LOCUS       NM_198782               3915 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus diacylglycerol kinase, iota (Dgki), mRNA.
ACCESSION   NM_198782 XM_342659
VERSION     NM_198782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Yang,J., Seo,J., Nair,R., Han,S., Jang,S., Kim,K., Han,K.,
            Paik,S.K., Choi,J., Lee,S., Bae,Y.C., Topham,M.K., Prescott,S.M.,
            Rhee,J.S., Choi,S.Y. and Kim,E.
  TITLE     DGKiota regulates presynaptic release during mGluR-dependent LTD
  JOURNAL   EMBO J 30 (1), 165-180 (2011)
   PUBMED   21119615
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Regier,D.S., Higbee,J., Lund,K.M., Sakane,F., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3
            and inhibits Rap1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (21), 7595-7600 (2005)
   PUBMED   15894621
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Ito,T., Hozumi,Y., Sakane,F., Saino-Saito,S., Kanoh,H., Aoyagi,M.,
            Kondo,H. and Goto,K.
  TITLE     Cloning and characterization of diacylglycerol kinase iota splice
            variants in rat brain
  JOURNAL   J Biol Chem 279 (22), 23317-23326 (2004)
   PUBMED   15024004
  REMARK    GeneRIF: novel splice variants, which contain either insertion 1
            (71 bp) or insertion 2 (19 bp) or both in the carboxyl-terminal
            portion
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Sommer,W., Arlinde,C., Caberlotto,L., Thorsell,A., Hyytia,P. and
            Heilig,M.
  TITLE     Differential expression of diacylglycerol kinase iota and L18A
            mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding
            ANA rats
  JOURNAL   Mol Psychiatry 6 (1), 103-8 (2001)
   PUBMED   11244494
  REMARK    GeneRIF: Diacylglycerol kinase iota is exclusively found in the
            brain and is expressed in a distinct regional pattern. Differential
            expression of splice variants in the cortex of alcohol accepting
            (AA) and alcohol non-accepting (ANA) rat lines.
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Ding,L., Traer,E., McIntyre,T.M., Zimmerman,G.A. and Prescott,S.M.
  TITLE     The cloning and characterization of a novel human diacylglycerol
            kinase, DGKiota
  JOURNAL   J Biol Chem 273 (49), 32746-32752 (1998)
   PUBMED   9830018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, AB058962.1, AW526027.1 and CN544764.1.
            
            On Oct 19, 2007 this sequence version replaced NM_198782.1.
            
            Sequence Note: The RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB058962.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000004.1  66839575-66839790   c
            217-544             AB058962.1         217-544
            545-963             AW526027.1         1-419
            964-1313            AB058962.1         964-1313
            1314-1315           JAXUCZ010000004.1  66591429-66591430   c
            1316-1517           AB058962.1         1316-1517
            1518-1575           JAXUCZ010000004.1  66550253-66550310   c
            1576-2078           AB058962.1         1519-2021
            2079-2136           JAXUCZ010000004.1  66550253-66550310   c
            2137-2189           AB058962.1         2023-2075
            2190-2247           JAXUCZ010000004.1  66550253-66550310   c
            2248-2327           AB058962.1         2134-2213
            2328-2406           JAXUCZ010000004.1  66538270-66538348   c
            2407-3862           AB058962.1         2293-3748
            3863-4029           CN544764.1         1-167               c
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3915
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /note="diacylglycerol kinase, iota"
                     /db_xref="GeneID:688705"
                     /db_xref="RGD:735049"
     exon            1..626
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..3393
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /EC_number="2.7.1.107"
                     /note="diglyceride kinase iota; DGK-iota; DAG kinase iota;
                     diacylglycerol kinase iota-3"
                     /codon_start=1
                     /product="diacylglycerol kinase iota"
                     /protein_id="NP_942077.2"
                     /db_xref="GeneID:688705"
                     /db_xref="RGD:735049"
                     /translation="MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSA
                     AAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPA
                     AAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRA
                     TLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIE
                     QLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEI
                     VAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNR
                     KKKRTSFKRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMF
                     MWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPP
                     VGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPE
                     ELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSD
                     FLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDF
                     EPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLA
                     PAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKEK
                     LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISA
                     QRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGM
                     PDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHA
                     ILQAVITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELL
                     DMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAA
                     YLESRQNYKIIGHEDLETAV"
     exon            627..735
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..831
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..906
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..963
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1029
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1101
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1218
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1293
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1392
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1475
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1536
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1650
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1788
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1867
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1923
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1986
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2060
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2172
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2372
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2473
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2553
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2598
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2668
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2709
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2837
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2954
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..2980
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3018
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3139
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3176
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3276
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3898
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatggctcc cacccttccc ctctctcctc cactgcggtc cattgcctgc aggcagagtt
       61 caagttcagt cccagctttt gctctggatt tagaaaaagg agaaggggtg ggagaattgg
      121 agggagccgg ctggtcgggc gaggccgagg ggaggcggag agaggtggcc tctgattggt
      181 tggggagggg gagtggaggc acggagtttc ccacaatgcc ccggtgcggt gcagccgcgg
      241 atggatgctg cgggaagggg ctgccatttg ctgcccctgc cagcggcgcg cggacctgcc
      301 cgcgctcccg ccgcctccag cgccctcagc ccggccggcc tctgcagcgg caccgcctcg
      361 gcttcttccg cggccgccgg agcggtcgcc atgaacccca gctcctcggc gggagaggag
      421 agaggggcga cgggcggtag cagcagcagc ggaagcggcg ccgggagctg ctgcctgggc
      481 gccgagggcg gcgtggaccc gcggggtgca ggggcagcgg cggctgctgc cttggaggag
      541 cccgcggccg ccggacagaa agagaaggaa gaggcgctgg aggagaagct gagggactta
      601 actttccgga agcaggtctc ttacaggaaa gccatctccc ggacaggcct ccagcatctg
      661 gctcctgcac atcctcttgg tcttcctgtg gcaaacggtc cagcgaagga gcccagagcg
      721 actctggact ggagtgagaa tgctgtgaat ggggagcacc tatggctgga gaccaacgtc
      781 tcgggggacc tctgctactt gggggaggag aactgccaag tccgatttgc aaaatccgct
      841 ctcaggagga agtgtgctgt ctgcaaaatt gtggtccaca ccgcctgcat tgagcaacta
      901 gagaagatta atttcagatg taaacctaca tttcgggaag gaggctccag atcgccaaga
      961 gaaaactttg tgcgccatca ctgggtccac aggaggcggc aggagggaaa atgtaagcag
     1021 tgtggtaagg gcttccagca aaagttctcc ttccacagta aagagatcgt ggccatcagc
     1081 tgttcttggt gcaagcaggc gtttcacaat aaagtgacct gcttcatgct gcatcacatc
     1141 gaggaaccct gctccctggg ggctcatgct gctgttattg tcccgcccac ctggatcatt
     1201 aaggtgaaga aacctcagaa ctccctgaag gcttccaacc ggaagaagaa aagaacaagt
     1261 tttaaaagga aagccagtaa aagaggaacc gagcaggaaa acaaaggtcg tccttttgtg
     1321 atcaagccca tctcctctcc tctcatgaag cctttgcttg tctttgtgaa cccaaagagt
     1381 gggggaaacc agggaaccaa agtcctacag atgtttatgt ggtacctgaa tccacggcaa
     1441 gtctttgacc tttctcagga agggccaaaa gatgcgctgg agctgtacag gaaggtacca
     1501 aatctgcgaa ttctggcctg cggtggggat ggaacggtgg gctggatcct ctccatcctg
     1561 gacgagctgc agctgagccc acagcctcct gtgggggtgc ttccgctggg gactgggaac
     1621 gacctggctc ggacgctcaa ctggggaggg ggttacaccg atgagcctgt ttctaagatc
     1681 ctgtgccagg tggaagacgg gaccattgta cagttggatc gctggaacct ccatgtggag
     1741 agaaacccag acttgccacc tgaagaactt gaagatggcg tgtgtaagct tcctctgaat
     1801 gtcttcaata attacttcag ccttggattt gacgctcatg tcacattgga gttccatgaa
     1861 tcccgagaag caaatccaga gaaattcaat agtcgttttc gaaataaaat gttctatgcg
     1921 ggggcagcct tttctgattt cctacagaga agttctagag atctatccaa gcacgtcaaa
     1981 gttgtttgtg atgggacaga cctcactcca aagatccagg acctgaagtt ccagtgtata
     2041 gtatttttaa atattcccag atattgtgct ggcacaatgc cttggggaaa ccctggagat
     2101 catcatgact ttgaacccca gcgtcatgat gatggttaca ttgaagtcat cggattcact
     2161 atggcctctt tggctgccct gcaagtcggg ggccacggag aaaggttgca ccaatgtcgg
     2221 gaagtgatgc ttctgacgta caagtccatt cccatgcaag tggacgggga gccatgtagg
     2281 ttggcgcctg ctatgattcg gatctccttg aggaatcagg ccaacatggt acagaagagc
     2341 aagcggagaa cctcaatgcc tttgctcaat gatccccagt ctgtcccaga tcgcctgagg
     2401 atccgcgtga acaaaatcag tttacaagac tatgaaggac tccactatga caaggagaaa
     2461 ctccgggaag cgtccatccc cctgggtatt ctagttgttc gtggagactg tgatttggag
     2521 acttgccgta tgtacataga ccgcctgcag gaggacttgc agtcagtttc ttctgggtca
     2581 cagagagttc attaccagga ccaagaaact tccttcccca gggcgatctc agctcagagg
     2641 ctgtccccac ggtggtgctt cctagacgca acttctgctg accgctttta tcgaatagac
     2701 agatctcagg aacatttgca ctttgtgatg gagatttctc atgatgagat ttttattctg
     2761 gacccagata tggtggtgtc acagcaggca gggacacctc caggaatgcc agacctagtg
     2821 gttgaacagg cttctgggct gtctgactgg tggaaccctg ccctgaggaa acgtatgctg
     2881 agtgacagtg ggatgatcac accccactat gaggactcag atctgaaaga cttcagccac
     2941 tccagagtgc tacagtcacc agtctcttcg gaagatcatg caattctgca ggcagtcata
     3001 actggtgacc ttatgaagct catggaaagc tataagaatg gagggagttt attaattcag
     3061 ggacccgggc actgttccct ccttcactac gcagccaaga ctggcaatgg ggagatcgtg
     3121 aagtacatcc ttgaccatgg acctgcggaa ttactggaca tggcagacag tgaaacgggt
     3181 gagactgcac tgcacaaggc cgcctgccaa aggaaccggg ctgtatgcca gcttctggtg
     3241 gacgcaggag catctctgag acagacagac tccaagggaa agacacccca agagcgagca
     3301 cagcaggctg gggacccgga tttggctgct tacctagaaa gccgacagaa ctataagatc
     3361 attggccacg aagacctgga aactgctgtt tgaccctggt agacagtcaa gaagaacttg
     3421 atcaagcgta tcacctggtg cgccctccca gccactgggc agctcccctg gaagaagcta
     3481 acggaatcca tatccgcctc tctcccgcaa ggctctctct gagaaaatgc tatcaggttt
     3541 taagggctac ggggatgtac aacaggacat gatagcccat tgagaagggg gcaggctacc
     3601 ggagatttgt ggagtacacg ttccacaaaa tctgatcctt attgcttcca gcaagtagca
     3661 tggacttctg tgttcacccc tctaatttat tttaaagatt ctgaagattt tcactgctcc
     3721 cccctccctc ttggcatcca tctctcccct gtacctcata actctactgt aatcacccat
     3781 cgacttagaa aacatgctct cgtctcttta ttttcagtct tccaaccaca acattgtcta
     3841 aaggtctttg aaaccctccc ggatgtctta cagaaatata tctatgaaac cacttccaaa
     3901 aaaaaaaaaa aaaaa
//
