagca gcaggaagtg gagctgccca gcattgaggg tcttatcttc
     2521 attaacatcc ccagctgggg ctcaggggct gacctgtggg gctctgacag tgactcaagg
     2581 tttgagaagc cacgcataga cgacgggctg ttggaggtgg tgggtgtgac aggtgtcgtg
     2641 cacatgggcc aggtacaagg tgggctgcgc tctggaatcc gaatcgccca gggctcctac
     2701 ttccgtgtca cactcctcaa ggctactcca gtgcaggtgg acggtgagcc ctggattcag
     2761 gccccaggtc acatgatcat ctctgctact gcacctaagg ttcacatgct gaggaaagct
     2821 aagcagaagc ccaggaaggc tggcgccatc agggataccc gagtggacac cttgcctgct
     2881 cctgagggca atcctttata gaggagccaa gatgaaaggt ctcagccacc cagcctttct
     2941 catctttggt tggtcacacg ctggctggcc aacagatgga cttagctgta gcactgacca
     3001 tagaatctcc atgggtcttg ggatgtttcg atccctcatc cttatccagt atcacgtgca
     3061 aacttaggag agggtaggta atggtcacta ctcactccgc cttagtacca aggtattgac
     3121 tgggcacaag gctctggaaa gcttgtattc tgcacaagac tgattctcac aggatgagcg
     3181 aagctggtcc ttcctgttag ccacattcct tccctccttt gaaacctctc ttaagaactc
     3241 tcttggacct aatacatctg gatgcaggcc atccaggtgg gtcctctgat ttcactttat
     3301 gttctttcaa aacagctaac catgttgggc cctggcctcc atgctgcctg ttctcctgta
     3361 ctgattagat ggatgtggca tcctcaagtc ccctgggctt atcactagac agcaatttgg
     3421 gctgaagata gttacaaggt ctcatccagc tggcagccat gaactgacca agttgtactt
     3481 agggatggga atctttgtct accctgaggg taggtgagtt tagctatcac gcatgtgtca
     3541 cacacagctg gagtgtgtgc taggccgtgt gtccctcctt gaccactgag tgggcaccta
     3601 gtgcccagaa aggatcagaa caggccgggt ggtacctggc tgaggagtgt gtaaataact
     3661 cctgctgtgg agcagctaga actcccttag actcgactta cagcacttta tagacatggt
     3721 atttgcctgc ctacagccct tccttgtaga tgtagagctt ctactctggc tcctaaacaa
     3781 atggaagcag ctctgatggc caggccttgc tggagacact gggttcacag aatgagacaa
     3841 atgctgtctc ttccatgcac ccaagaattc attgtcacac ctcagaccct aggaagaatc
     3901 tgcccagaaa tgagctgtct aggtaagcct ggtacatgcc aataatgggc taaagcataa
     3961 ctgtgtcata gagctaaata aagcccctgt cagaaagtga acacgttaaa gacattgaaa
     4021 gctctagcct cagccctgga tagggggaga ctcacatgga aagtctcctg tgatgcttac
     4081 ctcccacccc caaaagtatg tctagagcct tttccagttt gtcattactc agcttgtgga
     4141 caccttcaga agtgtgacac tggggtggtg tggaccaggg tgtctacctg cctggcagct
     4201 tcataggacc attgtgccac ccgctcacct gcttctgcca aaactgcata caagtacatc
     4261 agatagccat ttgtgatctc agtgtggatg atcatgttta caccattttc aatgttcaaa
     4321 agaaattcgt tgtgatgtag tttttccttt ttatttcaat ctgtagaact gtgtgtaaat
     4381 tatggtcagt gtagcatgtc ctctgtattt aagtgagact gtcctcttgt ggagtgtgtc
     4441 ctgtctactg gtcctgtctt tgtctgtaaa tttatcacta cctgaatgtg atctaattta
     4501 tatctgggcc aaatatagtg tgggctttgc tgtccc
//
