LOCUS       NM_001105865            4538 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DGCR8 microprocessor complex subunit (Dgcr8),
            mRNA.
ACCESSION   NM_001105865 XM_001064513 XM_221273
VERSION     NM_001105865.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4538)
  AUTHORS   Pidikova,P., Chovancova,B., Mravec,B. and Herichova,I.
  TITLE     The 24-h pattern of dgcr8, drosha, and dicer expression in the rat
            suprachiasmatic nuclei and peripheral tissues and its modulation by
            angiotensin II
  JOURNAL   Gen Physiol Biophys 41 (5), 417-430 (2022)
   PUBMED   36222340
  REMARK    GeneRIF: The 24-h pattern of dgcr8, drosha, and dicer expression in
            the rat suprachiasmatic nuclei and peripheral tissues and its
            modulation by angiotensin II.
REFERENCE   2  (bases 1 to 4538)
  AUTHORS   Shi,C., Jin,J., Xu,H., Ma,J., Li,T., Xie,Y. and Li,Z.
  TITLE     CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK
            phosphorylation to promote spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Gene Ther 29 (6), 379-389 (2022)
   PUBMED   34413501
  REMARK    GeneRIF: CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK
            phosphorylation to promote spinal nerve ligation-induced
            neuropathic pain.
REFERENCE   3  (bases 1 to 4538)
  AUTHORS   Ushakov,K., Koffler-Brill,T., Rom,A., Perl,K., Ulitsky,I. and
            Avraham,K.B.
  TITLE     Genome-wide identification and expression profiling of long
            non-coding RNAs in auditory and vestibular systems
  JOURNAL   Sci Rep 7 (1), 8637 (2017)
   PUBMED   28819115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4538)
  AUTHORS   Gedik,H., Erdal,M.E., Yilmaz,S.G., Sengul,C., Sengul,C.B. and
            Herken,H.
  TITLE     Association of microRNA biogenesis pathway gene variants and
            alcohol dependence risk
  JOURNAL   DNA Cell Biol 34 (3), 220-226 (2015)
   PUBMED   25495208
REFERENCE   5  (bases 1 to 4538)
  AUTHORS   Quick-Cleveland,J., Jacob,J.P., Weitz,S.H., Shoffner,G.,
            Senturia,R. and Guo,F.
  TITLE     The DGCR8 RNA-binding heme domain recognizes primary microRNAs by
            clamping the hairpin
  JOURNAL   Cell Rep 7 (6), 1994-2005 (2014)
   PUBMED   24910438
REFERENCE   6  (bases 1 to 4538)
  AUTHORS   Krol,J., Loedige,I. and Filipowicz,W.
  TITLE     The widespread regulation of microRNA biogenesis, function and
            decay
  JOURNAL   Nat Rev Genet 11 (9), 597-610 (2010)
   PUBMED   20661255
  REMARK    Review article
REFERENCE   7  (bases 1 to 4538)
  AUTHORS   Sohn,S.Y., Bae,W.J., Kim,J.J., Yeom,K.H., Kim,V.N. and Cho,Y.
  TITLE     Crystal structure of human DGCR8 core
  JOURNAL   Nat Struct Mol Biol 14 (9), 847-853 (2007)
   PUBMED   17704815
REFERENCE   8  (bases 1 to 4538)
  AUTHORS   Faller,M., Matsunaga,M., Yin,S., Loo,J.A. and Guo,F.
  TITLE     Heme is involved in microRNA processing
  JOURNAL   Nat Struct Mol Biol 14 (1), 23-29 (2007)
   PUBMED   17159994
REFERENCE   9  (bases 1 to 4538)
  AUTHORS   Han,J., Lee,Y., Yeom,K.H., Kim,Y.K., Jin,H. and Kim,V.N.
  TITLE     The Drosha-DGCR8 complex in primary microRNA processing
  JOURNAL   Genes Dev 18 (24), 3016-3027 (2004)
   PUBMED   15574589
REFERENCE   10 (bases 1 to 4538)
  AUTHORS   Gregory,R.I., Yan,K.P., Amuthan,G., Chendrimada,T., Doratotaj,B.,
            Cooch,N. and Shiekhattar,R.
  TITLE     The Microprocessor complex mediates the genesis of microRNAs
  JOURNAL   Nature 432 (7014), 235-240 (2004)
   PUBMED   15531877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by
            NM_001105865.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_221273.4, XM_001064513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132296,
                              SAMD00132304 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4538
                     /gene="Dgcr8"
                     /note="DGCR8 microprocessor complex subunit"
                     /db_xref="GeneID:287954"
                     /db_xref="RGD:1306365"
     exon            1..138
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            139..346
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            347..1346
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..2948
                     /gene="Dgcr8"
                     /note="DiGeorge syndrome critical region gene 8"
                     /codon_start=1
                     /product="microprocessor complex subunit DGCR8"
                     /protein_id="NP_001099335.1"
                     /db_xref="GeneID:287954"
                     /db_xref="RGD:1306365"
                     /translation="METYESPSPLPHEPTGEAMMENRACPFQVLPHEQSPPPPLQTSS
                     DAEVMDVGSGGDGQSEPPADDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHA
                     PAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGVERSTRPECSQLLSPVCGDVH
                     ACPFGGSVGNGVGLGGESTDKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGTGG
                     FTANAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRMEEKYGGDSDHPSD
                     GETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYF
                     LGTGSIRKHDPPLSSIPCLHYKKMKDNEEREQSCDLAPSGEVSPVKPLGRSAELDFPL
                     EEPDSLGGDSGSLDEKDPLGAEAAAGALGQVRAKVEVCKDESVDLEEFRNYLEKRFDF
                     EQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPN
                     GKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKN
                     KAARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQIL
                     HECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQ
                     LLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQYAKKNRPNLHILSKLQEEMK
                     RLAAEREETRKKPKMSIVASAQPGGEPLCTVDV"
     exon            1347..1506
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1649
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1932
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2130
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2232
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2331
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2414
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2515
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2622
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2750
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2864
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..4538
                     /gene="Dgcr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcgcccg cgcggcagcg ggtctcaaga gccgagagct tgcaaaggcc ttcgcgggtt
       61 gcggcggcgc cggggcggtg agggtcggcc gactgtggtc gggctgcggg cggctcgggc
      121 aggtcgcggg cgccacagac accctccctc tactgggaat ggatctatgc tgccactcct
      181 ggtgacctca gcacgctgca tcactgtcct gtccacgtgc cacgttgtgg gcccaggaga
      241 gggggtcctt gggtagcaga gtgcctggct atatctctga ggtccctagt gccacagagt
      301 tgagctgagg gtctcactcg ccctctgact gacccagccc ttgcaggtgg aagaagaaag
      361 gtgccacttt ggcatgaaga tagactcact tagacgtcag tcttttaagc tgagtgcatt
      421 gtgatttcca ataattgagg cagtggttct aaaagctgtc tacattaatg aaaagagcaa
      481 tgtggccagc ttgactaaac cgccagtgtg tacagcgcgg gcaggacggc accgggtctc
      541 gacggacttg tgcatgttag cagtatagat ttatgtaagg tggtttaaaa ctctggtctt
      601 ttaaagtagt cttaactgct cataatatgg agacatatga gagtccctct cctctcccgc
      661 atgagcccac aggagaagca atgatggaga accgagcttg ccccttccaa gtgctgcccc
      721 atgaacagtc tccaccacct cccctgcaaa cgtccagtga tgcagaggta atggacgttg
      781 gctctggtgg tgatggacag tccgaacctc ctgccgacga cccattcaac ttctacggag
      841 cttctcttct ctccaaagga tccttctcta agggccgcct cctcatagac ccgaactgta
      901 gtggccacag cccgcgcact gcccggcacg cacctgcggt ccggaagttc tcccctgacc
      961 ttaagttgct taaggatgta aagattagcg tgagctttac tgagagctgc aggagtaagg
     1021 acaggaaggt gctgtacaca ggagtagaac gcagcactcg gcctgaatgt agccagctcc
     1081 ttagtcctgt ctgcggggac gtgcatgctt gtccctttgg cgggagtgtt ggtaatgggg
     1141 taggcctagg gggtgagagt acagataaga aggatgagga aaatgagctg gatcaggaaa
     1201 agagagtgga gtatgcagtg ctcgatgagt tagaagattt tactgacaat ttggagctag
     1261 atgaagaagg aacaggcggg ttcacggcta acgcaatcgt tcaaagagac agagtggatg
     1321 aagaggcctt gaatttctcc tatgaggatg actttgacaa tgatgtggat gctttactag
     1381 aagaaggtct ctgtgctccc aagaagaggc gaatggagga aaaatatggc ggagacagtg
     1441 atcatccgtc tgatggagag acaagtgtgc agccaatgat gaccaagatt aaaacagtgc
     1501 tcaaaagtcg tggccgtcca cctacagagc cattgcctga tggatggata atgacttttc
     1561 ataactctgg agtccctgta tacctgcaca gagagtctcg agtggtcacc tggtccagac
     1621 cctacttctt ggggacggga agcatacgga aacatgatcc tcctctaagc agcatccctt
     1681 gtctgcatta taagaaaatg aaggacaacg aggaacgaga gcaaagttgt gatcttgccc
     1741 ccagtggaga agtgtcacct gtcaagcccc tgggtcgctc tgcagagctg gatttccctc
     1801 tggaggagcc tgactccttg ggtggagact cagggtctct ggatgagaag gaccccctgg
     1861 gtgctgaggc agctgctgga gccctgggac aagtgagggc taaagttgag gtgtgcaaag
     1921 atgagtcagt tgatctggag gaatttcgta attacctgga gaagcgattt gactttgagc
     1981 aagtaactgt gaaaaaattc aggacttggg ctgaacgtcg tcaattcaac cgtgagatga
     2041 agcggaaaca ggcagagtca gagaggccca tcctgccagc caaccagaag ctgatcactc
     2101 tatctgtgca agatgcaccc acaaaaaaag agtttgtcat caatcccaat gggaagtctg
     2161 aggtttgcat cctgcacgaa tacatgcagc gtgtcctcaa ggtccgccct gtttataatt
     2221 tctttgaatg tgagaatcca agtgagcctt ttggtgcctc cgtgaccatt gatggtgtga
     2281 cttacggatc tggaactgca agcagcaaaa aacttgcgaa gaataaagct gcccgagcta
     2341 cactggaaat tctcatccct gactttgtta aacagacctc tgaggagaag cctaaagaca
     2401 gtgaggaact ggagtatttt aaccacatca gtattgagga ttcgcgagtc tacgagctga
     2461 caagcaaggc tgggctgttg tctccatatc agatcctcca tgagtgcctt aaaagaaacc
     2521 atggcatggg tgacacatcc atcaagtttg aagtggttcc tgggaaaaac cagaagagcg
     2581 aatatgttat ggcatgcggc aaacacacag tgcgcgggtg gtgtaagaat aaacgagttg
     2641 ggaaacaatt agcatctcag aaaatccttc agctgttgca cccccatgtc aagaactggg
     2701 ggtccttgct gcgcatgtat ggtcgtgaga gcagcaaaat ggtcaagcag gagacctctg
     2761 acaagagtgt gatagagcta caacagtatg ccaagaagaa caggcccaac cttcacatcc
     2821 tgagcaagct acaagaagag atgaagaggc tggctgcaga gcgggaggag actcggaaga
     2881 aacccaagat gtcaattgta gcatctgccc agcctggtgg tgagcccttg tgcacagtgg
     2941 atgtatgagg taggcagcat gggccaacag tgctaccagg agaccatcag ccacacatct
     3001 tcatcattct acagcaccag gcctccaacc taagttcctt ccctgtggct gtgtctgggc
     3061 tctggctctg gcacatgggg acagctgtga ccacacagca cacatgcaaa gcagcagttc
     3121 tggacaagct gctctcaatg tgactggata tacttatgga tcagttatat gttaactgca
     3181 caagtggaag ctgatagaca gctgtagatc ttgcttgtat gtatctgctg cggactgttt
     3241 ttatgaaggt tttcattaat tttagtacac tatatgcact gacaagaagt aatacttcat
     3301 tgatagatga gatgaccagg ttttatagct ttggctggcc tatgatgcca gatagcccct
     3361 ttgctatggt tctttctggt ggagccacag agacttggtc agaaggtgca ggtatcctag
     3421 tattacctgc tttgtgtgtt tcccattttc ttctgaaaaa gttataatag aaaggaatat
     3481 ttcaggctat tttggcttaa aataaaacaa aattttagca ccagaaatac tcttcagaga
     3541 ttgcagtgaa gataactgaa ccatcgagat actgagtgat agtctggttg acccttgggt
     3601 tgcagtctac ttttcttatg aagtcttaat gtcctaacag ctgtcttctg gatactgaag
     3661 cttcaccttc gataagctct agtaacagtt ttttacagag atttttgcac aatcaagccc
     3721 atctgttcat caatttttaa agcttttatg atgttataaa atttggaaac ttttacagta
     3781 agaatgattt agaatcatgc atttcaacag atggacatgt ataaatagga aacaggggcc
     3841 catcattgac caagagctgg ctagcacatt gtacatgata gttatagctt ctcttgatct
     3901 caagggtagc tgttctctgc agccaggcct gatttcaggt tgtttttgtc tgcctgcact
     3961 catgggatag cccctgtaga tgggtattga atagaagtgt attcagagcc ctagtcttgg
     4021 tcagttgttg gcctagcccc tagtacctgt tcatggggac tacactctac attctcagtg
     4081 tgtgtctcac catgtacctg aagagatggt gacatgtgct gtcagacaga cagaatggta
     4141 actgggactc ccaacagcat ctccctcctt aaccacatgt gtgacagcag ttaatgtctg
     4201 tgttaatctt ggcaaaaaga accctctatc aagttggtag acttagacac ttgattcttt
     4261 tctgcctccc attcagttgt gttcagtctt ttgactaacc attgccctta aaaacagatt
     4321 tgacattgaa aaagtataag gtaatggtgg tgtctctgca gcctcacaca caggtgctgc
     4381 cacacattcc tgtctccaat gccctccctg tcttacaggt gggtgagtct tctatgtaca
     4441 gccatgctgc aagggtggga gcctgtgctg atgctgcttc tgtgtgttgg ccaaggctgt
     4501 agggtgtacc ctgatggtct gaacacataa aactatcc
//
