LOCUS       NM_001399430            3657 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus derlin 2 (Derl2), mRNA.
ACCESSION   NM_001399430 XM_008767902
VERSION     NM_001399430.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3657)
  AUTHORS   Kadowaki,H., Nagai,A., Maruyama,T., Takami,Y., Satrimafitrah,P.,
            Kato,H., Honda,A., Hatta,T., Natsume,T., Sato,T., Kai,H., Ichijo,H.
            and Nishitoh,H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   2  (bases 1 to 3657)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   3  (bases 1 to 3657)
  AUTHORS   Tiwari,A., Schuiki,I., Zhang,L., Allister,E.M., Wheeler,M.B. and
            Volchuk,A.
  TITLE     SDF2L1 interacts with the ER-associated degradation machinery and
            retards the degradation of mutant proinsulin in pancreatic
            beta-cells
  JOURNAL   J Cell Sci 126 (Pt 9), 1962-1968 (2013)
   PUBMED   23444373
REFERENCE   4  (bases 1 to 3657)
  AUTHORS   Dougan,S.K., Hu,C.C., Paquet,M.E., Greenblatt,M.B., Kim,J.,
            Lilley,B.N., Watson,N. and Ploegh,H.L.
  TITLE     Derlin-2-deficient mice reveal an essential role for protein
            dislocation in chondrocytes
  JOURNAL   Mol Cell Biol 31 (6), 1145-1159 (2011)
   PUBMED   21220515
REFERENCE   5  (bases 1 to 3657)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3657)
  AUTHORS   Schaheen,B., Dang,H. and Fares,H.
  TITLE     Derlin-dependent accumulation of integral membrane proteins at cell
            surfaces
  JOURNAL   J Cell Sci 122 (Pt 13), 2228-2239 (2009)
   PUBMED   19509052
REFERENCE   7  (bases 1 to 3657)
  AUTHORS   Oda,Y., Okada,T., Yoshida,H., Kaufman,R.J., Nagata,K. and Mori,K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   8  (bases 1 to 3657)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
REFERENCE   9  (bases 1 to 3657)
  AUTHORS   Ying,H., Yu,Y. and Xu,Y.
  TITLE     Cloning and characterization of F-LANa, upregulated in human liver
            cancer
  JOURNAL   Biochem Biophys Res Commun 286 (2), 394-400 (2001)
   PUBMED   11500051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 7, 2022 this sequence version replaced XM_008767902.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.35707.1,
                                           SRR26643291.28295.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000010.1  56237880-56237993   c
            115-180             JAXUCZ010000010.1  56237035-56237100   c
            181-254             JAXUCZ010000010.1  56234288-56234361   c
            255-348             JAXUCZ010000010.1  56233121-56233214   c
            349-544             JAXUCZ010000010.1  56232059-56232254   c
            545-635             JAXUCZ010000010.1  56231723-56231813   c
            636-3657            JAXUCZ010000010.1  56226340-56229361   c
FEATURES             Location/Qualifiers
     source          1..3657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3657
                     /gene="Derl2"
                     /note="derlin 2"
                     /db_xref="GeneID:100910823"
                     /db_xref="RGD:6496100"
     exon            1..114
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..741
                     /gene="Derl2"
                     /note="Der1-like domain family, member 2; derlin-2-like"
                     /codon_start=1
                     /product="derlin-2"
                     /protein_id="NP_001386359.1"
                     /db_xref="GeneID:100910823"
                     /db_xref="RGD:6496100"
                     /translation="MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFN
                     PELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFL
                     FGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMG
                     FSLLLGNSIIVDLLGIAVGHIYFFLEDIFPNQPGGIRILKTPSILRTIFDTPDEDPNY
                     NPLPEERPGGFAWGEGQRLGG"
     exon            115..180
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..254
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..348
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..544
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..635
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..3657
                     /gene="Derl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcaggcg cggtgggaaa gatggcgtac cagagtctcc ggctggagta cctgcagatc
       61 ccgccggtca gccgcgccta cactaccgcc tgcgtcctca ccactgcggc cgtgcagttg
      121 gaattgatca caccttttca gttatacttc aatcctgaat taatttttaa gcactttcaa
      181 atctggaggc taatcaccaa tttcttattt tttggtccag ttggattcaa ttttttgttt
      241 aacatgattt ttctatatcg ttattgtcga atgctagaag aaggctcctt ccgaggtcgg
      301 acagcagact ttgtatttat gttccttttt ggtggatttt taatgactct ttttggtttg
      361 tttgtgagct tagttttttt aggccaggcc tttacaataa tgctggtcta cgtgtggagc
      421 cgacggaacc catatgtccg catgaacttc tttggtcttc taaacttcca ggcccccttt
      481 ctgccctggg tgctcatggg gttctccttg ttgctgggga actcgattat agtggacctt
      541 ttgggtattg cagttgggca tatatatttt ttcttggaag atatatttcc caatcagcct
      601 ggtggaataa gaattctgaa aacgccatct attttgagga ctatttttga tacaccagat
      661 gaggatccca attacaaccc actacctgaa gagcggccag gaggcttcgc ctggggtgag
      721 ggccagcgcc ttggagggta aagcagctgt gccaattacg agacccatct gagaaagact
      781 cagtgaaatg tccattggga tcttttatcc cttgttgcaa aagcgtcgac agttttgaca
      841 gcttgacata tttttaactc cagaagcact ttacgggatg gtacactgac taacacagaa
      901 gacatttcca gcagtttgcc aggggttcct cactatgctg gtactaaaag tataacctct
      961 tggagccaaa aactggagaa acagataccc tgcctggtgt ctctaacaag tacgtgggta
     1021 cttgagcttg gtggcataag gcaaggtttt cctcctcctc tttgatagac aaggccgtgg
     1081 tgtaaatgga agttacagag aggacaaaat aaaactgaat tccatctctc tcacactgta
     1141 tttaagcttt cgtgtgatct tttaatgtgt tctagctctc ctgcgtatgt ttgaacacag
     1201 cagtttccgt gcctgccctc acgtctccac ggctttcaac tggatttcat ttcaagattg
     1261 gaaatgcaca gctgttatgt acatctgact agttctagtt cagagtgcta gcctcagtgg
     1321 gaagaagatt ggtttctgcc attcagatag ttctccatct gaaaactatg aagcttcaag
     1381 tttagaccac agaaggaggg agaagggcag gtgatttctt gtagccaggg aatctgacta
     1441 tagagaagcc agctgtaaac aaaaacaact gtgacatctc tttgagctgg agtctctact
     1501 aagaaatacc cagattagca gtggccaccc tttgtcaaag cacaggagta agagtgggca
     1561 gcagttgggc atgcagtcct cttgtcattc atttcaggaa aagctcaaaa cctttccagg
     1621 cccaagtgcc tggttcacct tcccagtcca gtagaaatca gggtctttgg aaacagccac
     1681 actgatggtt cagtgaatac ttgtcaaaga tggttcatct cgtccgactc aagagcttta
     1741 catgcgtgct gctctgtcag aactcagaaa gatgattaag agagtgtgtt tcatgaacat
     1801 caaagaggca caggacgccc cagactggag cctcctattt aggctcagtt gcatttcaga
     1861 tgagattttt ctcaagggtt gacataggct aagtgagcta cagtaaacat ttgaggtgga
     1921 aagttccaga tagagttgaa gcggaacgta ttttaatgac taagtggaat ctgacaagga
     1981 gtggaacaag tgtggcttgt gtcctagtaa agagctgaag accattgtaa attcatggga
     2041 cggggccaat gggactgctt ttgtcttgct taaaaatctt taaagcgtaa tgacaatcct
     2101 agattgtatg atccttatgg gattcttaag tttgattatc attttttttg ttcaagaaag
     2161 ctttatcagt aacttttagg aatttatttt tattattatt gcttgctttt aagccagaaa
     2221 tgggtttctt tgaggtttta tttattttcc cttagttaat tttagatgta gctaattaat
     2281 ggagtaattg tgaccgattt ttaattctaa catctcttca ccagcttttt aaacatttta
     2341 aacagtgaat acctgtacat attaatgact gaaaaatgga aaatgtattt tggatgtata
     2401 gcctaaagcg gtctctgatt tttaggatgt gaattcctgg tggcaaaatg ccatgctgtg
     2461 tgccacaccg tctcctggca gtgcagatct cagtctcttg gcctctcagt agtttggcac
     2521 atctctggcc ctgggttgtt tgacaggatc cctgtgctca ctgggacatg aggaaaagtc
     2581 ctcacttccc caacaaacct cttgattctg attcttccaa aacaaacttt ctttttgtga
     2641 tgtgagttaa cagaaaagtg aggtcagatt atgggattct gtgaccactg aaacttacat
     2701 gaatatagtt tgaaccattt cctagattga ctgtaccaga aataaccgaa aagcacacca
     2761 aaagcatagg gcgttttgtt tcgttgttac aggaatacag tatatgttca tttgaaaatg
     2821 aatggacatg ccaattgcgt ctccatagga gatagatttt atatacttcg gtgtgttttt
     2881 ttcactatga atttttactt gttttttcca cttctttctc tgccattccg tgtcctcccg
     2941 tcttttatat ttcttttgta cttgcgtgag gcaaagtgtc cacatcctgg atcttgaaat
     3001 ggaaccataa cactgtcact agggtcctct gggaattagg aaacacattg gagctattgg
     3061 catgttgtgt aacatgcttc ctagagttgt catgccttcg gccactattt tattttgtgg
     3121 ctatattttc ctttcacagg tgagttctat ctgtgttagc taagattttg cccttccatc
     3181 ctcttcagga tgactaagct acttaagtat tttgagtttg cattaaagct cttgaacctt
     3241 gcttgtatcg ttgagccact ctgctccgaa gtctgcagtc atttcttagc ccttatcaaa
     3301 tgcatatttt gtgtctttct ctgagccctt ctcctacttc tccctagcag ggacgtcaat
     3361 ttaagtttct tcagtctttc aagaccctga cactaaaatc ttaaaactaa ggtctacttc
     3421 actgtcttct ttaaatcctt acgaagcttc aaatctgtac taaaattctt ataccaaatc
     3481 atatattgtc ttgtactgtt cttagctgct acatgtatgt tagttttgtt tccctcatga
     3541 gaatgtaagc tccttaaggg cagggactat gtcttaattt ttgtatccac cacagtgcct
     3601 agcactgtgc ttggcacatg ggtgctgaat aaatactttt gtttattgat cagcaaa
//
