LOCUS       NP_001014224             251 aa            linear   ROD 23-MAR-2023
DEFINITION  derlin-1 [Rattus norvegicus].
ACCESSION   NP_001014224 XP_343243
VERSION     NP_001014224.1
DBSOURCE    REFSEQ: accession NM_001014202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 251)
  AUTHORS   Zhang X, Ge Y, Bukhari AA, Zhu Q, Shen Y, Li M, Sun H, Su D and
            Liang X.
  TITLE     Estrogen negatively regulates the renal epithelial sodium channel
            (ENaC) by promoting Derlin-1 expression and AMPK activation
  JOURNAL   Exp Mol Med 51 (5), 1-12 (2019)
   PUBMED   31113930
  REMARK    GeneRIF: The results demonstrated that the loss of estrogen
            elevated systolic blood pressure in ovariectomized (OVX) rats. OVX
            rat kidneys showed increased alpha-ENaC expression but decreased
            derlin-1 expression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 251)
  AUTHORS   Osorio FG, Soria-Valles C, Santiago-Fernandez O, Bernal T,
            Mittelbrunn M, Colado E, Rodriguez F, Bonzon-Kulichenko E, Vazquez
            J, Porta-de-la-Riva M, Ceron J, Fueyo A, Li J, Green AR, Freije JM
            and Lopez-Otin C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
REFERENCE   3  (residues 1 to 251)
  AUTHORS   Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H,
            Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H and Nishitoh
            H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   4  (residues 1 to 251)
  AUTHORS   Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   5  (residues 1 to 251)
  AUTHORS   Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D and
            Lemberg MK.
  TITLE     Signal peptide peptidase functions in ERAD to cleave the unfolded
            protein response regulator XBP1u
  JOURNAL   EMBO J 33 (21), 2492-2506 (2014)
   PUBMED   25239945
REFERENCE   6  (residues 1 to 251)
  AUTHORS   Wang Q, Li L and Ye Y.
  TITLE     Regulation of retrotranslocation by p97-associated deubiquitinating
            enzyme ataxin-3
  JOURNAL   J Cell Biol 174 (7), 963-971 (2006)
   PUBMED   17000876
REFERENCE   7  (residues 1 to 251)
  AUTHORS   Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K and Mori K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   8  (residues 1 to 251)
  AUTHORS   Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E and Rapoport
            TA.
  TITLE     Recruitment of the p97 ATPase and ubiquitin ligases to the site of
            retrotranslocation at the endoplasmic reticulum membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14132-14138 (2005)
   PUBMED   16186510
REFERENCE   9  (residues 1 to 251)
  AUTHORS   Ye Y, Shibata Y, Yun C, Ron D and Rapoport TA.
  TITLE     A membrane protein complex mediates retro-translocation from the ER
            lumen into the cytosol
  JOURNAL   Nature 429 (6994), 841-847 (2004)
   PUBMED   15215856
REFERENCE   10 (residues 1 to 251)
  AUTHORS   Lilley BN and Ploegh HL.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085877.1.
            
            On Apr 1, 2005 this sequence version replaced XP_343243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085877.1, FQ218639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     Protein         1..251
                     /product="derlin-1"
                     /note="Der1-like domain family, member 1"
                     /calculated_mol_wt=28704
     Region          11..204
                     /region_name="DER1"
                     /note="Der1-like family; pfam04511"
                     /db_xref="CDD:427988"
     CDS             1..251
                     /gene="Derl1"
                     /gene_synonym="RGD1311835"
                     /coded_by="NM_001014202.1:49..804"
                     /db_xref="GeneID:362912"
                     /db_xref="RGD:1311835"
ORIGIN      
        1 msdigdwfrs ipaitrywfa atvavpligk lgiispayff lwpeaflyrf qiwrpftatf
       61 yfpvgpgtgf lylvnlyfly qystrleaga fdgrpadylf mllfnwiciv itglamdmql
      121 lmiplimsvl yvwaqlnrdl ivsfwfgtrf kacylpwvil gfnyiiggsv inelignlvg
      181 hlyfflmfry pmdlggrnfl stpqflyrwl psrrggvsgf gvppasmrra adqnggggrh
      241 nwgqgfrlgd q
//
