LOCUS       NM_001014202            2789 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus derlin 1 (Derl1), mRNA.
ACCESSION   NM_001014202 XM_343242
VERSION     NM_001014202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Zhang X, Ge Y, Bukhari AA, Zhu Q, Shen Y, Li M, Sun H, Su D and
            Liang X.
  TITLE     Estrogen negatively regulates the renal epithelial sodium channel
            (ENaC) by promoting Derlin-1 expression and AMPK activation
  JOURNAL   Exp Mol Med 51 (5), 1-12 (2019)
   PUBMED   31113930
  REMARK    GeneRIF: The results demonstrated that the loss of estrogen
            elevated systolic blood pressure in ovariectomized (OVX) rats. OVX
            rat kidneys showed increased alpha-ENaC expression but decreased
            derlin-1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Osorio FG, Soria-Valles C, Santiago-Fernandez O, Bernal T,
            Mittelbrunn M, Colado E, Rodriguez F, Bonzon-Kulichenko E, Vazquez
            J, Porta-de-la-Riva M, Ceron J, Fueyo A, Li J, Green AR, Freije JM
            and Lopez-Otin C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H,
            Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H and Nishitoh
            H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   5  (bases 1 to 2789)
  AUTHORS   Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D and
            Lemberg MK.
  TITLE     Signal peptide peptidase functions in ERAD to cleave the unfolded
            protein response regulator XBP1u
  JOURNAL   EMBO J 33 (21), 2492-2506 (2014)
   PUBMED   25239945
REFERENCE   6  (bases 1 to 2789)
  AUTHORS   Wang Q, Li L and Ye Y.
  TITLE     Regulation of retrotranslocation by p97-associated deubiquitinating
            enzyme ataxin-3
  JOURNAL   J Cell Biol 174 (7), 963-971 (2006)
   PUBMED   17000876
REFERENCE   7  (bases 1 to 2789)
  AUTHORS   Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K and Mori K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   8  (bases 1 to 2789)
  AUTHORS   Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E and Rapoport
            TA.
  TITLE     Recruitment of the p97 ATPase and ubiquitin ligases to the site of
            retrotranslocation at the endoplasmic reticulum membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14132-14138 (2005)
   PUBMED   16186510
REFERENCE   9  (bases 1 to 2789)
  AUTHORS   Ye Y, Shibata Y, Yun C, Ron D and Rapoport TA.
  TITLE     A membrane protein complex mediates retro-translocation from the ER
            lumen into the cytosol
  JOURNAL   Nature 429 (6994), 841-847 (2004)
   PUBMED   15215856
REFERENCE   10 (bases 1 to 2789)
  AUTHORS   Lilley BN and Ploegh HL.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085877.1.
            
            On Apr 1, 2005 this sequence version replaced XM_343242.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085877.1, FQ218639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2789
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /note="derlin 1"
                     /db_xref="GeneID:362912"
                     /db_xref="RGD:1311835"
     exon            1..201
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..804
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /note="Der1-like domain family, member 1"
                     /codon_start=1
                     /product="derlin-1"
                     /protein_id="NP_001014224.1"
                     /db_xref="GeneID:362912"
                     /db_xref="RGD:1311835"
                     /translation="MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPE
                     AFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFML
                     LFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVIL
                     GFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVS
                     GFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ"
     exon            202..313
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            314..378
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            379..405
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            406..501
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            502..554
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            555..665
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
     exon            666..2765
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgggagga cgcgcggcgc tgcgcagccg tccacctgac gggcgaccat gtcggacatc
       61 ggggactggt tcaggagcat cccggccatc acgcgctact ggtttgctgc caccgtcgcg
      121 gtccccttga tcggcaagct cggtattatc agcccggcct acttcttcct ctggcccgaa
      181 gccttcctct atcgcttcca gatatggagg ccgttcactg ccacctttta tttccccgtg
      241 gggcccggaa ctggatttct ttatttggtc aatttatatt tcttatatca gtattctaca
      301 cggcttgagg caggagcttt tgacgggagg ccagcagact atttattcat gcttctcttc
      361 aactggatct gcattgttat tactggctta gccatggata tgcagttgct gatgattcct
      421 ctaatcatgt cagtacttta cgtctgggcc cagctgaaca gagacctgat tgtatcattt
      481 tggtttggaa cacgatttaa ggcctgttac ttaccttggg ttatcctcgg attcaactat
      541 atcattggag gctcggtcat caatgagctc attggaaacc ttgtcggaca tctttatttc
      601 ttcctgatgt tcagataccc aatggatttg ggaggaagga attttctgtc cacacctcag
      661 tttttgtacc gctggctacc cagcaggaga ggaggggtgt caggcttcgg tgtgccccct
      721 gcaagcatga ggcgagctgc tgatcagaat ggcggaggtg ggagacacaa ctggggccag
      781 ggcttccgac ttggagacca gtgaggagca gccctggcct gctcaccagc catgctaagc
      841 agatgacagt ctcctcccag tgctgggcac gcttaatggc cgagctcttg ctgccgctct
      901 tggacctgac ccacactgaa tgtagtcttt tggtacaaga cacattttta aatcccgaag
      961 gaaaatacaa gtgttcctca agtttcatga ttctcattca agtcctttct gctgtgaaga
     1021 gcaaatgtca gctgtgcaga tttcagaact gactcatgtt ctgctgtctt ctcctctccc
     1081 cttccttctg attaatgaac tgggcaagag gggctgatga gtcaaatcct ctcagaggac
     1141 cctctcctct ctcacacgtc cccaatcccg tcagaggacc ctctcctctc tcacacgtcc
     1201 ccagagctgc agctagcatt gtccacagaa ggattttgcc tttgacaaac ttactgactt
     1261 gccaaagctt ggtcacaaag agctggctca cacatggtcc ttggccatca ctggcaggac
     1321 tgtaactgta gggagaagat tggagcagca gaggaagaac tttctccgct gtggggcctg
     1381 cattagcctg tcagcagtgc tgccatttgc tgcctctcac atatttatac acaaaggcac
     1441 ctctgagtca gtgagggccc ggactgggag taacgaggat taggacttgt tgctaggcac
     1501 tcctatccct ctgagctgag tgatcaaaac catagtggag ttgctcctga cacaggggat
     1561 gggtttaatc acaatccctt gtgtttcttc atggggtgaa ctggctttgt gtgcccagag
     1621 cagctgtgct gtgctgtgct atgttaggag gttcctgatc acatggccag acagacacac
     1681 gtccctggag gcactgattc tgtttggtcc tcattgcggg tgtgttcatt cagtcggtgg
     1741 agaagagagg tttagactct aaatttttag ttaactgttt tttggaccat gccttttctg
     1801 gtcaagtgtt tatgttaatg ctaagggaag tgcctcttca gatgtgtgtt ggtcagtttt
     1861 taaggctaat ggaggcacat ctgaaggggt cactcgtaat tagaggttcc aatagcttta
     1921 ggatcatttg catttgaagg tcttcattac cttgggtcat gcatgtatac actttgtgaa
     1981 tcagacctgc tcccttttta taggtgggct tttgccagca gagctcagct tatcactaaa
     2041 taaagttttc tgaaggctcc agggctttac agttacttta tgctttcatt ctggaatcag
     2101 gctgctggct gcagtgggac gggccagtat gctctgaagg cttttgatac tttggttttt
     2161 cccttgagga aatgtgccca aacagggtga cttacccttc tctgctcatt aaaactgtga
     2221 tgtgtattat attaggaagt gggagtttga aaaagagctc cccctttctc atgtgtacct
     2281 ctccatattt aatttatatg ataaactatt gagtggagag aggctgatcc tgaaccatct
     2341 ggttctcctg ctgacctgag gctatgataa atgtgtgtct gtcagattca ggaaggattg
     2401 ccatttgagt gagcaggaga ttatgcttcg tcctggtacc aggctgtctc ctgagagcac
     2461 tggcttttct aaggatctgc aagtacagag agcttttctg tacagggaaa atgttcagaa
     2521 aattctttct cctggacatg attgggaagc tgataatttt attatcttgc ctggattact
     2581 agtccttcca agatagtttt accaaagtga gctgtttgag tattgacttc acaaggtaag
     2641 aattcacagt gggttctctt tatgaatgtg aaaaaaaaaa acccttattt tgtacagaca
     2701 gctttccttt ttgtaactaa tcctttttac tggtaaacat tgtaaattaa aatatgcaac
     2761 ttgaaaaaaa aaaaaaaaaa aaaaaaaaa
//
