LOCUS       NM_001012345            2320 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus diacylglycerol O-acyltransferase 2 (Dgat2), mRNA.
ACCESSION   NM_001012345 XM_341887
VERSION     NM_001012345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Ma,Z., Onorato,J.M., Chen,L., Nelson,D.W., Yen,C.E. and Cheng,D.
  TITLE     Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid
            acyltransferases
  JOURNAL   J Lipid Res 58 (6), 1091-1099 (2017)
   PUBMED   28420705
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Brandt,C., McFie,P.J. and Stone,S.J.
  TITLE     Biochemical characterization of human acyl coenzyme A:
            2-monoacylglycerol acyltransferase-3 (MGAT3)
  JOURNAL   Biochem Biophys Res Commun 475 (3), 264-270 (2016)
   PUBMED   27184406
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Cote,I., Chapados,N.A. and Lavoie,J.M.
  TITLE     Impaired VLDL assembly: a novel mechanism contributing to hepatic
            lipid accumulation following ovariectomy and
            high-fat/high-cholesterol diets?
  JOURNAL   Br J Nutr 112 (10), 1592-1600 (2014)
   PUBMED   25263431
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Jin,Y., McFie,P.J., Banman,S.L., Brandt,C. and Stone,S.J.
  TITLE     Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol
            acyltransferase-2 (MGAT2) interact to promote triacylglycerol
            synthesis
  JOURNAL   J Biol Chem 289 (41), 28237-28248 (2014)
   PUBMED   25164810
  REMARK    GeneRIF: The interaction of DGAT2 and MGAT2 serves to channel lipid
            substrates efficiently for triacylglycerol biosynthesis.
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Stone,S.J., Myers,H.M., Watkins,S.M., Brown,B.E., Feingold,K.R.,
            Elias,P.M. and Farese,R.V. Jr.
  TITLE     Lipopenia and skin barrier abnormalities in DGAT2-deficient mice
  JOURNAL   J Biol Chem 279 (12), 11767-11776 (2004)
   PUBMED   14668353
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Wakimoto,K., Chiba,H., Michibata,H., Seishima,M., Kawasaki,S.,
            Okubo,K., Mitsui,H., Torii,H. and Imai,Y.
  TITLE     A novel diacylglycerol acyltransferase (DGAT2) is decreased in
            human psoriatic skin and increased in diabetic mice
  JOURNAL   Biochem Biophys Res Commun 310 (2), 296-302 (2003)
   PUBMED   14521909
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Waterman,I.J., Price,N.T. and Zammit,V.A.
  TITLE     Distinct ontogenic patterns of overt and latent DGAT activities of
            rat liver microsomes
  JOURNAL   J Lipid Res 43 (9), 1555-1562 (2002)
   PUBMED   12235188
  REMARK    GeneRIF: ontogeny of the two functional diacylglycerol
            acyltransferase (DGAT) activities (overt and latent) during
            postnatal development in rat liver
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Yen,C.L., Stone,S.J., Cases,S., Zhou,P. and Farese,R.V. Jr.
  TITLE     Identification of a gene encoding MGAT1, a monoacylglycerol
            acyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8512-8517 (2002)
   PUBMED   12077311
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Cases,S., Stone,S.J., Zhou,P., Yen,E., Tow,B., Lardizabal,K.D.,
            Voelker,T. and Farese,R.V. Jr.
  TITLE     Cloning of DGAT2, a second mammalian diacylglycerol
            acyltransferase, and related family members
  JOURNAL   J Biol Chem 276 (42), 38870-38876 (2001)
   PUBMED   11481335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089846.1.
            
            On Feb 18, 2005 this sequence version replaced XM_341887.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089846.1, SRR8487231.101396.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2320
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /note="diacylglycerol O-acyltransferase 2"
                     /db_xref="GeneID:252900"
                     /db_xref="RGD:620329"
     exon            1..298
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1344
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.76"
                     /note="diglyceride acyltransferase 2; retinol
                     O-fatty-acyltransferase; acyl-CoA retinol
                     O-fatty-acyltransferase"
                     /codon_start=1
                     /product="diacylglycerol O-acyltransferase 2"
                     /protein_id="NP_001012345.1"
                     /db_xref="GeneID:252900"
                     /db_xref="RGD:620329"
                     /translation="MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGS
                     SILSALQDIFSVTWLNRSKVEKHLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLI
                     AALYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGY
                     HPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNR
                     DTIDYLLSKNGSGNAIVIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPT
                     YSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPI
                     TTVVGEPITVPKLEHPTQKDIDLYHTMYMEALVKLFDNHKTKFGLPETEVLEVN"
     exon            299..427
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            428..535
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            536..606
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            607..811
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            812..986
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1189
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..2294
                     /gene="Dgat2"
                     /gene_synonym="ARAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctagggtg gcagcggcta cctacctcgg atctcgacct gctgccacca cggcctgagc
       61 gctgtccctc ggctcccgga gctcagcgcg aagccctggc cccggcggct ggggcatgga
      121 tcaggggcgc tgcgtgaggc ggcttcctgc acggccgtga cgtgcaccgg cttcagcatg
      181 aagaccctca tcgctgccta ctccggggtc ctgcggggtg agcgtcgggc cgaagctgcc
      241 cgcagcgaga acaagaataa aggatctgcc ctgtcacgcg aggggtctgg gcgatggggc
      301 actggctcca gcatcctctc ggccctccaa gacatcttct ctgtcacctg gctcaacaga
      361 tccaaggtgg aaaaacacct acaggtcatc tcagtcctac agtgggtcct atccttcctg
      421 gtgctaggag tggcctgcag tgtcatcctc atgtacacct tctgcactga ctgctggctg
      481 atagctgctc tctacttcac ctggctggca tttgactgga acacgcccaa gaaaggtggc
      541 aggagatcac agtgggtgcg aaactgggcc gtgtggcgct attttcgaga ctactttccc
      601 atccagctgg tgaagacaca caacctgctg accaccagga actatatctt tggataccat
      661 ccccatggca tcatgggcct gggtgccttc tgtaacttca gcacggaggc caccgaagtt
      721 agcaagaagt tccctggcat aaggccttat ttggccacat tggctggcaa cttccggatg
      781 cctgtgcttc gggagtacct gatgtctgga ggcatctgcc ctgtcaacag agacaccata
      841 gactacttgc tttccaagaa tgggagtggt aatgccattg tcatcgtggt gggaggtgca
      901 gctgaatccc tgagctccat gcctggcaag aacgcagtca ccctgcggaa ccgcaaaggc
      961 tttgtaaagc tggccctgcg ccatggagct gatctggttc ccacctattc ctttggagag
     1021 aatgaggtat acaagcaggt gatctttgag gagggctcct ggggccgatg ggtccagaag
     1081 aagttccaga agtatattgg tttcgccccc tgcatcttcc atggccgagg tctcttctcc
     1141 tctgacacct gggggctggt gccctactcc aagcccatca ccaccgttgt gggggagccc
     1201 atcaccgtcc ctaagctgga gcacccgacc cagaaagaca tcgacctgta ccacaccatg
     1261 tacatggagg ccctggtgaa gctctttgac aatcacaaga ccaaattcgg ccttccagag
     1321 actgaggtgc tggaggtgaa ctgacccagc ccatgggtgc cagctcctgg aaggaatgac
     1381 tgcaaatcct tttctaccaa gttctcaagt gcattttgtt ctgtaaattt ggaagcgtca
     1441 tgggtgtctg tgggttattt aaaagaaatt ataatttgtt aaaccattgc aatgttagat
     1501 cttttttaag aagggaagag tcagtatttt aagctcactt ctagtgtgtc ctgcctaagg
     1561 tggtggctga catttatagg ccttgatggt ttctatccac cccttctagt gttccccaaa
     1621 caacagacac ttggccctag ttaattgggg aagggcagcc cttagtgact cagccattta
     1681 atcctcttcg ctctagggat tctcaagaga cggaggccac gtttaaaaac acctccattc
     1741 ccacccacaa cacgtgactg ctggtcaggt ttttcttact taggggagga tgagggggca
     1801 tagctggttc cgcttgggga gagtggtaga taacatctgg aatgcccggc tcgagtgtcc
     1861 tctgctcccc acctactcct cttctccaat ctgagcctac cctggcctcc tgtacactgt
     1921 gctagggaca gggctgtccc acaggtgcca tgttgggtta tctcgctgct gttggctggt
     1981 tttactctgg agattggcat cgtgaacaca gctcagcgtc attctggaga tgttctccca
     2041 gccacctgag ctctcctgag ccacacccca agtctggtgt gaggagaggc ctctgttctt
     2101 cacagaggtg cctggcttcc tgtgcagcac actgggtcca ggacaggagg ccacccccaa
     2161 ccaagcctca cctgtgtgcc tttatgaggc gtcgggagaa agccaccctc ctgtgtattc
     2221 tgctttctcc atgagatttt gccatgtcac acttttgtat attcctagac taataaatgg
     2281 aaacaagaac agccaaaaaa aaaaaaaaaa aaaaaaaaaa
//
