LOCUS       NM_001013873            2080 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus desumoylating isopeptidase 2 (Desi2), mRNA.
ACCESSION   NM_001013873 XM_213951
VERSION     NM_001013873.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Li,S.Y., Wang,C.Y., Zhao,J.J., Long,C.Y., Xiao,Y.X., Tang,X.B.,
            Yuan,Z.W. and Bai,Y.Z.
  TITLE     Upregulation of PPPDE1 contributes to anorectal malformations via
            the mitochondrial apoptosis pathway during hindgut development in
            rats
  JOURNAL   Exp Cell Res 402 (2), 112574 (2021)
   PUBMED   33794264
  REMARK    GeneRIF: Upregulation of PPPDE1 contributes to anorectal
            malformations via the mitochondrial apoptosis pathway during
            hindgut development in rats.
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Xie,X., Wang,X., Jiang,D., Wang,J., Fei,R., Cong,X., Wei,L.,
            Wang,Y. and Chen,H.
  TITLE     PPPDE1 is a novel deubiquitinase belonging to a cysteine
            isopeptidase family
  JOURNAL   Biochem Biophys Res Commun 488 (2), 291-296 (2017)
   PUBMED   28483520
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Shin,E.J., Shin,H.M., Nam,E., Kim,W.S., Kim,J.H., Oh,B.H. and
            Yun,Y.
  TITLE     DeSUMOylating isopeptidase: a second class of SUMO protease
  JOURNAL   EMBO Rep 13 (4), 339-346 (2012)
   PUBMED   22370726
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Cai,P., Xia,X., Li,F., Cui,Y., Yang,Q. and Chen,M.
  TITLE     PNAS4 knockout does not induce obviously neurocytes apoptosis and
            abnormal development in mice brain
  JOURNAL   Mol Biol Rep 39 (1), 621-628 (2012)
   PUBMED   21553223
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083584.1.
            
            On Apr 20, 2005 this sequence version replaced XM_213951.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083584.1, FQ226068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q25"
     gene            1..2080
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /note="desumoylating isopeptidase 2"
                     /db_xref="GeneID:289277"
                     /db_xref="RGD:1359392"
     exon            1..444
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..987
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /EC_number="3.1.2.22"
                     /EC_number="3.4.19.12"
                     /note="PPPDE peptidase domain-containing protein 1; family
                     with sequence similarity 152, member A; PPPDE peptidase
                     domain containing 1; S-depalmitoylase DESI2; palmitoyl
                     protein thioesterase DESI2"
                     /codon_start=1
                     /product="deubiquitinase DESI2"
                     /protein_id="NP_001013895.1"
                     /db_xref="GeneID:289277"
                     /db_xref="RGD:1359392"
                     /translation="MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGG
                     HPYPFSGIFEISPGNAAELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYH
                     LMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVS
                     QELQDELEEAEDAAASTAMASAAAGGRTGRHTKL"
     exon            445..517
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..611
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..753
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2051
                     /gene="Desi2"
                     /gene_synonym="CGI-146; DeSI-2; Fam152a; PNAS-4; Pppde1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacccaac ccgccgccat tttaggtctc gaggtgcagc gcctgagaga gtcagcgcgc
       61 aggcgggctc agccctggct ccgagcgggc cccgcctcca gggtgcctgg agcccgcccc
      121 tcgcccaggc tccgccttcc cccacgtgtc tgcggccgag gggaggcgcc tgagccggag
      181 cgggctctcc accggtctgg cccggtcctc atacaggttt ctgacagcgg ctcccgggag
      241 cggccccggc tgccggatgc ttccgccccg actgcggcgg gccgggctgg acgcttagtg
      301 cccggctcga gccctgcctg aggctcccgc gggggtggca gcggcctccg ccccgcggag
      361 accgagcggc tggaggacga ggcggcggtc gtggggagga ggatgggggc taaccagtta
      421 gtggtgctca acgtctacga catgtactgg atgaatgaat acacctcatc tatcggaatt
      481 ggagtttttc attctggaat tgaagtatat ggcagagaat tcgcttatgg tggccatcct
      541 tatccttttt ctggaatatt tgaaatttcc ccaggaaatg ctgctgagct aggagaaaca
      601 tttaaattta aagaagctgt tgttctaggg agtacggact tcctggaaga tgacatagaa
      661 aagattgtgg aagagctggg gaaagagtac aaaggcaacg cctaccatct gatgcacaag
      721 aactgcaacc acttctcctc cgccctgtca gagattctct gtgggaaaga gattcctcgc
      781 tggatcaacc ggctggccta cttcagctcc tgtataccct ttctacagag ttgcctccca
      841 aaggagtggc tcactcctgc ggcactgcag tctagtgtca gccaagaact ccaggatgaa
      901 ctggaagaag cagaggacgc agccgcatcc actgccatgg caagtgctgc agctggaggc
      961 agaactgggc gtcacactaa actataatta tgatctctgc cgtctgcctt cagaacggtc
     1021 tctggcagtt gagtgtcact agagaaaaag aaaatagagt aaatgtcctt tggatatttt
     1081 gtatgcaaag atggctctcc cccaaatccc agtttttcag ctcaggatta tatttgtaat
     1141 caaaaacaaa aaagaaaaaa aatcactcgg cacaggaggg agaacttcgt acgaagctgc
     1201 cctcttctct tttcttttta acccacttgt aaatttggat tcacttcctc tgttttatac
     1261 gagctctgtt aaattacgtt tacagtattt tgtaccactg tttacaaatc ttgcatggac
     1321 ttctgccacc gtgaaggaag agtatcctcc tcttcagacg tgaggcagac catctctgta
     1381 cacttcctga cagctgcaga gccacggcct aatagtgggc acaagagaag gctctcacga
     1441 ctgcaggtct catcacctgc tcacaggctg tcccttagag tcccatttgg cacccagaca
     1501 caggagtgcc agctggcctc atgtgaagga gcacacatgg ccagagggct ccttgggccc
     1561 caggtcagct cctttccaca cctccttcct gttccgagca gcacattccc caaggtgccc
     1621 atggagcaac tggtttcatc ccaaacacac ctgctcagca gggggggggt gtcgtgtctg
     1681 ccggctagat gcctctgacc ctttaatgaa gatgtgttca tggaagacac tcttataacg
     1741 atgagtggtt tgcacatgtc ttacagaggg gcctcatttt tactttagta cattctaaac
     1801 tcctccctgt acaggatatt tttggtgggc tgggagtatc ctaacctagc ttcctgagca
     1861 gcagtctaaa ctgacattaa actgcttttt aactagccag actacctttt atactggaca
     1921 ttgaaaacta gaatctgaaa cacacctaac atttaatact tgtgtacacc atatcagaaa
     1981 tggcttgttg gagttttagt tcatggggga gtggttgcac ctcataatag agattctatt
     2041 ttcattgata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
