LOCUS       NM_022531               2169 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus desmin (Des), mRNA.
ACCESSION   NM_022531
VERSION     NM_022531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Takamatu,M., Kazama,S., Suzuki,T., Miyazaki,Y., Tanaka,K., Usami,M.
            and Takizawa,T.
  TITLE     Differential expression of desmin in the uterine myometrium and
            cervix as a possible mechanism for successful parturition in rats
  JOURNAL   Reprod Biol 23 (1), 100726 (2023)
   PUBMED   36603297
  REMARK    GeneRIF: Differential expression of desmin in the uterine
            myometrium and cervix as a possible mechanism for successful
            parturition in rats.
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Langer,H.T., Mossakowski,A.A., Avey,A.M., Wohlgemuth,R.P.,
            Smith,L.R., Zbinden-Foncea,H. and Baar,K.
  TITLE     A mutation in desmin makes skeletal muscle less vulnerable to acute
            muscle damage after eccentric loading in rats
  JOURNAL   FASEB J 35 (9), e21860 (2021)
   PUBMED   34411340
  REMARK    GeneRIF: A mutation in desmin makes skeletal muscle less vulnerable
            to acute muscle damage after eccentric loading in rats.
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Yan,S., Chen,J., Zhang,T., Zhou,J., Wang,G. and Li,Y.
  TITLE     Micro-RNA-338-3p Promotes the Development of Atherosclerosis by
            Targeting Desmin and Promoting Proliferation
  JOURNAL   Mol Biotechnol 63 (9), 840-848 (2021)
   PUBMED   34100182
  REMARK    GeneRIF: Micro-RNA-338-3p Promotes the Development of
            Atherosclerosis by Targeting Desmin and Promoting Proliferation.
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Chen,L., Wang,L., Li,X., Wang,C., Hong,M., Li,Y., Cao,J. and Fu,L.
  TITLE     The role of desmin alterations in mechanical electrical feedback in
            heart failure
  JOURNAL   Life Sci 241, 117119 (2020)
   PUBMED   31794771
  REMARK    GeneRIF: Desmin participates in the mechanoelectric feedback in
            heart failure through the NF-kappaB pathway.
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Alam,S., Abdullah,C.S., Aishwarya,R., Miriyala,S.,
            Panchatcharam,M., Peretik,J.M., Orr,A.W., James,J., Robbins,J. and
            Bhuiyan,M.S.
  TITLE     Aberrant Mitochondrial Fission Is Maladaptive in Desmin
            Mutation-Induced Cardiac Proteotoxicity
  JOURNAL   J Am Heart Assoc 7 (14), e009289 (2018)
   PUBMED   29987122
  REMARK    GeneRIF: Aberrant mitochondrial fission results in mitochondrial
            respiratory defects and apoptotic cell death in D7-Des Tg hearts.
            Inhibition of aberrant mitochondrial fission using mitochondrial
            division inhibitor significantly preserved mitochondrial function
            and decreased apoptotic cell death
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Zhang,J., Kumar,A., Stalker,H.J., Virdi,G., Ferrans,V.J.,
            Horiba,K., Fricker,F.J. and Wallace,M.R.
  TITLE     Clinical and molecular studies of a large family with
            desmin-associated restrictive cardiomyopathy
  JOURNAL   Clin Genet 59 (4), 248-256 (2001)
   PUBMED   11298680
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Milner,D.J., Taffet,G.E., Wang,X., Pham,T., Tamura,T., Hartley,C.,
            Gerdes,A.M. and Capetanaki,Y.
  TITLE     The absence of desmin leads to cardiomyocyte hypertrophy and
            cardiac dilation with compromised systolic function
  JOURNAL   J Mol Cell Cardiol 31 (11), 2063-2076 (1999)
   PUBMED   10591032
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Yang,Q., Sanbe,A., Osinska,H., Hewett,T.E., Klevitsky,R. and
            Robbins,J.
  TITLE     In vivo modeling of myosin binding protein C familial hypertrophic
            cardiomyopathy
  JOURNAL   Circ Res 85 (9), 841-847 (1999)
   PUBMED   10532952
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   van der Flier,A., Gaspar,A.C., Thorsteinsdottir,S., Baudoin,C.,
            Groeneveld,E., Mummery,C.L. and Sonnenberg,A.
  TITLE     Spatial and temporal expression of the beta1D integrin during mouse
            development
  JOURNAL   Dev Dyn 210 (4), 472-486 (1997)
   PUBMED   9415431
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   van Groningen,J.J., Bloemers,H.P. and Swart,G.W.
  TITLE     Rat desmin gene structure and expression
  JOURNAL   Biochim Biophys Acta 1217 (1), 107-109 (1994)
   PUBMED   8286410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214848.1, BC061872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               JAXUCZ010000009.1  84299626-84300281
            657-717             JAXUCZ010000009.1  84301385-84301445
            718-813             JAXUCZ010000009.1  84301544-84301639
            814-975             JAXUCZ010000009.1  84301889-84302050
            976-1101            JAXUCZ010000009.1  84302218-84302343
            1102-1322           JAXUCZ010000009.1  84302789-84303009
            1323-1366           JAXUCZ010000009.1  84304929-84304972
            1367-1449           JAXUCZ010000009.1  84306372-84306454
            1450-2169           JAXUCZ010000009.1  84306625-84307344
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2169
                     /gene="Des"
                     /note="desmin"
                     /db_xref="GeneID:64362"
                     /db_xref="RGD:620686"
     exon            1..656
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1491
                     /gene="Des"
                     /codon_start=1
                     /product="desmin"
                     /protein_id="NP_071976.2"
                     /db_xref="GeneID:64362"
                     /db_xref="RGD:620686"
                     /translation="MSQAYSSSQRVSSYRRTFGGAPGFSLGSPLSSPVFPRAGFGTKG
                     SSSSVTSRVYQVSRTSGGAGGLGSLRASRLGTTRAPSYGAGELLDFSLADAVNQEFLA
                     TRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEEMRE
                     LRRQVEVLTNQRARVDVERDNLIDDLQRLKAKLQEEIQLREEAENNLAAFRADVDAAT
                     LARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDI
                     RAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEI
                     DALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLN
                     VKMALDVEIATYRKLLEGEESRINLPIQTFSALNFRETSPEQRGSEVHTKKTVMIKTI
                     ETRDGEVVSEATQQQHEVL"
     exon            657..717
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            718..813
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            814..975
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1101
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1322
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1366
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1449
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..2169
                     /gene="Des"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcttcata tccactctcc agccggctgc ccgcctgctg cctcctcttt gcgtccgctc
       61 agcctcgtcc acgccgccac catgagccag gcctactcgt ccagccagcg cgtgtcctcc
      121 taccgccgca ccttcggcgg cgccccgggc ttctcgctcg gttccccgct gagctctccg
      181 gtgttcccac gagcaggctt cggtaccaag ggctcctcga gctcagtgac atcccgcgtg
      241 taccaggtgt cgcgcacgtc gggcggggcc ggaggcttgg ggtcgctgcg ggctagccgg
      301 ctggggacca cccgagcacc atcctatggc gcgggcgagc tgctggactt ctcgctggcc
      361 gacgcagtga accaggagtt cctggccacg cgcaccaacg agaaggtgga gctgcaagag
      421 ctcaatgacc gcttcgccaa ctacatcgag aaggtgcgct ttttggaaca gcagaacgcc
      481 gcgctcgccg ccgaggtcaa ccggctcaag ggccgagagc cgactcgggt cgccgagctc
      541 tacgaggagg agatgcgaga gctgcggcgc caagtggagg tcctcaccaa ccagcgcgcc
      601 cgcgtcgacg tggagcgtga caacctgata gacgacctgc agaggctcaa ggccaagcta
      661 caggaggaaa tccaactgag agaagaagca gagaacaact tggctgcctt ccgagcggat
      721 gtggatgcag ccactctggc tcgaattgac ctagagcgca gaattgagtc actcaacgag
      781 gagattgcat tccttaagaa agtgcacgaa gaggagatcc gtgagctcca ggcccagctt
      841 caggaacagc aggtccaggt agagatggac atgtccaagc cagacctcac agccgccctc
      901 agggacatcc gtgctcagta tgagaccatt gcggctaaga acatctctga ggctgaagaa
      961 tggtacaagt ccaaggtttc agacttgact caggcagcca ataagaacaa cgatgcgctg
     1021 cgccaagcca agcaggagat gatggaatac cgacaccaga tccagtccta cacctgcgag
     1081 attgatgctc tcaagggcac caacgactcc ttgatgaggc agatgaggga gctggaggat
     1141 cgcttcgcca gcgaggccag tggctatcag gacaacatcg cgcgcctgga ggaggagatc
     1201 cgacacctaa aggatgagat ggcccgccat ctgcgggagt accaggatct gctcaatgtg
     1261 aagatggcct tggatgtgga gattgccacc taccggaagc tgctggaggg cgaggagagc
     1321 aggatcaacc ttccgatcca gaccttctct gctctcaact tccgagaaac cagccctgag
     1381 caaaggggtt ccgaagtcca caccaaaaag acagtgatga tcaagaccat tgagacccgg
     1441 gatggagagg tcgtcagcga ggccacacag caacaacatg aagtgctgta agccaggaat
     1501 tcagtgtcct ggccccgtcc tcactgcctc ctgaagccag ccttttccac tctcggatgt
     1561 cacacccagt cgcttttctc ctctcacagc ctctgaaccc tcctcacaat cacctctttg
     1621 tggtcttcat gctgcccagc ctcaggaaac ccctcagcca cctctgcaga ccctcccatg
     1681 agccctggct attggcaact gtcaagcctg gctcttaaga gagaacctag ctcaaggcct
     1741 gacccttttc cctgccatct ttgtgacctc tggcttagaa gggggtacca gagagggcga
     1801 tgggaccggc agggtcagga cagagctttg tggatatccc cacattcgac ccccagcctg
     1861 ggtcagagac agaatgaagc ctcagcgagc tgagatggag aagggggggc ctgaaaaatg
     1921 tcctcgtggc ccctctcttt cccaccccag ctcaggatag gcttggaaag caggggctgt
     1981 aagagagaac tggaaggtgc tggatgtggg agcaggagat acagaaggag agaggatggg
     2041 tgagaagttg gagaggaaag aagagagagg cagagagtgg gctcaggttg gtgggaggat
     2101 gccacctccc ctgcctgccc ctcccaccgc aggggccctg gacagaaaca ataaagagat
     2161 aagcacaaa
//
