LOCUS       NP_942077               1050 aa            linear   ROD 30-MAR-2024
DEFINITION  diacylglycerol kinase iota [Rattus norvegicus].
ACCESSION   NP_942077 XP_342660
VERSION     NP_942077.2
DBSOURCE    REFSEQ: accession NM_198782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Yang,J., Seo,J., Nair,R., Han,S., Jang,S., Kim,K., Han,K.,
            Paik,S.K., Choi,J., Lee,S., Bae,Y.C., Topham,M.K., Prescott,S.M.,
            Rhee,J.S., Choi,S.Y. and Kim,E.
  TITLE     DGKiota regulates presynaptic release during mGluR-dependent LTD
  JOURNAL   EMBO J 30 (1), 165-180 (2011)
   PUBMED   21119615
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Regier,D.S., Higbee,J., Lund,K.M., Sakane,F., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3
            and inhibits Rap1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (21), 7595-7600 (2005)
   PUBMED   15894621
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Ito,T., Hozumi,Y., Sakane,F., Saino-Saito,S., Kanoh,H., Aoyagi,M.,
            Kondo,H. and Goto,K.
  TITLE     Cloning and characterization of diacylglycerol kinase iota splice
            variants in rat brain
  JOURNAL   J Biol Chem 279 (22), 23317-23326 (2004)
   PUBMED   15024004
  REMARK    GeneRIF: novel splice variants, which contain either insertion 1
            (71 bp) or insertion 2 (19 bp) or both in the carboxyl-terminal
            portion
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Sommer,W., Arlinde,C., Caberlotto,L., Thorsell,A., Hyytia,P. and
            Heilig,M.
  TITLE     Differential expression of diacylglycerol kinase iota and L18A
            mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding
            ANA rats
  JOURNAL   Mol Psychiatry 6 (1), 103-8 (2001)
   PUBMED   11244494
  REMARK    GeneRIF: Diacylglycerol kinase iota is exclusively found in the
            brain and is expressed in a distinct regional pattern. Differential
            expression of splice variants in the cortex of alcohol accepting
            (AA) and alcohol non-accepting (ANA) rat lines.
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Ding,L., Traer,E., McIntyre,T.M., Zimmerman,G.A. and Prescott,S.M.
  TITLE     The cloning and characterization of a novel human diacylglycerol
            kinase, DGKiota
  JOURNAL   J Biol Chem 273 (49), 32746-32752 (1998)
   PUBMED   9830018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, AB058962.1, AW526027.1 and CN544764.1.
            
            On Oct 19, 2007 this sequence version replaced NP_942077.1.
            
            Sequence Note: The RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB058962.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     Protein         1..1050
                     /product="diacylglycerol kinase iota"
                     /EC_number="2.7.1.107"
                     /note="diglyceride kinase iota; DGK-iota; DAG kinase iota;
                     diacylglycerol kinase iota-3"
                     /calculated_mol_wt=115763
     Region          52..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1MAB7.1)"
     Region          163..235
                     /region_name="C1_DGKiota_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in diacylglycerol kinase iota (DAG kinase
                     iota) and similar proteins; cd20850"
                     /db_xref="CDD:410400"
     Region          244..318
                     /region_name="C1_DGKiota_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in diacylglycerol kinase iota (DAG kinase
                     iota) and similar proteins; cd20896"
                     /db_xref="CDD:410446"
     Region          325..356
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1MAB7.1)"
     Region          373..494
                     /region_name="DAGKc"
                     /note="Diacylglycerol kinase catalytic domain (presumed);
                     smart00046"
                     /db_xref="CDD:214487"
     Region          521..678
                     /region_name="DAGKa"
                     /note="Diacylglycerol kinase accessory domain (presumed);
                     smart00045"
                     /db_xref="CDD:214486"
     Region          910..941
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <932..1049
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          943..972
                     /region_name="ANK 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1MAB7.1)"
     Site            order(945,949..950,953..955,957..958,962,965,976,978,981,
                     985..986,989..991,993..994,998,1001,1010,1012,1014,
                     1018..1019,1022..1024,1026..1027,1031)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          945..976
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          978..1010
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          979..1008
                     /region_name="ANK 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (F1MAB7.1)"
     Region          1048..1050
                     /region_name="PDZ-binding.
                     /evidence=ECO:0000269|PubMed:21119615"
                     /note="propagated from UniProtKB/Swiss-Prot (F1MAB7.1)"
     CDS             1..1050
                     /gene="Dgki"
                     /gene_synonym="rDGKi-3"
                     /coded_by="NM_198782.2:241..3393"
                     /db_xref="GeneID:688705"
                     /db_xref="RGD:735049"
ORIGIN      
        1 mdaagrgchl lplpaargpa rapaassals paglcsgtas assaaagava mnpsssagee
       61 rgatggssss gsgagscclg aeggvdprga gaaaaaalee paaagqkeke ealeeklrdl
      121 tfrkqvsyrk aisrtglqhl apahplglpv angpakepra tldwsenavn gehlwletnv
      181 sgdlcylgee ncqvrfaksa lrrkcavcki vvhtacieql ekinfrckpt freggsrspr
      241 enfvrhhwvh rrrqegkckq cgkgfqqkfs fhskeivais cswckqafhn kvtcfmlhhi
      301 eepcslgaha avivpptwii kvkkpqnslk asnrkkkrts fkrkaskrgt eqenkgrpfv
      361 ikpissplmk pllvfvnpks ggnqgtkvlq mfmwylnprq vfdlsqegpk dalelyrkvp
      421 nlrilacggd gtvgwilsil delqlspqpp vgvlplgtgn dlartlnwgg gytdepvski
      481 lcqvedgtiv qldrwnlhve rnpdlppeel edgvcklpln vfnnyfslgf dahvtlefhe
      541 sreanpekfn srfrnkmfya gaafsdflqr ssrdlskhvk vvcdgtdltp kiqdlkfqci
      601 vflnipryca gtmpwgnpgd hhdfepqrhd dgyievigft maslaalqvg ghgerlhqcr
      661 evmlltyksi pmqvdgepcr lapamirisl rnqanmvqks krrtsmplln dpqsvpdrlr
      721 irvnkislqd yeglhydkek lreasiplgi lvvrgdcdle tcrmyidrlq edlqsvssgs
      781 qrvhyqdqet sfpraisaqr lsprwcflda tsadrfyrid rsqehlhfvm eishdeifil
      841 dpdmvvsqqa gtppgmpdlv veqasglsdw wnpalrkrml sdsgmitphy edsdlkdfsh
      901 srvlqspvss edhailqavi tgdlmklmes yknggslliq gpghcsllhy aaktgngeiv
      961 kyildhgpae lldmadsetg etalhkaacq rnravcqllv dagaslrqtd skgktpqera
     1021 qqagdpdlaa ylesrqnyki ighedletav
//
