LOCUS       NM_001109577            1357 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus derlin 3 (Derl3), mRNA.
ACCESSION   NM_001109577 XM_001070872 XM_001070957
VERSION     NM_001109577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H,
            Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H and Nishitoh
            H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H,
            Okiyoneda T, Kokame K, Kaneko M, Taura M, Miyata M, Chosa K, Koga
            T, Morino-Koga S, Wada I and Kai H.
  TITLE     STT3B-dependent posttranslational N-glycosylation as a surveillance
            system for secretory protein
  JOURNAL   Mol Cell 47 (1), 99-110 (2012)
   PUBMED   22607976
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N,
            Gude N, Hilton B, Wolkowicz R, Sussman MA and Glembotski CC.
  TITLE     Roles for endoplasmic reticulum-associated degradation and the
            novel endoplasmic reticulum stress response gene Derlin-3 in the
            ischemic heart
  JOURNAL   Circ Res 106 (2), 307-316 (2010)
   PUBMED   19940266
  REMARK    GeneRIF: Study describes a potentially protective role for Derl3 in
            the heart.
REFERENCE   5  (bases 1 to 1357)
  AUTHORS   Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K and Mori K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473988.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070872.1, XM_001070957.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO398849.1, DN934789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1357
                     /gene="Derl3"
                     /note="derlin 3"
                     /db_xref="GeneID:690315"
                     /db_xref="RGD:1597373"
     exon            1..120
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..714
                     /gene="Derl3"
                     /note="Der1-like domain family, member 3"
                     /codon_start=1
                     /product="derlin-3"
                     /protein_id="NP_001103047.2"
                     /db_xref="GeneID:690315"
                     /db_xref="RGD:1597373"
                     /translation="MAGQRLAADFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFN
                     PHLVFRKFQVWRLITTFLFFGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFL
                     FGGVLMTLLGFLGSMFFLGQALMAMLVYVWSRRSPHVRVNFFGLLNFQAPFLPWALMG
                     FSLLLGNSVITDLLGIIVGHIYYFLEDVFPNQPGGKRLLLTPSFLKLLLDDPQEDPNY
                     LPLPEEHPEA"
     exon            121..186
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     exon            187..260
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..354
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     exon            355..550
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..641
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..1357
                     /gene="Derl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcgcgc gcgctgaaga tttttcgatg gctgggcaga ggctggcggc ggatttcctg
       61 caggtgccgg cggtgacacg agcctacacc gcggcctgcg tcctcaccac ggccgcagtg
      121 cagctggagc tcctcagccc cttccagctc tacttcaacc cgcatctggt gttccggaag
      181 ttccaggtct ggaggctcat cactaccttc ctcttcttcg ggcccctggg attcggcttc
      241 tttttcaaca tgctcttcgt gttccgctac tgccgcatgc tggaggaggg ttctttccgt
      301 ggccgcaagg ccgacttcgt tttcatgttt ctcttcggtg gtgttcttat gactctgctg
      361 ggattcctgg gcagcatgtt tttcctggga caggccctca tggccatgct ggtctatgtg
      421 tggagccgtc gcagcccgca tgtgagggtc aacttctttg gcttactcaa cttccaggcg
      481 ccattcctgc cctgggccct catgggcttc tcgctgcttc tgggcaactc ggttatcaca
      541 gacctgctag ggatcattgt gggccacatc tactacttcc tagaagatgt ctttcccaac
      601 cagcctggag gcaagagact gctgctgacc cctagcttct tgaagctact actagatgac
      661 cctcaggagg accccaatta cctgcccctc cctgaggagc atccagaggc ctaactgcag
      721 ctcctggaac agtaagcgca ctctggtcag ccccaggctt tagacagcac tctatccttc
      781 ccctccacct cagctcgagc tgagcagcac tcggaaggct gggcctccct gcagccttgg
      841 tgcctcagcc agcaacacca tgcacttctc tgtatcgtct ctccgctcaa ccacagtgac
      901 aggacacgga gcccagagag gcctaagact gcctagagat gcccggcaga gttctgaact
      961 acagacccaa ggactcatct tcacgctgtc tgtctgtcag ggtcttgatg gggacctcag
     1021 tcccagtcat tagagctggt gccatccgcc tagcctgtct ttgtcctcac cttctctagc
     1081 tggtcccatg gacaagtttg gctctctgcc atgctagtga gcccagggcc ttgagctcta
     1141 tttaagcagc agcccgggta cagcagaggt agttctggga catcccatct gtcttgcagc
     1201 tgaaggcctg tgtgggcagg tgtccctacc tggttttcct tgttggtata catctgcccc
     1261 acggggctta ctcctgaatg cccacccaac agcatgggaa ttccccgtac cattgcctgt
     1321 catttctatg gtaacaaaaa tgttttctac tgagtct
//
