LOCUS       NM_013126               3467 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus diacylglycerol kinase, gamma (Dgkg), mRNA.
ACCESSION   NM_013126 XM_346420
VERSION     NM_013126.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3467)
  AUTHORS   Hozumi,Y., Nakano,T. and Goto,K.
  TITLE     Cellular expression and subcellular localization of diacylglycerol
            kinase gamma in rat brain
  JOURNAL   Biomed Res 42 (1), 33-42 (2021)
   PUBMED   33563877
  REMARK    GeneRIF: Cellular expression and subcellular localization of
            diacylglycerol kinase gamma in rat brain.
REFERENCE   2  (bases 1 to 3467)
  AUTHORS   Sakuma,M., Shirai,Y., Ueyama,T. and Saito,N.
  TITLE     Diacylglycerol kinase gamma regulates antigen-induced mast cell
            degranulation by mediating Ca(2+) influxes
  JOURNAL   Biochem Biophys Res Commun 445 (2), 340-345 (2014)
   PUBMED   24513282
  REMARK    GeneRIF: Knockdown of Dgkg, but not DGK-alpha, inhibited
            degranulation in mast cells.
REFERENCE   3  (bases 1 to 3467)
  AUTHORS   Gellett,A.M., Kharel,Y., Sunkara,M., Morris,A.J. and Lynch,K.R.
  TITLE     Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol
            kinases
  JOURNAL   Biochem Biophys Res Commun 422 (4), 758-763 (2012)
   PUBMED   22627129
REFERENCE   4  (bases 1 to 3467)
  AUTHORS   Yamaguchi,Y., Shirai,Y., Matsubara,T., Sanse,K., Kuriyama,M.,
            Oshiro,N., Yoshino,K., Yonezawa,K., Ono,Y. and Saito,N.
  TITLE     Phosphorylation and up-regulation of diacylglycerol kinase gamma
            via its interaction with protein kinase C gamma
  JOURNAL   J Biol Chem 281 (42), 31627-31637 (2006)
   PUBMED   16905533
  REMARK    GeneRIF: localization and activation of the functionally correlated
            kinases, gammaPKC and DGKgamma, are spatio-temporally orchestrated
            by their direct association and phosphorylation, contributing to
            subtype-specific regulation of DGKgamma and DAG signaling
REFERENCE   5  (bases 1 to 3467)
  AUTHORS   Adachi,N., Oyasu,M., Taniguchi,T., Yamaguchi,Y., Takenaka,R.,
            Shirai,Y. and Saito,N.
  TITLE     Immunocytochemical localization of a neuron-specific diacylglycerol
            kinase beta and gamma in the developing rat brain
  JOURNAL   Brain Res Mol Brain Res 139 (2), 288-299 (2005)
   PUBMED   16019106
  REMARK    GeneRIF: In brain, DGKgamma showed sustained expression throughout
            the postnatal developmental periods. And In the hippocampal
            pyramidal cell, Dgkg localized in the cytosol.
REFERENCE   6  (bases 1 to 3467)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 3467)
  AUTHORS   Goto,K., Funayama,M. and Kondo,H.
  TITLE     Cloning and expression of a cytoskeleton-associated diacylglycerol
            kinase that is dominantly expressed in cerebellum
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13042-13046 (1994)
   PUBMED   7809169
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013126.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38448.1, FQ231209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000011.1  91889036-91889097
            63-376              JAXUCZ010000011.1  91927902-91928215
            377-453             JAXUCZ010000011.1  91940422-91940498
            454-619             JAXUCZ010000011.1  91949242-91949407
            620-673             JAXUCZ010000011.1  91949961-91950014
            674-844             JAXUCZ010000011.1  91958843-91959013
            845-894             JAXUCZ010000011.1  91962779-91962828
            895-969             JAXUCZ010000011.1  91966697-91966771
            970-1092            JAXUCZ010000011.1  91967352-91967474
            1093-1210           JAXUCZ010000011.1  91970903-91971020
            1211-1299           JAXUCZ010000011.1  91972530-91972618
            1300-1416           JAXUCZ010000011.1  91975412-91975528
            1417-1509           JAXUCZ010000011.1  91976457-91976549
            1510-1569           JAXUCZ010000011.1  91978223-91978282
            1570-1649           JAXUCZ010000011.1  91981212-91981291
            1650-1724           JAXUCZ010000011.1  91982302-91982376
            1725-1810           JAXUCZ010000011.1  91984757-91984842
            1811-1900           JAXUCZ010000011.1  91989406-91989495
            1901-2061           JAXUCZ010000011.1  91991111-91991271
            2062-2126           JAXUCZ010000011.1  92000797-92000861
            2127-2217           JAXUCZ010000011.1  92027522-92027612
            2218-2395           JAXUCZ010000011.1  92048885-92049062
            2396-2516           JAXUCZ010000011.1  92068215-92068335
            2517-2577           JAXUCZ010000011.1  92071235-92071295
            2578-3467           JAXUCZ010000011.1  92080880-92081769
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3467
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /note="diacylglycerol kinase, gamma"
                     /db_xref="GeneID:25666"
                     /db_xref="RGD:2499"
     exon            1..62
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            63..376
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2676
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /EC_number="2.7.1.107"
                     /note="DGK-gamma; DAG kinase gamma; diglyceride kinase
                     gamma; 88 kDa diacylglycerol kinase; Diacylglycerol kinase
                     3 (gamma)"
                     /codon_start=1
                     /product="diacylglycerol kinase gamma"
                     /protein_id="NP_037258.1"
                     /db_xref="GeneID:25666"
                     /db_xref="RGD:2499"
                     /translation="MSDGQWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLKQY
                     DPHKPISYDVFKLFMRAYLEVDLPQPLSTNLFLAFSQKPRQETPDHPKEGASSSEPNV
                     SDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAPASSSDAPIVYLKD
                     VVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTEL
                     RPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHF
                     KKPTYCNFCHIMLMGVRKQGLCCIYCKYAVHQRCVSNSIPGCVKTYSKAKRSGEVMQH
                     AWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTACDGGELKDHILLP
                     TSIYPVTRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLVLVNPKSGGRQGERILQ
                     KFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTKH
                     PPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVE
                     NGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAA
                     TCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRK
                     SVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKL
                     LPMQVDGEPWMQPPCMIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD"
     exon            377..453
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            454..619
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            620..673
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            674..844
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            845..894
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            895..969
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1092
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1210
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1299
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1416
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1509
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1569
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1649
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1724
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1810
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1900
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2061
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2126
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2217
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2395
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2516
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2577
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..3467
                     /gene="Dgkg"
                     /gene_synonym="Dagk3; DGK-III; DGKIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaataag cggctaggag ggagctcccc ggcaagcgcg caaccaagtg ttgcatggtg
       61 aggaattgac agcgttttgg gattggcctg gactacagca ggaacatgtt acctgaggag
      121 tagcacaagt ctttcactag ctgccgagag gagtccacag ctgtcatcca ccctcaagtg
      181 ccctacaagt cccaaaggca tcactcactg cacatctgta atgagccagg ccctgagccg
      241 ggcctcggct tcttgctggt gaccggaact ccatccgtgg gtcttgaagc gatcacactc
      301 ggctgaaaga tgagtgacgg gcaatgggtc tgtctctcat cagaagaatt tgatcaactt
      361 cagaaatact ctgaatattc ctccaagaag ataaaagatg tgttggctga gtttaatgaa
      421 ggtggaagcc tcaagcaata tgacccacac aagcccatta gctatgatgt cttcaagctg
      481 ttcatgaggg catacctgga ggtggatctt cctcagccac tgagcacaaa cctcttcctg
      541 gccttcagcc agaagcccag acaagagaca cctgaccacc caaaggaggg ggccagcagt
      601 agtgagccca atgtctcaga ttctaatgcg gagagcactg ccaaagcgga tgctgcctgc
      661 gctccagaca ctgaatcaaa accgatcaag acacaagtac cgtctgaaga actagaggct
      721 gcagccccat ggggagaacc taacgctccg gcttcaagct ccgatgcccc catagtgtac
      781 ctgaaggatg tggtgtgtta cttgtccctg atggagaccg ggaggcctca ggataaacta
      841 gaattcatgt ttcgtctcta tgattcggat gaaaatgaac tcctggacca agcggagctg
      901 gatcaaattg tgagccaaat gctacatgtt gcccagtacc tggagtggga tcccacagag
      961 ctcagaccta tactgaagga gatgttgcaa ggcatggact acaacaagga tggcttcgtg
     1021 tctctagagg agtgggtcag tggggggatg accaccatcc cgttgctggt cctcctggga
     1081 atggatgact ccgcctccaa gggggatggg aggcacgcct ggaccctgaa gcacttcaag
     1141 aagcccactt actgcaactt ctgccacatc atgctgatgg gcgttcggaa gcaaggcctg
     1201 tgctgcatct actgtaaata tgctgtccac caacgctgtg tatccaacag cattcctgga
     1261 tgtgtgaaaa catactccaa agccaaaagg agcggtgagg tgatgcagca cgcgtgggtg
     1321 gaagggaact cctccgtcaa gtgtgaccgg tgccacaaaa gtatcaagtg ctaccagagt
     1381 gtcaccgcgc ggcactgcgt gtggtgccgg atgacgtttc accgcaaatg tgaattgtcg
     1441 acagcgtgcg atggtgggga actcaaagac cacattttgc tgcctacctc catataccct
     1501 gtcacccgag accggcaagc agggaagtcc gatagcggtg cggccgccaa gggtgaactt
     1561 gtaatgcagt ataagatcat cccaagtccg gggacgcatc ccctgctggt cctggtgaac
     1621 cccaagagtg gaggaagaca aggagaaaga attcttcaga aattccacta cctgctcaac
     1681 cccaaacaag ttttcaacct ggacaaaggg gggcctacgc caggattgaa cttctttcag
     1741 gataccccgg acttccgtgt tcttgcctgt ggcggagatg ggacagttgg ctggattttg
     1801 gattgcattg acaaggccaa cttcacaaag catccaccgg tggctgtcct gcctcttggg
     1861 acagggaacg acctcgcacg atgtcttcgc tggggaggag gttatgaggg gggcagcttg
     1921 accaaaatcc tgaaggaaat tgaacagagc cccttggtga tgctggaccg ttggtaccta
     1981 gaggtcatgc ccagggaaga ggtggagaac ggagaccagg tcccatacaa catcatgaac
     2041 aactatttct ccattggtgt ggatgcttca attgcacaca gattccatgt gatgagagag
     2101 aaacaccctg aaaaattcaa cagcaggatg aagaacaagc tgtggtattt cgaatttggt
     2161 acctctgaaa cctttgcagc tacctgcaag aaactccatg accacataga gctggagtgc
     2221 gatggcgttg aggtggacct gagcaatatc ttcctggaag gcattgccat tcttaacatt
     2281 cccagcatgt acggaggcac caatctctgg ggagaaacca agaagaaccg agctgtgatc
     2341 cgggaaagca ggaagagcgt cacagaccca aaggagctga aatgttgtgt ccaagacctc
     2401 agtgaccagc ttcttgaagt ggtgggtcta gagggagcca tggagatggg acagatctat
     2461 accggcctga agagtgcagg caggaggcta gcccagtgct cctctgtcac cattaggact
     2521 aagaagcttc tgccgatgca agtggatgga gaaccctgga tgcagccgcc atgcatgatt
     2581 aaaatcactc acaaaaacca ggcacctatg atgatggggc ctccccagaa gagcagcttc
     2641 ttttctctga ggaggaaaag ccgttcaaag gactaaacga tatgccaagc accagctcta
     2701 ccaagaaagg aaagaagaat atacacgcac acacacatgc acacgcacca atgcagacac
     2761 acgcgcacac gagcacgcac acacgtacga acgcacgcat gcacctataa ccagaggaag
     2821 caaagccacc ttccacctgc catgtggtct acctattttg aaaatggatc cactcctaac
     2881 agagccaata cccatgagat atcccggatg gactcagggc ccacgaagac cgggttggct
     2941 catacagcga ctttcacatt cccacaggct ttagactttg agcctgaagg agacatctcc
     3001 ctttttctgc accacactcc agtaaggctc caggctgtag gtttcctgcc tacagcaaga
     3061 tcggatgtgg tcaagggaaa gagctccaac ccagaaaact tacacaaaag tccttctgta
     3121 caaaaacaaa acagcctaca gctctccaag caaaatcctt ggcagggctc attgagcaca
     3181 ggatggtctc tttgccgtcc ttcaagcaac agctcctccc ttaacttgca gaggaaagcc
     3241 aagaagctgt ggaaagccgt ttccattctt ggttccctct gctgtccatg ggtacttgtt
     3301 cgcttcctga agcatctctt ggtgtctgtt ttgcttagag agcaaacaag gctgctgggg
     3361 cagcatactt tagatgtggt atttattttc atagttccta tgaacacttg ggagggagag
     3421 ctgagaaagt ggactttatt tttcaaattg atgtcataat gttgtgt
//
